Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55853490 . C A CCDS32450.1:NM_001025195.1:c.863cGa>cTa_NP_001020366.1:p.288R>L Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 ARG A:269 A:1287 75.0 0.333 H -69.7 -22.7 75.0 0.333 0.0 HOH
 2.757
 O
 O
ARG B:269 B:2287 68.0 0.302 H -71.2 -22.9 68.0 0.302 0.0 HOH
 2.801
 O
 O
ARG C:269 C:3287 64.0 0.284 H -72.2 -23.5 64.0 0.284 0.0 HOH
 2.772
 O
 O
ARG D:269 D:4287 74.0 0.329 H -69.5 -18.7 74.0 0.329 0.0 HOH
 2.897
 NH1
 O
ARG E:269 E:5287 71.0 0.316 H -69.4 -23.3 71.0 0.316 0.0 HOH
 2.813
 O
 O
ARG F:269 F:6287 63.0 0.28 H -70.8 -18.1 63.0 0.28 0.0 HOH
 3.011
 O
 O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 ARG A:269 A:1287 73.0 0.324 H -77.3 -29.4 73.0 0.324 0.0 HOH
 2.746
 O
 O
ARG B:269 B:2287 56.0 0.249 H -71.2 -28.0 56.0 0.249 0.0 HOH
 2.859
 NH2
 O
ARG C:269 C:3287 61.0 0.271 H -75.5 -27.8 61.0 0.271 0.0 HOH
 2.571
 O
 O
ARG D:269 D:4287 59.0 0.262 H -66.4 -24.5 NA NA NA
ARG E:269 E:5287 71.0 0.316 H -67.2 -20.2 NA NA NA
ARG F:269 F:6287 66.0 0.293 H -74.1 -23.0 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 ARG A:269 A:1287 65.0 0.289 H -69.0 -19.4 65.0 0.289 0.0 HOH
 2.757
 NH1
 O
ARG B:269 B:2287 72.0 0.32 H -75.2 -26.0 72.0 0.32 0.0 HOH
 2.802
 O
 O
ARG C:269 C:3287 72.0 0.32 H -75.8 -10.0 72.0 0.32 0.0 HOH
 3.870
 O
 O
ARG D:269 D:4287 69.0 0.307 H -63.5 -20.0 69.0 0.307 0.0 HOH
 2.730
 O
 O
ARG E:269 E:5287 69.0 0.307 T -73.2 -2.3 69.0 0.307 0.0 HOH
 3.016
 O
 O
ARG F:269 F:6287 77.0 0.342 T -75.2 -14.8 77.0 0.342 0.0 HOH
 2.971
 O
 O
ARG G:269 G:1287 75.0 0.333 H -59.4 -21.4 NA NA NA
ARG H:269 H:2287 71.0 0.316 H -89.5 -17.3 NA NA NA
ARG I:269 I:3287 76.0 0.338 T -56.5 -11.6 NA NA NA
ARG J:269 J:4287 72.0 0.32 H -83.8 -16.0 NA NA NA
ARG K:269 K:5287 82.0 0.364 T -60.4 -13.7 NA NA NA
ARG L:269 L:6287 71.0 0.316 H -60.0 -30.8 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ARG A:269 A:1287 59.0 0.262 H -67.8 -15.9 59.0 0.262 0.0 SO4
SO4
SO4
HOH
 2.788
8.609
3.268
3.562
 NH1
O
O
NH2
 O4
O2
O1
O
ARG B:269 B:2287 61.0 0.271 H -67.6 -17.9 61.0 0.271 0.0 SO4
SO4
SO4
SO4
HOH
 3.698
7.241
9.978
8.644
2.810
 NH1
C
O
O
O
 O4
O4
O4
O3
O
ARG C:269 C:3287 62.0 0.276 H -67.6 -18.0 62.0 0.276 0.0 SO4
SO4
SO4
SO4
HOH
 9.522
8.789
2.906
7.354
3.058
 O
O
NH1
N
O
 O2
O2
O2
O4
O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ARG A:269 A:1287 67.0 0.298 H -68.1 -23.6 67.0 0.298 0.0 SO4
SO4
SO4
SO4
HOH
 2.834
5.766
8.949
8.574
3.155
 NH1
O
O
C
NH2
 O1
O4
O1
O3
O
ARG B:269 B:2287 58.0 0.258 H -69.8 -24.0 58.0 0.258 0.0 SO4
SO4
SO4
SO4
HOH
 9.015
3.207
5.865
9.006
2.734
 N
NH1
O
O
O
 O3
O4
O1
O1
O
ARG C:269 C:3287 64.0 0.284 H -71.2 -13.3 64.0 0.284 0.0 SO4
SO4
SO4
SO4
HOH
 8.978
8.762
5.555
2.794
2.998
 O
C
O
NH1
O
 O4
O1
O4
O3
O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ARG A:269 A:1287 70.0 0.311 H -65.8 -25.5 70.0 0.311 0.0 SO4
SO4
SO4
SO4
HOH
 3.021
5.721
9.227
8.650
5.765
 NH1
O
O
C
O
 O1
O2
O1
O3
O
ARG B:269 B:2287 72.0 0.32 H -65.2 -26.1 72.0 0.32 0.0 SO4
SO4
SO4
SO4
HOH
 9.251
3.029
6.142
9.085
4.522
 N
NH1
O
O
O
 O3
O4
O2
O1
O
ARG C:269 C:3287 72.0 0.32 H -64.7 -25.2 72.0 0.32 0.0 SO4
SO4
SO4
SO4
HOH
 8.888
8.675
5.022
3.100
5.970
 O
C
O
NH1
O
 O4
O1
O4
O3
O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 ARG A:269 A:1287 75.0 0.333 H -71.7 -21.4 75.0 0.333 0.0 SO4
SO4
SO4
SO4
HOH
 3.016
5.294
8.620
8.887
2.709
 NH1
O
O
C
O
 O1
O1
O4
O3
O
ARG B:269 B:2287 70.0 0.311 H -68.9 -20.8 70.0 0.311 0.0 SO4
SO4
SO4
SO4
HOH
 8.579
3.164
6.077
8.795
2.729
 C
NH1
O
O
O
 O4
O3
O3
O3
O
ARG C:269 C:3287 65.0 0.289 H -71.6 -17.9 65.0 0.289 0.0 SO4
SO4
SO4
SO4
HOH
 9.133
8.877
6.165
3.159
2.590
 O
C
O
NH1
NH2
 O3
O1
O2
O2
O
ARG D:269 D:4287 73.0 0.324 H -71.7 -15.7 73.0 0.324 0.0 SO4
SO4
SO4
SO4
HOH
 8.621
3.151
6.421
8.531
2.793
 C
NH1
O
O
O
 O2
O4
O1
O1
O
ARG E:269 E:5287 68.0 0.302 H -72.5 -19.0 65.0 0.289 0.013 F:P23141:0.013
 SO4
SO4
SO4
SO4
HOH
 5.410
9.053
3.206
8.709
2.834
 O
O
CD
C
O
 O1
O1
O4
O3
O
ARG F:269 F:6287 69.0 0.307 H -72.1 -19.1 69.0 0.307 0.0 SO4
SO4
SO4
SO4
HOH
 8.826
8.640
5.915
3.051
2.595
 C
O
O
NH1
O
 O4
O3
O2
O3
O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ARG A:267 A:287 62.0 0.276 H -60.1 -32.1 62.0 0.276 0.0 SO4
SO4
SO4
SO4
HOH
 2.556
5.672
9.087
8.568
4.099
 NH1
O
O
C
NH1
 O1
O4
O3
O3
O
ARG B:267 B:287 59.0 0.262 H -60.4 -30.0 59.0 0.262 0.0 SO4
SO4
SO4
SO4
HOH
 8.754
2.851
6.107
9.063
3.364
 N
NH1
O
O
O
 O3
O4
O2
O1
O
ARG C:267 C:287 62.0 0.276 H -61.2 -26.7 62.0 0.276 0.0 SO4
SO4
SO4
SO4
HOH
 8.872
8.067
5.129
3.145
4.642
 O
C
O
NH1
NH1
 O4
O1
O4
O3
O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ARG A:267 A:287 68.0 0.302 T -59.3 -26.5 68.0 0.302 0.0 SO4
SO4
SO4
SO4
HOH
 2.896
6.379
9.145
8.841
3.154
 NH1
O
O
C
NH2
 O1
O1
O4
O1
O
ARG B:267 B:287 63.0 0.28 H -70.5 -20.7 63.0 0.28 0.0 SO4
SO4
SO4
SO4
HOH
 9.036
2.918
5.620
9.289
3.282
 C
NH1
O
O
CD
 O2
O2
O1
O1
O
ARG C:267 C:287 69.0 0.307 H -71.3 -18.9 69.0 0.307 0.0 SO4
SO4
SO4
SO4
HOH
 9.004
8.694
5.283
2.823
2.517
 O
N
O
NH1
O
 O4
O2
O2
O2
O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ARG A:267 A:287 59.0 0.262 H -74.7 -17.9 59.0 0.262 0.0 SO4
SO4
SO4
SO4
HOH
 3.116
2.947
9.388
8.652
5.956
 NH1
O
O
N
NH2
 O3
O1
O1
O1
O
ARG B:267 B:287 57.0 0.253 H -69.3 -25.4 57.0 0.253 0.0 SO4
SO4
SO4
SO4
HOH
 8.177
3.150
9.579
7.609
2.824
 C
NH1
O
O
O
 O4
O2
O4
O2
O
ARG C:267 C:287 61.0 0.271 H -75.3 -18.0 61.0 0.271 0.0 SO4
SO4
SO4
SO4
HOH
 9.444
6.124
2.927
6.716
2.737
 O
O
NH1
C
O
 O4
O3
O2
O1
O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 ARG A:267 A:287 62.0 0.276 H -52.7 -30.0 58.0 0.258 0.018 C:P23141:0.018
 SO4
SO4
SO4
SO4
HOH
 2.988
5.997
9.097
8.512
4.737
 NH1
O
O
C
O
 O1
O3
O3
O4
O
ARG B:267 B:287 73.0 0.324 H -69.5 -23.5 73.0 0.324 0.0 SO4
SO4
SO4
SO4
HOH
 8.564
2.822
5.506
9.308
6.063
 C
NH1
O
O
NH2
 O1
O4
O3
O2
O
ARG C:267 C:287 70.0 0.311 T -75.5 -17.1 65.0 0.289 0.022 B:P23141:0.022
 SO4
SO4
SO4
SO4
HOH
 8.985
8.455
5.327
2.864
6.122
 O
N
O
NH1
NH1
 O4
O4
O1
O1
O
ARG D:267 D:287 61.0 0.271 H -67.4 -33.0 NA NA NA
ARG E:267 E:287 60.0 0.267 H -62.8 -33.9 NA NA NA
ARG F:267 F:287 62.0 0.276 T -69.5 -21.3 NA NA NA
ARG G:267 G:287 63.0 0.28 H -77.4 -20.8 NA NA NA
ARG H:267 H:287 56.0 0.249 T -68.0 -8.7 NA NA NA
ARG I:267 I:287 59.0 0.262 H -76.2 -31.6 NA NA NA
ARG J:267 J:287 63.0 0.28 H -71.9 -19.6 NA NA NA
ARG K:267 K:287 60.0 0.267 H -82.9 -30.5 NA NA NA
ARG L:267 L:287 71.0 0.316 H -57.0 -35.6 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 ARG A:267 A:1287 66.0 0.293 H -67.6 -19.2 66.0 0.293 0.0 SO4
SO4
SO4
SO4
HOH
 3.076
5.938
8.978
9.043
3.039
 NH1
O
O
N
NH2
 O1
O1
O2
O3
O
ARG B:267 B:2287 73.0 0.324 T -66.9 -12.7 73.0 0.324 0.0 SO4
SO4
SO4
SO4
HOH
 9.278
3.068
5.880
8.688
2.679
 C
NH1
O
O
O
 O2
O3
O4
O4
O
ARG C:267 C:3287 66.0 0.293 H -69.6 -20.3 66.0 0.293 0.0 SO4
SO4
SO4
SO4
HOH
 9.297
8.324
5.970
3.142
2.849
 O
N
O
CD
NH1
 O3
O3
O2
O2
O
ARG D:267 D:4287 65.0 0.289 T -68.4 -16.7 NA NA NA
ARG E:267 E:5287 67.0 0.298 H -68.0 -21.0 NA NA NA
ARG F:267 F:6287 58.0 0.258 H -73.1 -21.9 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 ARG A:267 A:1287 62.0 0.276 H -66.8 -24.0 62.0 0.276 0.0 SO4
SO4
SO4
SO4
HOH
 2.812
6.324
9.653
8.804
2.770
 NH1
O
O
N
O
 O2
O1
O4
O4
O
ARG B:267 B:2287 68.0 0.302 T -71.3 3.6 68.0 0.302 0.0 SO4
SO4
SO4
HOH
 9.355
3.086
9.195
2.851
 N
NH1
O
O
 O4
O2
O4
O
ARG C:267 C:3287 59.0 0.262 H -73.3 -21.1 59.0 0.262 0.0 SO4
SO4
SO4
HOH
 9.231
5.737
2.817
2.853
 O
O
NH1
O
 O1
O3
O3
O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 ARG A:267 A:287 68.0 0.302 H -65.6 -18.6 68.0 0.302 0.0 SCN
SCN
SCN
HOH
 3.821
8.981
9.449
2.881
 O
O
O
O
 S
N
S
O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 ARG A:267 A:287 61.0 0.271 H -63.7 -15.5 61.0 0.271 0.0 PO4
PO4
HOH
 7.499
3.887
2.721
 C
O
O
 O3
O2
O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 ARG A:267 A:287 61.0 0.271 H -66.4 -15.5 61.0 0.271 0.0 HOH
 2.645
 NH1
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 ARG A:266 A:287 62.0 0.276 T -63.6 -16.1 62.0 0.276 0.0 IOD
IOD
HOH
 4.408
7.634
2.862
 CD
N
O
 I
I
O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 ARG A:264 A:1287 69.0 0.307 H -68.9 -20.7 69.0 0.307 0.0 HOH
 6.469
 NH2
 O
ARG B:264 B:2287 70.0 0.311 H -70.5 -19.7 70.0 0.311 0.0 HOH
 2.705
 NH1
 O
ARG C:264 C:3287 70.0 0.311 H -69.1 -19.7 70.0 0.311 0.0 HOH
 2.944
 NH2
 O
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 ARG A:264 A:286 72.0 0.32 H -66.0 -18.6 72.0 0.32 0.0 HOH
 2.923
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 ARG A:287 A:287 62.0 0.276 H -70.5 -24.2