Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 18243425 . T A CCDS11196.1:NM_004169.3:c.746cAt>cTt_NP_004160.3:p.249H>L Homo sapiens serine hydroxymethyltransferase 1 (SHMT1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6m5w 1 P34896 100.0 0.0 X-RAY
 2021-01-20 HIS A:269 A:249 12.0 0.062 S -82.5 -33.5 12.0 0.062 0.0
6fl5 1 P34896 99.36 0.0 X-RAY
 2018-10-10 HIS A:239 A:249 8.0 0.041 S -86.5 -45.8 8.0 0.041 0.0
HIS B:239 D:249 9.0 0.046 S -92.4 -40.0 9.0 0.046 0.0
HIS C:239 G:249 9.0 0.046 S -91.2 -36.3 9.0 0.046 0.0
HIS D:239 J:249 9.0 0.046 S -92.2 -38.1 9.0 0.046 0.0
1bj4 1 P34896 99.36 0.0 X-RAY
 1999-08-16 HIS A:239 A:249 12.0 0.062 S -88.0 -34.8 12.0 0.062 0.0 HOH
 3.101
 NE2
 O
1ls3 1 p07511 92.92 0.0 X-RAY
 2003-02-04 HIS A:248 A:221 12.0 0.062 S -83.2 -36.0 12.0 0.062 0.0 HOH
 3.286
 NE2
 O
HIS B:248 B:221 1.0 0.005 S -77.5 -37.8 1.0 0.005 0.0 HOH
 9.415
 N
 O
HIS C:248 C:221 1.0 0.005 S -86.7 -33.2 1.0 0.005 0.0 HOH
 3.383
 NE2
 O
HIS D:248 D:221 13.0 0.067 S -79.3 -37.2 13.0 0.067 0.0 HOH
 4.672
 CD2
 O
1rvu 1 P07511 92.71 0.0 X-RAY
 2004-06-15 HIS A:248 A:249 0.0 0.0 S -92.2 -31.3 0.0 0.0 0.0 HOH
 7.521
 O
 O
HIS B:248 B:249 0.0 0.0 S -91.0 -32.6 0.0 0.0 0.0 HOH
 7.501
 O
 O
1rvy 1 P07511 92.71 0.0 X-RAY
 2004-06-15 HIS A:248 A:249 0.0 0.0 S -90.4 -30.3 0.0 0.0 0.0 HOH
 7.615
 O
 O
HIS B:248 B:249 0.0 0.0 S -89.7 -29.9 0.0 0.0 0.0 HOH
 7.102
 O
 O
1rv3 1 P07511 92.71 0.0 X-RAY
 2004-06-15 HIS A:248 A:249 0.0 0.0 S -91.5 -31.0 0.0 0.0 0.0 HOH
 7.515
 O
 O
HIS B:248 B:249 0.0 0.0 S -90.4 -32.1 0.0 0.0 0.0 HOH
 7.510
 O
 O
1rv4 1 P07511 92.71 0.0 X-RAY
 2004-06-15 HIS A:248 A:249 0.0 0.0 S -94.9 -32.6 0.0 0.0 0.0 HOH
 7.323
 O
 O
HIS B:248 B:249 0.0 0.0 S -93.8 -33.7 0.0 0.0 0.0 HOH
 7.232
 O
 O
1cj0 1 P07511 93.4 0.0 X-RAY
 1999-05-06 HIS A:235 A:221 0.0 0.0 S -88.5 -29.0 0.0 0.0 0.0
HIS B:235 B:221 0.0 0.0 S -89.9 -26.1 0.0 0.0 0.0
1eji 1 P50431 91.19 0.0 X-RAY
 2000-11-03 HIS A:243 A:249 0.0 0.0 S -85.9 -31.0 0.0 0.0 0.0
HIS B:243 B:249 0.0 0.0 S -85.6 -32.3 0.0 0.0 0.0
HIS C:243 C:249 10.0 0.051 S -85.9 -32.1 10.0 0.051 0.0
HIS D:243 D:249 0.0 0.0 S -86.7 -31.2 0.0 0.0 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p34896-f1 1 P34896 100.0 0.0 HIS A:249 A:249 2.0 0.01 S -83.7 -37.2