Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr15 | 99491894 | . | G | A | CCDS10378.1:NM_000875.3:c.3679Gag>Aag_NP_000866.1:p.1227E>K | Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6jk8 | 1 | P08069 | 100.0 | 0.0 |
EM |
2020-03-04 | GLU | A:1227 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:1227 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pyh | 1 | Q60751 | 95.96 | 0.0 |
EM |
2019-10-23 | GLU | A:1199 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | C:1199 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3lvp | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | GLU | A:277 | A:1227 | 153.0 | 0.805 | T | -99.2 | 13.1 | 153.0 | 0.805 | 0.0 | ||||||
| GLU | B:277 | B:1227 | 166.0 | 0.874 | T | -100.8 | 39.9 | NA | NA | NA | |||||||||||||
| GLU | C:277 | C:1227 | 176.0 | 0.926 | T | -66.2 | -0.8 | NA | NA | NA | |||||||||||||
| GLU | D:277 | D:1227 | 153.0 | 0.805 | H | -82.3 | -8.4 | NA | NA | NA | |||||||||||||
| 1m7n | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2003-01-07 | GLU | A:255 | A:1224 | 143.0 | 0.753 | T | -84.7 | -0.7 | 143.0 | 0.753 | 0.0 |
HOH |
3.763 |
CB |
O |
||
| GLU | B:255 | B:1224 | 117.0 | 0.616 | T | -89.4 | 8.0 | NA | NA | NA | |||||||||||||
| 1p4o | 1 | P08069 | 99.38 | 0.0 |
X-RAY |
2003-04-29 | GLU | A:255 | A:1197 | 136.0 | 0.716 | T | -88.3 | 5.6 | 136.0 | 0.716 | 0.0 |
HOH |
2.775 |
O |
O |
||
| GLU | B:255 | B:1197 | 151.0 | 0.795 | T | -90.8 | 9.6 | NA | NA | NA | |||||||||||||
| 5fxq | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | GLU | A:249 | A:1227 | 162.0 | 0.853 | T | -103.1 | 11.5 | 162.0 | 0.853 | 0.0 |
HOH |
4.202 |
O |
O |
||
| 5fxr | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | GLU | A:249 | A:1227 | 164.0 | 0.863 | T | -99.0 | 14.1 | 164.0 | 0.863 | 0.0 |
HOH |
3.167 |
O |
O |
||
| 1jqh | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2002-04-19 | GLU | A:249 | A:1227 | 151.0 | 0.795 | T | -91.5 | 8.4 | 151.0 | 0.795 | 0.0 |
HOH |
5.006 |
C |
O |
||
| GLU | B:249 | B:1227 | 150.0 | 0.789 | T | -91.7 | 9.3 | NA | NA | NA | |||||||||||||
| GLU | C:249 | C:1227 | 144.0 | 0.758 | T | -91.5 | 10.2 | NA | NA | NA | |||||||||||||
| 2zm3 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-06-10 | GLU | A:249 | A:1227 | 159.0 | 0.837 | T | -99.4 | 9.4 | 159.0 | 0.837 | 0.0 |
HOH |
2.725 |
OE1 |
O |
||
| GLU | B:249 | B:1227 | 159.0 | 0.837 | T | -97.5 | 10.4 | NA | NA | NA | |||||||||||||
| GLU | C:249 | C:1227 | 160.0 | 0.842 | T | -97.8 | 9.2 | NA | NA | NA | |||||||||||||
| GLU | D:249 | D:1227 | 163.0 | 0.858 | T | -94.3 | 8.9 | NA | NA | NA | |||||||||||||
| 3f5p | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-12-30 | GLU | A:249 | A:1227 | 159.0 | 0.837 | T | -89.0 | 11.3 | 159.0 | 0.837 | 0.0 | ||||||
| GLU | B:249 | B:1227 | 154.0 | 0.811 | T | -95.7 | 3.8 | NA | NA | NA | |||||||||||||
| GLU | C:249 | C:1227 | 170.0 | 0.895 | H | -87.8 | -13.5 | NA | NA | NA | |||||||||||||
| GLU | D:249 | D:1227 | 158.0 | 0.832 | H | -95.5 | -3.5 | NA | NA | NA | |||||||||||||
| GLU | E:249 | E:1227 | 176.0 | 0.926 | T | -79.1 | -0.3 | NA | NA | NA | |||||||||||||
| GLU | F:249 | F:1227 | 169.0 | 0.889 | T | -91.6 | 1.9 | NA | NA | NA | |||||||||||||
| GLU | G:249 | G:1227 | 170.0 | 0.895 | T | -94.6 | 7.5 | NA | NA | NA | |||||||||||||
| GLU | H:249 | H:1227 | 172.0 | 0.905 | T | -85.4 | -2.6 | NA | NA | NA | |||||||||||||
| GLU | I:249 | I:1227 | 169.0 | 0.889 | T | -92.7 | -5.9 | NA | NA | NA | |||||||||||||
| GLU | J:249 | J:1227 | 164.0 | 0.863 | T | -96.7 | 5.2 | NA | NA | NA | |||||||||||||
| GLU | K:249 | K:1227 | 159.0 | 0.837 | T | -97.8 | -3.6 | NA | NA | NA | |||||||||||||
| GLU | L:249 | M:1227 | 163.0 | 0.858 | T | -91.8 | -2.4 | NA | NA | NA | |||||||||||||
| GLU | M:249 | L:1227 | 156.0 | 0.821 | T | -89.0 | -11.3 | NA | NA | NA | |||||||||||||
| GLU | N:249 | R:1227 | 159.0 | 0.837 | T | -92.7 | 3.2 | NA | NA | NA | |||||||||||||
| GLU | O:249 | S:1227 | 145.0 | 0.763 | T | -96.5 | 7.7 | NA | NA | NA | |||||||||||||
| GLU | P:249 | T:1227 | 177.0 | 0.932 | T | -88.7 | 4.3 | NA | NA | NA | |||||||||||||
| 3i81 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2009-12-22 | GLU | A:248 | A:1197 | 160.0 | 0.842 | T | -85.2 | -0.3 | 160.0 | 0.842 | 0.0 |
HOH |
3.674 |
OE1 |
O |
||
| 5fxs | 1 | P08069 | 99.35 | 0.0 |
X-RAY |
2016-10-19 | GLU | A:249 | A:1227 | 112.0 | NA | T | -89.7 | 8.9 | 112.0 | NA | NA |
HOH |
5.274 |
C |
O |
||
| 2oj9 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2007-05-01 | GLU | A:248 | A:1197 | 126.0 | 0.663 | T | -97.8 | 24.3 | 126.0 | 0.663 | 0.0 |
HOH |
2.251 |
OE1 |
O |
||
| 3nw5 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLU | A:248 | A:1197 | 163.0 | 0.858 | T | -87.7 | 0.8 | 163.0 | 0.858 | 0.0 |
HOH |
3.454 |
OE2 |
O |
||
| 3nw6 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLU | A:248 | A:1197 | 164.0 | 0.863 | T | -90.1 | 16.4 | 164.0 | 0.863 | 0.0 |
HOH |
5.055 |
C |
O |
||
| 3nw7 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLU | A:248 | A:1197 | 137.0 | 0.721 | T | -87.6 | 2.7 | 137.0 | 0.721 | 0.0 |
HOH |
3.982 |
CG |
O |
||
| 3o23 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2011-05-04 | GLU | A:246 | A:1227 | 128.0 | 0.674 | T | -102.1 | 12.9 | 128.0 | 0.674 | 0.0 |
HOH |
2.404 |
O |
O |
||
| 3lw0 | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2010-09-29 | GLU | A:245 | A:1227 | 138.0 | 0.726 | T | -86.9 | 13.8 | 138.0 | 0.726 | 0.0 |
HOH |
2.502 |
OE1 |
O |
||
| GLU | B:245 | B:1227 | 136.0 | 0.716 | T | -87.9 | 14.2 | NA | NA | NA | |||||||||||||
| GLU | C:245 | C:1227 | 136.0 | 0.716 | T | -86.0 | 12.9 | NA | NA | NA | |||||||||||||
| GLU | D:245 | D:1227 | 133.0 | 0.7 | T | -88.1 | 13.0 | NA | NA | NA | |||||||||||||
| 5hzn | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2016-04-06 | GLU | A:245 | A:1224 | 149.0 | 0.784 | T | -93.5 | 10.4 | 149.0 | 0.784 | 0.0 |
HOH |
2.589 |
OE2 |
O |
||
| GLU | B:245 | B:1224 | 150.0 | 0.789 | T | -94.1 | 9.6 | NA | NA | NA | |||||||||||||
| GLU | C:245 | C:1224 | 152.0 | 0.8 | T | -91.0 | 9.6 | NA | NA | NA | |||||||||||||
| GLU | D:245 | D:1224 | 149.0 | 0.784 | T | -91.5 | 8.2 | NA | NA | NA | |||||||||||||
| GLU | E:245 | E:1224 | 148.0 | 0.779 | T | -94.1 | 11.5 | NA | NA | NA | |||||||||||||
| GLU | F:245 | F:1224 | 148.0 | 0.779 | T | -94.9 | 9.6 | NA | NA | NA | |||||||||||||
| GLU | G:245 | G:1224 | 147.0 | 0.774 | T | -91.1 | 8.0 | NA | NA | NA | |||||||||||||
| GLU | H:245 | H:1224 | 150.0 | 0.789 | T | -96.2 | 10.4 | NA | NA | NA | |||||||||||||
| 4d2r | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2015-04-22 | GLU | A:243 | A:1227 | 158.0 | 0.832 | T | -88.9 | 5.5 | 158.0 | 0.832 | 0.0 |
HOH |
3.780 |
CB |
O |
||
| 3d94 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2008-07-29 | GLU | A:242 | A:1197 | 129.0 | 0.679 | T | -97.2 | 15.8 | 129.0 | 0.679 | 0.0 |
HOH |
2.951 |
O |
O |
||
| 3qqu | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2011-04-20 | GLU | A:242 | A:1224 | 141.0 | 0.742 | T | -93.4 | 2.9 | 141.0 | 0.742 | 0.0 |
HOH |
6.470 |
C |
O |
||
| GLU | B:242 | B:1224 | 130.0 | 0.684 | T | -117.1 | 9.1 | NA | NA | NA | |||||||||||||
| GLU | C:242 | C:1224 | 146.0 | 0.768 | T | -101.0 | 17.2 | NA | NA | NA | |||||||||||||
| GLU | D:242 | D:1224 | 155.0 | 0.816 | T | -83.2 | 2.7 | NA | NA | NA | |||||||||||||
| 1k3a | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2001-11-28 | GLU | A:240 | A:1197 | 161.0 | 0.847 | T | -92.3 | -0.3 | 161.0 | 0.847 | 0.0 |
HOH |
5.110 |
C |
O |
||
| 2z8c | 1 | P06213 | 80.2 | 1e-175 |
X-RAY |
2008-08-12 | ASP | A:244 | A:1224 | 143.0 | 0.953 | H | -58.0 | -43.8 | 143.0 | 0.953 | 0.0 | ||||||
| 1gag | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2001-01-17 | ASP | A:247 | A:1224 | 106.0 | 0.707 | T | -91.8 | 7.6 | 106.0 | 0.707 | 0.0 |
HOH |
5.244 |
C |
O |
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| 1ir3 | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1998-01-07 | ASP | A:247 | A:1224 | 104.0 | 0.693 | T | -76.6 | -1.9 | 104.0 | 0.693 | 0.0 |
HOH |
3.775 |
C |
O |
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| 1irk | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1995-02-27 | ASP | A:247 | A:1224 | 110.0 | 0.733 | T | -79.8 | -6.1 | 110.0 | 0.733 | 0.0 |
HOH |
2.611 |
OD1 |
O |
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| 5e1s | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2015-10-14 | ASP | A:249 | A:1224 | 113.0 | 0.753 | T | -82.0 | -0.0 | 113.0 | 0.753 | 0.0 |
HOH |
3.342 |
OD2 |
O |
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| 1rqq | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2003-12-30 | ASP | A:247 | A:1224 | 114.0 | 0.76 | T | -95.5 | 15.3 | 114.0 | 0.76 | 0.0 |
HOH |
9.719 |
N |
O |
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| ASP | B:247 | B:1224 | 113.0 | 0.753 | T | -94.8 | 13.9 | 113.0 | 0.753 | 0.0 |
HOH |
4.995 |
N |
O |
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| 2auh | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-01 | ASP | A:247 | A:1224 | 104.0 | 0.693 | T | -80.4 | -12.5 | 104.0 | 0.693 | 0.0 | ||||||
| 2b4s | 2 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-15 | ASP | B:247 | B:1224 | 105.0 | 0.7 | T | -83.0 | 14.4 | 105.0 | 0.7 | 0.0 |
HOH |
5.069 |
C |
O |
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| ASP | D:247 | D:1224 | 109.0 | 0.727 | T | -96.7 | 13.1 | 109.0 | 0.727 | 0.0 |
HOH |
5.055 |
C |
O |
|||||||||
| 3bu3 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | ASP | A:247 | A:1224 | 147.0 | 0.98 | T | -86.4 | 5.1 | 147.0 | 0.98 | 0.0 |
HOH |
3.352 |
OD2 |
O |
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| 3bu5 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | ASP | A:247 | A:1224 | 150.0 | 1.0 | T | -90.2 | 5.7 | 150.0 | 1.0 | 0.0 |
HOH |
2.724 |
OD1 |
O |
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| 3bu6 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | ASP | A:247 | A:1224 | 147.0 | 0.98 | T | -88.0 | 11.1 | 147.0 | 0.98 | 0.0 |
HOH |
2.951 |
CB |
O |
||
| 5hhw | 1 | P06213 | 80.2 | 4e-175 |
X-RAY |
2016-04-13 | ASP | A:248 | A:1251 | 112.0 | 0.747 | T | -75.7 | -13.0 | 112.0 | 0.747 | 0.0 |
HOH |
2.699 |
OD2 |
O |
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| 4ibm | 1 | P06213 | 80.73 | 8e-175 |
X-RAY |
2013-08-21 | ASP | A:247 | A:1224 | 110.0 | 0.733 | T | -83.6 | 2.3 | 110.0 | 0.733 | 0.0 |
HOH |
2.836 |
OD1 |
O |
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| ASP | B:247 | B:1224 | 110.0 | 0.733 | T | -82.6 | -0.6 | NA | NA | NA | |||||||||||||
| 3eta | 1 | P06213 | 80.41 | 2e-170 |
X-RAY |
2009-05-26 | ASP | A:246 | A:1224 | 119.0 | 0.793 | T | -85.2 | -1.5 | 119.0 | 0.793 | 0.0 |
HOH |
5.019 |
C |
O |
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| ASP | B:246 | B:1224 | 148.0 | 0.987 | T | -92.7 | 7.1 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p08069-f1 | 1 | P08069 | 100.0 | 0.0 | GLU | A:1227 | A:1227 | 159.0 | 0.837 | T | -88.9 | 1.7 | |