Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 37864776 . G A CCDS32642.1:NM_004448.2:c.428cGa>cAa_NP_004439.2:p.143R>Q Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7mn5 3 P04626,P0AEX9 99.9 0.0 EM
 2021-10-27 ARG C:143 B:143 88.0 0.391 T -58.5 -38.7 88.0 0.391 0.0
7mn6 2 P04626,P0AEX9 99.81 0.0 EM
 2021-10-27 ARG B:143 B:143 93.0 0.413 T -55.3 -40.2 93.0 0.413 0.0
7mn8 3 P04626,P0AEX9 99.81 0.0 EM
 2021-11-10 ARG C:143 B:143 79.0 0.351 T -59.7 -41.2 79.0 0.351 0.0
6bgt 1 P04626 100.0 0.0 X-RAY
 2018-10-31 ARG A:143 C:121 58.0 0.258 T -77.6 -8.7 58.0 0.258 0.0 HOH
 3.210
 N
 O
5kwg 1 P04626 100.0 0.0 X-RAY
 2017-04-12 ARG A:121 C:121 103.0 0.458 T -71.3 -27.3 103.0 0.458 0.0
6att 1 P04626 100.0 0.0 X-RAY
 2018-04-25 ARG A:121 A:121 86.0 0.382 S -59.7 -42.6 86.0 0.382 0.0
1s78 1 P04626 100.0 0.0 X-RAY
 2004-04-27 ARG A:121 A:121 63.0 0.28 T -73.1 -6.6 63.0 0.28 0.0
ARG B:121 B:121 62.0 0.276 T -73.4 -7.3 NA NA NA
3be1 1 P04626 100.0 0.0 X-RAY
 2008-11-18 ARG A:121 A:121 60.0 0.267 T -71.3 -14.0 60.0 0.267 0.0
3mzw 1 P04626 100.0 0.0 X-RAY
 2010-07-28 ARG A:121 A:121 77.0 0.342 T -56.7 -19.7 77.0 0.342 0.0
3n85 1 P04626 100.0 0.0 X-RAY
 2010-07-28 ARG A:121 A:121 61.0 0.271 T -65.0 -16.6 61.0 0.271 0.0
5my6 1 P04626 100.0 0.0 X-RAY
 2017-08-09 ARG A:120 A:143 62.0 0.276 T -70.2 -12.7 62.0 0.276 0.0 HOH
 3.037
 O
 O
6oge 1 P04626 100.0 0.0 EM
 2019-05-15 ARG A:121 A:143 95.0 0.422 T -41.0 -35.2 95.0 0.422 0.0
6j71 1 P04626 100.0 0.0 X-RAY
 2019-02-27 ARG A:122 A:143 80.0 0.356 T -61.7 -14.6 80.0 0.356 0.0
1n8z 3 P04626 100.0 0.0 X-RAY
 2003-02-18 ARG C:121 C:121 78.0 0.347 T -61.2 -23.8 78.0 0.347 0.0 HOH
 8.081
 N
 O
5k33 2 P04626 100.0 0.0 X-RAY
 2017-04-12 ARG B:121 C:121 66.0 0.293 T -60.8 -40.3 66.0 0.293 0.0
5o4g 1 P04626 100.0 0.0 X-RAY
 2018-05-16 ARG A:121 C:121 57.0 0.253 T -76.4 -2.8 57.0 0.253 0.0
3wlw 1 P04626 100.0 0.0 X-RAY
 2015-05-27 ARG A:121 A:121 58.0 0.258 T -94.4 5.5 58.0 0.258 0.0 HOH
 6.394
 O
 O
ARG B:121 B:121 67.0 0.298 -81.6 -15.1 NA NA NA
3wsq 1 P04626 100.0 0.0 X-RAY
 2015-03-25 ARG A:121 A:121 67.0 0.298 T -48.7 43.8 67.0 0.298 0.0
1n8y 1 22651765 85.53 0.0 X-RAY
 2003-02-18 ARG A:122 C:122 57.0 0.253 T -70.6 -10.1 57.0 0.253 0.0 HOH
 3.398
 N
 O
2a91 1 P04626 99.61 0.0 X-RAY
 2005-07-26 ARG A:122 A:122 75.0 0.333 T -72.2 -3.7 75.0 0.333 0.0 HOH
 3.020
 O
 O
4hrl 1 P04626 98.47 3e-130 X-RAY
 2013-10-16 ARG A:121 C:121 92.0 0.409 T -82.2 -31.8 92.0 0.409 0.0 HOH
 8.412
 N
 O
4hrm 1 P04626 98.47 3e-130 X-RAY
 2013-10-16 ARG A:121 C:121 45.0 NA T -67.2 -19.1 45.0 NA NA
ARG B:121 A:121 95.0 NA 75.5 -42.9 95.0 NA NA
3h3b 1 P04626 99.48 3e-130 X-RAY
 2010-04-28 ARG A:123 A:121 96.0 0.427 T -64.3 -30.8 96.0 0.427 0.0 HOH
 2.793
 O
 O
ARG B:123 B:121 110.0 0.489 T -67.4 -30.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04626-f1 1 P04626 100.0 0.0 ARG A:143 A:143 87.0 0.387 T -61.0 -21.9