Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 4849268 . T A CCDS11061.1:NM_005022.3:c.350gAa>gTa_NP_005013.1:p.117E>V Homo sapiens profilin 1 (PFN1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4x1l 1 P07737 100.0 4e-103 X-RAY
 2015-06-10 GLU A:117 A:117 69.0 NA T -61.6 134.7 69.0 NA NA PO4
HOH
 7.804
3.178
 C
O
 O3
O
6nas 3 P07737 100.0 4e-103 X-RAY
 2020-01-29 GLU C:117 P:116 132.0 0.695 T -53.7 136.8 132.0 0.695 0.0
6nbe 3 P07737 100.0 4e-103 X-RAY
 2020-04-15 GLU C:117 P:116 140.0 0.737 T -57.6 137.4 140.0 0.737 0.0 HOH
 2.122
 H
 O
6nbw 3 P07737 100.0 4e-103 X-RAY
 2020-01-29 GLU C:117 P:116 135.0 0.711 T -59.0 137.0 135.0 0.711 0.0 HOH
 2.776
 HA
 O
7p1h 3 P07737 100.0 4e-103 EM
 2021-11-17 GLU C:117 P:116 110.0 0.579 T -34.6 121.3 89.0 0.468 0.111 A:P0AEX9+A0A0F6NGV0:0.111
1cjf 1 P07737 100.0 3e-102 X-RAY
 1999-07-07 GLU A:116 A:116 139.0 0.732 T -59.1 119.4 139.0 0.732 0.0
GLU C:116 B:116 141.0 0.742 T -63.3 125.5 141.0 0.742 0.0 HOH
 4.082
 C
 O
1fik 1 P07737 100.0 3e-102 X-RAY
 1996-11-08 GLU A:116 A:116 139.0 0.732 T -56.2 140.8 139.0 0.732 0.0 PO4
HOH
 7.924
2.948
 C
O
 O3
O
1fil 1 P07737 100.0 3e-102 X-RAY
 1996-11-08 GLU A:116 A:116 139.0 0.732 T -57.3 141.9 139.0 0.732 0.0 SO4
HOH
 7.679
3.096
 C
O
 O3
O
1pfl 1 P07737 100.0 3e-102 NMR
 1995-03-31 GLU A:116 A:116 162.0 0.853 S -119.8 89.7 162.0 0.853 0.0
2pav 2 P07737 100.0 3e-102 X-RAY
 2007-10-23 GLU B:116 P:116 142.0 0.747 T -56.6 132.8 142.0 0.747 0.0 HOH
 2.739
 O
 O
2pbd 2 P07737 100.0 3e-102 X-RAY
 2007-11-13 GLU B:116 P:116 138.0 0.726 T -55.1 133.4 98.0 0.516 0.21 C:P50552:0.211
 HOH
 2.572
 OE2
 O
3chw 2 P07737 100.0 3e-102 X-RAY
 2008-08-19 GLU B:116 P:116 137.0 0.721 T -62.0 134.3 137.0 0.721 0.0 HOH
 3.048
 N
 O
4x25 1 P07737 99.29 4e-102 X-RAY
 2015-06-10 GLU A:117 A:117 73.0 NA T -63.9 138.0 73.0 NA NA HOH
 3.124
 CB
 O
GLU B:117 B:117 86.0 NA T -70.2 133.6 NA NA NA
4x1m 1 P07737 99.29 9e-102 X-RAY
 2015-06-10 GLY A:117 A:117 50.0 0.667 T -58.5 136.0 50.0 0.667 0.0 HOH
 4.007
 CA
 O
1awi 1 P07737 100.0 1e-101 X-RAY
 1998-10-28 GLU A:115 A:116 136.0 0.716 T -62.6 133.3 136.0 0.716 0.0 HOH
 6.827
 CA
 H1
GLU B:115 B:116 137.0 0.721 T -60.6 137.1 137.0 0.721 0.0 HOH
 3.751
 N
 H1
1cf0 1 P07737 100.0 1e-101 X-RAY
 1999-07-06 GLU A:115 A:116 137.0 0.721 T -55.8 127.6 137.0 0.721 0.0 HOH
 5.219
 N
 O
GLU B:115 B:116 130.0 0.684 T -56.0 135.0 NA NA NA
1hlu 2 P02584 94.96 1e-98 X-RAY
 1997-10-15 GLU B:117 P:116 122.0 0.642 T -84.4 110.2 122.0 0.642 0.0
1pne 1 P02584 94.96 1e-98 X-RAY
 1995-07-31 GLU A:117 A:116 133.0 0.7 T -62.4 138.6 133.0 0.7 0.0 HOH
 3.020
 N
 O
2btf 2 P02584 94.96 1e-98 X-RAY
 1994-06-22 GLU B:117 P:116 126.0 0.663 T -57.5 135.0 126.0 0.663 0.0
3u4l 2 P02584 94.96 1e-98 X-RAY
 2012-04-25 GLU B:117 P:116 130.0 0.684 T -60.4 124.8 130.0 0.684 0.0 HOH
 8.177
 O
 O
3ub5 2 P02584 94.96 1e-98 X-RAY
 2012-04-25 GLU B:117 P:116 137.0 0.721 T -50.1 131.5 137.0 0.721 0.0 HOH
 4.685
 OE2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p07737-f1 1 P07737 100.0 2e-103 GLU A:117 A:117 132.0 0.695 T -51.5 136.6