Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr16 55862835 . A C CCDS32450.1:NM_001025195.1:c.104cTg>cGg_NP_001020366.1:p.35L>R Homo sapiens carboxylesterase 1 (CES1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1mx1 1 P23141 99.82 0.0 X-RAY
 2003-04-22 LEU A:16 A:1034 33.0 0.194 E -116.1 123.9 33.0 0.194 0.0 NAG
SIA
HOH
 4.531
5.521
4.173
 CG
O
CD1
 C8
O1B
O
LEU B:16 B:2034 29.0 0.171 E -107.4 129.2 29.0 0.171 0.0 NAG
SIA
HOH
 3.689
5.855
4.046
 CD1
O
CD1
 O6
O1B
O
LEU C:16 C:3034 34.0 0.2 E -104.9 125.2 34.0 0.2 0.0 NAG
NDG
HOH
 4.568
7.627
3.054
 CG
CD1
CD1
 C8
O7
O
LEU D:16 D:4034 47.0 0.276 E -107.2 124.9 47.0 0.276 0.0 NAG
SIA
HOH
 3.468
6.871
6.131
 CD2
O
CD2
 C8
O1A
O
LEU E:16 E:5034 25.0 0.147 E -112.1 129.7 25.0 0.147 0.0 NAG
SIA
HOH
 3.637
6.739
3.419
 CG
O
CD1
 O7
O10
O
LEU F:16 F:6034 34.0 0.2 E -113.0 123.3 34.0 0.2 0.0 NAG
NAG
HOH
 4.545
9.735
3.282
 CD1
CD1
CD1
 N2
O6
O
1mx5 1 P23141 99.82 0.0 X-RAY
 2003-04-08 LEU A:16 A:1034 24.0 0.141 E -104.7 128.0 24.0 0.141 0.0 NAG
SIA
HOH
 4.494
6.424
4.122
 CD1
O
CD1
 N2
O4
O
LEU B:16 B:2034 34.0 0.2 E -112.6 125.1 34.0 0.2 0.0 NAG
SIA
HOH
 4.430
6.187
3.291
 CD1
O
CD1
 O5
O4
O
LEU C:16 C:3034 33.0 0.194 E -123.2 117.7 33.0 0.194 0.0 NAG
HOH
 4.583
4.277
 CD1
CD1
 N2
O
LEU D:16 D:4034 29.0 0.171 E -116.3 119.1 NA NA NA
LEU E:16 E:5034 28.0 0.165 E -110.9 119.3 NA NA NA
LEU F:16 F:6034 28.0 0.165 E -114.2 126.5 NA NA NA
1mx9 1 P23141 99.82 0.0 X-RAY
 2003-04-08 LEU A:16 A:1034 28.0 0.165 E -125.4 111.5 28.0 0.165 0.0 NAG
NAG
HOH
 5.264
9.060
3.910
 CD1
CD1
CD1
 O6
C6
O
LEU B:16 B:2034 38.0 0.224 E -117.7 123.9 38.0 0.224 0.0 NAG
HOH
 4.082
6.018
 CD1
O
 C8
O
LEU C:16 C:3034 37.0 0.218 E -102.1 119.5 37.0 0.218 0.0 NAG
HOH
 4.288
6.924
 CD1
CB
 O5
O
LEU D:16 D:4034 34.0 0.2 E -106.9 139.0 34.0 0.2 0.0 NAG
HOH
 4.788
6.478
 CD1
CD1
 C1
O
LEU E:16 E:5034 39.0 0.229 E -111.7 113.2 39.0 0.229 0.0 NAG
HOH
 5.112
3.390
 CD1
CD1
 C1
O
LEU F:16 F:6034 26.0 0.153 E -117.9 124.8 26.0 0.153 0.0 NAG
HOH
 4.640
5.762
 CD1
O
 O5
O
LEU G:16 G:1034 33.0 0.194 E -129.1 112.1 NA NA NA
LEU H:16 H:2034 38.0 0.224 E -114.7 126.7 NA NA NA
LEU I:16 I:3034 32.0 0.188 E -115.2 106.8 NA NA NA
LEU J:16 J:4034 41.0 0.241 E -96.7 125.0 NA NA NA
LEU K:16 K:5034 27.0 0.159 E -121.7 105.0 NA NA NA
LEU L:16 L:6034 31.0 0.182 E -122.3 117.0 NA NA NA
2dqy 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:16 A:1034 24.0 0.141 E -110.1 130.6 24.0 0.141 0.0 NAG
SIA
HOH
 3.823
7.310
3.678
 CD1
O
CD1
 O6
O7
O
LEU B:16 B:2034 26.0 0.153 E -110.2 130.0 26.0 0.153 0.0 NAG
SIA
HOH
 3.882
6.981
6.806
 CD1
O
CD1
 O5
O2
O
LEU C:16 C:3034 24.0 0.141 E -110.3 131.4 24.0 0.141 0.0 NAG
SIA
HOH
 3.995
7.165
5.990
 CD1
O
CD1
 C8
O7
O
2dqz 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:16 A:1034 25.0 0.147 E -115.2 124.7 25.0 0.147 0.0 NAG
SIA
HOH
 4.517
7.638
3.683
 CD1
O
CD1
 O6
O1B
O
LEU B:16 B:2034 26.0 0.153 E -107.3 141.5 26.0 0.153 0.0 NAG
SIA
HOH
 3.966
6.838
8.375
 CD1
CB
N
 O5
O1A
O
LEU C:16 C:3034 24.0 0.141 E -111.0 135.8 24.0 0.141 0.0 NAG
SIA
HOH
 5.322
7.155
3.349
 CD1
O
CD1
 O5
O1B
O
2dr0 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:16 A:1034 26.0 0.153 E -106.1 124.3 26.0 0.153 0.0 NAG
SIA
HOH
 5.558
7.422
5.822
 CD1
O
CD1
 C1
O7
O
LEU B:16 B:2034 26.0 0.153 E -105.5 126.0 26.0 0.153 0.0 NAG
SIA
HOH
 3.633
6.840
3.434
 CD1
O
CD1
 O5
O2
O
LEU C:16 C:3034 24.0 0.141 E -106.5 125.4 24.0 0.141 0.0 NAG
SIA
HOH
 3.359
6.847
3.658
 CD1
O
CD1
 O6
O2
O
2h7c 1 P23141 99.82 0.0 X-RAY
 2006-08-29 LEU A:16 A:1034 36.0 0.212 E -108.0 130.0 36.0 0.212 0.0 NAG
NAG
HOH
 5.081
9.032
3.239
 CD1
CD1
CD1
 N2
C1
O
LEU B:16 B:2034 32.0 0.188 E -106.8 126.4 32.0 0.188 0.0 NAG
HOH
 5.376
3.746
 CD1
CD1
 N2
O
LEU C:16 C:3034 24.0 0.141 E -104.3 126.1 24.0 0.141 0.0 NAG
HOH
 5.096
3.518
 CD1
CD1
 N2
O
LEU D:16 D:4034 30.0 0.176 E -102.0 132.0 30.0 0.176 0.0 NAG
SIA
HOH
 4.924
7.354
3.577
 CD1
O
CD1
 N2
O4
O
LEU E:16 E:5034 29.0 0.171 E -112.0 129.6 29.0 0.171 0.0 NAG
SIA
HOH
 4.096
6.847
3.541
 CD1
O
CD1
 C8
O1B
O
LEU F:16 F:6034 44.0 0.259 E -103.6 124.7 44.0 0.259 0.0 NAG
NAG
HOH
 3.426
9.632
4.439
 CD2
CD2
CG
 C8
C1
O
1ya4 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:14 A:34 26.0 0.153 E -104.1 132.9 26.0 0.153 0.0 NAG
SIA
HOH
 4.897
7.172
5.495
 CD1
O
O
 C1
O7
O
LEU B:14 B:34 25.0 0.147 E -102.3 127.6 25.0 0.147 0.0 NAG
SIA
HOH
 4.105
6.696
4.185
 CD1
O
CD2
 O5
O2
O
LEU C:14 C:34 25.0 0.147 E -105.5 131.8 25.0 0.147 0.0 NAG
SIA
HOH
 3.862
6.866
3.357
 CD1
O
CD1
 O5
O2
O
1ya8 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:14 A:34 28.0 0.165 E -110.2 124.1 28.0 0.165 0.0 NAG
SIA
HOH
 4.348
7.198
5.348
 CD1
O
CD1
 O5
O1B
O
LEU B:14 B:34 29.0 0.171 E -115.2 128.7 29.0 0.171 0.0 NAG
SIA
HOH
 4.047
6.864
6.488
 CD1
O
O
 O5
O2
O
LEU C:14 C:34 31.0 0.182 E -110.7 119.8 31.0 0.182 0.0 NAG
SIA
HOH
 3.751
7.824
3.653
 CD1
O
CD1
 O6
O1A
O
1yah 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:14 A:34 28.0 0.165 E -111.8 125.2 28.0 0.165 0.0 NAG
SIA
HOH
 5.024
7.621
6.589
 CD1
O
O
 O3
O2
O
LEU B:14 B:34 28.0 0.165 E -105.3 123.1 28.0 0.165 0.0 NAG
SIA
HOH
 3.921
7.120
4.269
 CD1
O
CD2
 O6
O2
O
LEU C:14 C:34 29.0 0.171 E -109.1 120.8 29.0 0.171 0.0 SIA
NAG
HOH
 7.445
3.925
3.592
 O
CD1
CD1
 O7
O6
O
1yaj 1 P23141 99.81 0.0 X-RAY
 2005-08-02 LEU A:14 A:34 29.0 0.171 E -99.2 121.0 29.0 0.171 0.0 NAG
SIA
HOH
 4.468
7.084
7.452
 CD1
O
CB
 O5
O7
O
LEU B:14 B:34 21.0 0.124 E -127.8 127.3 21.0 0.124 0.0 NAG
SIA
 3.994
6.446
 CD1
O
 C6
O2
LEU C:14 C:34 26.0 0.153 E -107.8 129.8 26.0 0.153 0.0 SIA
NAG
HOH
 7.493
4.304
9.336
 O
CD1
O
 O7
C6
O
LEU D:14 D:34 32.0 0.188 E -100.2 140.5 NA NA NA
LEU E:14 E:34 16.0 0.094 E -129.1 124.8 NA NA NA
LEU F:14 F:34 31.0 0.182 E -107.3 128.2 NA NA NA
LEU G:14 G:34 25.0 0.147 E -114.8 121.7 NA NA NA
LEU H:14 H:34 39.0 0.229 E -103.6 131.6 NA NA NA
LEU I:14 I:34 24.0 0.141 E -114.6 129.5 NA NA NA
LEU J:14 J:34 23.0 0.135 E -97.8 135.8 NA NA NA
LEU K:14 K:34 20.0 0.118 E -105.1 148.7 NA NA NA
LEU L:14 L:34 23.0 0.135 E -128.2 122.4 NA NA NA
2hrq 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 LEU A:14 A:1034 24.0 0.141 E -116.9 121.6 24.0 0.141 0.0 NAG
SIA
HOH
 4.213
7.448
4.703
 CD1
O
CD1
 O7
O9
O
LEU B:14 B:2034 27.0 0.159 E -111.1 130.7 27.0 0.159 0.0 NAG
SIA
HOH
 4.148
6.883
3.993
 CD1
O
CD1
 O6
O2
O
LEU C:14 C:3034 29.0 0.171 E -106.2 126.1 29.0 0.171 0.0 NAG
SIA
HOH
 5.784
7.495
3.517
 CD1
O
CD1
 O6
O2
O
LEU D:14 D:4034 26.0 0.153 E -112.0 124.0 NA NA NA
LEU E:14 E:5034 26.0 0.153 E -110.8 131.5 NA NA NA
LEU F:14 F:6034 28.0 0.165 E -101.8 128.7 NA NA NA
2hrr 1 Q9UK77 99.81 0.0 X-RAY
 2007-05-01 LEU A:14 A:1034 32.0 0.188 E -116.0 118.6 32.0 0.188 0.0 NAG
SIA
HOH
 4.076
7.756
6.398
 CD1
O
O
 N2
O1B
O
LEU B:14 B:2034 25.0 0.147 E -111.3 123.1 25.0 0.147 0.0 NAG
SIA
HOH
 4.193
6.734
3.400
 CD1
O
CD1
 O5
O2
O
LEU C:14 C:3034 29.0 0.171 E -103.1 121.3 29.0 0.171 0.0 NAG
SIA
HOH
 3.513
6.623
3.708
 CG
O
CD1
 C8
O2
O
4ab1 1 P23141 99.81 0.0 X-RAY
 2012-03-07 LEU A:14 A:34 26.0 0.153 E -111.2 130.2 26.0 0.153 0.0 NAG
HOH
 4.458
3.870
 CD1
CD1
 C8
O
5a7f 1 P23141-3 99.81 0.0 X-RAY
 2016-01-13 LEU A:14 A:34 31.0 0.182 E -110.4 130.2 31.0 0.182 0.0 NAG
HOH
 4.327
3.837
 CD1
CD1
 N2
O
5a7g 1 P23141 99.62 0.0 X-RAY
 2016-01-13 LEU A:14 A:34 47.0 0.276 E -107.7 124.8 47.0 0.276 0.0 NAG
HOH
 4.013
4.061
 CD2
CD2
 O7
O
5a7h 1 P23141 99.62 0.0 X-RAY
 2016-01-13 LEU A:13 A:34 40.0 0.235 E -114.0 127.3 40.0 0.235 0.0 IOD
HOH
 9.400
5.963
 N
O
 I
O
3k9b 1 P23141 99.81 0.0 X-RAY
 2010-01-19 LEU A:11 A:1034 54.0 0.318 E -108.5 125.4 54.0 0.318 0.0 HOH
 9.251
 N
 O
LEU B:11 B:2034 60.0 0.353 E -108.7 124.4 60.0 0.353 0.0 HOH
 8.568
 O
 O
LEU C:11 C:3034 57.0 0.335 E -108.2 125.1 57.0 0.335 0.0 HOH
 4.920
 CD2
 O
1k4y 1 3219695 82.06 0.0 X-RAY
 2002-05-01 LEU A:12 A:34 38.0 0.224 E -111.3 112.6 38.0 0.224 0.0 NAG
NAG
HOH
 3.806
8.527
6.228
 CD1
CD1
O
 C8
O6
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p23141-f1 1 P23141 99.82 0.0 LEU A:34 A:34 49.0 0.288 E -99.5 121.3
af-q9uky3-f1 1 Q9UKY3 93.63 3e-170 LEU A:35 A:35 51.0 0.3 E -98.7 120.5