Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 30492823 . C A CCDS32433.1:NM_002209.2:c.640Cgg>Agg_NP_002200.2:p.214R>R Homo sapiens integrin subunit alpha L (ITGAL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5e6r 1 P20701 99.6 0.0 X-RAY
 2016-03-02 TRP A:189 A:189 151.0 0.592 T -137.6 -50.8 151.0 0.592 0.0 HOH
 4.082
 CD2
 O
5e6s 1 P20701 99.6 0.0 X-RAY
 2016-03-02 TRP A:189 A:189 165.0 0.647 H -117.7 -44.1 165.0 0.647 0.0 HOH
 2.716
 NE1
 O
TRP C:189 C:189 153.0 0.6 H -106.7 -46.3 NA NA NA
TRP E:189 E:189 158.0 0.62 H -106.7 -48.9 NA NA NA
5e6u 1 P20701 99.6 0.0 X-RAY
 2016-04-06 TRP A:189 A:189 161.0 0.631 T -128.6 -53.1 161.0 0.631 0.0 HOH
 6.987
 CZ3
 O
7kc3 1 P20701 98.98 1e-132 X-RAY
 2021-10-06 ARG A:69 C:189 138.0 0.613 -123.5 78.0 138.0 0.613 0.0 HOH
 4.465
 HH12
 O
1rd4 1 P20701 98.43 4e-128 X-RAY
 2004-03-30 ARG A:69 A:189 163.0 0.724 H -104.7 -44.9 163.0 0.724 0.0
ARG B:69 B:189 142.0 0.631 H -106.0 -40.5 NA NA NA
ARG C:69 C:189 127.0 0.564 H -105.1 -42.5 NA NA NA
ARG D:69 D:189 143.0 0.636 H -105.3 -41.7 NA NA NA
1lfa 1 P20701 100.0 7e-128 X-RAY
 1996-01-29 ARG A:65 A:189 119.0 0.529 -145.5 111.6 119.0 0.529 0.0 HOH
 4.692
 HH11
 H2
ARG B:65 B:189 116.0 0.516 -147.4 92.2 116.0 0.516 0.0 HOH
 3.004
 HH22
 H2
1zon 1 P20701 100.0 7e-128 X-RAY
 1996-12-07 ARG A:65 A:189 144.0 0.64 -133.4 100.6 144.0 0.64 0.0 HOH
 5.973
 O
 H1
1zoo 1 P20701 100.0 7e-128 X-RAY
 1996-12-07 ARG A:65 A:189 141.0 0.627 -137.6 101.0 141.0 0.627 0.0
ARG B:65 B:189 123.0 0.547 -136.4 86.5 123.0 0.547 0.0
1zop 1 P20701 100.0 7e-128 X-RAY
 1996-12-07 ARG A:65 A:189 131.0 0.582 -137.6 101.0 131.0 0.582 0.0 HOH
 7.123
 O
 H2
ARG B:65 B:189 123.0 0.547 -136.5 86.5 123.0 0.547 0.0 HOH
 7.273
 O
 O
1dgq 1 P20701 99.46 1e-124 NMR
 2000-02-03 TRP A:66 A:189 147.0 0.576 H -89.4 -37.2 147.0 0.576 0.0
1xdd 1 P20701 99.46 1e-124 X-RAY
 2004-09-21 TRP A:66 A:189 169.0 0.663 H -99.7 -37.9 169.0 0.663 0.0 HOH
 6.809
 CD1
 O
TRP B:66 B:189 147.0 0.576 H -92.4 -33.9 NA NA NA
1xdg 1 P20701 99.46 1e-124 X-RAY
 2004-09-21 TRP A:66 A:189 162.0 0.635 H -98.0 -30.7 162.0 0.635 0.0 HOH
 2.713
 NE1
 O
TRP B:66 B:189 154.0 0.604 H -98.3 -34.8 NA NA NA
1xuo 1 P20701 99.46 1e-124 X-RAY
 2005-10-26 TRP A:66 A:189 146.0 0.573 H -95.7 -29.5 146.0 0.573 0.0 HOH
 7.400
 NE1
 O
TRP B:66 B:189 213.0 0.835 H -121.3 -14.4 NA NA NA
4ixd 1 P20701 99.46 1e-124 X-RAY
 2014-01-29 TRP A:66 A:189 145.0 0.569 H -94.9 -40.3 145.0 0.569 0.0 HOH
 2.700
 O
 O
7kc5 1 P20701 100.0 3e-123 X-RAY
 2021-10-06 ARG A:64 A:189 132.0 0.587 H -102.3 -27.4 132.0 0.587 0.0 HOH
 4.265
 HG3
 O
ARG B:64 C:189 144.0 0.64 -134.6 90.3 NA NA NA
7kc6 1 P20701 100.0 3e-123 X-RAY
 2021-10-06 ARG A:64 C:189 138.0 0.613 H -99.2 -38.0 138.0 0.613 0.0 HOH
 3.082
 NH1
 O
ARG B:64 A:189 113.0 0.502 H -104.8 -35.3 NA NA NA
3e2m 1 P20701 99.45 6e-123 X-RAY
 2008-08-19 TRP A:65 A:189 153.0 0.6 H -106.8 -36.3 153.0 0.6 0.0 HOH
 2.921
 NE1
 O
TRP B:65 B:189 153.0 0.6 H -102.0 -51.1 153.0 0.6 0.0 HOH
 2.805
 O
 O
3eoa 3 P20701 100.0 8e-123 X-RAY
 2009-04-14 ARG E:62 I:189 130.0 0.578 H -82.7 -53.0 122.0 0.542 0.036 C:None:0.036
 HOH
 2.541
 NE
 O
ARG F:62 J:189 166.0 0.738 H -87.0 -48.9 NA NA NA
3eob 3 P20701 100.0 8e-123 X-RAY
 2009-04-14 ARG C:62 I:189 134.0 0.596 H -94.3 -56.6 134.0 0.596 0.0
ARG F:62 J:189 130.0 0.578 H -112.3 -36.9 NA NA NA
1cqp 1 P20701 99.45 2e-122 X-RAY
 2000-08-07 TRP A:62 A:189 156.0 0.612 H -98.9 -22.8 156.0 0.612 0.0 HOH
 2.678
 NE1
 O
TRP B:62 B:189 161.0 0.631 H -103.1 -24.5 NA NA NA
3bqm 1 P20701 99.45 2e-122 X-RAY
 2008-08-19 TRP A:62 B:189 159.0 0.624 H -99.9 -36.3 159.0 0.624 0.0 HOH
 2.693
 NE1
 O
TRP B:62 C:189 161.0 0.631 H -99.5 -45.9 NA NA NA
3bqn 1 P20701 99.45 2e-122 X-RAY
 2008-08-19 TRP A:62 B:189 156.0 0.612 H -102.7 -33.1 156.0 0.612 0.0 HOH
 2.993
 NE1
 O
TRP B:62 C:189 153.0 0.6 H -100.9 -45.8 NA NA NA
2ica 1 P20701 100.0 3e-121 X-RAY
 2006-12-19 ARG A:65 A:189 143.0 0.636 H -108.6 -44.9 143.0 0.636 0.0 HOH
 3.245
 O
 O
2o7n 1 P20701 100.0 3e-121 X-RAY
 2007-03-20 ARG A:65 A:189 209.0 0.929 H -142.4 -0.6 209.0 0.929 0.0 HOH
 2.951
 N
 O
3m6f 1 P20701 100.0 3e-121 X-RAY
 2010-05-12 ARG A:65 A:189 156.0 0.693 H -113.9 -42.8 156.0 0.693 0.0 HOH
 3.223
 NH1
 O
3f74 1 P20701 99.44 5e-121 X-RAY
 2009-06-23 TRP A:63 A:189 137.0 0.537 H -97.0 -42.9 137.0 0.537 0.0 HOH
 2.782
 NE1
 O
TRP B:63 B:189 159.0 0.624 H -105.7 -33.3 NA NA NA
TRP C:63 C:189 151.0 0.592 H -99.0 -39.0 NA NA NA
3f78 1 P20701 99.44 5e-121 X-RAY
 2009-06-23 TRP A:63 A:189 139.0 0.545 H -99.6 -42.8 139.0 0.545 0.0 HOH
 2.737
 NE1
 O
TRP B:63 B:189 158.0 0.62 H -103.6 -35.1 NA NA NA
TRP C:63 C:189 152.0 0.596 H -100.6 -38.9 NA NA NA
3hi6 1 P20701 98.33 3e-119 X-RAY
 2009-09-22 TRP A:62 A:189 144.0 0.565 H -93.2 -44.3 NA NA NA
TRP B:62 B:189 165.0 0.647 H -105.2 -54.6 165.0 0.647 0.0 HOH
 2.775
 NE1
 O
1mjn 1 P20701 98.88 3e-119 X-RAY
 2003-01-28 ARG A:62 A:189 136.0 0.604 H -98.0 -30.0 136.0 0.604 0.0 HOH
 2.619
 NH1
 O
1mq9 1 P20701 98.88 6e-119 X-RAY
 2003-01-14 ARG A:63 A:189 157.0 0.698 H -93.6 -35.8 157.0 0.698 0.0 HOH
 3.184
 CG
 O
1mqa 1 P20701 98.88 6e-119 X-RAY
 2003-01-14 ARG A:63 A:189 164.0 0.729 H -110.1 -46.5 164.0 0.729 0.0 HOH
 6.264
 CG
 O
3tcx 2 P20701 98.88 7e-119 X-RAY
 2011-08-31 TRP B:62 B:189 171.0 0.671 T -61.2 -47.4 171.0 0.671 0.0
TRP D:62 D:189 172.0 0.675 T -58.5 -48.1 NA NA NA
TRP F:62 F:189 170.0 0.667 T -61.1 -47.2 NA NA NA
TRP H:62 H:189 170.0 0.667 T -62.8 -45.8 NA NA NA
TRP J:62 J:189 173.0 0.678 T -59.9 -46.9 NA NA NA
TRP L:62 L:189 170.0 0.667 T -60.3 -46.3 NA NA NA
TRP N:62 N:189 172.0 0.675 T -61.3 -45.6 NA NA NA
TRP P:62 P:189 171.0 0.671 T -60.7 -46.9 NA NA NA
TRP R:62 R:189 171.0 0.671 T -61.5 -45.8 NA NA NA
TRP T:62 T:189 172.0 0.675 H -62.2 -43.7 NA NA NA
TRP V:62 V:189 174.0 0.682 T -58.9 -49.8 NA NA NA
TRP X:62 X:189 171.0 0.671 T -62.3 -48.2 NA NA NA
TRP Z:62 Z:189 172.0 0.675 T -59.3 -46.9 NA NA NA
TRP BA:62 b:189 172.0 0.675 T -60.5 -46.3 NA NA NA
1mq8 2 P20701 98.87 2e-117 X-RAY
 2003-01-14 ARG B:60 B:189 179.0 0.796 S -138.6 61.2 179.0 0.796 0.0
ARG D:60 D:189 180.0 0.8 S -138.4 62.0 NA NA NA
3bn3 1 P20701 98.32 2e-117 X-RAY
 2008-08-19 TRP A:62 A:189 139.0 0.545 H -94.9 -42.2 139.0 0.545 0.0 HOH
 3.080
 O
 O
6bxb 1 P05106,P20701 99.44 4e-113 X-RAY
 2018-08-01 TRP A:171 A:171 172.0 0.675 H -104.0 -40.0 172.0 0.675 0.0 HOH
 5.302
 CD1
 O
TRP B:171 B:171 141.0 0.553 H -88.2 -63.8 NA NA NA
6ckb 1 P05106,P20701 99.44 4e-113 X-RAY
 2018-08-01 TRP A:171 A:171 171.0 0.671 H -108.6 -56.1 171.0 0.671 0.0 NAG
 9.782
 O
 C8
TRP B:171 B:171 108.0 0.424 T -135.8 50.2 NA NA NA
6bxf 1 P05106,P20701 99.44 5e-113 X-RAY
 2018-08-01 TRP A:171 A:171 161.0 0.631 H -89.2 -58.6 161.0 0.631 0.0
TRP B:171 B:171 179.0 0.702 H -113.1 -49.1 NA NA NA
6bxj 1 P05106,P20701 99.44 8e-112 X-RAY
 2018-10-03 TRP A:171 A:171 148.0 0.58 H -96.6 -35.0 148.0 0.58 0.0 MG
HOH
 3.844
3.404
 CE2
NE1
 MG
O
1t0p 1 P20701 98.28 3e-111 X-RAY
 2005-03-08 TRP A:63 A:189 141.0 0.553 H -94.2 -41.0 141.0 0.553 0.0 HOH
 3.351
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p20701-f1 1 P20701 100.0 0.0 ARG A:214 A:214 138.0 0.613 H -110.9 -44.4