Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr15 | 99491900 | . | G | A | CCDS10378.1:NM_000875.3:c.3685Ggc>Agc_NP_000866.1:p.1229G>S | Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6jk8 | 1 | P08069 | 100.0 | 0.0 |
EM |
2020-03-04 | GLY | A:1229 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLY | B:1229 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pyh | 1 | Q60751 | 95.96 | 0.0 |
EM |
2019-10-23 | GLY | A:1201 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLY | C:1201 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3lvp | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | GLY | A:279 | A:1229 | 12.0 | 0.16 | -60.6 | 161.6 | 12.0 | 0.16 | 0.0 | |||||||
| GLY | B:279 | B:1229 | 6.0 | 0.08 | -64.8 | 154.9 | NA | NA | NA | ||||||||||||||
| GLY | C:279 | C:1229 | 12.0 | 0.16 | -70.2 | 157.9 | NA | NA | NA | ||||||||||||||
| GLY | D:279 | D:1229 | 11.0 | 0.147 | -59.2 | 154.6 | NA | NA | NA | ||||||||||||||
| 1m7n | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2003-01-07 | GLY | A:257 | A:1226 | 14.0 | 0.187 | -76.4 | 134.1 | 14.0 | 0.187 | 0.0 |
HOH |
2.602 |
O |
O |
|||
| GLY | B:257 | B:1226 | 9.0 | 0.12 | -67.6 | 144.0 | NA | NA | NA | ||||||||||||||
| 1p4o | 1 | P08069 | 99.38 | 0.0 |
X-RAY |
2003-04-29 | GLY | A:257 | A:1199 | 13.0 | 0.173 | -68.0 | 150.5 | 13.0 | 0.173 | 0.0 |
HOH |
2.688 |
O |
O |
|||
| GLY | B:257 | B:1199 | 13.0 | 0.173 | -65.5 | 151.4 | NA | NA | NA | ||||||||||||||
| 5fxq | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | GLY | A:251 | A:1229 | 13.0 | 0.173 | -64.0 | 147.4 | 13.0 | 0.173 | 0.0 |
HOH |
2.897 |
O |
O |
|||
| 5fxr | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | GLY | A:251 | A:1229 | 13.0 | 0.173 | -65.6 | 153.9 | 13.0 | 0.173 | 0.0 |
HOH |
2.854 |
O |
O |
|||
| 1jqh | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2002-04-19 | GLY | A:251 | A:1229 | 10.0 | 0.133 | -69.0 | 146.0 | 10.0 | 0.133 | 0.0 |
HOH |
2.723 |
O |
O |
|||
| GLY | B:251 | B:1229 | 10.0 | 0.133 | -69.6 | 148.1 | NA | NA | NA | ||||||||||||||
| GLY | C:251 | C:1229 | 9.0 | 0.12 | -68.3 | 148.5 | NA | NA | NA | ||||||||||||||
| 2zm3 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-06-10 | GLY | A:251 | A:1229 | 16.0 | 0.213 | -69.3 | 152.1 | 16.0 | 0.213 | 0.0 |
HOH |
2.801 |
O |
O |
|||
| GLY | B:251 | B:1229 | 13.0 | 0.173 | -64.2 | 150.0 | NA | NA | NA | ||||||||||||||
| GLY | C:251 | C:1229 | 17.0 | 0.227 | -60.1 | 154.0 | NA | NA | NA | ||||||||||||||
| GLY | D:251 | D:1229 | 16.0 | 0.213 | -60.8 | 152.7 | NA | NA | NA | ||||||||||||||
| 3f5p | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-12-30 | GLY | A:251 | A:1229 | 11.0 | 0.147 | -51.5 | 148.7 | 11.0 | 0.147 | 0.0 | |||||||
| GLY | B:251 | B:1229 | 11.0 | 0.147 | -54.5 | 150.6 | NA | NA | NA | ||||||||||||||
| GLY | C:251 | C:1229 | 13.0 | 0.173 | -60.1 | 148.0 | NA | NA | NA | ||||||||||||||
| GLY | D:251 | D:1229 | 14.0 | 0.187 | -66.0 | 156.0 | NA | NA | NA | ||||||||||||||
| GLY | E:251 | E:1229 | 11.0 | 0.147 | -62.5 | 157.9 | NA | NA | NA | ||||||||||||||
| GLY | F:251 | F:1229 | 11.0 | 0.147 | -67.3 | 142.9 | NA | NA | NA | ||||||||||||||
| GLY | G:251 | G:1229 | 11.0 | 0.147 | -55.0 | 153.7 | NA | NA | NA | ||||||||||||||
| GLY | H:251 | H:1229 | 13.0 | 0.173 | -56.8 | 152.7 | NA | NA | NA | ||||||||||||||
| GLY | I:251 | I:1229 | 12.0 | 0.16 | -69.1 | 149.5 | NA | NA | NA | ||||||||||||||
| GLY | J:251 | J:1229 | 12.0 | 0.16 | -68.6 | 154.2 | NA | NA | NA | ||||||||||||||
| GLY | K:251 | K:1229 | 13.0 | 0.173 | -54.6 | 146.6 | NA | NA | NA | ||||||||||||||
| GLY | L:251 | M:1229 | 13.0 | 0.173 | -57.1 | 157.1 | NA | NA | NA | ||||||||||||||
| GLY | M:251 | L:1229 | 15.0 | 0.2 | -58.3 | 151.8 | NA | NA | NA | ||||||||||||||
| GLY | N:251 | R:1229 | 15.0 | 0.2 | -56.8 | 166.2 | NA | NA | NA | ||||||||||||||
| GLY | O:251 | S:1229 | 14.0 | 0.187 | -66.9 | 143.1 | NA | NA | NA | ||||||||||||||
| GLY | P:251 | T:1229 | 13.0 | 0.173 | -60.2 | 153.5 | NA | NA | NA | ||||||||||||||
| 3i81 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2009-12-22 | GLY | A:250 | A:1199 | 13.0 | 0.173 | -71.0 | 146.4 | 13.0 | 0.173 | 0.0 |
HOH |
2.737 |
O |
O |
|||
| 5fxs | 1 | P08069 | 99.35 | 0.0 |
X-RAY |
2016-10-19 | GLY | A:251 | A:1229 | 13.0 | 0.173 | -69.3 | 147.9 | 13.0 | 0.173 | 0.0 |
HOH |
3.472 |
CA |
O |
|||
| 2oj9 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2007-05-01 | GLY | A:250 | A:1199 | 8.0 | 0.107 | -69.0 | 145.2 | 8.0 | 0.107 | 0.0 |
HOH |
2.822 |
O |
O |
|||
| 3nw5 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLY | A:250 | A:1199 | 11.0 | 0.147 | -79.6 | 144.8 | 11.0 | 0.147 | 0.0 |
HOH |
2.759 |
O |
O |
|||
| 3nw6 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLY | A:250 | A:1199 | 14.0 | 0.187 | -72.4 | 151.8 | 14.0 | 0.187 | 0.0 |
HOH |
2.715 |
O |
O |
|||
| 3nw7 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLY | A:250 | A:1199 | 11.0 | 0.147 | -75.0 | 148.2 | 11.0 | 0.147 | 0.0 |
HOH |
2.650 |
O |
O |
|||
| 3o23 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2011-05-04 | GLY | A:248 | A:1229 | 13.0 | 0.173 | -73.1 | 150.8 | 13.0 | 0.173 | 0.0 |
HOH |
2.827 |
O |
O |
|||
| 3lw0 | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2010-09-29 | GLY | A:247 | A:1229 | 15.0 | 0.2 | -74.9 | 150.0 | 15.0 | 0.2 | 0.0 |
HOH |
2.903 |
O |
O |
|||
| GLY | B:247 | B:1229 | 15.0 | 0.2 | -76.8 | 151.5 | NA | NA | NA | ||||||||||||||
| GLY | C:247 | C:1229 | 15.0 | 0.2 | -76.4 | 151.7 | NA | NA | NA | ||||||||||||||
| GLY | D:247 | D:1229 | 14.0 | 0.187 | -75.1 | 149.0 | NA | NA | NA | ||||||||||||||
| 5hzn | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2016-04-06 | GLY | A:247 | A:1226 | 13.0 | 0.173 | -62.1 | 145.6 | 13.0 | 0.173 | 0.0 |
HOH |
2.792 |
O |
O |
|||
| GLY | B:247 | B:1226 | 12.0 | 0.16 | -60.0 | 146.4 | NA | NA | NA | ||||||||||||||
| GLY | C:247 | C:1226 | 13.0 | 0.173 | -53.6 | 141.7 | NA | NA | NA | ||||||||||||||
| GLY | D:247 | D:1226 | 13.0 | 0.173 | -62.5 | 148.0 | NA | NA | NA | ||||||||||||||
| GLY | E:247 | E:1226 | 12.0 | 0.16 | -63.3 | 145.3 | NA | NA | NA | ||||||||||||||
| GLY | F:247 | F:1226 | 12.0 | 0.16 | -62.3 | 147.9 | NA | NA | NA | ||||||||||||||
| GLY | G:247 | G:1226 | 14.0 | 0.187 | -58.1 | 143.3 | NA | NA | NA | ||||||||||||||
| GLY | H:247 | H:1226 | 12.0 | 0.16 | -59.7 | 145.8 | NA | NA | NA | ||||||||||||||
| 4d2r | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2015-04-22 | GLY | A:245 | A:1229 | 13.0 | 0.173 | -67.9 | 144.8 | 13.0 | 0.173 | 0.0 |
HOH |
2.734 |
O |
O |
|||
| 3d94 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2008-07-29 | GLY | A:244 | A:1199 | 13.0 | 0.173 | -67.0 | 146.9 | 13.0 | 0.173 | 0.0 |
HOH |
2.877 |
O |
O |
|||
| 3qqu | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2011-04-20 | GLY | A:244 | A:1226 | 11.0 | 0.147 | -94.4 | 155.0 | 11.0 | 0.147 | 0.0 |
HOH |
4.519 |
O |
O |
|||
| GLY | B:244 | B:1226 | 8.0 | 0.107 | -80.9 | 144.8 | NA | NA | NA | ||||||||||||||
| GLY | C:244 | C:1226 | 14.0 | 0.187 | -66.9 | 150.6 | NA | NA | NA | ||||||||||||||
| GLY | D:244 | D:1226 | 16.0 | 0.213 | -77.1 | 155.4 | NA | NA | NA | ||||||||||||||
| 1k3a | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2001-11-28 | GLY | A:242 | A:1199 | 14.0 | 0.187 | -74.1 | 157.5 | 14.0 | 0.187 | 0.0 |
HOH |
2.761 |
O |
O |
|||
| 2z8c | 1 | P06213 | 80.2 | 1e-175 |
X-RAY |
2008-08-12 | GLY | A:246 | A:1226 | 12.0 | 0.16 | -85.9 | 171.0 | 12.0 | 0.16 | 0.0 | |||||||
| 1gag | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2001-01-17 | GLY | A:249 | A:1226 | 10.0 | 0.133 | -73.7 | 165.7 | 10.0 | 0.133 | 0.0 |
HOH |
2.657 |
O |
O |
|||
| 1ir3 | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1998-01-07 | GLY | A:249 | A:1226 | 10.0 | 0.133 | -82.2 | 165.6 | 10.0 | 0.133 | 0.0 |
HOH |
2.775 |
O |
O |
|||
| 1irk | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1995-02-27 | GLY | A:249 | A:1226 | 15.0 | 0.2 | -67.9 | 158.8 | 15.0 | 0.2 | 0.0 |
HOH |
2.450 |
O |
O |
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| 5e1s | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2015-10-14 | GLY | A:251 | A:1226 | 12.0 | 0.16 | -71.6 | 149.4 | 12.0 | 0.16 | 0.0 |
HOH |
2.746 |
O |
O |
|||
| 1rqq | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2003-12-30 | GLY | A:249 | A:1226 | 16.0 | 0.213 | -74.7 | 168.8 | 16.0 | 0.213 | 0.0 |
HOH |
5.144 |
O |
O |
|||
| GLY | B:249 | B:1226 | 10.0 | 0.133 | -76.6 | 167.6 | 10.0 | 0.133 | 0.0 |
HOH |
5.076 |
O |
O |
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| 2auh | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-01 | GLY | A:249 | A:1226 | 11.0 | 0.147 | -89.3 | 159.0 | 11.0 | 0.147 | 0.0 | |||||||
| 2b4s | 2 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-15 | GLY | B:249 | B:1226 | 11.0 | 0.147 | -90.0 | 165.9 | 11.0 | 0.147 | 0.0 |
HOH |
2.680 |
O |
O |
|||
| GLY | D:249 | D:1226 | 11.0 | 0.147 | -95.6 | 155.7 | 11.0 | 0.147 | 0.0 |
HOH |
2.739 |
O |
O |
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| 3bu3 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | GLY | A:249 | A:1226 | 11.0 | 0.147 | -73.7 | 153.0 | 11.0 | 0.147 | 0.0 |
HOH |
2.772 |
O |
O |
|||
| 3bu5 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | GLY | A:249 | A:1226 | 10.0 | 0.133 | -68.8 | 146.0 | 10.0 | 0.133 | 0.0 |
HOH |
2.757 |
O |
O |
|||
| 3bu6 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | GLY | A:249 | A:1226 | 10.0 | 0.133 | -73.0 | 153.6 | 10.0 | 0.133 | 0.0 |
HOH |
2.740 |
O |
O |
|||
| 5hhw | 1 | P06213 | 80.2 | 4e-175 |
X-RAY |
2016-04-13 | GLY | A:250 | A:1253 | 13.0 | 0.173 | -76.4 | 154.2 | 13.0 | 0.173 | 0.0 |
HOH |
2.848 |
O |
O |
|||
| 4ibm | 1 | P06213 | 80.73 | 8e-175 |
X-RAY |
2013-08-21 | GLY | A:249 | A:1226 | 14.0 | 0.187 | -76.0 | 157.9 | 14.0 | 0.187 | 0.0 |
HOH |
2.778 |
O |
O |
|||
| GLY | B:249 | B:1226 | 12.0 | 0.16 | -73.8 | 155.7 | NA | NA | NA | ||||||||||||||
| 3eta | 1 | P06213 | 80.41 | 2e-170 |
X-RAY |
2009-05-26 | GLY | A:248 | A:1226 | 12.0 | 0.16 | -75.4 | 148.0 | 12.0 | 0.16 | 0.0 |
HOH |
2.688 |
O |
O |
|||
| GLY | B:248 | B:1226 | 12.0 | 0.16 | -74.2 | 157.9 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p08069-f1 | 1 | P08069 | 100.0 | 0.0 | GLY | A:1229 | A:1229 | 15.0 | 0.2 | -71.1 | 139.9 | ||