Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 56356496 . A C CCDS11604.1:NM_000250.1:c.758aTg>aGg_NP_000241.1:p.253M>R Homo sapiens myeloperoxidase (MPO), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bmt 1 P05164 100.0 0.0 X-RAY
 2018-01-03 MET A:253 A:253 16.0 0.086 H -53.4 -49.9 16.0 0.086 0.0 HEM
HOH
 3.482
7.193
 O
N
 CMC
O
5mfa 1 P05164 100.0 0.0 X-RAY
 2017-04-05 MET A:205 A:253 12.0 0.065 H -63.9 -47.1 12.0 0.065 0.0 HEM
HOH
 2.492
2.820
 HG2
HE2
 HMCB
O
5uzu 2 P05164 100.0 0.0 X-RAY
 2017-07-26 MET B:87 A:253 11.0 0.059 H -63.7 -46.6 11.0 0.059 0.0 HOH
 7.358
 N
 O
6azp 1 P05164 100.0 0.0 X-RAY
 2017-12-27 MET A:87 A:253 10.0 0.054 H -69.6 -45.5 10.0 0.054 0.0 HOH
 3.885
 CE
 O
3f9p 1 P05164 100.0 1e-76 X-RAY
 2009-07-14 MET A:89 A:87 101.0 0.546 H -74.0 -50.1 12.0 0.065 0.481 B:P05164:0.481
 HEM
 3.118
 O
 CMC
MET C:89 B:87 96.0 0.519 H -70.4 -52.2 NA NA NA
3zs1 1 P05164 100.0 1e-76 X-RAY
 2011-08-31 MET A:89 A:87 96.0 0.519 H -65.9 -50.8 NA NA NA
MET B:89 B:87 99.0 0.535 H -62.6 -50.1 11.0 0.059 0.476 D:P05164:0.476
 HEM
HOH
 3.218
3.348
 O
O
 CMC
O
4ejx 2 P05164 100.0 1e-76 X-RAY
 2013-04-10 MET B:89 B:87 98.0 0.53 H -62.6 -50.0 11.0 0.059 0.471 C:P05164:0.47
 HEM
 3.314
 O
 CMC
1mhl 1 P05164 100.0 3e-72 X-RAY
 1996-01-06 MET A:89 A:87 101.0 0.546 H -73.6 -46.4 12.0 0.065 0.481 B:P05164:0.481
 HEM
HOH
 3.341
3.695
 O
CE
 CMC
O
MET C:89 B:87 94.0 0.508 H -74.4 -49.3 11.0 0.059 0.449 D:P05164:0.449
 HEM
HOH
 3.414
3.816
 O
O
 CMC
O
1myp 1 P05164 100.0 3e-72 X-RAY
 1994-01-31 MET A:89 A:87 99.0 0.535 H -68.3 -15.0 12.0 0.065 0.47 B:P05164:0.47
 HEM
 2.965
 O
 CBB
MET C:89 B:87 107.0 0.578 H -84.6 -35.3 14.0 0.076 0.502 D:P05164:0.503
 HEM
 2.911
 SD
 CBB
3zs0 1 P05164 100.0 3e-72 X-RAY
 2011-08-31 MET A:89 A:87 96.0 0.519 H -66.1 -46.6 13.0 0.07 0.449 C:P05164:0.449
 HEM
HOH
 3.119
3.670
 O
O
 CMC
O
MET B:89 B:87 98.0 0.53 H -67.9 -48.0 12.0 0.065 0.465 D:P05164:0.465
 HEM
HOH
 3.176
3.570
 O
O
 CMC
O
4c1m 1 P05164 100.0 3e-72 X-RAY
 2013-11-13 MET A:89 A:87 96.0 0.519 H -60.1 -44.3 NA NA NA
MET B:89 B:87 92.0 0.497 H -67.1 -49.0 10.0 0.054 0.443 D:P05164:0.443
 HEM
NIH
HOH
 3.193
8.284
3.345
 O
SD
O
 CMC
O11
O
5fiw 1 P05164 100.0 5e-70 X-RAY
 2015-10-14 MET A:87 A:87 97.0 0.524 H -62.6 -49.3 11.0 0.059 0.465 C:P05164:0.465
 HEM
HOH
 3.350
3.628
 O
O
 CMC
O
MET B:87 B:87 99.0 0.535 H -61.6 -48.5 NA NA NA
5qj2 1 P05164 100.0 5e-70 X-RAY
 2019-02-06 MET A:87 A:87 92.0 0.497 H -61.6 -46.7 9.0 0.049 0.448 B:P05164:0.449
 HEM
JXS
 3.354
8.908
 O
SD
 CMC
N20
MET C:87 D:87 96.0 0.519 H -57.8 -49.3 NA NA NA
MET E:87 F:87 99.0 0.535 H -77.6 -49.5 NA NA NA
MET G:87 H:87 98.0 0.53 H -56.0 -51.1 NA NA NA
5qj3 1 P05164 100.0 5e-70 X-RAY
 2019-02-06 MET A:87 A:87 96.0 0.519 H -66.5 -47.3 9.0 0.049 0.47 B:P05164:0.47
 HEM
HOH
 3.153
3.602
 O
CE
 CMC
O
MET C:87 D:87 99.0 0.535 H -73.1 -38.9 NA NA NA
5wdj 1 P05164 100.0 5e-70 X-RAY
 2018-04-18 MET A:87 A:87 95.0 0.514 H -64.3 -55.8 13.0 0.07 0.444 B:P05164:0.443
 AEY
HEM
HOH
 9.042
3.415
3.688
 SD
O
O
 N15
CMC
O
MET C:87 D:87 93.0 0.503 H -69.2 -46.6 11.0 0.059 0.444 D:P05164:0.443
 HEM
AEY
HOH
 3.215
8.935
3.541
 O
SD
O
 CMC
N15
O
6wxz 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:87 A:87 95.0 0.514 H -65.7 -50.8 10.0 0.054 0.46 B:P05164:0.459
 HEC
HOH
 3.290
3.752
 O
CE
 CMC
O
MET C:87 D:87 95.0 0.514 H -65.5 -50.8 NA NA NA
6wy0 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:87 A:87 95.0 0.514 H -66.3 -53.8 11.0 0.059 0.455 B:P05164:0.454
 HEC
UFA
HOH
 3.444
9.818
7.810
 O
SD
CG
 CMC
N3
O
MET C:87 D:87 99.0 0.535 H -66.8 -54.0 NA NA NA
MET E:87 F:87 99.0 0.535 H -66.4 -54.6 NA NA NA
MET G:87 H:87 99.0 0.535 H -66.2 -53.6 NA NA NA
6wy5 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:87 A:87 125.0 0.676 H -67.2 -55.9 21.0 0.114 0.562 B:P05164:0.562
 HEC
UF7
 3.413
9.990
 O
SD
 CMC
N4
MET C:87 D:87 98.0 0.53 H -67.8 -55.6 NA NA NA
6wy7 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:87 A:87 96.0 0.519 H -66.0 -49.4 12.0 0.065 0.454 B:P05164:0.454
 HEC
HOH
 3.274
3.502
 O
CE
 CMC
O
MET C:87 D:87 97.0 0.524 H -66.9 -49.1 NA NA NA
6wyd 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:87 A:87 95.0 0.514 H -70.3 -53.9 11.0 0.059 0.455 B:P05164:0.454
 HEC
7GD
HOH
 3.101
9.326
3.469
 O
SD
O
 CMC
N15
O
MET C:87 D:87 100.0 0.541 H -59.0 -53.7 NA NA NA
MET E:87 F:87 100.0 0.541 H -66.9 -44.4 NA NA NA
MET G:87 H:87 100.0 0.541 H -61.4 -57.1 NA NA NA
7lae 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:87 A:87 64.0 NA H -93.5 34.3 10.0 NA NA B:P05164:NA
 HEM
 3.881
 O
 CMC
MET C:87 D:87 98.0 0.53 H -66.2 -52.0 NA NA NA
7lag 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:87 A:87 91.0 0.492 H -69.0 -52.9 10.0 0.054 0.438 B:P05164:0.438
 HEM
XSD
 3.293
9.693
 O
SD
 CMC
N6
MET C:87 D:87 95.0 0.514 H -69.3 -52.3 NA NA NA
MET E:87 F:87 97.0 0.524 H -69.0 -52.6 NA NA NA
MET G:87 H:87 94.0 0.508 H -68.6 -52.6 NA NA NA
7lal 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:87 A:87 125.0 0.676 H -62.1 -65.8 26.0 0.141 0.535 B:P05164:0.535
 HEM
 3.496
 O
 CMC
MET C:87 D:87 100.0 0.541 H -61.1 -61.7 NA NA NA
7lan 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:87 A:87 99.0 0.535 H -69.8 -47.5 10.0 0.054 0.481 B:P05164:0.481
 HEM
XS1
HOH
 3.188
9.945
3.454
 O
SD
CE
 CMC
H5
O
MET C:87 D:87 97.0 0.524 H -71.7 -52.6 NA NA NA
MET E:87 F:87 101.0 0.546 H -65.2 -52.6 NA NA NA
MET G:87 H:87 97.0 0.524 H -69.3 -52.2 NA NA NA
1cxp 1 P05164 100.0 2e-69 X-RAY
 2000-04-24 MET A:87 A:87 95.0 0.514 H -63.2 -47.2 11.0 0.059 0.455 B:P05164:0.454
 HEM
HOH
 3.182
3.629
 O
CA
 CMC
O
MET C:87 B:87 95.0 0.514 H -65.6 -48.9 10.0 0.054 0.46 D:P05164:0.459
 HEM
HOH
 3.253
3.532
 O
O
 CMC
O
1d2v 1 P05164 100.0 2e-69 X-RAY
 2000-04-24 MET A:87 A:87 96.0 0.519 H -63.3 -49.7 12.0 0.065 0.454 B:P05164:0.454
 BR
HEM
HOH
 9.766
3.319
3.611
 SD
O
CE
 BR
CMC
O
MET C:87 B:87 93.0 0.503 H -65.3 -47.3 10.0 0.054 0.449 D:P05164:0.449
 BR
HEM
HOH
 9.667
3.152
3.482
 SD
O
O
 BR
CMC
O
1d5l 1 P05164 100.0 2e-69 X-RAY
 2001-12-12 MET A:87 A:87 97.0 0.524 H -63.1 -49.7 12.0 0.065 0.459 B:P05164:0.459
 CYN
HEM
HOH
 8.220
3.131
3.568
 SD
O
CE
 C
CMC
O
MET C:87 B:87 96.0 0.519 H -66.8 -49.1 10.0 0.054 0.465 D:P05164:0.465
 CYN
HEM
HOH
 8.375
3.239
3.487
 SD
O
CE
 C
CMC
O
1d7w 1 P05164 100.0 2e-69 X-RAY
 2001-12-12 MET A:87 A:87 95.0 0.514 H -62.4 -53.3 14.0 0.076 0.438 B:P05164:0.438
 CYN
HEM
HOH
 7.858
3.174
3.559
 SD
O
O
 C
CMC
O
MET C:87 B:87 100.0 0.541 H -66.7 -53.8 11.0 0.059 0.482 D:P05164:0.481
 CYN
HEM
HOH
 8.165
3.227
3.206
 SD
O
CE
 C
CMC
O
1dnu 1 P05164 100.0 2e-69 X-RAY
 2001-12-21 MET A:87 A:87 95.0 0.514 H -65.1 -47.8 11.0 0.059 0.455 B:P05164:0.454
 SCN
HEM
HOH
 9.412
3.159
3.646
 SD
O
CE
 N
CMC
O
MET C:87 B:87 96.0 0.519 H -67.4 -47.7 10.0 0.054 0.465 D:P05164:0.465
 SCN
HEM
HOH
 9.361
3.293
3.611
 SD
O
CE
 N
CMC
O
1dnw 1 P05164 100.0 2e-69 X-RAY
 2001-12-21 MET A:87 A:87 94.0 0.508 H -69.8 -49.1 10.0 0.054 0.454 B:P05164:0.454
 CYN
SCN
HEM
HOH
 8.253
9.639
3.136
3.543
 SD
SD
O
CE
 N
N
CMC
O
MET C:87 B:87 100.0 0.541 H -69.4 -48.1 10.0 0.054 0.487 D:P05164:0.486
 SCN
CYN
HEM
HOH
 9.570
8.507
3.176
3.621
 SD
SD
O
CE
 N
C
CMC
O
4dl1 1 P05164 100.0 2e-69 X-RAY
 2012-03-21 MET A:87 A:87 99.0 0.535 H -69.0 -49.7 14.0 0.076 0.459 B:P05164:0.459
 HEM
HOH
 3.215
3.673
 O
CE
 CMC
O
MET C:87 B:87 94.0 0.508 H -55.8 -50.1 11.0 0.059 0.449 D:P05164:0.449
 HEM
HOH
 3.054
3.572
 O
O
 CMC
O
MET E:87 E:87 99.0 0.535 H -66.1 -48.9 NA NA NA
MET G:87 F:87 99.0 0.535 H -68.3 -59.5 NA NA NA
MET I:87 I:87 96.0 0.519 H -65.7 -47.8 NA NA NA
MET K:87 J:87 96.0 0.519 H -63.4 -48.8 NA NA NA
MET M:87 M:87 97.0 0.524 H -67.4 -43.0 NA NA NA
MET O:87 N:87 99.0 0.535 H -61.0 -50.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p05164-f1 1 P05164 100.0 0.0 MET A:253 A:253 12.0 0.065 H -63.3 -47.1