Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 49245634 . T A CCDS32682.1:NM_001018136.2:c.503aTt>aAt_NP_001018146.1:p.168I>N Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1nsk 1 P22392 100.0 9e-113 X-RAY
 1995-10-15 ILE A:53 R:53 74.0 0.423 G -52.6 -42.0 74.0 0.423 0.0
ILE B:53 L:53 73.0 0.417 G -52.7 -41.8 73.0 0.417 0.0
ILE C:53 T:53 77.0 0.44 G -51.3 -44.6 77.0 0.44 0.0
ILE D:53 U:53 72.0 0.411 G -51.4 -44.3 72.0 0.411 0.0
ILE E:53 N:53 76.0 0.434 G -50.4 -43.6 76.0 0.434 0.0
ILE F:53 O:53 80.0 0.457 G -51.7 -45.2 80.0 0.457 0.0
7kpf 1 P22392 100.0 9e-113 X-RAY
 2022-02-02 ILE A:53 A:53 82.0 0.469 G -58.1 -33.7 82.0 0.469 0.0 WYV
 8.391
 N
 H4B
ILE B:53 B:53 68.0 0.389 G -58.2 -35.9 68.0 0.389 0.0 WYV
HOH
 8.684
9.082
 N
HG22
 H4B
O
ILE C:53 C:53 61.0 0.349 G -55.7 -36.6 61.0 0.349 0.0 WYV
HOH
 8.577
2.934
 N
HG22
 H4B
O
ILE D:53 D:53 147.0 0.84 S -60.5 124.2 147.0 0.84 0.0
ILE E:53 NA:NA DO NA DO DO DO NA NA NA
ILE F:53 NA:NA DO NA DO DO DO NA NA NA
1nue 1 P22392 100.0 7e-112 X-RAY
 1996-04-03 ILE A:52 A:53 65.0 0.371 G -56.9 -28.4 65.0 0.371 0.0 MG
GDP
HOH
 8.286
9.139
5.716
 N
N
N
 MG
C5'
O
ILE B:52 B:53 62.0 0.354 G -48.9 -39.8 62.0 0.354 0.0 GDP
HOH
 8.875
5.444
 N
N
 O1A
O
ILE C:52 C:53 72.0 0.411 G -60.9 -25.1 72.0 0.411 0.0 MG
GDP
HOH
 7.959
8.793
5.109
 N
N
O
 MG
O1A
O
ILE D:52 D:53 64.0 0.366 G -62.3 -28.9 64.0 0.366 0.0 GDP
HOH
 8.712
5.697
 N
N
 O1A
O
ILE E:52 E:53 51.0 0.291 G -53.2 -34.5 51.0 0.291 0.0 GDP
HOH
 8.979
5.078
 N
O
 C5'
O
ILE F:52 F:53 57.0 0.326 G -43.3 -45.9 57.0 0.326 0.0 GDP
HOH
 9.162
5.967
 N
N
 O1A
O
3bbb 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 ILE A:52 A:53 90.0 0.514 G -50.0 -35.3 90.0 0.514 0.0 HOH
 4.743
 O
 O
ILE B:52 B:53 51.0 0.291 G -54.6 -36.7 51.0 0.291 0.0 HOH
 2.705
 O
 O
ILE C:52 C:53 56.0 0.32 G -58.1 -36.5 56.0 0.32 0.0 DA
DG
HOH
 9.955
8.521
3.656
 N
N
CG1
 O5'
C2'
O
ILE D:52 D:53 83.0 0.474 G -50.7 -35.1 83.0 0.474 0.0 HOH
 7.346
 O
 O
ILE E:52 E:53 55.0 0.314 G -56.3 -37.3 55.0 0.314 0.0 DG
HOH
 9.772
3.257
 N
N
 C2'
O
ILE F:52 F:53 72.0 0.411 G -59.7 -32.6 72.0 0.411 0.0 DG
HOH
 9.232
3.007
 N
N
 C5'
O
3bbf 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 ILE A:52 A:53 63.0 0.36 G -52.1 -34.9 63.0 0.36 0.0 GDP
MG
HOH
 8.714
7.919
2.617
 N
N
O
 O1A
MG
O
ILE B:52 B:53 61.0 0.349 G -60.3 -35.4 61.0 0.349 0.0 GDP
MG
HOH
 8.417
7.676
4.980
 N
N
O
 O1A
MG
O
ILE C:52 C:53 76.0 0.434 G -58.0 -36.1 76.0 0.434 0.0 GDP
MG
HOH
 8.608
7.895
2.847
 N
N
O
 O1A
MG
O
ILE D:52 D:53 59.0 0.337 G -59.8 -38.3 59.0 0.337 0.0 GDP
MG
HOH
 8.679
7.770
5.684
 N
N
N
 O1A
MG
O
ILE E:52 E:53 54.0 0.309 G -54.9 -36.3 54.0 0.309 0.0 GDP
MG
HOH
 8.865
7.801
5.000
 N
N
O
 O1A
MG
O
ILE F:52 F:53 43.0 0.246 G -57.2 -38.9 43.0 0.246 0.0 GDP
MG
HOH
 8.870
7.680
5.017
 N
N
O
 C5'
MG
O
3bbc 1 P22392 99.34 7e-111 X-RAY
 2008-09-23 ILE A:52 A:53 56.0 0.32 G -58.6 -37.9 56.0 0.32 0.0 HOH
 2.786
 O
 O
ILE B:52 B:53 53.0 0.303 G -51.2 -36.0 53.0 0.303 0.0 HOH
 2.505
 CD1
 O
ILE C:52 C:53 74.0 0.423 G -60.0 -29.9 74.0 0.423 0.0 HOH
 3.703
 CG2
 O
ILE D:52 D:53 60.0 0.343 G -58.9 -32.7 60.0 0.343 0.0 HOH
 2.546
 O
 O
ILE E:52 E:53 60.0 0.343 G -52.3 -35.7 60.0 0.343 0.0 HOH
 2.757
 CD1
 O
ILE F:52 F:53 78.0 0.446 G -50.4 -34.7 78.0 0.446 0.0 HOH
 2.814
 O
 O
1bhn 1 P52174 90.13 1e-102 X-RAY
 1999-02-16 ILE A:53 A:53 86.0 0.491 G -53.0 -34.2 86.0 0.491 0.0 35G
GDP
HOH
 9.428
9.577
6.229
 N
N
C
 C5'
C5'
O
ILE B:53 B:53 76.0 0.434 G -19.8 -53.9 76.0 0.434 0.0 35G
GDP
HOH
 9.270
8.908
4.438
 N
N
N
 C5'
O1A
O
ILE C:53 C:53 62.0 0.354 G -49.3 -55.7 62.0 0.354 0.0 35G
GDP
HOH
 9.072
9.076
3.685
 N
N
N
 C5'
C5'
O
ILE D:53 D:53 69.0 0.394 G -72.6 -21.6 69.0 0.394 0.0 35G
GDP
HOH
 8.559
8.969
3.472
 N
N
N
 C5'
O1A
O
ILE E:53 E:53 50.0 0.286 G -28.4 -56.0 50.0 0.286 0.0 35G
GDP
HOH
 9.051
8.834
3.772
 N
N
O
 C5'
O1A
O
ILE F:53 F:53 73.0 0.417 G -62.5 -38.8 73.0 0.417 0.0 35G
GDP
HOH
 8.685
8.873
4.884
 N
N
CD1
 C5'
C5'
O
1be4 1 P52175 90.07 7e-102 X-RAY
 1999-01-13 ILE A:52 A:53 72.0 0.411 G -32.6 -49.5 72.0 0.411 0.0 PCG
HOH
 9.135
2.739
 N
N
 C5'
O
ILE B:52 B:53 46.0 0.263 -77.6 -38.7 46.0 0.263 0.0 PCG
HOH
 9.241
6.329
 N
N
 C5'
O
ILE C:52 C:53 64.0 0.366 G -57.8 -49.5 64.0 0.366 0.0 PCG
HOH
 8.790
4.810
 N
CD1
 C5'
O
5ui4 1 P15531 88.16 3e-100 X-RAY
 2018-01-17 VAL A:60 A:53 46.0 0.297 G -65.9 -31.5 46.0 0.297 0.0 A7Z
HOH
 9.542
6.317
 N
O
 C15
O
VAL B:60 B:53 55.0 0.355 G -66.0 -31.7 55.0 0.355 0.0 A7Z
 9.497
 N
 C23
VAL C:60 C:53 52.0 0.335 G -66.7 -31.2 52.0 0.335 0.0 A7Z
 9.515
 N
 C23
VAL D:60 D:53 43.0 0.277 G -66.3 -31.5 43.0 0.277 0.0 A7Z
 9.456
 N
 C23
VAL E:60 E:53 53.0 0.342 G -66.2 -32.0 53.0 0.342 0.0 A7Z
HOH
 9.540
2.861
 N
O
 C23
O
VAL F:60 F:53 54.0 0.348 G -66.2 -31.6 54.0 0.348 0.0 A7Z
 9.407
 N
 C23
1jxv 1 P15531 88.16 3e-100 X-RAY
 2002-04-10 VAL A:53 A:53 56.0 0.361 G -77.1 -28.4 56.0 0.361 0.0
VAL B:53 B:53 59.0 0.381 G -77.5 -29.2 59.0 0.381 0.0 HOH
 9.432
 N
 O
VAL C:53 C:53 58.0 0.374 G -78.0 -28.4 58.0 0.374 0.0
VAL D:53 D:53 58.0 0.374 G -77.4 -29.9 58.0 0.374 0.0 HOH
 9.216
 N
 O
VAL E:53 E:53 58.0 0.374 G -77.3 -28.3 58.0 0.374 0.0 HOH
 9.342
 N
 O
VAL F:53 F:53 58.0 0.374 G -77.3 -28.7 58.0 0.374 0.0
2hvd 1 P15531 88.16 3e-100 X-RAY
 2006-09-19 VAL A:53 A:53 53.0 0.342 G -58.8 -40.2 53.0 0.342 0.0 ADP
HOH
 8.685
9.116
 N
O
 O1A
O
VAL B:53 B:53 43.0 0.277 G -56.5 -37.0 43.0 0.277 0.0 ADP
HOH
 9.098
3.308
 N
N
 O1A
O
VAL C:53 C:53 49.0 0.316 G -68.9 -39.7 49.0 0.316 0.0 ADP
HOH
 8.726
5.574
 N
N
 C5'
O
4eno 1 P15531 88.16 3e-100 X-RAY
 2013-03-27 VAL A:53 A:53 51.0 0.329 G -66.7 -36.3 51.0 0.329 0.0 HOH
 8.287
 O
 O
VAL B:53 B:53 53.0 0.342 G -60.6 -24.8 53.0 0.342 0.0 HOH
 5.340
 CG2
 O
3l7u 1 P15531 88.16 9e-100 X-RAY
 2010-11-10 VAL A:73 A:53 49.0 0.316 G -62.8 -32.0 49.0 0.316 0.0 HOH
 7.267
 CG2
 O
VAL B:73 B:53 51.0 0.329 G -65.7 -28.9 51.0 0.329 0.0 HOH
 6.830
 N
 O
VAL C:73 C:53 37.0 0.239 G -58.4 -37.3 37.0 0.239 0.0 HOH
 3.025
 N
 O
2hve 1 P15531 87.5 2e-99 X-RAY
 2006-09-19 VAL A:53 A:53 52.0 0.335 G -60.1 -39.5 52.0 0.335 0.0 ADP
HOH
 8.876
6.020
 N
CG1
 O1A
O
VAL B:53 B:53 33.0 0.213 G -56.3 -39.5 33.0 0.213 0.0 ADP
HOH
 9.005
3.055
 N
N
 O1A
O
VAL C:53 C:53 40.0 0.258 G -48.3 -45.5 40.0 0.258 0.0 ADP
HOH
 9.131
5.522
 N
CG1
 C5'
O
1ucn 1 P15531 86.84 8e-98 X-RAY
 2003-09-30 VAL A:53 A:53 44.0 0.284 G -59.9 -39.5 44.0 0.284 0.0 PO4
CA
ADP
HOH
 9.030
9.459
9.029
5.311
 N
N
N
N
 O3
CA
C5'
O
VAL B:53 B:53 41.0 0.265 G -48.7 -41.6 41.0 0.265 0.0 PO4
CA
ADP
HOH
 8.976
9.795
9.154
3.513
 N
N
N
CA
 O2
CA
C5'
O
VAL C:53 C:53 44.0 0.284 G -45.7 -53.6 44.0 0.284 0.0 PO4
CA
ADP
HOH
 9.242
9.437
8.975
4.076
 N
N
N
CG2
 O2
CA
O1A
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p22392-f1 1 P22392 100.0 4e-113 ILE A:53 A:53 56.0 0.32 G -57.2 -32.6
af-p15531-f1 1 P15531 88.16 1e-100 VAL A:53 A:53 50.0 0.323 G -56.3 -33.8
af-o60361-f1 1 O60361 96.35 7e-96 ILE A:38 A:38 56.0 0.32 G -56.9 -32.6