Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55844871 . T A CCDS32450.1:NM_001025195.1:c.1138Atg>Ttg_NP_001020366.1:p.380M>L Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 MET A:360 A:1379 64.0 0.346 H -67.6 -32.8 64.0 0.346 0.0 HOH
 3.113
 O
 O
MET B:360 B:2379 64.0 0.346 H -63.6 -37.1 64.0 0.346 0.0 HOH
 4.167
 O
 O
MET C:360 C:3379 65.0 0.351 H -63.8 -35.4 65.0 0.351 0.0 HOH
 3.138
 O
 O
MET D:360 D:4379 59.0 0.319 H -55.5 -40.6 59.0 0.319 0.0 HOH
 3.183
 CE
 O
MET E:360 E:5379 66.0 0.357 H -65.7 -37.3 66.0 0.357 0.0 HOH
 3.487
 SD
 O
MET F:360 F:6379 64.0 0.346 H -61.6 -39.9 64.0 0.346 0.0 HOH
 3.523
 CE
 O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 MET A:360 A:1379 60.0 0.324 H -66.6 -19.8 60.0 0.324 0.0 HOH
 4.705
 N
 O
MET B:360 B:2379 49.0 0.265 H -63.4 -43.4 49.0 0.265 0.0 HOH
 3.763
 CB
 O
MET C:360 C:3379 57.0 0.308 H -60.7 -36.6 57.0 0.308 0.0 HOH
 3.359
 CB
 O
MET D:360 D:4379 53.0 0.286 H -62.6 -49.5 NA NA NA
MET E:360 E:5379 53.0 0.286 H -61.9 -41.2 NA NA NA
MET F:360 F:6379 62.0 0.335 H -58.5 -21.0 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 MET A:360 A:1379 55.0 0.297 H -65.9 -31.2 55.0 0.297 0.0 HOH
 4.609
 O
 O
MET B:360 B:2379 57.0 0.308 H -63.6 -33.3 57.0 0.308 0.0 HOH
 8.460
 N
 O
MET C:360 C:3379 63.0 0.341 H -69.1 -31.2 63.0 0.341 0.0 HOH
 5.109
 CB
 O
MET D:360 D:4379 59.0 0.319 H -53.3 -51.9 59.0 0.319 0.0 HOH
 3.729
 SD
 O
MET E:360 E:5379 66.0 0.357 H -50.7 -40.8 66.0 0.357 0.0 HOH
 7.008
 O
 O
MET F:360 F:6379 58.0 0.314 H -68.1 -29.7 58.0 0.314 0.0 HOH
 6.616
 O
 O
MET G:360 G:1379 54.0 0.292 H -68.7 -48.7 NA NA NA
MET H:360 H:2379 55.0 0.297 H -82.3 -30.2 NA NA NA
MET I:360 I:3379 67.0 0.362 H -57.6 -51.1 NA NA NA
MET J:360 J:4379 55.0 0.297 H -66.9 -41.3 NA NA NA
MET K:360 K:5379 61.0 0.33 H -51.1 -27.1 NA NA NA
MET L:360 L:6379 69.0 0.373 H -70.3 -23.7 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 MET A:360 A:1379 61.0 0.33 H -55.9 -25.3 61.0 0.33 0.0 HOH
 7.128
 O
 O
MET B:360 B:2379 60.0 0.324 H -55.8 -25.8 60.0 0.324 0.0 HOH
 5.357
 O
 O
MET C:360 C:3379 61.0 0.33 H -55.7 -25.0 61.0 0.33 0.0 HOH
 4.166
 CB
 O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 MET A:360 A:1379 58.0 0.314 H -58.1 -21.2 58.0 0.314 0.0 HOH
 7.004
 O
 O
MET B:360 B:2379 56.0 0.303 H -62.0 -27.6 56.0 0.303 0.0 HOH
 7.481
 O
 O
MET C:360 C:3379 54.0 0.292 H -56.6 -39.1 54.0 0.292 0.0 HOH
 3.146
 CE
 O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 MET A:360 A:1379 48.0 0.259 H -56.1 -36.5 48.0 0.259 0.0 HOH
 6.841
 O
 O
MET B:360 B:2379 48.0 0.259 H -55.9 -36.2 48.0 0.259 0.0 HOH
 4.517
 O
 O
MET C:360 C:3379 48.0 0.259 H -56.4 -36.3 48.0 0.259 0.0
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 MET A:360 A:1379 65.0 0.351 H -60.2 -38.7 65.0 0.351 0.0 HOH
 3.005
 O
 O
MET B:360 B:2379 67.0 0.362 H -60.4 -40.6 67.0 0.362 0.0 HOH
 3.123
 O
 O
MET C:360 C:3379 62.0 0.335 H -61.3 -35.9 62.0 0.335 0.0 HOH
 2.961
 O
 O
MET D:360 D:4379 61.0 0.33 H -62.8 -40.5 61.0 0.33 0.0 HOH
 2.733
 O
 O
MET E:360 E:5379 64.0 0.346 H -66.5 -35.0 64.0 0.346 0.0 HOH
 3.056
 O
 O
MET F:360 F:6379 58.0 0.314 H -59.5 -32.2 58.0 0.314 0.0 HOH
 2.958
 O
 O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 MET A:358 A:379 48.0 0.259 H -44.4 -29.1 48.0 0.259 0.0 HOH
 4.722
 SD
 O
MET B:358 B:379 47.0 0.254 H -46.2 -29.4 47.0 0.254 0.0 HOH
 5.593
 SD
 O
MET C:358 C:379 49.0 0.265 H -45.2 -33.5 49.0 0.265 0.0 HOH
 4.345
 O
 O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 MET A:358 A:379 53.0 0.286 H -56.0 -26.7 53.0 0.286 0.0 HOH
 7.693
 CE
 O
MET B:358 B:379 64.0 0.346 H -64.4 -17.2 64.0 0.346 0.0 HOH
 2.833
 O
 O
MET C:358 C:379 59.0 0.319 H -54.3 -40.3 59.0 0.319 0.0 HOH
 7.748
 CE
 O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 MET A:358 A:379 57.0 0.308 H -61.6 -33.6 57.0 0.308 0.0 HOH
 7.138
 O
 O
MET B:358 B:379 59.0 0.319 H -55.1 -32.0 59.0 0.319 0.0 HOH
 5.922
 CE
 O
MET C:358 C:379 59.0 0.319 H -57.5 -36.8 59.0 0.319 0.0 HOH
 6.916
 O
 O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 MET A:358 A:379 45.0 0.243 H -73.4 -38.4 45.0 0.243 0.0
MET B:358 B:379 63.0 0.341 H -36.5 -36.5 63.0 0.341 0.0
MET C:358 C:379 53.0 0.286 H -57.9 -31.6 53.0 0.286 0.0
MET D:358 D:379 66.0 0.357 H -83.0 -57.2 NA NA NA
MET E:358 E:379 67.0 0.362 H -47.6 -36.8 NA NA NA
MET F:358 F:379 59.0 0.319 H -60.9 -24.7 NA NA NA
MET G:358 G:379 61.0 0.33 H -65.3 -30.1 NA NA NA
MET H:358 H:379 44.0 0.238 H -55.2 -53.5 NA NA NA
MET I:358 I:379 62.0 0.335 H -55.0 -37.3 NA NA NA
MET J:358 J:379 49.0 0.265 H -61.9 -33.7 NA NA NA
MET K:358 K:379 56.0 0.303 H -63.5 -40.8 NA NA NA
MET L:358 L:379 59.0 0.319 H -52.1 -50.0 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 MET A:358 A:1379 65.0 0.351 H -67.0 -29.8 65.0 0.351 0.0 HOH
 4.723
 CB
 O
MET B:358 B:2379 59.0 0.319 H -64.0 -28.9 59.0 0.319 0.0 HOH
 7.704
 O
 O
MET C:358 C:3379 56.0 0.303 H -61.8 -42.8 56.0 0.303 0.0 HOH
 6.848
 O
 O
MET D:358 D:4379 61.0 0.33 H -70.2 -25.1 NA NA NA
MET E:358 E:5379 59.0 0.319 H -70.3 -29.1 NA NA NA
MET F:358 F:6379 57.0 0.308 H -61.9 -45.1 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 MET A:358 A:1379 60.0 0.324 H -67.5 -24.6 60.0 0.324 0.0 HOH
 4.538
 O
 O
MET B:358 B:2379 54.0 0.292 H -58.6 -29.9 54.0 0.292 0.0 HOH
 9.433
 CG
 O
MET C:358 C:3379 53.0 0.286 H -61.7 -42.3 53.0 0.286 0.0 HOH
 3.273
 O
 O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 MET A:358 A:379 53.0 0.286 H -61.4 -45.1 53.0 0.286 0.0 HOH
 3.881
 CE
 O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 MET A:358 A:378 60.0 0.324 H -66.6 -43.1 60.0 0.324 0.0 HOH
 6.444
 C
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 MET A:358 A:378 62.0 0.335 H -68.7 -47.0 62.0 0.335 0.0 HOH
 3.024
 CE
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 MET A:357 A:378 60.0 0.324 H -71.6 -36.1 60.0 0.324 0.0 HOH
 3.098
 O
 O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 MET A:355 A:1379 67.0 0.362 H -55.9 -35.7 67.0 0.362 0.0 HOH
 8.375
 O
 O
MET B:355 B:2379 97.0 0.524 H -55.2 -35.0 97.0 0.524 0.0 HOH
 7.224
 SD
 O
MET C:355 NA:NA DO NA DO DO DO NA NA NA
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 THR A:356 A:378 17.0 0.121 H -57.5 -24.4 17.0 0.121 0.0 HOH
 7.189
 OG1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 MET A:379 A:379 64.0 0.346 H -62.0 -43.3