Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55844909 . T A CCDS32450.1:NM_001025195.1:c.1100tAt>tTt_NP_001020366.1:p.367Y>F Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 TYR A:347 A:1366 21.0 0.091 -69.4 143.6 16.0 0.07 0.021 F:P23141:0.022
 THA
HOH
 7.827
2.833
 CE1
O
 N15
O
TYR B:347 B:2366 20.0 0.087 -63.8 130.4 14.0 0.061 0.026 E:P23141:0.026
 THA
HOH
 9.534
2.789
 N
O
 C11
O
TYR C:347 C:3366 16.0 0.07 -60.3 132.4 11.0 0.048 0.022 D:P23141:0.022
 THA
HOH
 9.467
3.316
 CD1
O
 N15
O
TYR D:347 D:4366 18.0 0.078 -71.2 136.9 14.0 0.061 0.017 C:P23141:0.017
 THA
HOH
 7.529
3.127
 CE1
O
 N15
O
TYR E:347 E:5366 18.0 0.078 -59.9 127.6 14.0 0.061 0.017 B:P23141:0.017
 THA
HOH
 9.343
3.171
 CD1
O
 C5
O
TYR F:347 F:6366 18.0 0.078 -57.9 133.2 12.0 0.052 0.026 A:P23141:0.026
 THA
HOH
 9.104
3.294
 N
O
 C1
O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 TYR A:347 A:1366 19.0 0.083 -72.2 138.0 19.0 0.083 0.0 HTQ
HTQ
HOH
 9.039
2.997
4.429
 CE1
O
N
 C7
C17
O
TYR B:347 B:2366 21.0 0.091 -70.0 129.9 21.0 0.091 0.0 HTQ
HTQ
HOH
 9.271
5.084
6.147
 CE1
CB
N
 C7
O20
O
TYR C:347 C:3366 20.0 0.087 -68.5 138.3 20.0 0.087 0.0 HTQ
HTQ
HOH
 8.707
5.479
2.862
 CE1
O
O
 C7
O12
O
TYR D:347 D:4366 20.0 0.087 -70.6 134.6 NA NA NA
TYR E:347 E:5366 29.0 0.126 -83.7 148.9 NA NA NA
TYR F:347 F:6366 19.0 0.083 -66.8 131.9 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 TYR A:347 A:1366 23.0 0.1 -56.5 137.4 15.0 0.065 0.035 F:P23141:0.035
 NLX
HOH
 7.893
2.800
 CE1
N
 C7
O
TYR B:347 B:2366 22.0 0.096 -68.7 139.1 12.0 0.052 0.044 E:P23141:0.043
 NLX
HOH
 8.462
2.826
 CD1
O
 C8
O
TYR C:347 C:3366 18.0 0.078 -63.1 135.7 11.0 0.048 0.03 D:P23141:0.03
 NLX
HOH
 7.183
4.616
 CD1
O
 C18
O
TYR D:347 D:4366 21.0 0.091 -75.7 149.8 13.0 0.057 0.034 C:P23141:0.035
 NLX
HOH
 8.881
2.987
 CD1
O
 C8
O
TYR E:347 E:5366 20.0 0.087 -65.5 134.7 12.0 0.052 0.035 B:P23141:0.035
 NLX
HOH
 8.803
3.053
 CD1
O
 C16
O
TYR F:347 F:6366 18.0 0.078 -58.1 133.1 13.0 0.057 0.021 A:P23141:0.022
 NLX
HOH
 8.953
4.249
 N
O
 C20
O
TYR G:347 G:1366 25.0 0.109 -74.6 139.4 NA NA NA
TYR H:347 H:2366 16.0 0.07 -57.5 128.7 NA NA NA
TYR I:347 I:3366 18.0 0.078 -62.2 129.1 NA NA NA
TYR J:347 J:4366 26.0 0.113 -89.5 144.8 NA NA NA
TYR K:347 K:5366 26.0 0.113 -69.0 145.8 NA NA NA
TYR L:347 L:6366 19.0 0.083 -55.1 138.8 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 TYR A:347 A:1366 15.0 0.065 -49.6 133.4 15.0 0.065 0.0 CHD
PLM
HOH
 5.171
9.733
8.726
 O
OH
OH
 C19
O2
O
TYR B:347 B:2366 14.0 0.061 -63.6 146.1 14.0 0.061 0.0 CHD
PLM
HOH
 5.666
8.821
9.495
 O
N
CD1
 C1
CC
O
TYR C:347 C:3366 19.0 0.083 -78.2 132.8 19.0 0.083 0.0 CHD
PLM
HOH
 4.198
9.278
8.847
 O
N
O
 C19
CA
O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 TYR A:347 A:1366 22.0 0.096 -91.3 137.3 22.0 0.096 0.0 HTQ
HOH
 3.590
8.564
 O
OH
 C17
O
TYR B:347 B:2366 18.0 0.078 -65.3 139.3 18.0 0.078 0.0 HTQ
HOH
 6.674
2.509
 O
O
 C13
O
TYR C:347 C:3366 23.0 0.1 -89.8 149.2 23.0 0.1 0.0 COA
HTQ
HOH
 9.245
5.675
6.794
 CE1
CB
N
 C3P
O20
O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 TYR A:347 A:1366 18.0 0.078 -71.4 133.2 18.0 0.078 0.0 TCH
TCH
HOH
 5.517
9.243
5.507
 O
CD1
CB
 C11
C7
O
TYR B:347 B:2366 18.0 0.078 -70.4 131.4 18.0 0.078 0.0 TCH
TCH
HOH
 5.493
8.141
4.261
 O
N
O
 C11
C26
O
TYR C:347 C:3366 17.0 0.074 -70.8 132.6 17.0 0.074 0.0 TCH
TCH
HOH
 5.461
8.300
4.180
 O
N
O
 C11
C25
O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 TYR A:347 A:1366 19.0 0.083 -73.3 136.1 13.0 0.057 0.026 F:P23141:0.026
 COA
COA
HOH
 8.181
5.663
2.625
 N
N
CD1
 N6A
N7A
O
TYR B:347 B:2366 18.0 0.078 -60.7 136.3 13.0 0.057 0.021 D:P23141:0.022
 COA
COA
HOH
 8.870
5.789
3.028
 N
N
O
 N1A
N7A
O
TYR C:347 C:3366 21.0 0.091 -69.3 140.3 15.0 0.065 0.026 E:P23141:0.026
 COA
COA
HOH
 8.438
5.751
2.801
 N
N
O
 N6A
N7A
O
TYR D:347 D:4366 19.0 0.083 -70.5 138.0 17.0 0.074 0.009 B:P23141:0.009
 COA
COA
HOH
 6.692
8.132
2.934
 N
N
O
 N7A
N1A
O
TYR E:347 E:5366 18.0 0.078 -64.0 130.5 11.0 0.048 0.03 C:P23141:0.03
 COA
COA
HOH
 6.032
8.157
2.987
 N
N
O
 N7A
N1A
O
TYR F:347 F:6366 18.0 0.078 -60.6 132.3 13.0 0.057 0.021 A:P23141:0.022
 COA
COA
HOH
 5.806
7.546
3.166
 N
N
O
 N7A
N6A
O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 TYR A:345 A:366 20.0 0.087 -109.0 148.7 20.0 0.087 0.0 CTX
CTX
HOH
 7.710
4.017
7.413
 CE1
CB
O
 C14
C10
O
TYR B:345 B:366 23.0 0.1 -84.8 130.3 23.0 0.1 0.0 CTX
CTX
HOH
 7.341
3.895
8.884
 CE1
O
CD1
 C14
C10
O
TYR C:345 C:366 20.0 0.087 -91.4 141.7 20.0 0.087 0.0 CTX
CTX
HOH
 7.436
4.824
6.643
 OH
O
OH
 C14
C10
O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 TYR A:345 A:366 17.0 0.074 -66.7 135.3 17.0 0.074 0.0 MVB
HOH
 4.703
9.435
 O
CB
 O1
O
TYR B:345 B:366 16.0 0.07 -50.2 138.0 16.0 0.07 0.0 SMB
HOH
 7.307
5.989
 O
O
 C4
O
TYR C:345 C:366 18.0 0.078 -58.9 135.0 18.0 0.078 0.0 MVB
HOH
 5.516
3.048
 O
O
 O1
O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 TYR A:345 A:366 22.0 0.096 -77.8 145.2 22.0 0.096 0.0 EEE
HOH
 5.701
8.749
 O
CB
 C2
O
TYR B:345 B:366 23.0 0.1 -75.2 144.1 23.0 0.1 0.0 EEE
HOH
 5.480
7.428
 O
OH
 C2
O
TYR C:345 C:366 22.0 0.096 -73.1 143.9 22.0 0.096 0.0 EEE
EEE
HOH
 9.828
5.860
7.249
 CE1
O
OH
 C4
C2
O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 TYR A:345 A:366 15.0 0.065 -70.0 143.5 15.0 0.065 0.0 BEZ
HOH
 5.680
9.244
 O
CB
 C5
O
TYR B:345 B:366 19.0 0.083 -71.1 134.9 19.0 0.083 0.0 BEZ
BEZ
HOH
 5.892
9.949
7.924
 O
CE1
CB
 O1
C3
O
TYR C:345 C:366 20.0 0.087 -86.6 142.9 20.0 0.087 0.0 BEZ
BEZ
HOH
 9.729
6.472
5.902
 CE1
O
CB
 C4
C6
O
TYR D:345 D:366 13.0 0.057 -75.2 132.5 NA NA NA
TYR E:345 E:366 17.0 0.074 -70.0 142.6 NA NA NA
TYR F:345 F:366 19.0 0.083 -80.3 149.8 NA NA NA
TYR G:345 G:366 26.0 0.113 -90.3 154.1 NA NA NA
TYR H:345 H:366 15.0 0.065 -68.3 141.7 NA NA NA
TYR I:345 I:366 14.0 0.061 -54.7 141.9 NA NA NA
TYR J:345 J:366 24.0 0.104 -85.9 147.4 NA NA NA
TYR K:345 K:366 19.0 0.083 -70.5 142.5 NA NA NA
TYR L:345 L:366 16.0 0.07 -49.1 140.2 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 TYR A:345 A:1366 23.0 0.1 -97.2 141.6 23.0 0.1 0.0 GLC
FRU
GD7
HOH
 5.169
6.470
8.550
5.517
 O
O
CE1
O
 O6
O1
C2
O
TYR B:345 B:2366 19.0 0.083 -75.6 137.5 19.0 0.083 0.0 GLC
FRU
GD7
HOH
 5.074
6.009
7.880
6.666
 O
O
CE1
N
 C6
C6
C2
O
TYR C:345 C:3366 20.0 0.087 -77.6 141.7 20.0 0.087 0.0 GLC
FRU
GD7
HOH
 4.939
5.832
8.016
2.870
 O
O
CE1
O
 O6
O6
C2
O
TYR D:345 D:4366 23.0 0.1 -86.6 144.1 NA NA NA
TYR E:345 E:5366 19.0 0.083 -74.4 140.0 NA NA NA
TYR F:345 F:6366 21.0 0.091 -74.3 144.8 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 TYR A:345 A:1366 18.0 0.078 -67.0 141.4 18.0 0.078 0.0 GLC
FRU
HOH
 5.381
5.800
8.408
 O
O
OH
 O6
O1
O
TYR B:345 B:2366 21.0 0.091 -72.9 144.0 21.0 0.091 0.0 GLC
FRU
HOH
 4.750
5.364
2.679
 O
O
O
 C6
C6
O
TYR C:345 C:3366 19.0 0.083 -63.1 139.2 19.0 0.083 0.0 GLC
FRU
HOH
 5.448
6.224
2.821
 O
O
O
 O5
O6
O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 TYR A:345 A:366 17.0 0.074 -55.3 131.3 12.0 0.052 0.022 A:P23141:0.022
 HOH
 3.049
 O
 O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 TYR A:345 A:365 13.0 0.057 -76.4 136.8 13.0 0.057 0.0 HOH
 5.001
 N
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 TYR A:345 A:365 14.0 0.061 -58.4 131.2 14.0 0.061 0.0 HOH
 3.001
 O
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 TYR A:344 A:365 11.0 0.048 -69.9 141.6 11.0 0.048 0.0 HOH
 4.398
 CE2
 O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 TYR A:342 A:1366 35.0 0.152 -61.9 140.7 35.0 0.152 0.0 WW2
HOH
 9.569
2.689
 CD1
O
 C2
O
TYR B:342 B:2366 22.0 0.096 -60.4 139.8 22.0 0.096 0.0 HOH
 9.748
 CB
 O
TYR C:342 NA:NA DO NA DO DO DO NA NA NA
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 TYR A:343 NA:NA DO NA DO DO DO NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 TYR A:366 A:366 9.0 0.039 -64.9 136.8