Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 56356471 . G A CCDS11604.1:NM_000250.1:c.783caC>caT_NP_000241.1:p.261H>H Homo sapiens myeloperoxidase (MPO), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bmt 1 P05164 100.0 0.0 X-RAY
 2018-01-03 HIS A:261 A:261 12.0 0.062 H -79.9 -8.9 12.0 0.062 0.0 CA
HEM
HOH
 5.966
5.258
2.840
 O
NE2
O
 CA
ND
O
5mfa 1 P05164 100.0 0.0 X-RAY
 2017-04-05 HIS A:213 A:261 11.0 0.056 H -78.1 -3.9 11.0 0.056 0.0 HEM
CA
TRS
HOH
 4.340
5.967
9.466
1.836
 HD2
O
HE1
HE2
 HBD
CA
O2
O
5uzu 2 P05164 100.0 0.0 X-RAY
 2017-07-26 HIS B:95 A:261 7.0 0.036 H -74.8 -4.3 7.0 0.036 0.0 CA
CL
HOH
 5.975
2.654
2.452
 O
O
ND1
 CA
CL
O
6azp 1 P05164 100.0 0.0 X-RAY
 2017-12-27 HIS A:95 A:261 6.0 0.031 H -82.7 1.8 6.0 0.031 0.0 CA
HOH
 5.981
2.754
 O
O
 CA
O
3f9p 1 P05164 100.0 1e-76 X-RAY
 2009-07-14 HIS A:97 A:95 128.0 0.656 H -81.5 -0.5 8.0 0.041 0.615 B:P05164:0.615
 HEM
CA
 5.422
6.072
 NE2
O
 ND
CA
HIS C:97 B:95 130.0 0.667 H -79.7 -2.5 NA NA NA
3zs1 1 P05164 100.0 1e-76 X-RAY
 2011-08-31 HIS A:97 A:95 128.0 0.656 H -74.4 -1.6 NA NA NA
HIS B:97 B:95 127.0 0.651 H -75.6 -6.9 9.0 0.046 0.605 D:P05164:0.605
 HEM
PVW
CA
HOH
 5.023
5.532
5.761
2.687
 NE2
CE1
O
ND1
 ND
O9
CA
O
4ejx 2 P05164 100.0 1e-76 X-RAY
 2013-04-10 HIS B:97 B:95 123.0 0.631 H -75.7 -7.0 9.0 0.046 0.585 C:P05164:0.585
 HEM
 4.998
 NE2
 ND
1mhl 1 P05164 100.0 3e-72 X-RAY
 1996-01-06 HIS A:97 A:95 123.0 0.631 H -74.6 -3.1 10.0 0.051 0.58 B:P05164:0.579
 CA
HEM
HOH
 5.876
5.255
2.620
 O
NE2
O
 CA
NC
O
HIS C:97 B:95 121.0 0.621 H -75.9 -0.3 10.0 0.051 0.57 D:P05164:0.569
 CA
HEM
HOH
 5.789
5.264
2.676
 O
NE2
NE2
 CA
C1D
O
1myp 1 P05164 100.0 3e-72 X-RAY
 1994-01-31 HIS A:97 A:95 130.0 0.667 H -53.8 -7.5 15.0 0.077 0.59 B:P05164:0.59
 CA
HEM
 5.984
5.498
 O
NE2
 CA
NB
HIS C:97 B:95 130.0 0.667 H -60.8 -11.4 14.0 0.072 0.595 D:P05164:0.595
 CA
HEM
 5.482
5.410
 O
NE2
 CA
FE
3zs0 1 P05164 100.0 3e-72 X-RAY
 2011-08-31 HIS A:97 A:95 126.0 0.646 H -77.4 -6.1 9.0 0.046 0.6 C:P05164:0.6
 ZS0
HEM
CA
HOH
 6.535
5.627
5.931
2.721
 CE1
NE2
O
O
 O10
ND
CA
O
HIS B:97 B:95 127.0 0.651 H -70.3 -0.8 10.0 0.051 0.6 D:P05164:0.6
 ZS0
HEM
CA
HOH
 6.077
5.396
6.133
2.667
 CE1
NE2
O
ND1
 O10
ND
CA
O
4c1m 1 P05164 100.0 3e-72 X-RAY
 2013-11-13 HIS A:97 A:95 126.0 0.646 H -76.1 -10.8 NA NA NA
HIS B:97 B:95 123.0 0.631 H -69.6 -9.8 9.0 0.046 0.585 D:P05164:0.585
 HEM
NIH
CA
HOH
 5.621
2.576
5.810
2.544
 NE2
NE2
O
O
 ND
O11
CA
O
5fiw 1 P05164 100.0 5e-70 X-RAY
 2015-10-14 HIS A:95 A:95 126.0 0.646 H -74.6 -8.7 9.0 0.046 0.6 C:P05164:0.6
 HEM
CA
HOH
 5.439
5.966
4.241
 CE1
O
CE1
 C1D
CA
O
HIS B:95 B:95 127.0 0.651 H -73.2 -7.9 NA NA NA
5qj2 1 P05164 100.0 5e-70 X-RAY
 2019-02-06 HIS A:95 A:95 133.0 0.682 T -80.6 -7.4 12.0 0.062 0.62 B:P05164:0.621
 HEM
JXS
CA
 5.108
2.893
6.003
 NE2
NE2
O
 ND
N21
CA
HIS C:95 D:95 130.0 0.667 T -82.8 -3.2 NA NA NA
HIS E:95 F:95 126.0 0.646 H -80.2 -7.0 NA NA NA
HIS G:95 H:95 126.0 0.646 H -86.2 -9.2 NA NA NA
5qj3 1 P05164 100.0 5e-70 X-RAY
 2019-02-06 HIS A:95 A:95 123.0 0.631 H -77.5 -6.2 7.0 0.036 0.595 B:P05164:0.595
 HEM
CA
JXP
HOH
 5.415
5.911
3.625
2.786
 NE2
O
NE2
NE2
 ND
CA
N4
O
HIS C:95 D:95 125.0 0.641 H -77.7 -5.5 NA NA NA
5wdj 1 P05164 100.0 5e-70 X-RAY
 2018-04-18 HIS A:95 A:95 125.0 0.641 H -84.1 -1.7 9.0 0.046 0.595 B:P05164:0.595
 AEY
HEM
CA
HOH
 2.761
5.255
5.882
2.707
 NE2
NE2
O
ND1
 N16
NC
CA
O
HIS C:95 D:95 126.0 0.646 H -79.1 -1.0 9.0 0.046 0.6 D:P05164:0.6
 HEM
CA
AEY
HOH
 5.215
5.999
2.587
2.670
 NE2
O
NE2
O
 NC
CA
N16
O
6wxz 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 HIS A:95 A:95 126.0 0.646 H -75.7 -7.7 8.0 0.041 0.605 B:P05164:0.605
 CA
HEC
UEY
HOH
 5.874
5.322
3.918
2.601
 O
NE2
NE2
NE2
 CA
ND
N3
O
HIS C:95 D:95 127.0 0.651 H -75.7 -6.5 NA NA NA
6wy0 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 HIS A:95 A:95 123.0 0.631 H -85.0 -0.5 8.0 0.041 0.59 B:P05164:0.59
 HEC
CA
UFA
 5.388
5.788
3.431
 NE2
O
NE2
 ND
CA
N2
HIS C:95 D:95 128.0 0.656 H -79.6 -2.9 NA NA NA
HIS E:95 F:95 124.0 0.636 H -82.5 -2.0 NA NA NA
HIS G:95 H:95 127.0 0.651 H -81.4 -1.4 NA NA NA
6wy5 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 HIS A:95 A:95 127.0 0.651 H -81.8 1.6 12.0 0.062 0.589 B:P05164:0.59
 HEC
CA
UF7
 5.187
5.820
3.259
 CE1
O
NE2
 ND
CA
N3
HIS C:95 D:95 126.0 0.646 H -82.3 1.9 NA NA NA
6wy7 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 HIS A:95 A:95 128.0 0.656 H -78.3 -3.9 9.0 0.046 0.61 B:P05164:0.61
 HEC
CA
UFD
HOH
 5.351
5.898
3.699
2.704
 NE2
O
NE2
O
 ND
CA
N2
O
HIS C:95 D:95 126.0 0.646 H -77.2 -4.6 NA NA NA
6wyd 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 HIS A:95 A:95 126.0 0.646 H -78.0 -6.3 9.0 0.046 0.6 B:P05164:0.6
 HEC
7GD
CA
HOH
 5.286
2.996
5.973
2.993
 NE2
NE2
O
O
 ND
N16
CA
O
HIS C:95 D:95 126.0 0.646 H -81.0 -3.5 NA NA NA
HIS E:95 F:95 126.0 0.646 H -75.0 -3.3 NA NA NA
HIS G:95 H:95 128.0 0.656 H -71.0 -7.5 NA NA NA
7lae 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 HIS A:95 A:95 124.0 0.636 H -84.9 -1.7 8.0 0.041 0.595 B:P05164:0.595
 HEM
CA
XRV
 5.267
5.700
2.820
 NE2
O
NE2
 ND
CA
N6
HIS C:95 D:95 131.0 0.672 H -81.0 -1.4 NA NA NA
7lag 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 HIS A:95 A:95 127.0 0.651 H -79.3 -2.2 9.0 0.046 0.605 B:P05164:0.605
 HEM
CA
XSD
 5.384
5.838
3.184
 NE2
O
NE2
 ND
CA
N5
HIS C:95 D:95 129.0 0.662 H -76.5 -0.2 NA NA NA
HIS E:95 F:95 127.0 0.651 H -76.6 -3.6 NA NA NA
HIS G:95 H:95 131.0 0.672 H -80.3 -1.9 NA NA NA
7lal 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 HIS A:95 A:95 125.0 0.641 H -78.6 -4.9 9.0 0.046 0.595 B:P05164:0.595
 HEM
CA
 5.260
5.987
 NE2
O
 ND
CA
HIS C:95 D:95 123.0 0.631 H -78.3 -5.9 NA NA NA
7lan 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 HIS A:95 A:95 129.0 0.662 H -78.9 -4.8 10.0 0.051 0.611 B:P05164:0.61
 HEM
CA
XS1
HOH
 5.263
5.929
3.111
2.717
 NE2
O
NE2
O
 ND
CA
H5
O
HIS C:95 D:95 125.0 0.641 H -79.0 -4.4 NA NA NA
HIS E:95 F:95 125.0 0.641 H -75.2 -4.5 NA NA NA
HIS G:95 H:95 125.0 0.641 H -79.0 -4.3 NA NA NA
1cxp 1 P05164 100.0 2e-69 X-RAY
 2000-04-24 HIS A:95 A:95 125.0 0.641 H -74.0 -8.2 11.0 0.056 0.585 B:P05164:0.585
 HEM
CA
HOH
 5.421
5.851
2.672
 NE2
O
ND1
 ND
CA
O
HIS C:95 B:95 124.0 0.636 H -75.1 -5.8 11.0 0.056 0.58 D:P05164:0.579
 HEM
CA
HOH
 5.369
5.886
2.724
 NE2
O
ND1
 ND
CA
O
1d2v 1 P05164 100.0 2e-69 X-RAY
 2000-04-24 HIS A:95 A:95 129.0 0.662 H -73.8 -8.5 11.0 0.056 0.606 B:P05164:0.605
 CA
BR
HEM
HOH
 5.898
3.472
5.488
2.591
 O
CE1
CD2
O
 CA
BR
CBD
O
HIS C:95 B:95 125.0 0.641 H -78.0 -10.0 12.0 0.062 0.579 D:P05164:0.579
 CA
BR
HEM
HOH
 5.996
3.346
5.355
2.618
 O
CE1
NE2
NE2
 CA
BR
ND
O
1d5l 1 P05164 100.0 2e-69 X-RAY
 2001-12-12 HIS A:95 A:95 126.0 0.646 H -76.9 -7.5 8.0 0.041 0.605 B:P05164:0.605
 CYN
HEM
CA
HOH
 2.685
5.556
5.851
2.595
 NE2
NE2
O
ND1
 N
ND
CA
O
HIS C:95 B:95 125.0 0.641 H -74.7 -3.9 8.0 0.041 0.6 D:P05164:0.6
 CYN
HEM
CA
HOH
 2.637
5.464
5.904
2.700
 NE2
NE2
O
O
 N
ND
CA
O
1d7w 1 P05164 100.0 2e-69 X-RAY
 2001-12-12 HIS A:95 A:95 126.0 0.646 H -73.8 -9.7 9.0 0.046 0.6 B:P05164:0.6
 CYN
HEM
CA
BR
HOH
 2.955
5.603
5.873
6.158
2.580
 NE2
NE2
O
CE1
O
 N
FE
CA
BR
O
HIS C:95 B:95 129.0 0.662 H -75.5 -3.3 11.0 0.056 0.606 D:P05164:0.605
 CYN
HEM
CA
BR
HOH
 2.740
5.365
5.900
6.030
2.749
 NE2
NE2
O
CE1
O
 N
FE
CA
BR
O
1dnu 1 P05164 100.0 2e-69 X-RAY
 2001-12-21 HIS A:95 A:95 125.0 0.641 H -79.0 -5.1 9.0 0.046 0.595 B:P05164:0.595
 SCN
CA
HEM
HOH
 3.269
5.921
5.417
2.680
 CE1
O
NE2
NE2
 N
CA
ND
O
HIS C:95 B:95 124.0 0.636 H -76.5 -4.5 10.0 0.051 0.585 D:P05164:0.585
 SCN
HEM
CA
HOH
 3.190
5.291
5.943
2.653
 CE1
NE2
O
O
 N
ND
CA
O
1dnw 1 P05164 100.0 2e-69 X-RAY
 2001-12-21 HIS A:95 A:95 125.0 0.641 H -74.1 -3.6 7.0 0.036 0.605 B:P05164:0.605
 CYN
CA
SCN
HEM
HOH
 2.959
5.847
3.200
5.588
2.680
 NE2
O
CE1
NE2
ND1
 N
CA
N
FE
O
HIS C:95 B:95 126.0 0.646 H -72.4 2.6 8.0 0.041 0.605 D:P05164:0.605
 SCN
CYN
HEM
CA
HOH
 3.025
2.835
5.450
5.936
2.669
 CE1
NE2
NE2
O
O
 N
N
FE
CA
O
4dl1 1 P05164 100.0 2e-69 X-RAY
 2012-03-21 HIS A:95 A:95 123.0 0.631 H -82.3 -2.2 10.0 0.051 0.58 B:P05164:0.579
 0KY
HEM
CA
HOH
 5.678
5.457
5.878
2.555
 CE1
NE2
O
O
 O2
FE
CA
O
HIS C:95 B:95 123.0 0.631 H -80.1 -3.4 8.0 0.041 0.59 D:P05164:0.59
 HEM
0KY
CA
HOH
 5.558
5.484
5.890
2.618
 NE2
CE1
O
O
 FE
O2
CA
O
HIS E:95 E:95 125.0 0.641 H -82.1 -8.0 NA NA NA
HIS G:95 F:95 123.0 0.631 H -81.8 -3.6 NA NA NA
HIS I:95 I:95 126.0 0.646 H -88.0 -0.1 NA NA NA
HIS K:95 J:95 127.0 0.651 H -80.7 -8.5 NA NA NA
HIS M:95 M:95 128.0 0.656 H -83.9 -2.6 NA NA NA
HIS O:95 N:95 125.0 0.641 H -81.1 -4.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p05164-f1 1 P05164 100.0 0.0 HIS A:261 A:261 5.0 0.026 H -75.2 -8.5