Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55854290 . C A CCDS32450.1:NM_001025195.1:c.795ttG>ttT_NP_001020366.1:p.265L>F Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 LEU A:246 A:1264 15.0 0.088 H -68.4 -41.3 15.0 0.088 0.0 HOH
 3.187
 N
 O
LEU B:246 B:2264 18.0 0.106 H -60.4 -41.4 18.0 0.106 0.0 HOH
 4.027
 CB
 O
LEU C:246 C:3264 14.0 0.082 H -71.1 -44.0 14.0 0.082 0.0 HOH
 3.072
 N
 O
LEU D:246 D:4264 17.0 0.1 H -63.6 -46.2 17.0 0.1 0.0 HOH
 3.086
 N
 O
LEU E:246 E:5264 16.0 0.094 H -64.9 -42.8 16.0 0.094 0.0 HOH
 3.138
 N
 O
LEU F:246 F:6264 24.0 0.141 H -62.8 -46.6 24.0 0.141 0.0 HOH
 3.098
 N
 O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 LEU A:246 A:1264 25.0 0.147 H -59.2 -48.0 25.0 0.147 0.0 HOH
 3.279
 CB
 O
LEU B:246 B:2264 17.0 0.1 H -70.0 -30.9 17.0 0.1 0.0 HOH
 3.045
 N
 O
LEU C:246 C:3264 21.0 0.124 H -61.0 -42.6 21.0 0.124 0.0 HOH
 3.654
 CA
 O
LEU D:246 D:4264 22.0 0.129 H -63.9 -45.9 NA NA NA
LEU E:246 E:5264 15.0 0.088 H -63.0 -36.9 NA NA NA
LEU F:246 F:6264 20.0 0.118 H -61.9 -45.2 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 LEU A:246 A:1264 26.0 0.153 H -66.9 -51.7 26.0 0.153 0.0 HOH
 3.400
 N
 O
LEU B:246 B:2264 17.0 0.1 H -72.4 -35.8 17.0 0.1 0.0 HOH
 4.111
 CG
 O
LEU C:246 C:3264 15.0 0.088 H -61.1 -51.0 15.0 0.088 0.0 HOH
 2.942
 CD1
 O
LEU D:246 D:4264 22.0 0.129 H -66.4 -40.7 22.0 0.129 0.0 HOH
 4.165
 CD1
 O
LEU E:246 E:5264 19.0 0.112 H -77.3 -33.5 19.0 0.112 0.0 HOH
 7.938
 CD2
 O
LEU F:246 F:6264 26.0 0.153 H -69.5 -34.7 26.0 0.153 0.0 HOH
 2.781
 N
 O
LEU G:246 G:1264 22.0 0.129 H -74.3 -45.2 NA NA NA
LEU H:246 H:2264 22.0 0.129 H -69.4 -51.2 NA NA NA
LEU I:246 I:3264 24.0 0.141 H -73.7 -40.7 NA NA NA
LEU J:246 J:4264 22.0 0.129 H -77.8 -36.1 NA NA NA
LEU K:246 K:5264 12.0 0.071 H -79.4 -45.2 NA NA NA
LEU L:246 L:6264 23.0 0.135 H -75.1 -37.8 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:246 A:1264 16.0 0.094 H -66.0 -42.6 16.0 0.094 0.0 HOH
 5.778
 CD2
 O
LEU B:246 B:2264 21.0 0.124 H -67.0 -42.6 21.0 0.124 0.0 HOH
 5.150
 CD1
 O
LEU C:246 C:3264 25.0 0.147 H -66.8 -42.4 25.0 0.147 0.0 HOH
 8.331
 CD1
 O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:246 A:1264 19.0 0.112 H -71.7 -43.6 19.0 0.112 0.0 NAG
HOH
 9.442
4.537
 N
CD1
 C8
O
LEU B:246 B:2264 18.0 0.106 H -71.8 -48.7 18.0 0.106 0.0 HOH
 4.215
 CD1
 O
LEU C:246 C:3264 20.0 0.118 H -59.7 -42.2 20.0 0.118 0.0 HOH
 2.720
 N
 O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:246 A:1264 30.0 0.176 H -64.0 -37.7 30.0 0.176 0.0 HOH
 5.847
 O
 O
LEU B:246 B:2264 31.0 0.182 H -61.1 -38.8 31.0 0.182 0.0 HOH
 4.681
 CD2
 O
LEU C:246 C:3264 34.0 0.2 H -63.8 -38.4 34.0 0.2 0.0 HOH
 8.711
 CD1
 O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:246 A:1264 31.0 0.182 H -61.3 -45.9 31.0 0.182 0.0 HOH
 3.052
 N
 O
LEU B:246 B:2264 22.0 0.129 H -67.9 -41.0 22.0 0.129 0.0 HOH
 3.165
 N
 O
LEU C:246 C:3264 19.0 0.112 H -66.8 -39.7 19.0 0.112 0.0 HOH
 3.283
 N
 O
LEU D:246 D:4264 23.0 0.135 H -71.3 -41.5 23.0 0.135 0.0 HOH
 3.201
 CD1
 O
LEU E:246 E:5264 23.0 0.135 H -68.8 -40.1 23.0 0.135 0.0 HOH
 3.079
 N
 O
LEU F:246 F:6264 24.0 0.141 H -71.8 -42.5 24.0 0.141 0.0 HOH
 3.361
 CD2
 O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:244 A:264 20.0 0.118 H -64.0 -38.4 20.0 0.118 0.0 HOH
 5.798
 CD2
 O
LEU B:244 B:264 28.0 0.165 H -56.6 -45.2 28.0 0.165 0.0 HOH
 4.734
 CD2
 O
LEU C:244 C:264 23.0 0.135 H -67.0 -42.5 23.0 0.135 0.0 HOH
 5.086
 CA
 O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:244 A:264 13.0 0.076 H -68.8 -38.9 13.0 0.076 0.0 HOH
 3.048
 CB
 O
LEU B:244 B:264 30.0 0.176 H -63.7 -34.6 30.0 0.176 0.0 HOH
 3.103
 CD2
 O
LEU C:244 C:264 22.0 0.129 H -55.0 -27.0 22.0 0.129 0.0 HOH
 3.313
 CD2
 O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:244 A:264 26.0 0.153 H -62.1 -37.7 26.0 0.153 0.0 HOH
 2.756
 N
 O
LEU B:244 B:264 26.0 0.153 H -62.4 -41.4 26.0 0.153 0.0 HOH
 3.549
 CG
 O
LEU C:244 C:264 26.0 0.153 H -63.9 -41.5 26.0 0.153 0.0 HOH
 4.006
 CD1
 O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:244 A:264 17.0 0.1 H -55.2 -54.5 17.0 0.1 0.0 HOH
 5.465
 CG
 O
LEU B:244 B:264 21.0 0.124 H -61.2 -38.7 21.0 0.124 0.0 HOH
 3.739
 CD1
 O
LEU C:244 C:264 24.0 0.141 H -62.8 -35.9 24.0 0.141 0.0 HOH
 8.601
 CD1
 O
LEU D:244 D:264 30.0 0.176 H -72.6 -41.6 NA NA NA
LEU E:244 E:264 23.0 0.135 H -76.0 -46.7 NA NA NA
LEU F:244 F:264 25.0 0.147 H -64.3 -41.3 NA NA NA
LEU G:244 G:264 26.0 0.153 H -73.1 -37.9 NA NA NA
LEU H:244 H:264 17.0 0.1 H -74.9 -37.0 NA NA NA
LEU I:244 I:264 31.0 0.182 H -67.6 -45.8 NA NA NA
LEU J:244 J:264 19.0 0.112 H -75.9 -39.5 NA NA NA
LEU K:244 K:264 17.0 0.1 H -76.9 -44.2 NA NA NA
LEU L:244 L:264 29.0 0.171 H -64.8 -40.3 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 LEU A:244 A:1264 14.0 0.082 H -69.7 -45.2 14.0 0.082 0.0 NAG
HOH
 9.651
2.763
 N
N
 O7
O
LEU B:244 B:2264 19.0 0.112 H -61.0 -45.5 19.0 0.112 0.0 HOH
 4.065
 CD1
 O
LEU C:244 C:3264 17.0 0.1 H -66.1 -39.2 17.0 0.1 0.0 HOH
 4.347
 CD1
 O
LEU D:244 D:4264 15.0 0.088 H -67.7 -48.3 NA NA NA
LEU E:244 E:5264 21.0 0.124 H -66.9 -45.8 NA NA NA
LEU F:244 F:6264 20.0 0.118 H -67.5 -40.8 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 LEU A:244 A:1264 11.0 0.065 H -68.6 -33.9 11.0 0.065 0.0 HOH
 3.222
 N
 O
LEU B:244 B:2264 24.0 0.141 H -62.3 -48.8 24.0 0.141 0.0 HOH
 4.169
 CD1
 O
LEU C:244 C:3264 22.0 0.129 H -60.4 -39.4 22.0 0.129 0.0 HOH
 3.148
 N
 O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 LEU A:244 A:264 26.0 0.153 H -62.3 -41.9 26.0 0.153 0.0 HOH
 3.265
 N
 O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 LEU A:244 A:264 19.0 0.112 H -73.1 -41.9 19.0 0.112 0.0 HOH
 2.942
 N
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 LEU A:244 A:264 37.0 0.218 H -60.9 -47.1 37.0 0.218 0.0 HOH
 3.048
 N
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 LEU A:243 A:264 23.0 0.135 H -63.6 -48.3 23.0 0.135 0.0 HOH
 3.315
 N
 O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 LEU A:241 A:1264 65.0 0.382 H -71.9 -36.9 65.0 0.382 0.0
LEU B:241 B:2264 54.0 0.318 H -71.7 -37.2 54.0 0.318 0.0
LEU C:241 C:3264 61.0 0.359 H -71.1 -36.5 61.0 0.359 0.0 HOH
 8.892
 CD1
 O
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 LEU A:241 A:263 3.0 0.018 H -64.3 -51.3 3.0 0.018 0.0 HOH
 3.839
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 LEU A:264 A:264 12.0 0.071 H -66.3 -40.2
af-q9uky3-f1 1 Q9UKY3 93.63 3e-170 LEU A:265 A:265 117.0 0.688 H -69.2 -40.4