Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 49238616 . C A CCDS11578.1:NM_198175.1:c.399ttC>ttA_NP_937818.1:p.133F>L Homo sapiens NME/NM23 nucleoside diphosphate kinase 1 (NME1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3l7u 1 P15531 100.0 6e-113 X-RAY
 2010-11-10 PHE A:128 A:108 44.0 0.21 H -118.8 -8.6 4.0 0.019 0.191 B:P15531:0.19
 HOH
 3.588
 CZ
 O
PHE B:128 B:108 52.0 0.248 H -122.5 -11.0 8.0 0.038 0.21 C:P15531:0.21
 PO4
HOH
 8.762
3.848
 O
CZ
 O1
O
PHE C:128 C:108 45.0 0.214 H -118.2 -8.9 4.0 0.019 0.195 A:P15531:0.195
 PO4
HOH
 8.556
3.855
 O
CZ
 O3
O
1jxv 1 P15531 100.0 6e-113 X-RAY
 2002-04-10 PHE A:108 A:108 46.0 0.219 H -115.3 -8.0 4.0 0.019 0.2 C:P15531:0.2
 HOH
 4.837
 N
 O
PHE B:108 B:108 46.0 0.219 H -115.7 -8.2 4.0 0.019 0.2 A:P15531:0.2
 HOH
 3.691
 CZ
 O
PHE C:108 C:108 47.0 0.224 H -116.7 -8.2 4.0 0.019 0.205 B:P15531:0.205
 HOH
 3.477
 CZ
 O
PHE D:108 D:108 48.0 0.229 H -118.8 -6.8 5.0 0.024 0.205 F:P15531:0.205
 HOH
 4.824
 N
 O
PHE E:108 E:108 48.0 0.229 H -117.9 -6.8 6.0 0.029 0.2 D:P15531:0.2
 HOH
 3.268
 CZ
 O
PHE F:108 F:108 47.0 0.224 H -116.6 -8.5 5.0 0.024 0.2 E:P15531:0.2
 HOH
 4.762
 CE2
 O
2hvd 1 P15531 100.0 6e-113 X-RAY
 2006-09-19 PHE A:108 A:108 48.0 0.229 H -117.6 -2.2 7.0 0.033 0.196 B:P15531:0.195
 HOH
 4.828
 N
 O
PHE B:108 B:108 45.0 0.214 H -120.2 -0.1 5.0 0.024 0.19 C:P15531:0.19
 HOH
 3.428
 CZ
 O
PHE C:108 C:108 47.0 0.224 H -113.9 -9.9 4.0 0.019 0.205 A:P15531:0.205
 HOH
 3.875
 CE1
 O
4eno 1 P15531 100.0 6e-113 X-RAY
 2013-03-27 PHE A:108 A:108 51.0 0.243 H -122.4 -28.3 4.0 0.019 0.224 A:P15531:0.224
 HOH
 7.127
 CZ
 O
PHE B:108 B:108 47.0 0.224 H -124.6 -31.5 3.0 0.014 0.21 B:P15531:0.21
 HOH
 5.480
 O
 O
5ui4 1 P15531 100.0 7e-113 X-RAY
 2018-01-17 PHE A:115 A:108 44.0 0.21 H -120.2 -0.9 2.0 0.01 0.2 B:P15531:0.2
 HOH
 4.812
 O
 O
PHE B:115 B:108 43.0 0.205 H -120.3 -0.7 3.0 0.014 0.191 C:P15531:0.19
 HOH
 4.433
 CE1
 O
PHE C:115 C:108 42.0 0.2 H -120.2 -0.7 3.0 0.014 0.186 A:P15531:0.186
 HOH
 3.887
 CE1
 O
PHE D:115 D:108 43.0 0.205 H -120.4 -1.0 2.0 0.01 0.195 E:P15531:0.195
 HOH
 4.065
 CE1
 O
PHE E:115 E:108 44.0 0.21 H -120.3 -0.9 4.0 0.019 0.191 F:P15531:0.19
 HOH
 4.883
 O
 O
PHE F:115 F:108 41.0 0.195 H -119.9 -0.9 3.0 0.014 0.181 D:P15531:0.181
 HOH
 4.752
 O
 O
2hve 1 P15531 99.34 4e-112 X-RAY
 2006-09-19 PHE A:108 A:108 47.0 0.224 H -120.8 -4.7 8.0 0.038 0.186 B:P15531:0.186
 HOH
 3.923
 CE1
 O
PHE B:108 B:108 46.0 0.219 H -116.4 -0.8 7.0 0.033 0.186 C:P15531:0.186
 HOH
 3.444
 CZ
 O
PHE C:108 C:108 49.0 0.233 H -121.0 -7.5 6.0 0.029 0.204 A:P15531:0.205
 HOH
 3.588
 CZ
 O
1ucn 1 P15531 98.68 2e-110 X-RAY
 2003-09-30 PHE A:108 A:108 47.0 0.224 H -114.7 -5.5 5.0 0.024 0.2 B:P15531:0.2
 HOH
 5.052
 O
 O
PHE B:108 B:108 46.0 0.219 H -114.2 0.4 4.0 0.019 0.2 C:P15531:0.2
 HOH
 3.549
 CZ
 O
PHE C:108 C:108 39.0 0.186 H -112.2 -3.0 2.0 0.01 0.176 A:P15531:0.176
 HOH
 3.543
 CZ
 O
1bhn 1 P52174 94.08 8e-108 X-RAY
 1999-02-16 PHE A:108 A:108 45.0 0.214 H -91.8 -8.0 6.0 0.029 0.185 B:P52174:0.186
 HOH
 3.679
 CD1
 O
PHE B:108 B:108 48.0 0.229 H -127.2 35.5 1.0 0.005 0.224 C:P52174:0.224
 HOH
 5.101
 CD1
 O
PHE C:108 C:108 43.0 0.205 H -139.7 9.0 2.0 0.01 0.195 A:P52174:0.195
 HOH
 4.244
 CE1
 O
PHE D:108 D:108 44.0 0.21 H -123.5 22.7 5.0 0.024 0.186 E:P52174:0.186
 HOH
 3.632
 CD2
 O
PHE E:108 E:108 45.0 0.214 H -123.7 4.1 4.0 0.019 0.195 F:P52174:0.195
 HOH
 4.025
 CE1
 O
PHE F:108 F:108 46.0 0.219 H -124.7 14.0 5.0 0.024 0.195 D:P52174:0.195
 HOH
 3.472
 CZ
 O
1be4 1 P52175 93.38 2e-105 X-RAY
 1999-01-13 PHE A:107 A:108 50.0 0.238 H -102.9 23.0 6.0 0.029 0.209 B:P52175:0.21
 HOH
 3.506
 CZ
 O
PHE B:107 B:108 52.0 0.248 H -137.3 1.6 9.0 0.043 0.205 C:P52175:0.205
 HOH
 4.833
 CZ
 O
PHE C:107 C:108 38.0 0.181 H -111.4 -13.6 5.0 0.024 0.157 A:P52175:0.157
 HOH
 2.955
 O
 O
1nsk 1 P22392 88.16 4e-100 X-RAY
 1995-10-15 PHE A:108 R:108 41.0 0.195 H -114.5 -11.5 3.0 0.014 0.181 C:P22392:0.181
PHE B:108 L:108 43.0 0.205 H -114.8 -10.8 4.0 0.019 0.186 E:P22392:0.186
PHE C:108 T:108 42.0 0.2 H -114.0 -8.2 3.0 0.014 0.186 D:P22392:0.186
PHE D:108 U:108 42.0 0.2 H -111.5 -13.2 3.0 0.014 0.186 A:P22392:0.186
PHE E:108 N:108 44.0 0.21 H -112.0 -11.8 3.0 0.014 0.196 F:P22392:0.195
PHE F:108 O:108 42.0 0.2 H -114.6 -8.0 3.0 0.014 0.186 B:P22392:0.186
7kpf 1 P22392 88.16 4e-100 X-RAY
 2022-02-02 PHE A:108 A:108 44.0 0.21 H -125.6 -3.6 3.0 0.014 0.196 F:P22392:0.195
 HOH
 3.401
 HE1
 O
PHE B:108 B:108 45.0 0.214 H -123.7 -2.0 3.0 0.014 0.2 A:P22392:0.2
 HOH
 4.671
 HZ
 O
PHE C:108 C:108 45.0 0.214 H -123.2 -1.2 5.0 0.024 0.19 E:P22392:0.19
 HOH
 3.393
 HE1
 O
PHE D:108 D:108 45.0 0.214 H -122.8 -3.6 4.0 0.019 0.195 C:P22392:0.195
 HOH
 4.932
 O
 O
PHE E:108 E:108 46.0 0.219 H -123.5 -3.7 4.0 0.019 0.2 D:P22392:0.2
 HOH
 3.582
 HE1
 O
PHE F:108 F:108 50.0 0.238 H -122.7 -2.0 7.0 0.033 0.205 B:P22392:0.205
 HOH
 2.857
 HE1
 O
1nue 1 P22392 88.08 4e-99 X-RAY
 1996-04-03 PHE A:107 A:108 42.0 0.2 H -115.5 -3.5 1.0 0.005 0.195 B:P22392:0.195
 HOH
 4.851
 O
 O
PHE B:107 B:108 39.0 0.186 H -115.6 -3.4 0.0 0.0 0.186 C:P22392:0.186
 HOH
 4.936
 N
 O
PHE C:107 C:108 41.0 0.195 H -112.8 -4.2 0.0 0.0 0.195 A:P22392:0.195
 HOH
 4.842
 O
 O
PHE D:107 D:108 42.0 0.2 H -115.1 -5.3 1.0 0.005 0.195 F:P22392:0.195
 HOH
 4.814
 N
 O
PHE E:107 E:108 41.0 0.195 H -116.4 -5.7 1.0 0.005 0.19 D:P22392:0.19
 HOH
 4.808
 O
 O
PHE F:107 F:108 42.0 0.2 H -112.1 -6.4 0.0 0.0 0.2 E:P22392:0.2
 HOH
 4.846
 O
 O
3bbb 1 P22392 88.08 4e-99 X-RAY
 2008-09-23 PHE A:107 A:108 45.0 0.214 H -119.1 -4.4 4.0 0.019 0.195 B:P22392:0.195
 HOH
 3.776
 CZ
 O
PHE B:107 B:108 42.0 0.2 H -122.9 -0.1 5.0 0.024 0.176 C:P22392:0.176
 HOH
 3.829
 CZ
 O
PHE C:107 C:108 43.0 0.205 H -122.4 -6.7 3.0 0.014 0.191 A:P22392:0.19
 HOH
 3.556
 CZ
 O
PHE D:107 D:108 44.0 0.21 H -124.3 -2.1 4.0 0.019 0.191 F:P22392:0.19
 HOH
 3.823
 CZ
 O
PHE E:107 E:108 37.0 0.176 H -124.6 -0.4 1.0 0.005 0.171 D:P22392:0.171
 HOH
 3.879
 CZ
 O
PHE F:107 F:108 45.0 0.214 H -121.8 -1.0 4.0 0.019 0.195 E:P22392:0.195
 HOH
 3.670
 CZ
 O
3bbf 1 P22392 88.08 4e-99 X-RAY
 2008-09-23 PHE A:107 A:108 50.0 0.238 H -124.6 -8.5 5.0 0.024 0.214 B:P22392:0.214
 DTT
HOH
 8.666
3.874
 O
CD1
 S1
O
PHE B:107 B:108 45.0 0.214 H -118.8 -11.7 2.0 0.01 0.204 C:P22392:0.205
 DTT
HOH
 8.340
3.852
 O
CZ
 O2
O
PHE C:107 C:108 48.0 0.229 H -121.7 -15.5 2.0 0.01 0.219 A:P22392:0.219
 HOH
 3.700
 CD1
 O
PHE D:107 D:108 45.0 0.214 H -118.6 -14.2 4.0 0.019 0.195 F:P22392:0.195
 HOH
 3.673
 CZ
 O
PHE E:107 E:108 48.0 0.229 H -120.7 -8.2 6.0 0.029 0.2 D:P22392:0.2
 DTT
HOH
 8.590
4.052
 O
CD1
 S1
O
PHE F:107 F:108 49.0 0.233 H -119.1 -23.6 3.0 0.014 0.219 E:P22392:0.219
 DTT
HOH
 7.951
3.828
 O
CZ
 S1
O
3bbc 1 P22392 87.42 3e-98 X-RAY
 2008-09-23 PHE A:107 A:108 40.0 0.19 H -123.6 -3.9 2.0 0.01 0.18 B:P22392:0.181
 HOH
 3.868
 CZ
 O
PHE B:107 B:108 48.0 0.229 H -122.9 -6.0 7.0 0.033 0.196 C:P22392:0.195
 HOH
 3.719
 CZ
 O
PHE C:107 C:108 42.0 0.2 H -121.3 -10.0 2.0 0.01 0.19 A:P22392:0.19
 HOH
 3.949
 CZ
 O
PHE D:107 D:108 40.0 0.19 H -122.2 0.2 2.0 0.01 0.18 F:P22392:0.181
 HOH
 3.646
 CZ
 O
PHE E:107 E:108 39.0 0.186 H -123.4 -0.8 2.0 0.01 0.176 D:P22392:0.176
 HOH
 3.688
 CZ
 O
PHE F:107 F:108 47.0 0.224 H -121.3 -6.5 6.0 0.029 0.195 E:P22392:0.195
 HOH
 3.913
 CZ
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15531-f1 1 P15531 100.0 3e-113 PHE A:108 A:108 47.0 0.224 H -126.7 -3.5
af-p22392-f1 1 P22392 88.16 2e-100 PHE A:108 A:108 46.0 0.219 H -129.5 0.1
af-o60361-f1 1 O60361 84.67 2e-84 PHE A:93 A:93 62.0 0.295 H -131.8 1.9