Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55855311 . T A CCDS32450.1:NM_001025195.1:c.662gAg>gTg_NP_001020366.1:p.221E>V Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 GLU A:202 A:1220 1.0 0.005 E -119.9 139.5 1.0 0.005 0.0 THA
HOH
 4.407
2.871
 OE1
OE1
 C2
O
GLU B:202 B:2220 0.0 0.0 E -122.5 152.2 0.0 0.0 0.0 THA
HOH
 4.272
2.963
 OE2
CG
 C11
O
GLU C:202 C:3220 1.0 0.005 E -129.9 145.1 1.0 0.005 0.0 THA
HOH
 4.109
2.583
 OE2
OE1
 C2
O
GLU D:202 D:4220 1.0 0.005 E -118.8 138.2 1.0 0.005 0.0 THA
HOH
 4.332
2.978
 OE1
OE2
 C11
O
GLU E:202 E:5220 1.0 0.005 E -122.7 147.5 1.0 0.005 0.0 THA
HOH
 4.377
2.834
 OE2
OE2
 C11
O
GLU F:202 F:6220 0.0 0.0 E -127.5 152.5 0.0 0.0 0.0 THA
HOH
 4.449
2.853
 OE2
OE1
 C2
O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 GLU A:202 A:1220 0.0 0.0 E -119.4 140.2 0.0 0.0 0.0 CL
HTQ
HOH
 4.799
4.976
2.561
 O
OE1
OE1
 CL
O20
O
GLU B:202 B:2220 0.0 0.0 E -122.7 156.8 0.0 0.0 0.0 HTQ
HOH
 5.381
2.686
 OE2
OE1
 O20
O
GLU C:202 C:3220 0.0 0.0 E -128.8 155.2 0.0 0.0 0.0 HTQ
HOH
 5.156
3.006
 OE2
OE1
 O12
O
GLU D:202 D:4220 0.0 0.0 E -109.5 146.2 NA NA NA
GLU E:202 E:5220 0.0 0.0 E -116.7 140.3 NA NA NA
GLU F:202 F:6220 0.0 0.0 E -117.8 153.5 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 GLU A:202 A:1220 1.0 0.005 E -113.5 123.6 1.0 0.005 0.0 NLX
HOH
 3.672
2.951
 OE2
OE1
 O1
O
GLU B:202 B:2220 0.0 0.0 E -131.7 156.7 0.0 0.0 0.0 NLX
HOH
 5.143
2.843
 OE1
CG
 O2
O
GLU C:202 C:3220 1.0 0.005 E -119.5 151.4 1.0 0.005 0.0 NLX
HOH
 3.723
5.828
 OE2
OE1
 O1
O
GLU D:202 D:4220 1.0 0.005 E -118.8 142.4 1.0 0.005 0.0 NLX
HOH
 2.881
2.638
 OE1
OE2
 O1
O
GLU E:202 E:5220 0.0 0.0 E -124.1 156.9 0.0 0.0 0.0 NLX
HOH
 2.824
2.682
 OE2
OE1
 O3
O
GLU F:202 F:6220 0.0 0.0 E -127.1 148.5 0.0 0.0 0.0 NLX
HOH
 5.316
3.001
 OE2
OE1
 O4
O
GLU G:202 G:1220 0.0 0.0 E -137.7 139.0 NA NA NA
GLU H:202 H:2220 1.0 0.005 E -128.2 147.5 NA NA NA
GLU I:202 I:3220 0.0 0.0 E -113.8 171.1 NA NA NA
GLU J:202 J:4220 0.0 0.0 E -126.0 141.0 NA NA NA
GLU K:202 K:5220 1.0 0.005 E -117.1 142.2 NA NA NA
GLU L:202 L:6220 0.0 0.0 E -131.0 152.8 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 GLU A:202 A:1220 0.0 0.0 E -119.6 145.8 0.0 0.0 0.0 PLM
HOH
 6.755
2.821
 OE1
OE2
 C5
O
GLU B:202 B:2220 0.0 0.0 E -118.6 148.8 0.0 0.0 0.0 PLM
HOH
 6.658
2.924
 O
OE1
 O2
O
GLU C:202 C:3220 0.0 0.0 E -121.1 148.7 0.0 0.0 0.0 PLM
HOH
 7.081
2.793
 OE1
OE2
 C4
O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 GLU A:202 A:1220 0.0 0.0 E -120.9 143.3 0.0 0.0 0.0 F
PLM
HOH
 4.871
6.794
2.593
 O
OE1
OE2
 F
C3
O
GLU B:202 B:2220 0.0 0.0 E -117.8 148.0 0.0 0.0 0.0 F
PLM
HOH
 4.786
7.080
2.509
 O
OE2
OE2
 F
C2
O
GLU C:202 C:3220 0.0 0.0 E -119.9 143.9 0.0 0.0 0.0 F
COA
HOH
 4.592
6.209
2.803
 O
OE2
OE1
 F
O5P
O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 GLU A:202 A:1220 0.0 0.0 E -132.6 157.9 0.0 0.0 0.0 TCH
HOH
 7.002
2.615
 C
OE1
 O3
O
GLU B:202 B:2220 0.0 0.0 E -133.3 154.0 0.0 0.0 0.0 TCH
HOH
 6.305
2.761
 OE1
OE2
 O12
O
GLU C:202 C:3220 0.0 0.0 E -135.1 155.4 0.0 0.0 0.0 TCH
HOH
 7.567
2.716
 O
OE1
 O12
O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 GLU A:202 A:1220 1.0 0.005 E -118.5 141.8 1.0 0.005 0.0 COA
HOH
 5.396
2.857
 OE1
OE2
 O5P
O
GLU B:202 B:2220 0.0 0.0 E -120.9 144.5 0.0 0.0 0.0 COA
HOH
 5.591
2.722
 OE1
OE2
 O5P
O
GLU C:202 C:3220 0.0 0.0 E -127.9 151.2 0.0 0.0 0.0 COA
HOH
 5.200
2.559
 OE2
OE2
 O5P
O
GLU D:202 D:4220 0.0 0.0 E -123.2 143.6 0.0 0.0 0.0 COA
HOH
 5.190
2.746
 OE1
OE2
 O5P
O
GLU E:202 E:5220 0.0 0.0 E -119.9 142.3 0.0 0.0 0.0 COA
HOH
 5.267
2.405
 OE2
OE1
 O5P
O
GLU F:202 F:6220 0.0 0.0 E -123.2 147.9 0.0 0.0 0.0 COA
HOH
 5.095
2.624
 OE2
OE2
 O5P
O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 GLU A:200 A:220 0.0 0.0 E -124.5 132.2 0.0 0.0 0.0 CTX
HOH
 4.708
2.946
 OE1
CB
 C11
O
GLU B:200 B:220 0.0 0.0 E -116.3 138.4 0.0 0.0 0.0 CTX
HOH
 4.666
4.996
 OE1
O
 C11
O
GLU C:200 C:220 1.0 0.005 E -117.8 135.1 1.0 0.005 0.0 CTX
HOH
 4.550
2.992
 OE1
OE1
 C10
O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 GLU A:200 A:220 0.0 0.0 E -118.3 142.1 0.0 0.0 0.0 SMB
HOH
 5.242
2.422
 OE1
OE2
 O1
O
GLU B:200 B:220 0.0 0.0 E -124.1 141.3 0.0 0.0 0.0 SMB
HOH
 5.341
2.631
 OE1
OE2
 O1
O
GLU C:200 C:220 0.0 0.0 E -122.5 143.3 0.0 0.0 0.0 SMB
HOH
 5.036
2.900
 OE2
OE2
 O1
O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 GLU A:200 A:220 0.0 0.0 E -115.6 140.4 0.0 0.0 0.0 EEE
HOH
 6.679
2.623
 OE1
OE2
 O1
O
GLU B:200 B:220 0.0 0.0 E -125.9 142.8 0.0 0.0 0.0 EEE
HOH
 5.901
2.745
 OE1
OE2
 O1
O
GLU C:200 C:220 0.0 0.0 E -123.5 141.7 0.0 0.0 0.0 EEE
HOH
 6.067
2.835
 OE1
OE1
 O1
O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 GLU A:200 A:220 0.0 0.0 E -136.9 153.2 0.0 0.0 0.0 BEZ
HOH
 6.837
4.789
 OE1
O
 C6
O
GLU B:200 B:220 0.0 0.0 E -133.8 136.8 0.0 0.0 0.0 BEZ
HOH
 5.421
5.196
 OE2
O
 O2
O
GLU C:200 C:220 0.0 0.0 E -97.2 145.3 0.0 0.0 0.0 BEZ
HOH
 4.581
7.116
 O
O
 O2
O
GLU D:200 D:220 1.0 0.005 E -126.1 142.2 NA NA NA
GLU E:200 E:220 0.0 0.0 E -115.5 147.5 NA NA NA
GLU F:200 F:220 0.0 0.0 E -121.3 158.1 NA NA NA
GLU G:200 G:220 0.0 0.0 E -99.2 170.3 NA NA NA
GLU H:200 H:220 0.0 0.0 E -135.2 147.2 NA NA NA
GLU I:200 I:220 0.0 0.0 E -122.3 139.4 NA NA NA
GLU J:200 J:220 0.0 0.0 E -114.9 156.5 NA NA NA
GLU K:200 K:220 0.0 0.0 E -115.3 154.1 NA NA NA
GLU L:200 L:220 0.0 0.0 E -117.8 152.3 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 GLU A:200 A:1220 0.0 0.0 E -126.8 143.9 0.0 0.0 0.0 GD7
HOH
 4.453
2.766
 OE2
OE1
 C7
O
GLU B:200 B:2220 1.0 0.005 E -129.1 145.6 1.0 0.005 0.0 GD7
HOH
 4.144
2.723
 OE2
OE2
 C7
O
GLU C:200 C:3220 1.0 0.005 E -118.5 149.8 1.0 0.005 0.0 GD7
HOH
 4.188
2.952
 OE2
OE2
 C7
O
GLU D:200 D:4220 0.0 0.0 E -128.6 148.5 NA NA NA
GLU E:200 E:5220 1.0 0.005 E -127.8 143.9 NA NA NA
GLU F:200 F:6220 1.0 0.005 E -118.2 149.3 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 GLU A:200 A:1220 0.0 0.0 E -123.1 150.2 0.0 0.0 0.0 NTJ
HOH
 3.669
2.870
 OE2
OE2
 C2
O
GLU B:200 B:2220 1.0 0.005 E -130.3 149.0 1.0 0.005 0.0 NTJ
HOH
 4.217
2.964
 OE2
CG
 C2
O
GLU C:200 C:3220 1.0 0.005 E -124.7 145.0 1.0 0.005 0.0 NTJ
HOH
 3.370
3.033
 OE2
CG
 C2
O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 GLU A:200 A:220 0.0 0.0 E -118.9 134.4 0.0 0.0 0.0 HOH
 2.697
 OE2
 O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 GLU A:200 A:220 0.0 0.0 E -125.5 145.0 0.0 0.0 0.0 HOH
 2.561
 OE2
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 GLU A:200 A:220 0.0 0.0 E -123.9 136.4 0.0 0.0 0.0 HOH
 2.646
 OE2
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 GLU A:199 A:220 0.0 0.0 E -126.8 132.2 0.0 0.0 0.0 HOH
 2.576
 OE2
 O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 GLU A:197 A:1220 0.0 0.0 E -125.1 154.3 0.0 0.0 0.0 WW2
HOH
 4.006
7.601
 OE1
CG
 C7
O
GLU B:197 B:2220 0.0 0.0 E -124.5 153.3 0.0 0.0 0.0 WW2
HOH
 4.466
3.312
 OE1
O
 C7
O
GLU C:197 C:3220 0.0 0.0 E -124.9 153.9 0.0 0.0 0.0 WW2
HOH
 4.168
9.892
 OE1
OE2
 C7
O
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 GLU A:198 A:220 2.0 0.011 E -127.4 157.8 2.0 0.011 0.0 HOH
 2.834
 OE1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 GLU A:220 A:220 0.0 0.0 E -111.3 145.3
af-q9uky3-f1 1 Q9UKY3 93.63 3e-170 GLY A:221 A:221 15.0 0.2 E -102.8 140.3