Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 75257464 . A C CCDS32490.1:NM_001906.4:c.434gAc>gCc_NP_001897.4:p.145D>A Homo sapiens chymotrypsinogen B1 (CTRB1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1acb 1 P00766 81.63 3e-148 X-RAY
 1993-10-31 SER A:127 E:127 98.0 0.852 T -104.5 17.8 98.0 0.852 0.0 HOH
 2.675
 O
 O
1cgi 1 P00766 81.63 3e-148 X-RAY
 1993-10-31 SER A:127 E:127 107.0 0.93 T -61.7 -29.5 107.0 0.93 0.0 HOH
 2.196
 OG
 O
1cgj 1 P00766 81.63 3e-148 X-RAY
 1993-10-31 SER A:127 E:127 112.0 0.974 T -80.5 -2.1 112.0 0.974 0.0 HOH
 1.991
 OG
 O
1chg 1 P00766 81.63 3e-148 X-RAY
 1976-11-22 SER A:127 A:127 93.0 0.809 S -101.1 -41.7 93.0 0.809 0.0
1ex3 1 P00766 81.63 3e-148 X-RAY
 2000-05-17 SER A:127 A:127 102.0 0.887 T -61.0 -29.8 102.0 0.887 0.0 HOH
 6.258
 O
 O
1gcd 1 P00766 81.63 3e-148 X-RAY
 1994-06-22 SER A:127 A:127 114.0 0.991 T -80.4 -10.0 114.0 0.991 0.0 HOH
 3.166
 OG
 O
1gl0 1 P00766 81.63 3e-148 X-RAY
 2001-11-28 SER A:127 E:127 105.0 0.913 T -94.3 -20.4 105.0 0.913 0.0 HOH
 3.220
 O
 O
1gl1 1 P00766 81.63 3e-148 X-RAY
 2001-11-28 SER A:127 A:127 112.0 0.974 T -87.0 -10.9 112.0 0.974 0.0 HOH
 2.703
 OG
 O
SER B:127 B:127 103.0 0.896 T -99.9 1.2 NA NA NA
SER C:127 C:127 107.0 0.93 T -99.0 -11.4 NA NA NA
1k2i 1 P00766 81.63 3e-148 X-RAY
 2001-12-05 SER A:127 1:127 111.0 0.965 T -92.4 0.9 111.0 0.965 0.0 HOH
 2.895
 N
 O
1oxg 1 P00766 81.63 3e-148 X-RAY
 2004-05-18 SER A:127 A:127 103.0 0.896 T -88.1 -7.1 103.0 0.896 0.0 HOH
 2.743
 OG
 O
1p2m 1 P00766 81.63 3e-148 X-RAY
 2004-04-20 SER A:127 A:127 110.0 0.957 T -89.8 -2.4 110.0 0.957 0.0 HOH
 2.968
 OG
 O
SER C:127 C:127 108.0 0.939 T -92.0 -6.4 NA NA NA
1p2n 1 P00766 81.63 3e-148 X-RAY
 2004-04-20 SER A:127 A:127 111.0 0.965 T -93.6 -1.3 111.0 0.965 0.0 HOH
 2.982
 OG
 O
SER C:127 C:127 108.0 0.939 T -90.7 -6.6 NA NA NA
1p2o 1 P00766 81.63 3e-148 X-RAY
 2004-04-20 SER A:127 A:127 106.0 0.922 T -91.5 -6.1 106.0 0.922 0.0 HOH
 3.453
 OG
 O
SER C:127 C:127 108.0 0.939 T -91.4 -10.7 NA NA NA
1p2q 1 P00766 81.63 3e-148 X-RAY
 2004-04-20 SER A:127 A:127 111.0 0.965 T -91.9 -1.3 111.0 0.965 0.0 HOH
 3.061
 OG
 O
SER C:127 C:127 109.0 0.948 T -92.6 -6.8 NA NA NA
1t7c 1 P00766 81.63 3e-148 X-RAY
 2005-03-08 SER A:127 A:127 111.0 0.965 T -91.3 -1.1 111.0 0.965 0.0 HOH
 3.014
 OG
 O
SER C:127 C:127 107.0 0.93 T -91.5 -9.3 NA NA NA
1t8l 1 P00766 81.63 3e-148 X-RAY
 2005-03-08 SER A:127 A:127 104.0 0.904 T -91.2 2.2 104.0 0.904 0.0 HOH
 3.105
 OG
 O
SER C:127 C:127 107.0 0.93 T -93.8 -8.0 NA NA NA
1t8m 1 P00766 81.63 3e-148 X-RAY
 2005-03-08 SER A:127 A:127 109.0 0.948 T -90.7 -2.9 109.0 0.948 0.0 HOH
 3.068
 OG
 O
SER C:127 C:127 107.0 0.93 T -88.9 -14.2 NA NA NA
1t8n 1 P00766 81.63 3e-148 X-RAY
 2005-03-08 SER A:127 A:127 108.0 0.939 T -90.9 -3.9 108.0 0.939 0.0 HOH
 3.136
 OG
 O
SER C:127 C:127 109.0 0.948 T -92.6 -9.9 NA NA NA
1t8o 1 P00766 81.63 3e-148 X-RAY
 2005-03-08 SER A:127 A:127 109.0 0.948 T -90.5 -4.6 109.0 0.948 0.0 HOH
 2.950
 OG
 O
SER C:127 C:127 107.0 0.93 T -93.3 -6.2 NA NA NA
2cga 1 P00766 81.63 3e-148 X-RAY
 1987-04-16 SER A:127 A:127 106.0 0.922 T -103.1 2.1 106.0 0.922 0.0 HOH
 3.184
 C
 O
SER B:127 B:127 104.0 0.904 T -98.0 -14.9 104.0 0.904 0.0 HOH
 3.442
 O
 O
2y6t 1 P00766 81.63 3e-148 X-RAY
 2011-04-20 SER A:127 A:127 109.0 0.948 S -69.7 -45.0 107.0 0.93 0.018 F:B1JSA0:0.017
SER B:127 B:127 112.0 0.974 S -102.0 -19.5 112.0 0.974 0.0 HOH
 8.728
 N
 O
SER C:127 C:127 108.0 0.939 T -97.4 -18.3 NA NA NA
SER D:127 D:127 105.0 0.913 T -88.2 -7.1 NA NA NA
3t62 1 P00766 81.63 3e-148 X-RAY
 2012-08-01 SER A:127 A:127 108.0 0.939 T -102.5 3.7 108.0 0.939 0.0 SO4
HOH
 9.320
2.239
 N
OG
 O4
O
SER C:127 B:127 108.0 0.939 T -96.0 0.7 NA NA NA
SER E:127 C:127 107.0 0.93 T -100.5 1.3 NA NA NA
4q2k 1 P00766 81.63 3e-148 X-RAY
 2014-07-23 SER A:127 A:127 110.0 0.957 T -86.0 -0.5 110.0 0.957 0.0 HOH
 6.060
 O
 O
SER B:127 B:127 109.0 0.948 T -87.5 -6.2 NA NA NA
SER C:127 C:127 105.0 0.913 T -91.5 -12.1 NA NA NA
SER D:127 D:127 109.0 0.948 T -82.9 -6.4 109.0 0.948 0.0 HOH
 3.318
 OG
 O
5j4q 1 P00766 81.63 3e-148 X-RAY
 2017-04-12 SER A:127 A:127 105.0 0.913 T -116.7 -1.8 105.0 0.913 0.0 HOH
 7.093
 N
 O
5j4s 1 P00766 81.63 3e-148 X-RAY
 2017-04-12 SER A:127 A:127 105.0 0.913 T -96.5 -3.9 105.0 0.913 0.0 HOH
 2.610
 OG
 O
7kty 1 P00766 81.63 3e-148 X-RAY
 2021-03-10 SER A:127 A:127 107.0 0.93 T -98.9 6.3 107.0 0.93 0.0 HOH
 3.649
 C
 O
7ktz 1 P00766 81.63 3e-148 X-RAY
 2021-03-10 SER A:127 A:127 106.0 0.922 T -95.3 4.3 106.0 0.922 0.0 HOH
 2.746
 OG
 O
7ku0 1 P00766 81.63 3e-148 X-RAY
 2021-03-10 SER A:127 A:127 104.0 0.904 T -92.2 1.9 104.0 0.904 0.0 HOH
 2.613
 OG
 O
7ku1 1 P00766 81.63 3e-148 X-RAY
 2021-03-10 SER A:127 A:127 99.0 0.861 T -90.4 2.3 99.0 0.861 0.0 HOH
 2.517
 OG
 O
7ku2 1 P00766 81.63 3e-148 X-RAY
 2021-03-10 SER A:127 A:127 109.0 0.948 T -89.7 -0.6 109.0 0.948 0.0 HOH
 3.583
 C
 O
7ku3 1 P00766 81.63 3e-148 X-RAY
 2021-03-10 SER A:127 A:127 108.0 0.939 T -96.6 6.6 108.0 0.939 0.0 HOH
 2.729
 OG
 O
1dlk 2 P00766 80.87 2e-137 X-RAY
 2000-05-03 SER B:112 B:127 101.0 0.878 T -90.3 -3.6 101.0 0.878 0.0 HOH
 3.288
 OG
 O
SER D:112 D:127 108.0 0.939 T -95.8 4.6 NA NA NA
1kdq 1 P07338 89.31 3e-84 X-RAY
 2003-06-10 ASP A:112 A:127 139.0 0.927 T -109.8 8.7 139.0 0.927 0.0 HOH
 8.925
 N
 O
2jet 2 P07338 89.84 5e-83 X-RAY
 2007-09-18 ASP B:109 B:127 141.0 0.94 T -93.3 -10.4 141.0 0.94 0.0 HOH
 7.001
 C
 O
1ab9 2 P00766 83.21 3e-76 X-RAY
 1997-08-20 SER B:112 B:127 112.0 0.974 T -92.0 1.8 112.0 0.974 0.0 HOH
 3.349
 C
 O
1afq 2 P00766 83.21 3e-76 X-RAY
 1997-09-17 SER B:112 B:127 113.0 0.983 T -89.4 0.6 113.0 0.983 0.0 0FG
HOH
 8.696
2.862
 N
OG
 CE1
O
1ca0 2 P00766 83.21 3e-76 X-RAY
 1997-07-23 SER B:112 B:127 107.0 0.93 T -101.7 16.2 107.0 0.93 0.0 HOH
 4.275
 C
 O
SER F:112 G:127 104.0 0.904 T -103.2 -11.2 NA NA NA
1cbw 2 P00766 83.21 3e-76 X-RAY
 1997-07-23 SER B:112 B:127 113.0 0.983 T -75.0 -22.2 113.0 0.983 0.0 HOH
 3.615
 OG
 O
SER F:112 G:127 106.0 0.922 T -80.8 -0.5 NA NA NA
1cho 2 P00766 83.21 3e-76 X-RAY
 1988-07-16 SER B:112 F:127 106.0 0.922 T -82.8 -16.3 106.0 0.922 0.0 HOH
 3.357
 OG
 O
1gct 2 P00766 83.21 3e-76 X-RAY
 1991-10-15 SER B:112 B:127 106.0 0.922 T -82.3 -2.2 106.0 0.922 0.0 HOH
 2.879
 N
 O
1gg6 2 P00766 83.21 3e-76 X-RAY
 2000-09-20 SER B:112 B:127 113.0 0.983 T -91.4 1.5 113.0 0.983 0.0 SO4
HOH
 9.801
2.621
 O
OG
 O1
O
1ggd 2 P00766 83.21 3e-76 X-RAY
 2000-09-20 SER B:112 B:127 112.0 0.974 T -90.5 5.3 112.0 0.974 0.0 HOH
 2.902
 OG
 O
1gha 2 P00766 83.21 3e-76 X-RAY
 1994-06-22 SER B:112 F:127 105.0 0.913 T -90.2 0.9 105.0 0.913 0.0 HOH
 3.440
 C
 O
1ghb 2 P00766 83.21 3e-76 X-RAY
 1994-06-22 SER B:112 F:127 108.0 0.939 T -74.7 -12.9 108.0 0.939 0.0 HOH
 3.625
 O
 O
1gmc 2 P00766 83.21 3e-76 X-RAY
 1993-10-31 SER B:112 F:127 97.0 0.843 T -77.3 -21.3 97.0 0.843 0.0 HOH
 7.017
 N
 O
1gmd 2 P00766 83.21 3e-76 X-RAY
 1993-10-31 SER B:112 F:127 103.0 0.896 T -86.9 -11.6 103.0 0.896 0.0 HOH
 6.609
 O
 O
1gmh 2 P00766 83.21 3e-76 X-RAY
 1994-09-30 SER B:112 F:127 110.0 0.957 T -83.2 -1.8 110.0 0.957 0.0 HOH
 2.676
 OG
 O
1hja 2 P00766 83.21 3e-76 X-RAY
 1998-01-14 SER B:112 B:127 102.0 0.887 T -96.2 -16.5 102.0 0.887 0.0 HOH
 3.936
 C
 O
1mtn 2 P00766 83.21 3e-76 X-RAY
 1996-08-17 SER B:112 B:127 104.0 0.904 T -95.4 13.1 104.0 0.904 0.0 HOH
 2.822
 C
 O
SER F:112 F:127 104.0 0.904 T -104.8 -5.8 NA NA NA
1n8o 2 P00766 83.21 3e-76 X-RAY
 2002-12-18 SER B:112 B:127 105.0 0.913 T -83.7 -2.0 105.0 0.913 0.0 HOH
 2.976
 O
 O
1vgc 2 P00766 83.21 3e-76 X-RAY
 1997-11-12 SER B:112 B:127 109.0 0.948 T -101.5 11.9 109.0 0.948 0.0 HOH
 2.859
 N
 O
1yph 2 P00766 83.21 3e-76 X-RAY
 2006-02-14 SER B:112 C:127 117.0 1.0 T -90.2 1.7 117.0 1.0 0.0 HOH
 2.762
 OG
 O
SER E:112 D:127 110.0 0.957 T -90.1 0.5 110.0 0.957 0.0 HOH
 2.826
 OG
 O
2cha 2 P00766 83.21 3e-76 X-RAY
 1977-01-18 SER B:112 B:127 114.0 0.991 T -73.4 -39.4 114.0 0.991 0.0 HOH
 5.674
 N
 O
SER E:112 F:127 117.0 1.0 T -73.4 -39.4 117.0 1.0 0.0
2gch 2 P00766 83.21 3e-76 X-RAY
 1980-07-09 SER B:112 F:127 105.0 0.913 T -89.9 -17.0 105.0 0.913 0.0 HOH
 2.829
 OG
 O
2gct 2 P00766 83.21 3e-76 X-RAY
 1991-10-15 SER B:112 B:127 108.0 0.939 T -79.4 -2.3 108.0 0.939 0.0 HOH
 2.863
 CB
 O
2gmt 2 P00766 83.21 3e-76 X-RAY
 1994-11-01 SER B:112 B:127 112.0 0.974 T -104.7 12.5 112.0 0.974 0.0 HOH
 4.569
 CB
 O
2p8o 2 P00766 83.21 3e-76 X-RAY
 2007-05-08 SER B:112 B:127 112.0 0.974 T -88.1 -0.8 112.0 0.974 0.0 HOH
 2.648
 OG
 O
2vgc 2 P00766 83.21 3e-76 X-RAY
 1997-11-12 SER B:112 B:127 107.0 0.93 T -103.7 5.4 107.0 0.93 0.0 HOH
 2.892
 N
 O
3bg4 2 P00766 83.21 3e-76 X-RAY
 2008-07-29 SER B:112 B:127 112.0 0.974 T -100.2 0.5 112.0 0.974 0.0 HOH
 3.342
 O
 O
3gch 2 P00766 83.21 3e-76 X-RAY
 1990-10-15 SER B:112 B:127 102.0 0.887 S -62.6 -42.3 102.0 0.887 0.0 HOH
 6.431
 OG
 O
3gct 2 P00766 83.21 3e-76 X-RAY
 1991-10-15 SER B:112 F:127 111.0 0.965 T -94.7 1.9 111.0 0.965 0.0 HOH
 2.890
 OG
 O
3ru4 4 P00766 83.21 3e-76 X-RAY
 2012-08-29 SER D:112 D:127 104.0 0.904 T -90.4 -4.5 NA NA NA
3vgc 2 P00766 83.21 3e-76 X-RAY
 1997-11-12 SER B:112 B:127 108.0 0.939 T -102.8 9.3 108.0 0.939 0.0 HOH
 2.665
 OG
 O
4cha 2 P00766 83.21 3e-76 X-RAY
 1985-04-01 SER B:112 B:127 108.0 0.939 T -86.3 -11.5 108.0 0.939 0.0 HOH
 4.724
 N
 O
SER E:112 F:127 106.0 0.922 T -86.9 -7.9 106.0 0.922 0.0 HOH
 6.596
 N
 O
4gch 2 P00766 83.21 3e-76 X-RAY
 1990-10-15 SER B:112 F:127 103.0 0.896 T -65.6 -32.5 103.0 0.896 0.0 HOH
 6.162
 OG
 O
4vgc 2 P00766 83.21 3e-76 X-RAY
 1997-11-12 SER B:112 B:127 105.0 0.913 T -97.4 10.7 105.0 0.913 0.0 HOH
 3.011
 N
 O
5cha 2 P00766 83.21 3e-76 X-RAY
 1985-04-01 SER B:112 B:127 111.0 0.965 T -92.3 1.6 111.0 0.965 0.0 HOH
 3.491
 C
 O
SER E:112 F:127 108.0 0.939 T -92.7 5.9 108.0 0.939 0.0 HOH
 3.313
 C
 O
5gch 2 P00766 83.21 3e-76 X-RAY
 1990-10-15 SER B:112 F:127 101.0 0.878 T -68.5 -35.5 101.0 0.878 0.0 HOH
 6.664
 OG
 O
5r42 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 112.0 0.974 T -95.4 1.8 112.0 0.974 0.0 HOH
 2.949
 OG
 O
5r43 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 111.0 0.965 T -88.3 0.8 111.0 0.965 0.0 HOH
 2.762
 OG
 O
5r44 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 100.0 0.87 T -98.2 2.3 100.0 0.87 0.0 HOH
 2.707
 OG
 O
5r45 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 100.0 0.87 T -90.6 -2.5 100.0 0.87 0.0 HOH
 2.693
 OG
 O
5r46 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 112.0 0.974 T -93.9 2.4 112.0 0.974 0.0 HOH
 3.767
 C
 O
5r47 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 110.0 0.957 T -89.7 0.7 110.0 0.957 0.0 HOH
 2.786
 OG
 O
5r48 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 113.0 0.983 T -93.3 1.3 113.0 0.983 0.0 HOH
 3.639
 C
 O
5r49 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 110.0 0.957 T -88.4 0.6 110.0 0.957 0.0 HOH
 2.747
 O
 O
5r4a 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 112.0 0.974 T -95.2 2.1 112.0 0.974 0.0 HOH
 2.855
 OG
 O
5r4b 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 111.0 0.965 T -85.5 -1.8 111.0 0.965 0.0 HOH
 2.946
 OG
 O
5r4c 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 113.0 0.983 T -96.4 4.1 113.0 0.983 0.0 HOH
 3.773
 C
 O
5r4d 2 P00766 83.21 3e-76 X-RAY
 2021-09-01 SER B:112 B:127 111.0 0.965 T -89.8 1.7 111.0 0.965 0.0 HOH
 2.649
 OG
 O
6cha 2 P00766 83.21 3e-76 X-RAY
 1987-04-16 SER B:112 B:127 119.0 1.0 T -86.9 7.9 119.0 1.0 0.0 HOH
 3.335
 C
 O
SER E:112 F:127 102.0 0.887 T -81.8 -15.3 102.0 0.887 0.0 HOH
 2.394
 OG
 O
6di8 2 P00766 83.21 3e-76 X-RAY
 2019-01-23 SER B:112 B:127 110.0 0.957 T -90.1 -1.5 110.0 0.957 0.0 SO4
HOH
 9.537
2.903
 N
OG
 O1
O
SER E:112 E:127 102.0 0.887 T -90.5 -1.6 NA NA NA
SER H:112 H:127 109.0 0.948 T -90.5 -2.0 NA NA NA
SER K:112 K:127 102.0 0.887 T -90.7 -2.1 NA NA NA
6gch 2 P00766 83.21 3e-76 X-RAY
 1990-10-15 SER B:112 F:127 104.0 0.904 T -86.4 -12.0 104.0 0.904 0.0 HOH
 2.752
 OG
 O
7gch 2 P00766 83.21 3e-76 X-RAY
 1990-10-15 SER B:112 F:127 111.0 0.965 T -99.5 18.1 111.0 0.965 0.0 HOH
 2.374
 OG
 O
7jrx 2 P00766 83.21 3e-76 X-RAY
 2021-07-21 SER B:112 B:127 109.0 0.948 T -85.7 -7.6 109.0 0.948 0.0 HOH
 2.605
 OG
 O
SER F:112 b:127 107.0 0.93 T -86.0 -8.2 NA NA NA
8gch 2 P00766 83.21 3e-76 X-RAY
 1992-04-15 SER B:112 F:127 111.0 0.965 T -85.6 4.5 111.0 0.965 0.0 HOH
 3.435
 C
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p17538-f1 1 P17538 100.0 0.0 ASP A:145 A:145 152.0 1.0 T -103.3 -0.4
af-q6gpi1-f1 1 Q6GPI1 95.82 0.0 ASP A:145 A:145 154.0 1.0 T -98.1 0.7