Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55844877 . T A CCDS32450.1:NM_001025195.1:c.1132Aca>Tca_NP_001020366.1:p.378T>S Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 THR A:358 A:1377 52.0 0.371 H -67.7 -35.0 2.0 0.014 0.357 F:P23141:0.357
 HOH
 2.387
 OG1
 O
THR B:358 B:2377 58.0 0.414 H -68.1 -39.2 4.0 0.029 0.385 E:P23141:0.386
 HOH
 4.379
 CG2
 O
THR C:358 C:3377 55.0 0.393 H -68.8 -40.9 2.0 0.014 0.379 D:P23141:0.379
 HOH
 2.640
 OG1
 O
THR D:358 D:4377 52.0 0.371 H -62.7 -47.4 2.0 0.014 0.357 C:P23141:0.357
 HOH
 2.607
 OG1
 O
THR E:358 E:5377 58.0 0.414 H -70.2 -35.4 3.0 0.021 0.393 B:P23141:0.393
 HOH
 2.677
 OG1
 O
THR F:358 F:6377 56.0 0.4 H -67.2 -40.7 3.0 0.021 0.379 A:P23141:0.379
 HOH
 2.388
 OG1
 O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 THR A:358 A:1377 61.0 0.436 H -63.8 -38.3 61.0 0.436 0.0 HOH
 2.499
 O
 O
THR B:358 B:2377 65.0 0.464 H -57.8 -31.1 65.0 0.464 0.0 HOH
 3.683
 OG1
 O
THR C:358 C:3377 70.0 0.5 H -69.0 -33.2 70.0 0.5 0.0 HOH
 3.398
 CA
 O
THR D:358 D:4377 64.0 0.457 H -65.9 -37.9 NA NA NA
THR E:358 E:5377 63.0 0.45 H -60.1 -30.6 NA NA NA
THR F:358 F:6377 65.0 0.464 H -66.2 -38.8 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 THR A:358 A:1377 54.0 0.386 H -50.1 -25.1 0.0 0.0 0.386 F:P23141:0.386
 HOH
 6.764
 OG1
 O
THR B:358 B:2377 60.0 0.429 H -63.4 -33.5 6.0 0.043 0.386 E:P23141:0.386
 HOH
 2.379
 OG1
 O
THR C:358 C:3377 56.0 0.4 H -70.1 -26.2 1.0 0.007 0.393 D:P23141:0.393
 HOH
 3.350
 OG1
 O
THR D:358 D:4377 52.0 0.371 H -65.6 -52.3 1.0 0.007 0.364 C:P23141:0.364
 HOH
 5.863
 OG1
 O
THR E:358 E:5377 56.0 0.4 H -69.8 -33.7 3.0 0.021 0.379 B:P23141:0.379
 HOH
 4.796
 OG1
 O
THR F:358 F:6377 66.0 0.471 H -57.2 -32.5 6.0 0.043 0.428 A:P23141:0.429
 HOH
 2.877
 OG1
 O
THR G:358 G:1377 50.0 0.357 H -61.4 -67.5 NA NA NA
THR H:358 H:2377 64.0 0.457 H -58.5 -23.1 NA NA NA
THR I:358 I:3377 50.0 0.357 H -71.4 -29.3 NA NA NA
THR J:358 J:4377 58.0 0.414 H -72.3 -29.3 NA NA NA
THR K:358 K:5377 50.0 0.357 H -58.5 -44.5 NA NA NA
THR L:358 L:6377 61.0 0.436 H -59.1 -30.3 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 THR A:358 A:1377 63.0 0.45 H -66.4 -25.1 63.0 0.45 0.0 HOH
 4.342
 CG2
 O
THR B:358 B:2377 63.0 0.45 H -66.8 -24.6 63.0 0.45 0.0 HOH
 6.853
 O
 O
THR C:358 C:3377 63.0 0.45 H -68.1 -23.6 63.0 0.45 0.0 HOH
 8.636
 O
 O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 THR A:358 A:1377 66.0 0.471 H -73.0 -30.9 66.0 0.471 0.0 HOH
 9.593
 O
 O
THR B:358 B:2377 60.0 0.429 H -72.6 -34.7 60.0 0.429 0.0
THR C:358 C:3377 64.0 0.457 H -76.2 -18.7 64.0 0.457 0.0 HOH
 6.525
 O
 O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 THR A:358 A:1377 62.0 0.443 H -68.1 -23.1 62.0 0.443 0.0 HOH
 9.687
 N
 O
THR B:358 B:2377 63.0 0.45 H -68.1 -22.3 63.0 0.45 0.0 HOH
 4.903
 OG1
 O
THR C:358 C:3377 65.0 0.464 H -68.0 -22.7 65.0 0.464 0.0
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 THR A:358 A:1377 57.0 0.407 H -66.5 -41.3 2.0 0.014 0.393 F:P23141:0.393
 HOH
 2.534
 OG1
 O
THR B:358 B:2377 55.0 0.393 H -64.5 -39.6 5.0 0.036 0.357 D:P23141:0.357
 HOH
 2.748
 OG1
 O
THR C:358 C:3377 56.0 0.4 H -64.8 -38.4 3.0 0.021 0.379 E:P23141:0.379
 HOH
 2.612
 OG1
 O
THR D:358 D:4377 48.0 0.343 H -73.1 -38.6 1.0 0.007 0.336 B:P23141:0.336
 HOH
 2.573
 OG1
 O
THR E:358 E:5377 55.0 0.393 H -68.0 -39.3 3.0 0.021 0.372 C:P23141:0.371
 HOH
 2.589
 OG1
 O
THR F:358 F:6377 57.0 0.407 H -69.3 -33.9 4.0 0.029 0.378 A:P23141:0.379
 HOH
 2.526
 OG1
 O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 THR A:356 A:377 62.0 0.443 H -54.6 -45.3 62.0 0.443 0.0 HOH
 8.912
 N
 O
THR B:356 B:377 60.0 0.429 H -54.3 -45.2 60.0 0.429 0.0
THR C:356 C:377 62.0 0.443 H -57.2 -38.8 62.0 0.443 0.0 HOH
 7.042
 O
 O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 THR A:356 A:377 65.0 0.464 H -51.3 -32.6 65.0 0.464 0.0 HOH
 6.196
 N
 O
THR B:356 B:377 64.0 0.457 H -44.7 -41.9 64.0 0.457 0.0 HOH
 6.590
 O
 O
THR C:356 C:377 70.0 0.5 H -59.6 -22.4 70.0 0.5 0.0 HOH
 9.503
 N
 O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 THR A:356 A:377 58.0 0.414 H -61.1 -34.5 58.0 0.414 0.0 HOH
 6.999
 N
 O
THR B:356 B:377 55.0 0.393 H -59.0 -37.1 55.0 0.393 0.0 HOH
 4.783
 N
 O
THR C:356 C:377 57.0 0.407 H -63.6 -34.0 57.0 0.407 0.0
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 THR A:356 A:377 54.0 0.386 H -70.9 -46.5 54.0 0.386 0.0
THR B:356 B:377 67.0 0.479 H -49.8 -43.4 67.0 0.479 0.0
THR C:356 C:377 59.0 0.421 H -91.5 -50.1 59.0 0.421 0.0
THR D:356 D:377 70.0 0.5 H -70.8 -27.4 NA NA NA
THR E:356 E:377 65.0 0.464 H -45.4 -35.2 NA NA NA
THR F:356 F:377 62.0 0.443 H -81.5 -25.6 NA NA NA
THR G:356 G:377 60.0 0.429 H -106.9 -31.6 NA NA NA
THR H:356 H:377 62.0 0.443 H -68.1 -38.4 NA NA NA
THR I:356 I:377 56.0 0.4 H -80.6 -35.6 NA NA NA
THR J:356 J:377 71.0 0.507 H -77.1 -29.4 NA NA NA
THR K:356 K:377 53.0 0.379 H -88.9 -19.8 NA NA NA
THR L:356 L:377 68.0 0.486 H -63.2 -25.6 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 THR A:356 A:1377 67.0 0.479 H -62.4 -30.0 67.0 0.479 0.0 HOH
 5.704
 N
 O
THR B:356 B:2377 54.0 0.386 H -55.9 -40.5 54.0 0.386 0.0 HOH
 9.820
 O
 O
THR C:356 C:3377 63.0 0.45 H -74.7 -34.5 63.0 0.45 0.0 HOH
 3.820
 CG2
 O
THR D:356 D:4377 65.0 0.464 H -64.7 -22.1 NA NA NA
THR E:356 E:5377 56.0 0.4 H -66.9 -37.1 NA NA NA
THR F:356 F:6377 65.0 0.464 H -74.5 -31.5 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 THR A:356 A:1377 63.0 0.45 H -61.6 -28.9 63.0 0.45 0.0 HOH
 9.308
 O
 O
THR B:356 B:2377 60.0 0.429 H -55.3 -45.5 60.0 0.429 0.0
THR C:356 C:3377 63.0 0.45 H -78.5 -37.1 63.0 0.45 0.0 HOH
 2.723
 OG1
 O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 THR A:356 A:377 60.0 0.429 H -67.0 -35.1 6.0 0.043 0.386 A:P23141:0.386
 HOH
 2.453
 OG1
 O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 THR A:356 A:376 68.0 0.486 H -69.5 -43.2 68.0 0.486 0.0 HOH
 3.924
 CG2
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 THR A:356 A:376 63.0 0.45 H -63.8 -37.8 63.0 0.45 0.0 HOH
 3.143
 OG1
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 THR A:355 A:376 70.0 0.5 H -64.8 -46.6 70.0 0.5 0.0 HOH
 4.291
 O
 O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 THR A:353 A:1377 102.0 0.729 H -54.9 -43.8 102.0 0.729 0.0
THR B:353 NA:NA DO NA DO DO DO NA NA NA
THR C:353 NA:NA DO NA DO DO DO NA NA NA
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 THR A:354 A:376 49.0 0.35 H -76.6 -36.4 49.0 0.35 0.0 HOH
 8.664
 CG2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 THR A:377 A:377 65.0 0.464 H -64.0 -40.6