Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55860162 . A C CCDS32450.1:NM_001025195.1:c.306ttT>ttG_NP_001020366.1:p.102F>L Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 PHE A:83 A:1101 12.0 0.057 H -100.6 -14.0 12.0 0.057 0.0 THA
HOH
 3.431
2.928
 CE2
O
 C1
O
PHE B:83 B:2101 9.0 0.043 H -103.2 -15.6 9.0 0.043 0.0 THA
HOH
 3.482
2.716
 CZ
O
 C12
O
PHE C:83 C:3101 11.0 0.052 H -103.0 -21.1 11.0 0.052 0.0 THA
HOH
 3.543
2.969
 CE2
CE2
 C1
O
PHE D:83 D:4101 11.0 0.052 H -103.8 -20.1 11.0 0.052 0.0 THA
HOH
 3.451
3.941
 CZ
N
 C12
O
PHE E:83 E:5101 11.0 0.052 H -98.4 -15.4 11.0 0.052 0.0 THA
HOH
 3.683
3.165
 CE2
O
 C12
O
PHE F:83 F:6101 11.0 0.052 H -100.1 -22.4 11.0 0.052 0.0 THA
HOH
 4.184
2.918
 CZ
CE2
 C1
O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 PHE A:83 A:1101 7.0 0.033 H -106.2 -22.8 7.0 0.033 0.0 CL
HTQ
HOH
 6.664
3.304
2.820
 CE2
CE2
O
 CL
O20
O
PHE B:83 B:2101 8.0 0.038 H -98.7 -21.3 8.0 0.038 0.0 HTQ
HOH
 3.945
2.777
 CE2
O
 O20
O
PHE C:83 C:3101 9.0 0.043 H -98.5 -28.7 9.0 0.043 0.0 HTQ
HOH
 4.243
2.744
 CZ
O
 O20
O
PHE D:83 D:4101 8.0 0.038 H -97.8 -18.2 NA NA NA
PHE E:83 E:5101 8.0 0.038 H -100.3 -21.1 NA NA NA
PHE F:83 F:6101 7.0 0.033 H -104.0 -22.8 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 PHE A:83 A:1101 9.0 0.043 H -117.6 -20.8 9.0 0.043 0.0 NLX
HOH
 3.951
2.821
 CE2
O
 C2
O
PHE B:83 B:2101 10.0 0.048 H -118.7 -24.7 10.0 0.048 0.0 NLX
HOH
 3.801
4.166
 CE2
CD2
 O1
O
PHE C:83 C:3101 9.0 0.043 H -107.6 -20.6 9.0 0.043 0.0 NLX
HOH
 3.852
4.397
 CE2
CD2
 O1
O
PHE D:83 D:4101 10.0 0.048 H -114.1 -5.2 10.0 0.048 0.0 NLX
HOH
 3.341
4.174
 CZ
CD2
 C2
O
PHE E:83 E:5101 9.0 0.043 H -95.8 -18.1 9.0 0.043 0.0 NLX
HOH
 3.655
2.804
 CZ
O
 O3
O
PHE F:83 F:6101 12.0 0.057 H -82.8 -17.4 12.0 0.057 0.0 NLX
HOH
 5.271
3.347
 CE2
CE2
 C19
O
PHE G:83 G:1101 10.0 0.048 H -103.2 -30.5 NA NA NA
PHE H:83 H:2101 10.0 0.048 T -124.7 -27.1 NA NA NA
PHE I:83 I:3101 10.0 0.048 H -112.2 -34.6 NA NA NA
PHE J:83 J:4101 10.0 0.048 H -124.8 -19.7 NA NA NA
PHE K:83 K:5101 10.0 0.048 H -115.0 -13.9 NA NA NA
PHE L:83 L:6101 13.0 0.062 H -96.9 -15.3 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 PHE A:83 A:1101 9.0 0.043 H -108.1 -27.7 9.0 0.043 0.0 PLM
HOH
 6.008
4.198
 CZ
N
 C5
O
PHE B:83 B:2101 8.0 0.038 H -107.1 -28.3 8.0 0.038 0.0 PLM
HOH
 6.397
2.389
 CE2
O
 C5
O
PHE C:83 C:3101 9.0 0.043 H -108.3 -27.2 9.0 0.043 0.0 PLM
HOH
 6.477
4.842
 CE2
CD2
 C5
O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 PHE A:83 A:1101 7.0 0.033 H -111.7 -24.6 7.0 0.033 0.0 F
PLM
HOH
 6.633
6.240
2.808
 CE2
CZ
O
 F
C4
O
PHE B:83 B:2101 9.0 0.043 H -104.4 -21.2 9.0 0.043 0.0 F
PLM
HOH
 6.489
6.235
4.090
 CE2
CE2
C
 F
C5
O
PHE C:83 C:3101 9.0 0.043 H -118.3 -19.2 9.0 0.043 0.0 F
COA
HOH
 6.580
5.358
3.164
 CE2
CE2
O
 F
O5P
O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 PHE A:83 A:1101 7.0 0.033 H -115.3 -29.6 7.0 0.033 0.0 TCH
HOH
 6.007
2.815
 CZ
O
 C16
O
PHE B:83 B:2101 9.0 0.043 H -114.7 -29.0 9.0 0.043 0.0 TCH
HOH
 5.473
3.707
 CZ
C
 C17
O
PHE C:83 C:3101 8.0 0.038 H -114.3 -28.4 8.0 0.038 0.0 TCH
HOH
 6.577
2.902
 CZ
O
 C16
O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 PHE A:83 A:1101 9.0 0.043 H -104.5 -19.3 9.0 0.043 0.0 COA
HOH
 5.046
2.601
 CE2
O
 O5P
O
PHE B:83 B:2101 11.0 0.052 H -102.2 -17.9 11.0 0.052 0.0 COA
HOH
 5.209
2.861
 CE2
O
 O5P
O
PHE C:83 C:3101 11.0 0.052 H -108.1 -10.7 11.0 0.052 0.0 COA
HOH
 5.035
2.898
 CE2
O
 O5P
O
PHE D:83 D:4101 12.0 0.057 H -105.0 -18.1 12.0 0.057 0.0 COA
HOH
 4.790
2.935
 CE2
O
 O5P
O
PHE E:83 E:5101 11.0 0.052 H -107.3 -16.4 11.0 0.052 0.0 COA
HOH
 4.856
2.705
 CE2
CZ
 O5P
O
PHE F:83 F:6101 10.0 0.048 H -100.3 -18.6 10.0 0.048 0.0 COA
HOH
 4.928
2.864
 CE2
O
 O5P
O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 PHE A:81 A:101 9.0 0.043 H -119.9 -20.2 9.0 0.043 0.0 CTX
HOH
 3.545
4.082
 CZ
CE2
 C11
O
PHE B:81 B:101 10.0 0.048 H -119.3 -23.1 10.0 0.048 0.0 CTX
HOH
 3.364
7.228
 CZ
CE2
 C11
O
PHE C:81 C:101 8.0 0.038 H -113.7 -26.3 8.0 0.038 0.0 CTX
HOH
 3.441
4.078
 CZ
CE2
 C11
O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 PHE A:81 A:101 8.0 0.038 H -101.3 -26.5 8.0 0.038 0.0 SMB
HOH
 4.476
2.891
 CZ
O
 O2
O
PHE B:81 B:101 9.0 0.043 H -89.2 -24.6 9.0 0.043 0.0 SMB
HOH
 4.712
2.824
 CZ
O
 O1
O
PHE C:81 C:101 12.0 0.057 H -98.2 -21.2 12.0 0.057 0.0 SMB
HOH
 5.340
5.661
 CE2
CB
 O1
O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 PHE A:81 A:101 9.0 0.043 H -108.3 -22.8 9.0 0.043 0.0 EEE
HOH
 5.298
3.046
 CZ
O
 O1
O
PHE B:81 B:101 10.0 0.048 H -102.5 -23.7 10.0 0.048 0.0 EEE
HOH
 5.058
4.241
 CE2
CD2
 O1
O
PHE C:81 C:101 9.0 0.043 H -106.9 -18.7 9.0 0.043 0.0 EEE
HOH
 5.026
2.687
 CE2
O
 O1
O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 PHE A:81 A:101 10.0 0.048 H -77.9 -33.4 10.0 0.048 0.0 BEZ
HOH
 4.989
5.844
 CE2
CE2
 C5
O
PHE B:81 B:101 11.0 0.052 H -111.7 -21.8 11.0 0.052 0.0 BEZ
HOH
 5.221
3.117
 CZ
O
 O2
O
PHE C:81 C:101 8.0 0.038 H -118.2 -33.4 8.0 0.038 0.0 BEZ
HOH
 6.091
4.727
 CE2
CD2
 C
O
PHE D:81 D:101 7.0 0.033 H -105.3 -31.5 NA NA NA
PHE E:81 E:101 10.0 0.048 H -99.1 -21.0 NA NA NA
PHE F:81 F:101 8.0 0.038 H -115.4 -24.9 NA NA NA
PHE G:81 G:101 7.0 0.033 H -111.3 -24.4 NA NA NA
PHE H:81 H:101 9.0 0.043 H -91.6 -35.2 NA NA NA
PHE I:81 I:101 13.0 0.062 H -107.1 -24.0 NA NA NA
PHE J:81 J:101 8.0 0.038 H -113.7 -22.3 NA NA NA
PHE K:81 K:101 13.0 0.062 H -60.3 -38.5 NA NA NA
PHE L:81 L:101 11.0 0.052 H -101.7 -12.7 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 PHE A:81 A:1101 6.0 0.029 H -112.9 -26.6 6.0 0.029 0.0 GD7
HOH
 4.889
3.791
 CZ
CE2
 C7
O
PHE B:81 B:2101 7.0 0.033 H -104.5 -14.7 7.0 0.033 0.0 GD7
HOH
 4.603
3.971
 CE2
CD2
 C7
O
PHE C:81 C:3101 6.0 0.029 H -97.8 -15.5 6.0 0.029 0.0 GD7
HOH
 4.736
2.923
 CE2
O
 C7
O
PHE D:81 D:4101 6.0 0.029 H -116.4 -28.7 NA NA NA
PHE E:81 E:5101 9.0 0.043 H -101.3 -20.4 NA NA NA
PHE F:81 F:6101 8.0 0.038 H -97.2 -16.1 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 PHE A:81 A:1101 9.0 0.043 H -108.0 -16.0 9.0 0.043 0.0 NTJ
HOH
 3.538
3.036
 CE2
O
 C2
O
PHE B:81 B:2101 9.0 0.043 H -90.4 -18.8 9.0 0.043 0.0 NTJ
HOH
 3.986
4.142
 CE2
CD2
 C2
O
PHE C:81 C:3101 7.0 0.033 H -101.9 -21.4 7.0 0.033 0.0 NTJ
HOH
 3.638
2.853
 CE2
O
 C2
O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 PHE A:81 A:101 9.0 0.043 H -110.8 -15.2 9.0 0.043 0.0 HOH
 2.921
 O
 O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 PHE A:81 A:101 10.0 0.048 H -107.4 -14.3 10.0 0.048 0.0 HOH
 2.778
 O
 O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 PHE A:81 A:101 7.0 0.033 H -101.8 -17.1 7.0 0.033 0.0 HOH
 2.849
 O
 O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 PHE A:80 A:101 9.0 0.043 H -102.1 -10.3 9.0 0.043 0.0 IOD
HOH
 8.428
3.030
 C
O
 I
O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 PHE A:78 A:1101 13.0 0.062 H -103.8 -30.5 13.0 0.062 0.0 WW2
 4.160
 CE2
 C7
PHE B:78 B:2101 12.0 0.057 H -104.6 -30.5 12.0 0.057 0.0 WW2
HOH
 4.168
4.699
 CE2
CE2
 C7
O
PHE C:78 C:3101 12.0 0.057 H -104.2 -30.0 12.0 0.057 0.0 WW2
 4.338
 CE2
 C7
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 PHE A:79 A:101 25.0 0.119 H -124.0 -14.5 25.0 0.119 0.0 HOH
 2.463
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 PHE A:101 A:101 6.0 0.029 H -101.9 -15.1
af-q9uky3-f1 1 Q9UKY3 93.63 3e-170 PHE A:102 A:102 119.0 0.567 H -108.5 -9.2