Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 18250861 . G A CCDS11196.1:NM_004169.3:c.468gaC>gaT_NP_004160.3:p.156D>D Homo sapiens serine hydroxymethyltransferase 1 (SHMT1), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6m5w 1 P34896 100.0 0.0 X-RAY
 2021-01-20 ASP A:176 A:156 146.0 0.973 S -50.0 -36.7 37.0 0.247 0.726 A:P34896:0.727
6fl5 1 P34896 99.36 0.0 X-RAY
 2018-10-10 ASP A:146 A:156 178.0 1.0 S -65.7 -16.9 58.0 0.387 0.613 C:P34896:0.8
ASP B:146 D:156 180.0 1.0 S -60.3 -13.6 56.0 0.373 0.627 D:P34896:0.827
ASP C:146 G:156 159.0 1.0 S -55.6 -41.3 44.0 0.293 0.707 A:P34896:0.767
ASP D:146 J:156 178.0 1.0 S -64.8 -13.3 58.0 0.387 0.613 B:P34896:0.8
1bj4 1 P34896 99.36 0.0 X-RAY
 1999-08-16 ASP A:146 A:156 179.0 1.0 S -63.2 -28.8 179.0 1.0 0.0 HOH
 2.858
 OD2
 O
1ls3 1 p07511 92.92 0.0 X-RAY
 2003-02-04 ASP A:155 A:134 164.0 1.0 S -81.7 17.7 87.0 0.58 0.42 C:p07511:0.513
 HOH
 4.040
 CB
 O
ASP B:155 B:134 176.0 1.0 S -60.8 -28.8 98.0 0.653 0.347 D:p07511:0.52
 TGF
HOH
 8.629
9.958
 N
O
 OEB
O
ASP C:155 C:134 149.0 0.993 S -81.0 24.3 74.0 0.493 0.5 A:p07511:0.5
 HOH
 2.772
 OD1
 O
ASP D:155 D:134 173.0 1.0 S -103.2 17.9 103.0 0.687 0.313 B:p07511:0.467
 TGF
HOH
 8.170
3.243
 N
CB
 O13
O
1rvu 1 P07511 92.71 0.0 X-RAY
 2004-06-15 ASP A:155 A:156 148.0 0.987 S -77.6 -8.6 75.0 0.5 0.487 A:P07511:0.487
 HOH
 7.076
 O
 O
ASP B:155 B:156 148.0 0.987 S -77.8 -9.4 61.0 0.407 0.58 B:P07511:0.58
 HOH
 6.912
 O
 O
1rvy 1 P07511 92.71 0.0 X-RAY
 2004-06-15 ASP A:155 A:156 143.0 0.953 S -74.8 -9.3 71.0 0.473 0.48 A:P07511:0.48
 HOH
 7.095
 O
 O
ASP B:155 B:156 146.0 0.973 S -75.4 -10.3 57.0 0.38 0.593 B:P07511:0.593
 HOH
 7.055
 O
 O
1rv3 1 P07511 92.71 0.0 X-RAY
 2004-06-15 ASP A:155 A:156 152.0 1.0 S -71.4 -16.9 84.0 0.56 0.44 A:P07511:0.453
 HOH
 7.068
 O
 O
ASP B:155 B:156 150.0 1.0 S -71.5 -16.8 68.0 0.453 0.547 B:P07511:0.547
 HOH
 6.656
 O
 O
1rv4 1 P07511 92.71 0.0 X-RAY
 2004-06-15 ASP A:155 A:156 147.0 0.98 S -74.3 -24.2 82.0 0.547 0.433 A:P07511:0.433
 HOH
 6.792
 O
 O
ASP B:155 B:156 147.0 0.98 S -75.2 -24.2 72.0 0.48 0.5 B:P07511:0.5
 HOH
 6.342
 O
 O
1cj0 1 P07511 93.4 0.0 X-RAY
 1999-05-06 ASP A:142 A:134 174.0 1.0 S -67.8 -20.8 174.0 1.0 0.0
ASP B:142 B:134 169.0 1.0 S -70.2 -33.8 169.0 1.0 0.0 HOH
 9.735
 O
 O
1eji 1 P50431 91.19 0.0 X-RAY
 2000-11-03 ASP A:150 A:156 163.0 1.0 S -45.2 -34.4 84.0 0.56 0.44 C:P50431:0.527
 HOH
 9.233
 N
 O
ASP B:150 B:156 174.0 1.0 S -62.0 -36.2 103.0 0.687 0.313 D:P50431:0.473
 THF
HOH
 8.350
9.954
 N
N
 OE1
O
ASP C:150 C:156 150.0 1.0 S -82.5 -7.7 84.0 0.56 0.44 A:P50431:0.44
 HOH
 8.113
 OD2
 O
ASP D:150 D:156 155.0 1.0 S -68.4 -21.3 86.0 0.573 0.427 B:P50431:0.46
 THF
 8.881
 N
 OE2

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p34896-f1 1 P34896 100.0 0.0 ASP A:156 A:156 176.0 1.0 T -51.0 -24.2