Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55854337 . C A CCDS32450.1:NM_001025195.1:c.748Gtg>Ttg_NP_001020366.1:p.250V>L Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 VAL A:231 A:1249 0.0 0.0 -137.3 173.5 0.0 0.0 0.0 THA
HOH
 7.284
3.625
 N
CG1
 C1
O
VAL B:231 B:2249 0.0 0.0 -145.0 175.7 0.0 0.0 0.0 THA
HOH
 8.264
3.905
 N
CG1
 C13
O
VAL C:231 C:3249 0.0 0.0 -142.9 172.6 0.0 0.0 0.0 THA
HOH
 6.203
3.631
 N
CG1
 C12
O
VAL D:231 D:4249 0.0 0.0 -142.1 174.8 0.0 0.0 0.0 THA
HOH
 7.241
3.531
 N
CG1
 C1
O
VAL E:231 E:5249 0.0 0.0 -139.2 174.4 0.0 0.0 0.0 THA
HOH
 8.180
3.474
 O
CG1
 C12
O
VAL F:231 F:6249 0.0 0.0 -137.3 179.3 0.0 0.0 0.0 THA
HOH
 7.378
3.344
 N
CG1
 C6
O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 VAL A:231 A:1249 0.0 0.0 -142.6 173.3 0.0 0.0 0.0 CL
HTQ
HOH
 8.974
6.858
3.808
 N
N
CG1
 CL
C9
O
VAL B:231 B:2249 0.0 0.0 -143.7 168.0 0.0 0.0 0.0 HTQ
HOH
 7.115
3.927
 N
CG1
 C9
O
VAL C:231 C:3249 0.0 0.0 -133.0 172.8 0.0 0.0 0.0 HTQ
HOH
 7.181
3.673
 O
CG1
 C9
O
VAL D:231 D:4249 0.0 0.0 -133.7 176.1 NA NA NA
VAL E:231 E:5249 0.0 0.0 -133.2 175.9 NA NA NA
VAL F:231 F:6249 0.0 0.0 -145.5 171.1 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 VAL A:231 A:1249 0.0 0.0 -144.0 169.6 0.0 0.0 0.0 NLX
HOH
 9.723
8.283
 N
N
 O1
O
VAL B:231 B:2249 0.0 0.0 -143.7 173.6 0.0 0.0 0.0 NLX
HOH
 9.703
5.785
 N
CB
 C15
O
VAL C:231 C:3249 0.0 0.0 -148.9 179.3 0.0 0.0 0.0 NLX
HOH
 6.506
3.187
 N
CG1
 O3
O
VAL D:231 D:4249 0.0 0.0 -148.8 162.8 0.0 0.0 0.0 NLX
HOH
 8.801
6.160
 N
C
 O3
O
VAL E:231 E:5249 0.0 0.0 -142.7 169.2 0.0 0.0 0.0 NLX
HOH
 7.688
3.672
 N
CG1
 O1
O
VAL F:231 F:6249 0.0 0.0 -142.1 -178.8 0.0 0.0 0.0 NLX
HOH
 7.098
6.910
 N
O
 O3
O
VAL G:231 G:1249 1.0 0.006 -156.8 169.6 NA NA NA
VAL H:231 H:2249 0.0 0.0 -144.2 169.8 NA NA NA
VAL I:231 I:3249 0.0 0.0 -151.4 168.8 NA NA NA
VAL J:231 J:4249 0.0 0.0 -148.2 172.4 NA NA NA
VAL K:231 K:5249 0.0 0.0 -129.0 173.2 NA NA NA
VAL L:231 L:6249 0.0 0.0 -135.0 173.7 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 VAL A:231 A:1249 0.0 0.0 -141.2 -179.1 0.0 0.0 0.0 PLM
HOH
 7.346
3.686
 N
CG1
 O1
O
VAL B:231 B:2249 0.0 0.0 -139.2 -177.0 0.0 0.0 0.0 PLM
HOH
 7.764
4.046
 N
CG1
 O1
O
VAL C:231 C:3249 0.0 0.0 -139.6 -178.1 0.0 0.0 0.0 PLM
HOH
 8.017
3.825
 N
CG1
 O2
O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 VAL A:231 A:1249 0.0 0.0 -150.0 168.8 0.0 0.0 0.0 F
PLM
HOH
 9.524
8.535
3.432
 N
N
CG1
 F
O2
O
VAL B:231 B:2249 0.0 0.0 -142.2 169.8 0.0 0.0 0.0 F
PLM
HOH
 9.077
7.874
4.346
 N
N
CG1
 F
O1
O
VAL C:231 C:3249 0.0 0.0 -139.0 179.2 0.0 0.0 0.0 F
COA
PLM
HOH
 9.278
8.553
7.367
3.750
 N
N
O
CG1
 F
S1P
O1
O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 VAL A:231 A:1249 0.0 0.0 -134.5 175.9 0.0 0.0 0.0 TCH
HOH
 5.630
5.674
 N
CB
 O3
O
VAL B:231 B:2249 0.0 0.0 -132.9 177.5 0.0 0.0 0.0 TCH
HOH
 4.379
5.953
 N
CB
 O3
O
VAL C:231 C:3249 0.0 0.0 -133.0 176.1 0.0 0.0 0.0 TCH
HOH
 5.030
3.825
 O
CG1
 O3
O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 VAL A:231 A:1249 0.0 0.0 -144.2 175.7 0.0 0.0 0.0 COA
HOH
 9.737
3.654
 N
CG1
 C2P
O
VAL B:231 B:2249 0.0 0.0 -142.1 175.0 0.0 0.0 0.0 COA
HOH
 9.524
3.631
 N
CG1
 C2P
O
VAL C:231 C:3249 0.0 0.0 -141.6 176.1 0.0 0.0 0.0 COA
HOH
 9.557
3.648
 O
CG1
 C2P
O
VAL D:231 D:4249 0.0 0.0 -143.1 175.3 0.0 0.0 0.0 COA
HOH
 8.416
3.655
 N
CG1
 S1P
O
VAL E:231 E:5249 0.0 0.0 -141.1 173.7 0.0 0.0 0.0 COA
HOH
 9.709
3.571
 N
CG1
 C2P
O
VAL F:231 F:6249 0.0 0.0 -141.0 175.4 0.0 0.0 0.0 COA
HOH
 9.129
3.559
 N
CG1
 S1P
O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 VAL A:229 A:249 0.0 0.0 -139.0 -177.7 0.0 0.0 0.0 CTX
HOH
 8.948
3.321
 N
CG1
 CA
O
VAL B:229 B:249 1.0 0.006 -141.9 -176.5 1.0 0.006 0.0 CTX
HOH
 8.916
3.554
 N
CG1
 CA
O
VAL C:229 C:249 0.0 0.0 -137.9 -179.7 0.0 0.0 0.0 CTX
HOH
 9.013
3.570
 N
CG1
 CA
O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 VAL A:229 A:249 0.0 0.0 -140.7 -174.9 0.0 0.0 0.0 HOH
 3.877
 CG1
 O
VAL B:229 B:249 0.0 0.0 -137.8 -176.3 0.0 0.0 0.0 HOH
 4.306
 CG1
 O
VAL C:229 C:249 0.0 0.0 -135.8 176.4 0.0 0.0 0.0 HOH
 3.799
 CG1
 O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 VAL A:229 A:249 0.0 0.0 -139.6 178.8 0.0 0.0 0.0 EEE
HOH
 9.544
3.625
 O
CG1
 C4
O
VAL B:229 B:249 0.0 0.0 -140.9 -179.3 0.0 0.0 0.0 EEE
HOH
 9.241
3.299
 N
CG1
 C4
O
VAL C:229 C:249 0.0 0.0 -135.3 179.5 0.0 0.0 0.0 EEE
HOH
 9.822
4.028
 O
CG1
 C4
O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 VAL A:229 A:249 0.0 0.0 -141.4 179.4 0.0 0.0 0.0 BEZ
HOH
 9.127
3.136
 N
CG1
 O1
O
VAL B:229 B:249 0.0 0.0 -133.3 -174.2 0.0 0.0 0.0 BEZ
HOH
 8.455
4.437
 N
CG1
 C5
O
VAL C:229 C:249 0.0 0.0 -132.5 172.4 0.0 0.0 0.0 BEZ
HOH
 9.371
3.959
 N
CG1
 C
O
VAL D:229 D:249 0.0 0.0 -151.0 173.9 NA NA NA
VAL E:229 E:249 0.0 0.0 -129.0 -174.4 NA NA NA
VAL F:229 F:249 0.0 0.0 -149.0 154.8 NA NA NA
VAL G:229 G:249 0.0 0.0 -129.6 174.0 NA NA NA
VAL H:229 H:249 0.0 0.0 -140.2 162.2 NA NA NA
VAL I:229 I:249 0.0 0.0 -134.0 -179.9 NA NA NA
VAL J:229 J:249 0.0 0.0 -129.4 -175.9 NA NA NA
VAL K:229 K:249 0.0 0.0 -141.5 -179.1 NA NA NA
VAL L:229 L:249 0.0 0.0 -144.2 -176.2 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 VAL A:229 A:1249 0.0 0.0 -149.3 173.9 0.0 0.0 0.0 GD7
HOH
 8.051
4.071
 N
CG1
 C4
O
VAL B:229 B:2249 0.0 0.0 -145.2 171.0 0.0 0.0 0.0 GD7
HOH
 8.212
3.715
 N
CG1
 C4
O
VAL C:229 C:3249 0.0 0.0 -142.5 167.3 0.0 0.0 0.0 GD7
HOH
 8.489
3.475
 N
CG1
 C4
O
VAL D:229 D:4249 0.0 0.0 -151.0 173.2 NA NA NA
VAL E:229 E:5249 0.0 0.0 -142.9 175.1 NA NA NA
VAL F:229 F:6249 0.0 0.0 -144.8 167.9 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 VAL A:229 A:1249 0.0 0.0 -149.3 176.7 0.0 0.0 0.0 NTJ
HOH
 7.976
3.752
 N
CG1
 C3
O
VAL B:229 B:2249 0.0 0.0 -145.9 172.1 0.0 0.0 0.0 NTJ
HOH
 7.778
3.820
 N
CG1
 C3
O
VAL C:229 C:3249 0.0 0.0 -138.3 175.8 0.0 0.0 0.0 NTJ
HOH
 8.396
3.710
 N
CG1
 C3
O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 VAL A:229 A:249 7.0 0.045 -131.8 175.7 7.0 0.045 0.0 SCN
HOH
 7.370
3.071
 O
N
 S
O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 VAL A:229 A:249 0.0 0.0 -139.8 176.1 0.0 0.0 0.0 HOH
 3.765
 CG1
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 VAL A:229 A:249 0.0 0.0 -139.3 179.7 0.0 0.0 0.0 HOH
 3.696
 CG1
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 VAL A:228 A:249 0.0 0.0 -146.2 177.6 0.0 0.0 0.0 HOH
 3.607
 CG1
 O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 VAL A:226 A:1249 0.0 0.0 -129.8 173.9 0.0 0.0 0.0 WW2
HOH
 9.533
4.355
 N
CG1
 O1
O
VAL B:226 B:2249 0.0 0.0 -131.3 172.9 0.0 0.0 0.0 WW2
 9.983
 N
 P1
VAL C:226 C:3249 0.0 0.0 -131.0 174.1 0.0 0.0 0.0 WW2
 9.854
 N
 P1
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 VAL A:227 A:249 0.0 0.0 -142.0 168.9 0.0 0.0 0.0 HOH
 3.079
 CG1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 VAL A:249 A:249 0.0 0.0 -145.7 168.7
af-q9uky3-f1 1 Q9UKY3 93.63 3e-170 VAL A:250 A:250 60.0 0.387 -146.0 167.3