Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55844482 . A C CCDS32450.1:NM_001025195.1:c.1265aTa>aGa_NP_001020366.1:p.422I>R Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 ILE A:402 A:1421 0.0 0.0 H -66.5 -37.9 0.0 0.0 0.0 THA
HOH
 8.857
6.001
 CG2
C
 C6
O
ILE B:402 B:2421 0.0 0.0 H -59.6 -43.9 0.0 0.0 0.0 THA
HOH
 8.739
5.951
 CG2
C
 C12
O
ILE C:402 C:3421 0.0 0.0 H -65.8 -50.3 0.0 0.0 0.0 THA
HOH
 8.535
6.143
 O
C
 C13
O
ILE D:402 D:4421 0.0 0.0 H -57.8 -38.5 0.0 0.0 0.0 THA
HOH
 8.617
6.278
 CG2
C
 C13
O
ILE E:402 E:5421 0.0 0.0 H -66.5 -39.5 0.0 0.0 0.0 THA
HOH
 8.331
6.020
 CG2
C
 C12
O
ILE F:402 F:6421 0.0 0.0 H -60.2 -48.5 0.0 0.0 0.0 THA
HOH
 8.933
5.940
 CG2
C
 C6
O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 ILE A:402 A:1421 0.0 0.0 H -63.6 -41.6 0.0 0.0 0.0 HTQ
HTQ
HOH
 7.837
9.873
6.397
 CG2
CD1
C
 C7
C15
O
ILE B:402 B:2421 0.0 0.0 H -61.2 -42.4 0.0 0.0 0.0 HTQ
HTQ
HOH
 7.950
9.877
5.912
 CG2
CG1
C
 C7
O20
O
ILE C:402 C:3421 0.0 0.0 H -54.4 -50.2 0.0 0.0 0.0 HTQ
HTQ
HOH
 7.558
9.861
2.943
 CG2
CG1
CD1
 C7
O20
O
ILE D:402 D:4421 0.0 0.0 H -72.3 -39.3 NA NA NA
ILE E:402 E:5421 0.0 0.0 H -64.9 -47.0 NA NA NA
ILE F:402 F:6421 0.0 0.0 H -59.4 -53.2 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 ILE A:402 A:1421 0.0 0.0 H -52.6 -47.2 0.0 0.0 0.0 NLX
HOH
 8.854
7.086
 CG2
O
 C7
O
ILE B:402 B:2421 0.0 0.0 H -57.5 -46.7 0.0 0.0 0.0 NLX
HOH
 8.116
5.803
 CG2
C
 O4
O
ILE C:402 C:3421 0.0 0.0 H -49.8 -54.6 0.0 0.0 0.0 NLX
HOH
 8.399
6.672
 CG2
O
 C8
O
ILE D:402 D:4421 0.0 0.0 H -54.1 -30.9 0.0 0.0 0.0 NLX
HOH
 8.671
6.391
 CG2
C
 C7
O
ILE E:402 E:5421 0.0 0.0 H -51.5 -53.2 0.0 0.0 0.0 NLX
HOH
 9.390
6.035
 CG2
O
 O1
O
ILE F:402 F:6421 0.0 0.0 H -55.5 -53.3 0.0 0.0 0.0 NLX
HOH
 8.160
5.750
 CG2
C
 O1
O
ILE G:402 G:1421 0.0 0.0 H -65.5 -51.8 NA NA NA
ILE H:402 H:2421 0.0 0.0 H -58.6 -48.2 NA NA NA
ILE I:402 I:3421 0.0 0.0 H -47.9 -50.7 NA NA NA
ILE J:402 J:4421 0.0 0.0 H -46.7 -45.3 NA NA NA
ILE K:402 K:5421 0.0 0.0 H -53.5 -56.1 NA NA NA
ILE L:402 L:6421 0.0 0.0 H -37.4 -53.1 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ILE A:402 A:1421 0.0 0.0 H -60.3 -52.8 0.0 0.0 0.0 PLM
HOH
 8.222
6.396
 CG2
O
 O2
O
ILE B:402 B:2421 0.0 0.0 H -60.2 -52.4 0.0 0.0 0.0 PLM
HOH
 9.085
6.140
 CG2
O
 O1
O
ILE C:402 C:3421 0.0 0.0 H -60.2 -52.1 0.0 0.0 0.0 PLM
HOH
 9.176
5.801
 CG2
O
 O1
O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ILE A:402 A:1421 0.0 0.0 H -60.9 -43.0 0.0 0.0 0.0 PLM
HTQ
HOH
 9.019
9.483
6.400
 CG2
CD1
C
 O1
O20
O
ILE B:402 B:2421 0.0 0.0 H -71.7 -42.1 0.0 0.0 0.0 HOH
 6.821
 O
 O
ILE C:402 C:3421 0.0 0.0 H -60.1 -41.1 0.0 0.0 0.0 COA
PLM
HTQ
HOH
 9.395
6.649
9.099
6.350
 CG2
O
CD1
C
 S1P
O2
O20
O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ILE A:402 A:1421 2.0 0.011 H -62.5 -43.2 2.0 0.011 0.0 TCH
HOH
 7.622
6.210
 CG2
O
 C6
O
ILE B:402 B:2421 1.0 0.006 H -61.9 -42.7 1.0 0.006 0.0 TCH
HOH
 7.013
6.214
 CG2
O
 C6
O
ILE C:402 C:3421 1.0 0.006 H -64.0 -41.3 1.0 0.006 0.0 TCH
HOH
 6.683
6.119
 CG2
O
 C6
O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ILE A:402 A:1421 0.0 0.0 H -63.3 -47.3 0.0 0.0 0.0 COA
HOH
 9.105
6.185
 CG2
C
 S1P
O
ILE B:402 B:2421 0.0 0.0 H -61.9 -43.8 0.0 0.0 0.0 COA
HOH
 8.417
6.118
 CG2
C
 S1P
O
ILE C:402 C:3421 0.0 0.0 H -59.5 -46.4 0.0 0.0 0.0 COA
HOH
 8.352
5.991
 CG2
C
 S1P
O
ILE D:402 D:4421 0.0 0.0 H -60.2 -43.7 0.0 0.0 0.0 COA
HOH
 9.216
5.988
 CG2
C
 S1P
O
ILE E:402 E:5421 0.0 0.0 H -60.5 -44.1 0.0 0.0 0.0 COA
HOH
 9.206
6.079
 CG2
C
 S1P
O
ILE F:402 F:6421 0.0 0.0 H -63.5 -43.8 0.0 0.0 0.0 COA
HOH
 8.598
6.071
 CG2
C
 S1P
O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ILE A:400 A:421 0.0 0.0 H -69.8 -48.9 0.0 0.0 0.0 CTX
CTX
HOH
 8.351
9.828
7.171
 CG2
CD1
C
 C19
C10
O
ILE B:400 B:421 0.0 0.0 H -71.8 -50.4 0.0 0.0 0.0 CTX
HOH
 8.402
5.820
 CG2
C
 C19
O
ILE C:400 C:421 0.0 0.0 H -75.3 -45.6 0.0 0.0 0.0 CTX
HOH
 8.362
6.831
 CG2
O
 C19
O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ILE A:400 A:421 1.0 0.006 H -50.5 -55.7 1.0 0.006 0.0 MVB
HOH
 9.793
5.897
 CD1
C
 C9
O
ILE B:400 B:421 0.0 0.0 H -62.7 -44.8 0.0 0.0 0.0 HOH
 6.329
 C
 O
ILE C:400 C:421 0.0 0.0 H -61.9 -48.1 0.0 0.0 0.0 HOH
 6.189
 O
 O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ILE A:400 A:421 0.0 0.0 H -57.3 -54.6 0.0 0.0 0.0 EEE
HOH
 9.331
6.095
 CG2
C
 C4
O
ILE B:400 B:421 0.0 0.0 H -57.9 -54.7 0.0 0.0 0.0 EEE
HOH
 9.208
6.325
 CG2
O
 C4
O
ILE C:400 C:421 0.0 0.0 H -59.0 -52.6 0.0 0.0 0.0 EEE
HOH
 9.086
5.902
 CG2
C
 C4
O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ILE A:400 A:421 0.0 0.0 H -67.4 -40.5 0.0 0.0 0.0 BEZ
 9.377
 CG2
 O2
ILE B:400 B:421 0.0 0.0 H -53.4 -27.4 0.0 0.0 0.0 BEZ
HOH
 9.157
9.703
 CG2
O
 C4
O
ILE C:400 C:421 0.0 0.0 H -55.2 -31.9 0.0 0.0 0.0 BEZ
HOH
 9.803
6.104
 CG2
C
 C3
O
ILE D:400 D:421 0.0 0.0 H -63.0 -48.9 NA NA NA
ILE E:400 E:421 0.0 0.0 H -40.2 -53.4 NA NA NA
ILE F:400 F:421 0.0 0.0 H -55.4 -39.9 NA NA NA
ILE G:400 G:421 0.0 0.0 H -55.5 -51.8 NA NA NA
ILE H:400 H:421 0.0 0.0 H -61.2 -46.5 NA NA NA
ILE I:400 I:421 0.0 0.0 H -49.5 -42.7 NA NA NA
ILE J:400 J:421 0.0 0.0 H -53.0 -39.3 NA NA NA
ILE K:400 K:421 0.0 0.0 H -68.5 -46.4 NA NA NA
ILE L:400 L:421 2.0 0.011 H -68.5 -53.9 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 ILE A:400 A:1421 0.0 0.0 H -57.2 -49.7 0.0 0.0 0.0 GD7
HOH
 7.965
6.104
 CG2
C
 C2
O
ILE B:400 B:2421 0.0 0.0 H -71.2 -38.8 0.0 0.0 0.0 GD7
HOH
 7.731
6.041
 CG2
C
 C2
O
ILE C:400 C:3421 0.0 0.0 H -61.5 -45.8 0.0 0.0 0.0 GD7
HOH
 7.705
5.894
 CG2
C
 C2
O
ILE D:400 D:4421 0.0 0.0 H -55.1 -51.9 NA NA NA
ILE E:400 E:5421 0.0 0.0 H -67.1 -40.1 NA NA NA
ILE F:400 F:6421 0.0 0.0 H -60.6 -42.4 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 ILE A:400 A:1421 0.0 0.0 H -52.1 -56.0 0.0 0.0 0.0 NTJ
HOH
 9.417
6.317
 CG2
C
 C4
O
ILE B:400 B:2421 0.0 0.0 H -55.4 -49.6 0.0 0.0 0.0 NTJ
HOH
 9.212
6.085
 CG2
C
 C4
O
ILE C:400 C:3421 0.0 0.0 H -56.6 -51.6 0.0 0.0 0.0 NTJ
HOH
 9.368
5.930
 CG2
C
 C4
O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 ILE A:400 A:421 0.0 0.0 H -58.6 -46.3 0.0 0.0 0.0 HOH
 6.364
 C
 O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 ILE A:400 A:420 0.0 0.0 H -59.9 -48.8 0.0 0.0 0.0 HOH
 6.085
 C
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 ILE A:400 A:420 0.0 0.0 H -58.7 -47.8 0.0 0.0 0.0 HOH
 6.014
 C
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 ILE A:399 A:420 0.0 0.0 H -55.7 -46.0 0.0 0.0 0.0 HOH
 5.872
 C
 O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 ILE A:397 A:1421 1.0 0.006 H -43.8 -42.3 1.0 0.006 0.0 HOH
 5.875
 O
 O
ILE B:397 B:2421 1.0 0.006 H -43.6 -42.5 1.0 0.006 0.0 HOH
 7.301
 C
 O
ILE C:397 C:3421 43.0 0.246 H -44.2 -41.7 43.0 0.246 0.0 HOH
 7.007
 C
 O
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 LEU A:398 A:420 20.0 0.118 H -63.2 -25.9 20.0 0.118 0.0 HOH
 4.815
 CD2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 ILE A:421 A:421 0.0 0.0 H -65.8 -43.9