Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr17 | 49244216 | . | A | C | CCDS32682.1:NM_001018136.2:c.370Atc>Ctc_NP_001018146.1:p.124I>L | Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 1, mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1nsk | 1 | P22392 | 100.0 | 9e-113 |
X-RAY |
1995-10-15 | ILE | A:9 | R:9 | 1.0 | 0.006 | E | -117.5 | 128.4 | 1.0 | 0.006 | 0.0 | ||||||
| ILE | B:9 | L:9 | 1.0 | 0.006 | E | -117.2 | 127.8 | 1.0 | 0.006 | 0.0 | |||||||||||||
| ILE | C:9 | T:9 | 1.0 | 0.006 | E | -117.3 | 125.8 | 1.0 | 0.006 | 0.0 | |||||||||||||
| ILE | D:9 | U:9 | 1.0 | 0.006 | E | -116.5 | 128.8 | 1.0 | 0.006 | 0.0 | |||||||||||||
| ILE | E:9 | N:9 | 1.0 | 0.006 | E | -116.9 | 129.1 | 1.0 | 0.006 | 0.0 | |||||||||||||
| ILE | F:9 | O:9 | 1.0 | 0.006 | E | -116.8 | 126.2 | 1.0 | 0.006 | 0.0 | |||||||||||||
| 7kpf | 1 | P22392 | 100.0 | 9e-113 |
X-RAY |
2022-02-02 | ILE | A:9 | A:9 | 1.0 | 0.006 | E | -118.4 | 133.9 | 1.0 | 0.006 | 0.0 |
WYV HOH |
8.377 3.495 |
HA HD11 |
O7A O |
||
| ILE | B:9 | B:9 | 1.0 | 0.006 | E | -117.3 | 134.1 | 1.0 | 0.006 | 0.0 |
WYV HOH |
8.460 3.856 |
HA HD11 |
O8A O |
|||||||||
| ILE | C:9 | C:9 | 1.0 | 0.006 | E | -118.1 | 132.7 | 1.0 | 0.006 | 0.0 |
WYV HOH |
8.302 3.584 |
HA HD11 |
O7A O |
|||||||||
| ILE | D:9 | D:9 | 1.0 | 0.006 | E | -125.5 | 126.4 | 1.0 | 0.006 | 0.0 |
GOL MG HOH |
6.135 9.142 3.504 |
C HA HD11 |
H2 MG O |
|||||||||
| ILE | E:9 | E:9 | 1.0 | 0.006 | E | -123.2 | 128.0 | 1.0 | 0.006 | 0.0 |
MG HOH |
9.609 3.481 |
HA HD11 |
MG O |
|||||||||
| ILE | F:9 | F:9 | 1.0 | 0.006 | E | -123.6 | 127.4 | 1.0 | 0.006 | 0.0 |
MG HOH |
8.401 3.469 |
HA HD11 |
MG O |
|||||||||
| 1nue | 1 | P22392 | 100.0 | 7e-112 |
X-RAY |
1996-04-03 | ILE | A:8 | A:9 | 0.0 | 0.0 | E | -123.5 | 134.2 | 0.0 | 0.0 | 0.0 |
HOH |
4.429 |
CD1 |
O |
||
| ILE | B:8 | B:9 | 0.0 | 0.0 | E | -124.4 | 133.9 | 0.0 | 0.0 | 0.0 |
HOH |
4.378 |
CD1 |
O |
|||||||||
| ILE | C:8 | C:9 | 1.0 | 0.006 | E | -121.5 | 130.6 | 1.0 | 0.006 | 0.0 |
HOH |
4.316 |
CD1 |
O |
|||||||||
| ILE | D:8 | D:9 | 0.0 | 0.0 | E | -125.5 | 136.1 | 0.0 | 0.0 | 0.0 |
GDP HOH |
9.878 4.223 |
CD1 CD1 |
O1B O |
|||||||||
| ILE | E:8 | E:9 | 1.0 | 0.006 | E | -124.2 | 134.7 | 1.0 | 0.006 | 0.0 |
HOH |
4.318 |
CD1 |
O |
|||||||||
| ILE | F:8 | F:9 | 1.0 | 0.006 | E | -117.8 | 137.7 | 1.0 | 0.006 | 0.0 |
HOH |
4.282 |
CD1 |
O |
|||||||||
| 3bbb | 1 | P22392 | 100.0 | 7e-112 |
X-RAY |
2008-09-23 | ILE | A:8 | A:9 | 0.0 | 0.0 | E | -122.7 | 130.2 | 0.0 | 0.0 | 0.0 |
HOH |
4.192 |
CD1 |
O |
||
| ILE | B:8 | B:9 | 0.0 | 0.0 | E | -123.5 | 131.1 | 0.0 | 0.0 | 0.0 |
HOH |
4.246 |
CD1 |
O |
|||||||||
| ILE | C:8 | C:9 | 1.0 | 0.006 | E | -120.5 | 129.9 | 1.0 | 0.006 | 0.0 |
DG HOH |
9.475 4.174 |
CA CD1 |
OP2 O |
|||||||||
| ILE | D:8 | D:9 | 0.0 | 0.0 | E | -122.0 | 130.9 | 0.0 | 0.0 | 0.0 |
HOH |
4.136 |
CD1 |
O |
|||||||||
| ILE | E:8 | E:9 | 0.0 | 0.0 | E | -122.0 | 131.0 | 0.0 | 0.0 | 0.0 |
HOH |
4.250 |
CD1 |
O |
|||||||||
| ILE | F:8 | F:9 | 1.0 | 0.006 | E | -124.6 | 129.8 | 1.0 | 0.006 | 0.0 |
HOH |
4.164 |
CD1 |
O |
|||||||||
| 3bbf | 1 | P22392 | 100.0 | 7e-112 |
X-RAY |
2008-09-23 | ILE | A:8 | A:9 | 1.0 | 0.006 | E | -121.3 | 131.7 | 1.0 | 0.006 | 0.0 |
HOH |
4.251 |
CD1 |
O |
||
| ILE | B:8 | B:9 | 1.0 | 0.006 | E | -116.4 | 132.2 | 1.0 | 0.006 | 0.0 |
HOH |
4.154 |
CD1 |
O |
|||||||||
| ILE | C:8 | C:9 | 0.0 | 0.0 | E | -129.1 | 127.2 | 0.0 | 0.0 | 0.0 |
GDP HOH |
9.933 4.028 |
CD1 CD1 |
O3B O |
|||||||||
| ILE | D:8 | D:9 | 0.0 | 0.0 | E | -121.6 | 130.5 | 0.0 | 0.0 | 0.0 |
HOH |
4.130 |
CD1 |
O |
|||||||||
| ILE | E:8 | E:9 | 1.0 | 0.006 | E | -119.5 | 127.8 | 1.0 | 0.006 | 0.0 |
GDP HOH |
9.939 4.112 |
CD1 CD1 |
O3B O |
|||||||||
| ILE | F:8 | F:9 | 1.0 | 0.006 | E | -118.4 | 131.7 | 1.0 | 0.006 | 0.0 |
HOH |
4.052 |
CD1 |
O |
|||||||||
| 3bbc | 1 | P22392 | 99.34 | 7e-111 |
X-RAY |
2008-09-23 | ILE | A:8 | A:9 | 0.0 | 0.0 | E | -119.1 | 126.2 | 0.0 | 0.0 | 0.0 |
HOH |
4.356 |
CD1 |
O |
||
| ILE | B:8 | B:9 | 0.0 | 0.0 | E | -123.6 | 132.7 | 0.0 | 0.0 | 0.0 |
HOH |
4.062 |
CD1 |
O |
|||||||||
| ILE | C:8 | C:9 | 1.0 | 0.006 | E | -122.0 | 128.8 | 1.0 | 0.006 | 0.0 |
HOH |
4.110 |
CD1 |
O |
|||||||||
| ILE | D:8 | D:9 | 1.0 | 0.006 | E | -119.0 | 130.3 | 1.0 | 0.006 | 0.0 |
HOH |
4.180 |
CD1 |
O |
|||||||||
| ILE | E:8 | E:9 | 0.0 | 0.0 | E | -125.0 | 126.7 | 0.0 | 0.0 | 0.0 |
HOH |
3.923 |
CD1 |
O |
|||||||||
| ILE | F:8 | F:9 | 0.0 | 0.0 | E | -126.7 | 130.5 | 0.0 | 0.0 | 0.0 |
HOH |
4.118 |
CD1 |
O |
|||||||||
| 1bhn | 1 | P52174 | 90.13 | 1e-102 |
X-RAY |
1999-02-16 | ILE | A:9 | A:9 | 2.0 | 0.011 | E | -109.9 | 125.8 | 2.0 | 0.011 | 0.0 |
35G GDP HOH |
9.006 9.227 4.491 |
CD1 CD1 CD1 |
O2P O2B O |
||
| ILE | B:9 | B:9 | 2.0 | 0.011 | E | -111.5 | 126.9 | 2.0 | 0.011 | 0.0 |
35G GDP HOH |
8.684 8.864 7.708 |
CD1 CD1 CD1 |
O2P O2B O |
|||||||||
| ILE | C:9 | C:9 | 1.0 | 0.006 | E | -136.8 | 116.5 | 1.0 | 0.006 | 0.0 |
35G HOH |
8.881 7.657 |
C CA |
O1P O |
|||||||||
| ILE | D:9 | D:9 | 1.0 | 0.006 | E | -101.4 | 109.9 | 1.0 | 0.006 | 0.0 |
35G |
8.939 |
CD1 |
O2P |
|||||||||
| ILE | E:9 | E:9 | 0.0 | 0.0 | E | -112.9 | 121.6 | 0.0 | 0.0 | 0.0 |
35G GDP HOH |
8.420 9.710 7.277 |
C CD1 CD1 |
O1P O3B O |
|||||||||
| ILE | F:9 | F:9 | 1.0 | 0.006 | E | -125.4 | 124.7 | 1.0 | 0.006 | 0.0 |
35G GDP |
9.022 9.598 |
CA CD1 |
O2P O3B |
|||||||||
| 1be4 | 1 | P52175 | 90.07 | 7e-102 |
X-RAY |
1999-01-13 | ILE | A:8 | A:9 | 0.0 | 0.0 | E | -115.0 | 131.1 | 0.0 | 0.0 | 0.0 |
PCG HOH |
8.694 4.366 |
CD1 CD1 |
O2A O |
||
| ILE | B:8 | B:9 | 1.0 | 0.006 | E | -122.1 | 117.2 | 1.0 | 0.006 | 0.0 |
PCG HOH |
8.902 4.225 |
CD1 CD1 |
O2A O |
|||||||||
| ILE | C:8 | C:9 | 1.0 | 0.006 | E | -143.7 | 129.3 | 1.0 | 0.006 | 0.0 |
PCG HOH |
9.175 4.669 |
CD1 CD1 |
O2A O |
|||||||||
| 5ui4 | 1 | P15531 | 88.16 | 3e-100 |
X-RAY |
2018-01-17 | ILE | A:16 | A:9 | 0.0 | 0.0 | E | -115.3 | 136.0 | 0.0 | 0.0 | 0.0 |
A7Z HOH |
9.034 3.901 |
C CD1 |
O3 O |
||
| ILE | B:16 | B:9 | 0.0 | 0.0 | E | -109.4 | 142.3 | 0.0 | 0.0 | 0.0 |
A7Z HOH |
9.207 3.793 |
C CD1 |
O2 O |
|||||||||
| ILE | C:16 | C:9 | 0.0 | 0.0 | E | -116.4 | 134.4 | 0.0 | 0.0 | 0.0 |
A7Z HOH |
9.139 3.923 |
C CD1 |
O3 O |
|||||||||
| ILE | D:16 | D:9 | 0.0 | 0.0 | E | -121.5 | 134.2 | 0.0 | 0.0 | 0.0 |
A7Z HOH |
8.821 4.092 |
C CD1 |
O3 O |
|||||||||
| ILE | E:16 | E:9 | 0.0 | 0.0 | E | -120.5 | 127.7 | 0.0 | 0.0 | 0.0 |
A7Z HOH |
8.920 3.926 |
C CD1 |
O2 O |
|||||||||
| ILE | F:16 | F:9 | 0.0 | 0.0 | E | -122.9 | 125.8 | 0.0 | 0.0 | 0.0 |
A7Z HOH |
9.083 3.888 |
C CD1 |
O3 O |
|||||||||
| 1jxv | 1 | P15531 | 88.16 | 3e-100 |
X-RAY |
2002-04-10 | ILE | A:9 | A:9 | 0.0 | 0.0 | E | -123.4 | 126.3 | 0.0 | 0.0 | 0.0 |
HOH |
4.606 |
CD1 |
O |
||
| ILE | B:9 | B:9 | 0.0 | 0.0 | E | -126.2 | 125.8 | 0.0 | 0.0 | 0.0 |
HOH |
4.744 |
CD1 |
O |
|||||||||
| ILE | C:9 | C:9 | 0.0 | 0.0 | E | -123.9 | 126.6 | 0.0 | 0.0 | 0.0 |
HOH |
4.738 |
CD1 |
O |
|||||||||
| ILE | D:9 | D:9 | 1.0 | 0.006 | E | -125.2 | 125.4 | 1.0 | 0.006 | 0.0 |
HOH |
4.687 |
CD1 |
O |
|||||||||
| ILE | E:9 | E:9 | 0.0 | 0.0 | E | -124.5 | 126.7 | 0.0 | 0.0 | 0.0 |
HOH |
4.952 |
CD1 |
O |
|||||||||
| ILE | F:9 | F:9 | 0.0 | 0.0 | E | -124.9 | 124.3 | 0.0 | 0.0 | 0.0 |
HOH |
4.942 |
CD1 |
O |
|||||||||
| 2hvd | 1 | P15531 | 88.16 | 3e-100 |
X-RAY |
2006-09-19 | ILE | A:9 | A:9 | 1.0 | 0.006 | E | -126.2 | 126.8 | 1.0 | 0.006 | 0.0 |
ADP HOH |
9.885 7.415 |
CD1 CD1 |
O3B O |
||
| ILE | B:9 | B:9 | 0.0 | 0.0 | E | -124.0 | 126.6 | 0.0 | 0.0 | 0.0 |
HOH |
4.116 |
CD1 |
O |
|||||||||
| ILE | C:9 | C:9 | 1.0 | 0.006 | E | -121.7 | 128.0 | 1.0 | 0.006 | 0.0 |
HOH |
3.962 |
CD1 |
O |
|||||||||
| 4eno | 1 | P15531 | 88.16 | 3e-100 |
X-RAY |
2013-03-27 | ILE | A:9 | A:9 | 0.0 | 0.0 | E | -131.5 | 127.2 | 0.0 | 0.0 | 0.0 |
PO4 HOH |
8.581 4.382 |
CA CD1 |
O2 O |
||
| ILE | B:9 | B:9 | 2.0 | 0.011 | E | -124.1 | 131.1 | 2.0 | 0.011 | 0.0 |
PO4 HOH |
8.834 7.790 |
CA CG1 |
O3 O |
|||||||||
| 3l7u | 1 | P15531 | 88.16 | 9e-100 |
X-RAY |
2010-11-10 | ILE | A:29 | A:9 | 1.0 | 0.006 | E | -120.8 | 126.6 | 1.0 | 0.006 | 0.0 |
HOH |
4.050 |
CD1 |
O |
||
| ILE | B:29 | B:9 | 0.0 | 0.0 | E | -120.8 | 128.9 | 0.0 | 0.0 | 0.0 |
PO4 HOH |
9.304 3.891 |
CD1 CD1 |
O3 O |
|||||||||
| ILE | C:29 | C:9 | 1.0 | 0.006 | E | -125.8 | 127.6 | 1.0 | 0.006 | 0.0 |
HOH |
3.934 |
CD1 |
O |
|||||||||
| 2hve | 1 | P15531 | 87.5 | 2e-99 |
X-RAY |
2006-09-19 | ILE | A:9 | A:9 | 2.0 | 0.011 | E | -123.6 | 132.6 | 2.0 | 0.011 | 0.0 |
ADP HOH |
9.989 7.086 |
CD1 CD1 |
O1B O |
||
| ILE | B:9 | B:9 | 1.0 | 0.006 | E | -128.2 | 134.2 | 1.0 | 0.006 | 0.0 |
ADP HOH |
9.885 4.097 |
CD1 CD1 |
O3B O |
|||||||||
| ILE | C:9 | C:9 | 1.0 | 0.006 | E | -122.6 | 129.7 | 1.0 | 0.006 | 0.0 |
HOH |
3.963 |
CD1 |
O |
|||||||||
| 1ucn | 1 | P15531 | 86.84 | 8e-98 |
X-RAY |
2003-09-30 | ILE | A:9 | A:9 | 1.0 | 0.006 | E | -138.9 | 132.6 | 1.0 | 0.006 | 0.0 |
PO4 CA ADP HOH |
5.012 8.381 8.803 4.057 |
C CD1 CD1 CD1 |
O2 CA O1B O |
||
| ILE | B:9 | B:9 | 0.0 | 0.0 | E | -135.0 | 134.1 | 0.0 | 0.0 | 0.0 |
PO4 CA ADP HOH |
4.993 8.394 8.636 3.708 |
C CD1 CD1 CD1 |
O1 CA O1B O |
|||||||||
| ILE | C:9 | C:9 | 2.0 | 0.011 | E | -130.8 | 136.6 | 2.0 | 0.011 | 0.0 |
PO4 CA ADP HOH |
5.296 9.200 9.188 3.808 |
C CD1 CD1 CD1 |
O4 CA O1B O |
|||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p22392-f1 | 1 | P22392 | 100.0 | 4e-113 | ILE | A:9 | A:9 | 0.0 | 0.0 | E | -128.1 | 134.9 | |
| af-p15531-f1 | 1 | P15531 | 88.16 | 1e-100 | ILE | A:9 | A:9 | 0.0 | 0.0 | E | -129.4 | 131.2 | |