Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr15 | 99500414 | . | G | A | CCDS10378.1:NM_000875.3:c.3847Gag>Aag_NP_000866.1:p.1283E>K | Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6jk8 | 1 | P08069 | 100.0 | 0.0 |
EM |
2020-03-04 | GLU | A:1283 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:1283 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pyh | 1 | Q60751 | 95.96 | 0.0 |
EM |
2019-10-23 | GLU | A:1255 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | C:1255 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3lvp | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | GLU | A:333 | A:1283 | 159.0 | 0.837 | T | -84.9 | -3.0 | 159.0 | 0.837 | 0.0 | ||||||
| GLU | B:333 | B:1283 | 195.0 | 1.0 | T | -80.2 | 11.5 | NA | NA | NA | |||||||||||||
| GLU | C:333 | C:1283 | 172.0 | 0.905 | T | -74.9 | -40.9 | NA | NA | NA | |||||||||||||
| GLU | D:333 | D:1283 | 191.0 | 1.0 | T | -69.0 | -39.7 | NA | NA | NA | |||||||||||||
| 1m7n | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2003-01-07 | GLU | A:311 | A:1280 | 173.0 | 0.911 | T | -45.7 | -65.7 | 173.0 | 0.911 | 0.0 |
HOH |
6.754 |
N |
O |
||
| GLU | B:311 | B:1280 | 199.0 | 1.0 | T | -64.3 | -8.0 | NA | NA | NA | |||||||||||||
| 1p4o | 1 | P08069 | 99.38 | 0.0 |
X-RAY |
2003-04-29 | GLU | A:311 | A:1253 | 188.0 | 0.989 | T | -71.9 | -13.2 | 188.0 | 0.989 | 0.0 |
HOH |
4.318 |
O |
O |
||
| GLU | B:311 | B:1253 | 170.0 | 0.895 | G | -66.4 | -27.5 | NA | NA | NA | |||||||||||||
| 5fxq | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | GLU | A:305 | A:1283 | 184.0 | 0.968 | T | -68.6 | -13.6 | 184.0 | 0.968 | 0.0 |
HOH |
2.474 |
N |
O |
||
| 5fxr | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2016-10-19 | GLU | A:305 | A:1283 | 149.0 | NA | -79.2 | 360.0 | 149.0 | NA | NA |
HOH |
2.467 |
N |
O |
|||
| 1jqh | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2002-04-19 | GLU | A:305 | A:1283 | 191.0 | 1.0 | T | -71.5 | -28.0 | 191.0 | 1.0 | 0.0 |
HOH |
4.556 |
N |
O |
||
| GLU | B:305 | B:1283 | 194.0 | 1.0 | T | -71.1 | -30.8 | NA | NA | NA | |||||||||||||
| GLU | C:305 | C:1283 | 194.0 | 1.0 | T | -71.1 | -31.6 | NA | NA | NA | |||||||||||||
| 2zm3 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-06-10 | GLU | A:305 | A:1283 | 192.0 | 1.0 | S | -66.3 | -31.9 | 192.0 | 1.0 | 0.0 |
HOH |
2.963 |
OE2 |
O |
||
| GLU | B:305 | B:1283 | 196.0 | 1.0 | T | -66.2 | -30.8 | NA | NA | NA | |||||||||||||
| GLU | C:305 | C:1283 | 205.0 | 1.0 | T | -62.8 | -31.8 | NA | NA | NA | |||||||||||||
| GLU | D:305 | D:1283 | 198.0 | 1.0 | T | -65.3 | -32.5 | NA | NA | NA | |||||||||||||
| 3f5p | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2008-12-30 | GLU | A:305 | A:1283 | 185.0 | 0.974 | T | -60.9 | -47.8 | 185.0 | 0.974 | 0.0 | ||||||
| GLU | B:305 | B:1283 | 156.0 | 0.821 | S | -78.1 | -33.4 | NA | NA | NA | |||||||||||||
| GLU | C:305 | C:1283 | 183.0 | 0.963 | S | -65.8 | -40.3 | NA | NA | NA | |||||||||||||
| GLU | D:305 | D:1283 | 151.0 | 0.795 | T | -62.6 | -41.4 | NA | NA | NA | |||||||||||||
| GLU | E:305 | E:1283 | 184.0 | 0.968 | S | -65.1 | -51.4 | NA | NA | NA | |||||||||||||
| GLU | F:305 | F:1283 | 188.0 | 0.989 | T | -62.8 | -40.8 | NA | NA | NA | |||||||||||||
| GLU | G:305 | G:1283 | 182.0 | 0.958 | T | -56.8 | -47.3 | NA | NA | NA | |||||||||||||
| GLU | H:305 | H:1283 | 157.0 | 0.826 | T | -67.8 | -42.6 | NA | NA | NA | |||||||||||||
| GLU | I:305 | I:1283 | 193.0 | 1.0 | T | -62.4 | -42.3 | NA | NA | NA | |||||||||||||
| GLU | J:305 | J:1283 | 187.0 | 0.984 | T | -63.7 | -28.7 | NA | NA | NA | |||||||||||||
| GLU | K:305 | K:1283 | 195.0 | 1.0 | S | -72.1 | -31.2 | NA | NA | NA | |||||||||||||
| GLU | L:305 | M:1283 | 192.0 | 1.0 | S | -64.4 | -38.1 | NA | NA | NA | |||||||||||||
| GLU | M:305 | L:1283 | 188.0 | 0.989 | T | -53.1 | -46.9 | NA | NA | NA | |||||||||||||
| GLU | N:305 | R:1283 | 194.0 | 1.0 | S | -62.8 | -39.7 | NA | NA | NA | |||||||||||||
| GLU | O:305 | S:1283 | 159.0 | 0.837 | S | -74.4 | -38.2 | NA | NA | NA | |||||||||||||
| GLU | P:305 | T:1283 | 161.0 | 0.847 | T | -65.8 | -43.3 | NA | NA | NA | |||||||||||||
| 3i81 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2009-12-22 | GLU | A:304 | A:1253 | 163.0 | 0.858 | T | -67.0 | -21.6 | 163.0 | 0.858 | 0.0 |
HOH |
2.786 |
N |
O |
||
| 5fxs | 1 | P08069 | 99.35 | 0.0 |
X-RAY |
2016-10-19 | GLU | A:305 | A:1283 | 185.0 | 0.974 | T | -74.4 | -13.3 | 185.0 | 0.974 | 0.0 |
HOH |
2.968 |
N |
O |
||
| 2oj9 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2007-05-01 | GLU | A:304 | A:1253 | 190.0 | 1.0 | T | -68.3 | -19.1 | 190.0 | 1.0 | 0.0 |
HOH |
2.769 |
OE1 |
O |
||
| 3nw5 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLU | A:304 | A:1253 | 195.0 | 1.0 | T | -60.3 | -34.9 | 195.0 | 1.0 | 0.0 |
HOH |
2.633 |
N |
O |
||
| 3nw6 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLU | A:304 | A:1253 | 190.0 | 1.0 | T | -56.9 | -31.6 | 190.0 | 1.0 | 0.0 |
HOH |
2.614 |
O |
O |
||
| 3nw7 | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2010-07-28 | GLU | A:304 | A:1253 | 192.0 | 1.0 | T | -59.6 | -32.9 | 192.0 | 1.0 | 0.0 |
HOH |
2.669 |
O |
O |
||
| 3o23 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2011-05-04 | GLU | A:302 | A:1283 | 248.0 | 1.0 | -78.6 | 360.0 | 248.0 | 1.0 | 0.0 |
HOH |
6.314 |
N |
O |
|||
| 3lw0 | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2010-09-29 | GLU | A:301 | A:1283 | 184.0 | 0.968 | T | -62.5 | -27.1 | 184.0 | 0.968 | 0.0 |
HOH |
2.926 |
N |
O |
||
| GLU | B:301 | B:1283 | 174.0 | 0.916 | T | -62.8 | -26.2 | NA | NA | NA | |||||||||||||
| GLU | C:301 | C:1283 | 170.0 | 0.895 | T | -64.7 | -23.3 | NA | NA | NA | |||||||||||||
| GLU | D:301 | D:1283 | 167.0 | 0.879 | T | -62.8 | -27.1 | NA | NA | NA | |||||||||||||
| 5hzn | 1 | P08069 | 99.34 | 0.0 |
X-RAY |
2016-04-06 | GLU | A:301 | A:1280 | 175.0 | 0.921 | T | -75.3 | -14.9 | 175.0 | 0.921 | 0.0 |
HOH |
5.383 |
N |
O |
||
| GLU | B:301 | B:1280 | 194.0 | 1.0 | S | -76.4 | -34.2 | NA | NA | NA | |||||||||||||
| GLU | C:301 | C:1280 | 192.0 | 1.0 | T | -66.2 | -30.1 | NA | NA | NA | |||||||||||||
| GLU | D:301 | D:1280 | 185.0 | 0.974 | T | -61.0 | -30.3 | NA | NA | NA | |||||||||||||
| GLU | E:301 | E:1280 | 174.0 | 0.916 | T | -74.8 | -15.5 | NA | NA | NA | |||||||||||||
| GLU | F:301 | F:1280 | 196.0 | 1.0 | S | -76.1 | -34.2 | NA | NA | NA | |||||||||||||
| GLU | G:301 | G:1280 | 194.0 | 1.0 | T | -65.3 | -30.4 | NA | NA | NA | |||||||||||||
| GLU | H:301 | H:1280 | 198.0 | 1.0 | T | -61.1 | -30.3 | NA | NA | NA | |||||||||||||
| 4d2r | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2015-04-22 | GLU | A:299 | A:1283 | 182.0 | 0.958 | T | -70.7 | -21.1 | 182.0 | 0.958 | 0.0 |
HOH |
2.809 |
N |
O |
||
| 3d94 | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2008-07-29 | GLU | A:298 | A:1253 | 195.0 | 1.0 | S | -61.8 | -39.7 | 195.0 | 1.0 | 0.0 |
HOH |
5.561 |
N |
O |
||
| 3qqu | 1 | P08069 | 100.0 | 0.0 |
X-RAY |
2011-04-20 | GLU | A:298 | A:1280 | 106.0 | NA | T | -70.7 | -19.7 | 106.0 | NA | NA | ||||||
| GLU | B:298 | B:1280 | 168.0 | 0.884 | T | -65.6 | -24.6 | NA | NA | NA | |||||||||||||
| GLU | C:298 | C:1280 | 114.0 | NA | T | -81.2 | -14.3 | NA | NA | NA | |||||||||||||
| GLU | D:298 | D:1280 | 109.0 | NA | T | -55.6 | -31.3 | NA | NA | NA | |||||||||||||
| 1k3a | 1 | P08069 | 99.67 | 0.0 |
X-RAY |
2001-11-28 | GLU | A:296 | A:1253 | 187.0 | 0.984 | T | -69.8 | -23.9 | 187.0 | 0.984 | 0.0 |
HOH |
3.199 |
N |
O |
||
| 2z8c | 1 | P06213 | 80.2 | 1e-175 |
X-RAY |
2008-08-12 | GLU | A:300 | A:1280 | 101.0 | NA | T | -60.9 | -38.9 | 101.0 | NA | NA | ||||||
| 1gag | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2001-01-17 | GLU | A:303 | A:1280 | 98.0 | NA | T | -63.0 | -27.0 | 98.0 | NA | NA | ||||||
| 1ir3 | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1998-01-07 | GLU | A:303 | A:1280 | 102.0 | NA | T | -64.5 | -26.7 | 79.0 | NA | NA |
A:P06213:NA |
HOH |
5.512 |
N |
O |
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| 1irk | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
1995-02-27 | GLU | A:303 | A:1280 | 173.0 | 0.911 | T | -69.0 | -16.1 | 173.0 | 0.911 | 0.0 |
EMC HOH |
6.241 2.807 |
N N |
C2 O |
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| 5e1s | 1 | P06213 | 80.2 | 2e-175 |
X-RAY |
2015-10-14 | GLU | A:305 | A:1280 | 166.0 | 0.874 | T | -73.2 | -13.9 | 166.0 | 0.874 | 0.0 |
HOH |
3.049 |
N |
O |
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| 1rqq | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2003-12-30 | GLU | A:303 | A:1280 | 102.0 | NA | T | -70.7 | -28.3 | 102.0 | NA | NA |
HOH |
6.089 |
N |
O |
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| GLU | B:303 | B:1280 | 100.0 | NA | T | -69.1 | -31.5 | 100.0 | NA | NA | |||||||||||||
| 2auh | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-01 | GLU | A:303 | A:1280 | 96.0 | NA | T | -80.5 | -26.5 | 96.0 | NA | NA | ||||||
| 2b4s | 2 | P06213 | 80.2 | 3e-175 |
X-RAY |
2005-11-15 | GLU | B:303 | B:1280 | 104.0 | NA | T | -69.4 | -18.4 | 99.0 | NA | NA |
A:P18031:NA |
HOH |
5.539 |
N |
O |
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| GLU | D:303 | D:1280 | 104.0 | NA | T | -67.6 | -22.2 | 104.0 | NA | NA |
HOH |
2.835 |
N |
O |
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| 3bu3 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | GLU | A:303 | A:1280 | 106.0 | NA | T | -58.2 | -28.0 | 106.0 | NA | NA |
HOH |
2.937 |
N |
O |
||
| 3bu5 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | GLU | A:303 | A:1280 | 106.0 | NA | T | -56.5 | -25.4 | 106.0 | NA | NA |
HOH |
5.014 |
N |
O |
||
| 3bu6 | 1 | P06213 | 80.2 | 3e-175 |
X-RAY |
2008-02-19 | GLU | A:303 | A:1280 | 104.0 | NA | T | -64.6 | -26.3 | 104.0 | NA | NA |
HOH |
3.216 |
N |
O |
||
| 5hhw | 1 | P06213 | 80.2 | 4e-175 |
X-RAY |
2016-04-13 | GLU | A:304 | A:1307 | 175.0 | 0.921 | T | -71.0 | -14.6 | 175.0 | 0.921 | 0.0 |
HOH |
2.847 |
N |
O |
||
| 4ibm | 1 | P06213 | 80.73 | 8e-175 |
X-RAY |
2013-08-21 | GLU | A:303 | A:1280 | 114.0 | NA | T | -66.8 | -22.8 | 114.0 | NA | NA |
HOH |
2.877 |
O |
O |
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| GLU | B:303 | B:1280 | 143.0 | 0.753 | T | -62.7 | -26.6 | NA | NA | NA | |||||||||||||
| 3eta | 1 | P06213 | 80.41 | 2e-170 |
X-RAY |
2009-05-26 | GLU | A:302 | A:1280 | 176.0 | 0.926 | T | -57.1 | -37.9 | 176.0 | 0.926 | 0.0 |
HOH |
5.690 |
N |
O |
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| GLU | B:302 | B:1280 | 121.0 | NA | T | -61.7 | -21.8 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p08069-f1 | 1 | P08069 | 100.0 | 0.0 | GLU | A:1283 | A:1283 | 138.0 | 0.726 | G | -62.8 | -26.8 | |