Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 56356502 . A C CCDS11604.1:NM_000250.1:c.752aTg>aGg_NP_000241.1:p.251M>R Homo sapiens myeloperoxidase (MPO), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bmt 1 P05164 100.0 0.0 X-RAY
 2018-01-03 MET A:251 A:251 0.0 0.0 H -61.8 -23.5 0.0 0.0 0.0 HEM
HOH
 8.318
8.355
 O
CG
 CMC
O
5mfa 1 P05164 100.0 0.0 X-RAY
 2017-04-05 MET A:203 A:251 0.0 0.0 H -56.9 -28.1 0.0 0.0 0.0 HEM
HOH
 7.476
4.535
 O
HB3
 HMC
O
5uzu 2 P05164 100.0 0.0 X-RAY
 2017-07-26 MET B:85 A:251 0.0 0.0 H -63.2 -28.4 0.0 0.0 0.0 HOH
 4.792
 CB
 O
6azp 1 P05164 100.0 0.0 X-RAY
 2017-12-27 MET A:85 A:251 0.0 0.0 H -57.1 -23.6 0.0 0.0 0.0 HOH
 4.943
 CB
 O
3f9p 1 P05164 100.0 1e-76 X-RAY
 2009-07-14 MET A:87 A:85 132.0 0.714 H -67.1 -28.7 0.0 0.0 0.714 B:P05164:0.714
 HEM
 7.898
 O
 CMC
MET C:87 B:85 134.0 0.724 H -65.5 -29.8 NA NA NA
3zs1 1 P05164 100.0 1e-76 X-RAY
 2011-08-31 MET A:87 A:85 130.0 0.703 H -67.8 -27.6 NA NA NA
MET B:87 B:85 129.0 0.697 H -63.1 -25.2 0.0 0.0 0.697 D:P05164:0.697
 HEM
HOH
 8.093
6.075
 O
O
 CMC
O
4ejx 2 P05164 100.0 1e-76 X-RAY
 2013-04-10 MET B:87 B:85 129.0 0.697 H -63.1 -25.2 0.0 0.0 0.697 C:P05164:0.697
 HEM
 8.178
 O
 CMC
1mhl 1 P05164 100.0 3e-72 X-RAY
 1996-01-06 MET A:87 A:85 134.0 0.724 H -61.4 -29.2 0.0 0.0 0.724 B:P05164:0.724
 HEM
HOH
 8.118
4.572
 O
CB
 CMC
O
MET C:87 B:85 128.0 0.692 H -59.1 -32.3 0.0 0.0 0.692 D:P05164:0.692
 HEM
HOH
 8.062
4.618
 O
CB
 CMC
O
1myp 1 P05164 100.0 3e-72 X-RAY
 1994-01-31 MET A:87 A:85 127.0 0.686 G -41.4 -17.8 0.0 0.0 0.686 B:P05164:0.686
 HEM
 8.403
 O
 CBB
MET C:87 B:85 119.0 0.643 H -71.7 -6.4 5.0 0.027 0.616 D:P05164:0.616
 HEM
 8.593
 C
 CBB
3zs0 1 P05164 100.0 3e-72 X-RAY
 2011-08-31 MET A:87 A:85 130.0 0.703 H -66.3 -29.1 0.0 0.0 0.703 C:P05164:0.703
 HEM
HOH
 7.967
4.576
 O
CB
 CMC
O
MET B:87 B:85 131.0 0.708 H -63.3 -27.7 0.0 0.0 0.708 D:P05164:0.708
 HEM
HOH
 7.939
4.657
 O
CB
 CMC
O
4c1m 1 P05164 100.0 3e-72 X-RAY
 2013-11-13 MET A:87 A:85 131.0 0.708 H -57.6 -29.3 NA NA NA
MET B:87 B:85 130.0 0.703 H -57.2 -28.6 0.0 0.0 0.703 D:P05164:0.703
 HEM
HOH
 8.071
4.551
 O
CB
 CMC
O
5fiw 1 P05164 100.0 5e-70 X-RAY
 2015-10-14 MET A:85 A:85 132.0 0.714 H -59.6 -28.7 0.0 0.0 0.714 C:P05164:0.714
 HEM
HOH
 8.054
4.679
 O
CB
 CMC
O
MET B:85 B:85 129.0 0.697 H -60.2 -28.7 NA NA NA
5qj2 1 P05164 100.0 5e-70 X-RAY
 2019-02-06 MET A:85 A:85 137.0 0.741 H -63.4 -31.8 0.0 0.0 0.741 B:P05164:0.741
 HEM
 8.219
 O
 CMC
MET C:85 D:85 137.0 0.741 H -62.9 -32.0 NA NA NA
MET E:85 F:85 134.0 0.724 H -70.2 -34.5 NA NA NA
MET G:85 H:85 137.0 0.741 H -58.9 -30.7 NA NA NA
5qj3 1 P05164 100.0 5e-70 X-RAY
 2019-02-06 MET A:85 A:85 131.0 0.708 H -58.7 -33.7 0.0 0.0 0.708 B:P05164:0.708
 HEM
HOH
 7.897
8.122
 O
CG
 CMC
O
MET C:85 D:85 131.0 0.708 H -57.7 -35.2 NA NA NA
5wdj 1 P05164 100.0 5e-70 X-RAY
 2018-04-18 MET A:85 A:85 130.0 0.703 H -50.0 -35.3 0.0 0.0 0.703 B:P05164:0.703
 HEM
HOH
 7.983
4.411
 O
CB
 CMC
O
MET C:85 D:85 128.0 0.692 H -60.1 -22.2 0.0 0.0 0.692 D:P05164:0.692
 HEM
HOH
 8.236
4.379
 O
CB
 CMC
O
6wxz 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:85 A:85 127.0 0.686 H -63.2 -28.7 0.0 0.0 0.686 B:P05164:0.686
 HEC
HOH
 8.061
6.279
 O
O
 CMC
O
MET C:85 D:85 127.0 0.686 H -63.7 -28.7 NA NA NA
6wy0 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:85 A:85 133.0 0.719 H -60.8 -33.5 0.0 0.0 0.719 B:P05164:0.719
 HEC
 8.091
 O
 CMC
MET C:85 D:85 132.0 0.714 H -60.5 -33.1 NA NA NA
MET E:85 F:85 134.0 0.724 H -60.1 -34.2 NA NA NA
MET G:85 H:85 135.0 0.73 H -61.0 -33.7 NA NA NA
6wy5 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:85 A:85 128.0 0.692 H -65.8 -38.5 31.0 0.168 0.524 B:P05164:0.524
 HEC
 7.934
 O
 CMC
MET C:85 D:85 131.0 0.708 H -64.6 -39.1 NA NA NA
6wy7 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:85 A:85 132.0 0.714 H -60.3 -27.6 0.0 0.0 0.714 B:P05164:0.714
 HEC
HOH
 8.082
4.568
 O
CB
 CMC
O
MET C:85 D:85 130.0 0.703 H -60.9 -27.6 NA NA NA
6wyd 1 P05164 100.0 5e-70 X-RAY
 2020-10-14 MET A:85 A:85 129.0 0.697 H -65.9 -35.6 0.0 0.0 0.697 B:P05164:0.697
 HEC
HOH
 7.783
4.261
 O
CB
 CMC
O
MET C:85 D:85 131.0 0.708 H -67.7 -31.0 NA NA NA
MET E:85 F:85 131.0 0.708 H -62.0 -37.0 NA NA NA
MET G:85 H:85 135.0 0.73 H -58.9 -30.9 NA NA NA
7lae 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:85 A:85 135.0 0.73 T -56.3 -33.5 4.0 0.022 0.708 B:P05164:0.708
 HEM
 7.944
 O
 CMC
MET C:85 D:85 132.0 0.714 H -55.5 -35.4 NA NA NA
7lag 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:85 A:85 135.0 0.73 H -59.0 -35.6 0.0 0.0 0.73 B:P05164:0.73
 HEM
 8.115
 O
 CMC
MET C:85 D:85 134.0 0.724 H -56.8 -35.0 NA NA NA
MET E:85 F:85 133.0 0.719 H -58.0 -35.4 NA NA NA
MET G:85 H:85 135.0 0.73 H -57.7 -34.5 NA NA NA
7lal 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:85 A:85 119.0 0.643 H -60.4 -38.9 32.0 0.173 0.47 B:P05164:0.47
 HEM
 7.768
 O
 CMC
MET C:85 D:85 133.0 0.719 H -60.0 -39.1 NA NA NA
7lan 1 P05164 100.0 5e-70 X-RAY
 2021-04-21 MET A:85 A:85 130.0 0.703 H -61.8 -30.9 0.0 0.0 0.703 B:P05164:0.703
 HEM
HOH
 8.026
6.105
 O
O
 CMC
O
MET C:85 D:85 133.0 0.719 H -61.6 -31.4 NA NA NA
MET E:85 F:85 133.0 0.719 H -60.8 -29.2 NA NA NA
MET G:85 H:85 134.0 0.724 H -61.1 -31.8 NA NA NA
1cxp 1 P05164 100.0 2e-69 X-RAY
 2000-04-24 MET A:85 A:85 127.0 0.686 H -60.1 -32.1 0.0 0.0 0.686 B:P05164:0.686
 HEM
HOH
 7.903
4.648
 O
CB
 CMC
O
MET C:85 B:85 130.0 0.703 H -62.7 -26.5 0.0 0.0 0.703 D:P05164:0.703
 HEM
HOH
 8.035
4.703
 O
CB
 CMC
O
1d2v 1 P05164 100.0 2e-69 X-RAY
 2000-04-24 MET A:85 A:85 129.0 0.697 H -60.2 -30.9 0.0 0.0 0.697 B:P05164:0.697
 HEM
HOH
 7.939
4.480
 O
CB
 CMC
O
MET C:85 B:85 130.0 0.703 H -59.2 -27.4 0.0 0.0 0.703 D:P05164:0.703
 HEM
HOH
 7.897
4.802
 O
CB
 CMC
O
1d5l 1 P05164 100.0 2e-69 X-RAY
 2001-12-12 MET A:85 A:85 128.0 0.692 H -62.8 -32.2 0.0 0.0 0.692 B:P05164:0.692
 HEM
HOH
 7.859
4.631
 O
CB
 CMC
O
MET C:85 B:85 129.0 0.697 H -62.4 -25.8 0.0 0.0 0.697 D:P05164:0.697
 HEM
HOH
 7.995
4.690
 O
CB
 CMC
O
1d7w 1 P05164 100.0 2e-69 X-RAY
 2001-12-12 MET A:85 A:85 129.0 0.697 H -61.4 -30.6 0.0 0.0 0.697 B:P05164:0.697
 HEM
HOH
 7.822
4.480
 O
CB
 CMC
O
MET C:85 B:85 132.0 0.714 H -64.1 -24.1 0.0 0.0 0.714 D:P05164:0.714
 HEM
HOH
 7.957
4.854
 O
CB
 CMC
O
1dnu 1 P05164 100.0 2e-69 X-RAY
 2001-12-21 MET A:85 A:85 131.0 0.708 H -60.5 -28.8 0.0 0.0 0.708 B:P05164:0.708
 HEM
HOH
 8.010
4.571
 O
CB
 CMC
O
MET C:85 B:85 130.0 0.703 H -63.4 -26.4 0.0 0.0 0.703 D:P05164:0.703
 HEM
HOH
 7.999
4.782
 O
CB
 CMC
O
1dnw 1 P05164 100.0 2e-69 X-RAY
 2001-12-21 MET A:85 A:85 130.0 0.703 H -66.2 -28.0 0.0 0.0 0.703 B:P05164:0.703
 HEM
HOH
 7.881
4.676
 O
CB
 CMC
O
MET C:85 B:85 128.0 0.692 H -68.3 -27.7 0.0 0.0 0.692 D:P05164:0.692
 HEM
HOH
 7.818
4.746
 O
CB
 CMC
O
4dl1 1 P05164 100.0 2e-69 X-RAY
 2012-03-21 MET A:85 A:85 135.0 0.73 H -57.5 -31.0 0.0 0.0 0.73 B:P05164:0.73
 HEM
HOH
 8.106
4.707
 O
CB
 CMC
O
MET C:85 B:85 130.0 0.703 H -55.4 -31.3 0.0 0.0 0.703 D:P05164:0.703
 HEM
HOH
 7.907
4.942
 O
CB
 CMC
O
MET E:85 E:85 130.0 0.703 H -60.5 -25.1 NA NA NA
MET G:85 F:85 128.0 0.692 H -75.7 -22.1 NA NA NA
MET I:85 I:85 127.0 0.686 H -60.7 -23.3 NA NA NA
MET K:85 J:85 131.0 0.708 H -65.8 -31.7 NA NA NA
MET M:85 M:85 132.0 0.714 H -58.7 -24.7 NA NA NA
MET O:85 N:85 132.0 0.714 H -58.3 -31.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p05164-f1 1 P05164 100.0 0.0 MET A:251 A:251 0.0 0.0 H -55.5 -32.4