Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 49248852 . A C CCDS32682.1:NM_001018136.2:c.691Atc>Ctc_NP_001018146.1:p.231I>L Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1nsk 1 P22392 100.0 9e-113 X-RAY
 1995-10-15 ILE A:116 R:116 0.0 0.0 40.4 -16.9 0.0 0.0 0.0
ILE B:116 L:116 0.0 0.0 40.6 -17.3 0.0 0.0 0.0
ILE C:116 T:116 0.0 0.0 42.0 -20.7 0.0 0.0 0.0
ILE D:116 U:116 0.0 0.0 43.7 -26.0 0.0 0.0 0.0
ILE E:116 N:116 0.0 0.0 43.3 -25.6 0.0 0.0 0.0
ILE F:116 O:116 0.0 0.0 40.8 -20.1 0.0 0.0 0.0
7kpf 1 P22392 100.0 9e-113 X-RAY
 2022-02-02 ILE A:116 A:116 0.0 0.0 50.8 -14.5 0.0 0.0 0.0 WYV
HOH
 7.135
5.082
 N
HG23
 O9A
O
ILE B:116 B:116 0.0 0.0 55.1 -14.6 0.0 0.0 0.0 WYV
MG
HOH
 6.939
6.171
2.843
 N
H
HG22
 O7A
MG
O
ILE C:116 C:116 0.0 0.0 52.6 -13.6 0.0 0.0 0.0 WYV
HOH
 7.235
2.679
 N
HG22
 O9A
O
ILE D:116 D:116 0.0 0.0 52.3 -14.4 0.0 0.0 0.0 GOL
MG
HOH
 7.283
7.860
2.665
 O
N
HG23
 HO1
MG
O
ILE E:116 E:116 0.0 0.0 52.4 -13.1 0.0 0.0 0.0 MG
HOH
 7.641
2.994
 N
HG23
 MG
O
ILE F:116 F:116 0.0 0.0 55.5 -10.5 0.0 0.0 0.0 MG
HOH
 8.479
2.803
 C
HG23
 MG
O
1nue 1 P22392 100.0 7e-112 X-RAY
 1996-04-03 ILE A:115 A:116 0.0 0.0 38.5 -18.5 0.0 0.0 0.0 GDP
HOH
 6.770
3.511
 N
CG2
 O2'
O
ILE B:115 B:116 0.0 0.0 38.5 -16.4 0.0 0.0 0.0 GDP
HOH
 6.792
3.630
 N
CG2
 O2'
O
ILE C:115 C:116 0.0 0.0 38.1 -16.0 0.0 0.0 0.0 GDP
HOH
 6.773
3.397
 N
CG2
 O2'
O
ILE D:115 D:116 0.0 0.0 36.7 -15.2 0.0 0.0 0.0 GDP
HOH
 6.930
3.450
 N
CG2
 O2'
O
ILE E:115 E:116 0.0 0.0 39.8 -18.1 0.0 0.0 0.0 GDP
HOH
 6.815
3.396
 N
CG2
 O2'
O
ILE F:115 F:116 0.0 0.0 37.2 -18.3 0.0 0.0 0.0 GDP
HOH
 6.952
3.609
 N
CG2
 O2'
O
3bbb 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 ILE A:115 A:116 0.0 0.0 56.9 -23.1 0.0 0.0 0.0 HOH
 3.281
 CG2
 O
ILE B:115 B:116 0.0 0.0 54.7 -22.4 0.0 0.0 0.0 DG
HOH
 9.086
3.297
 N
CG2
 N7
O
ILE C:115 C:116 0.0 0.0 63.2 -24.8 0.0 0.0 0.0 DA
DG
HOH
 7.775
8.377
3.196
 N
C
CG2
 O3'
OP2
O
ILE D:115 D:116 0.0 0.0 56.4 -24.7 0.0 0.0 0.0 HOH
 3.336
 CG2
 O
ILE E:115 E:116 0.0 0.0 59.5 -24.6 0.0 0.0 0.0 DA
DG
HOH
 8.585
7.997
3.308
 N
N
CG2
 C4'
OP1
O
ILE F:115 F:116 0.0 0.0 62.4 -23.5 0.0 0.0 0.0 DG
HOH
 7.990
3.371
 N
CG2
 O3'
O
3bbf 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 ILE A:115 A:116 0.0 0.0 62.9 -22.1 0.0 0.0 0.0 GDP
DTT
HOH
 6.510
9.904
3.172
 N
CG2
CG2
 O2'
O3
O
ILE B:115 B:116 0.0 0.0 59.1 -20.9 0.0 0.0 0.0 GDP
DTT
HOH
 6.592
9.606
3.191
 N
CG2
CG2
 O2'
O3
O
ILE C:115 C:116 0.0 0.0 53.7 -15.9 0.0 0.0 0.0 GDP
HOH
 6.439
3.340
 N
CG2
 O2'
O
ILE D:115 D:116 0.0 0.0 50.9 -20.1 0.0 0.0 0.0 GDP
HOH
 6.623
3.130
 N
CG2
 O2'
O
ILE E:115 E:116 0.0 0.0 58.2 -18.5 0.0 0.0 0.0 DTT
GDP
HOH
 9.822
6.458
3.225
 CG2
N
CG2
 O3
O2'
O
ILE F:115 F:116 0.0 0.0 52.6 -18.8 0.0 0.0 0.0 GDP
DTT
HOH
 6.672
9.461
3.210
 N
CG2
CG2
 O2'
O3
O
3bbc 1 P22392 99.34 7e-111 X-RAY
 2008-09-23 ILE A:115 A:116 0.0 0.0 51.8 -25.4 0.0 0.0 0.0 HOH
 3.290
 CG2
 O
ILE B:115 B:116 0.0 0.0 54.0 -21.0 0.0 0.0 0.0 HOH
 3.237
 CG2
 O
ILE C:115 C:116 0.0 0.0 52.8 -20.8 0.0 0.0 0.0 HOH
 3.418
 CG2
 O
ILE D:115 D:116 0.0 0.0 60.7 -22.0 0.0 0.0 0.0 HOH
 3.294
 CG2
 O
ILE E:115 E:116 0.0 0.0 56.7 -24.0 0.0 0.0 0.0 HOH
 3.229
 CG2
 O
ILE F:115 F:116 0.0 0.0 56.0 -21.4 0.0 0.0 0.0 HOH
 3.284
 CG2
 O
1bhn 1 P52174 90.13 1e-102 X-RAY
 1999-02-16 ILE A:116 A:116 0.0 0.0 21.0 -7.6 0.0 0.0 0.0 35G
GDP
HOH
 7.002
6.854
3.213
 N
N
CG2
 O2'
O2'
O
ILE B:116 B:116 0.0 0.0 52.7 -19.2 0.0 0.0 0.0 35G
GDP
HOH
 6.720
6.574
3.396
 N
N
N
 O2'
O2'
O
ILE C:116 C:116 0.0 0.0 60.6 -25.6 0.0 0.0 0.0 35G
GDP
HOH
 7.258
6.534
3.271
 N
N
CG2
 O2'
O2'
O
ILE D:116 D:116 0.0 0.0 S 44.2 -25.4 0.0 0.0 0.0 35G
GDP
HOH
 6.850
6.972
3.607
 N
N
CG2
 O2'
O2'
O
ILE E:116 E:116 1.0 0.006 45.6 -8.9 1.0 0.006 0.0 35G
GDP
HOH
 6.632
6.890
3.107
 N
N
CG2
 O2'
O2'
O
ILE F:116 F:116 0.0 0.0 21.5 -11.5 0.0 0.0 0.0 35G
GDP
HOH
 6.785
7.130
3.643
 N
N
CG2
 O2'
O2'
O
1be4 1 P52175 90.07 7e-102 X-RAY
 1999-01-13 ILE A:115 A:116 0.0 0.0 52.1 -28.5 0.0 0.0 0.0 PCG
HOH
 6.840
3.469
 N
CG2
 O2'
O
ILE B:115 B:116 0.0 0.0 54.5 -1.6 0.0 0.0 0.0 PCG
HOH
 6.708
3.337
 N
CG2
 O2'
O
ILE C:115 C:116 0.0 0.0 33.2 -3.8 0.0 0.0 0.0 PCG
HOH
 6.707
3.010
 N
CG2
 O2'
O
5ui4 1 P15531 88.16 3e-100 X-RAY
 2018-01-17 ILE A:123 A:116 0.0 0.0 53.2 -21.4 0.0 0.0 0.0 A7Z
HOH
 6.159
3.206
 N
CG2
 O2
O
ILE B:123 B:116 0.0 0.0 52.7 -21.0 0.0 0.0 0.0 A7Z
HOH
 6.161
3.184
 N
CG2
 O3
O
ILE C:123 C:116 0.0 0.0 53.3 -21.8 0.0 0.0 0.0 A7Z
HOH
 6.183
3.284
 N
CG2
 O2
O
ILE D:123 D:116 0.0 0.0 53.3 -21.9 0.0 0.0 0.0 A7Z
HOH
 6.886
3.285
 N
CG2
 S
O
ILE E:123 E:116 0.0 0.0 53.8 -22.2 0.0 0.0 0.0 A7Z
HOH
 6.867
3.195
 N
CG2
 O3
O
ILE F:123 F:116 0.0 0.0 53.6 -22.1 0.0 0.0 0.0 A7Z
HOH
 6.370
3.285
 N
CG2
 O2
O
1jxv 1 P15531 88.16 3e-100 X-RAY
 2002-04-10 ILE A:116 A:116 0.0 0.0 74.6 -33.3 0.0 0.0 0.0 HOH
 2.691
 CD1
 O
ILE B:116 B:116 0.0 0.0 72.0 -33.5 0.0 0.0 0.0 HOH
 2.858
 CD1
 O
ILE C:116 C:116 0.0 0.0 74.7 -33.4 0.0 0.0 0.0 HOH
 2.962
 CD1
 O
ILE D:116 D:116 0.0 0.0 71.8 -32.2 0.0 0.0 0.0 HOH
 2.828
 CD1
 O
ILE E:116 E:116 0.0 0.0 71.7 -32.6 0.0 0.0 0.0 HOH
 2.745
 CD1
 O
ILE F:116 F:116 0.0 0.0 73.7 -33.1 0.0 0.0 0.0 HOH
 2.702
 CD1
 O
2hvd 1 P15531 88.16 3e-100 X-RAY
 2006-09-19 ILE A:116 A:116 0.0 0.0 54.0 -26.0 0.0 0.0 0.0 ADP
HOH
 6.460
3.252
 N
CG2
 O2'
O
ILE B:116 B:116 0.0 0.0 59.2 -19.9 0.0 0.0 0.0 ADP
HOH
 6.312
3.275
 N
CG2
 O2'
O
ILE C:116 C:116 0.0 0.0 50.2 -20.4 0.0 0.0 0.0 ADP
HOH
 6.541
3.180
 N
CG2
 O2'
O
4eno 1 P15531 88.16 3e-100 X-RAY
 2013-03-27 ILE A:116 A:116 2.0 0.011 S -97.5 -36.6 2.0 0.011 0.0 PO4
HOH
 7.106
9.722
 N
CG2
 O3
O
ILE B:116 B:116 3.0 0.017 S -85.6 -37.7 3.0 0.017 0.0 PO4
HOH
 7.416
3.517
 N
CD1
 O4
O
3l7u 1 P15531 88.16 9e-100 X-RAY
 2010-11-10 ILE A:136 A:116 0.0 0.0 50.9 -25.1 0.0 0.0 0.0 HOH
 3.303
 CG2
 O
ILE B:136 B:116 0.0 0.0 53.0 -23.8 0.0 0.0 0.0 PO4
PO4
HOH
 9.422
9.735
3.329
 C
CG2
CG2
 O3
O1
O
ILE C:136 C:116 0.0 0.0 52.7 -26.2 0.0 0.0 0.0 PO4
HOH
 9.521
3.334
 CG2
CG2
 O3
O
2hve 1 P15531 87.5 2e-99 X-RAY
 2006-09-19 ILE A:116 A:116 0.0 0.0 S 46.3 -19.1 0.0 0.0 0.0 ADP
HOH
 6.876
5.976
 N
CG2
 O2'
O
ILE B:116 B:116 0.0 0.0 56.6 -17.1 0.0 0.0 0.0 ADP
HOH
 6.382
3.225
 N
CG2
 O2'
O
ILE C:116 C:116 0.0 0.0 54.1 -22.3 0.0 0.0 0.0 ADP
HOH
 6.454
3.271
 N
CG2
 O2'
O
1ucn 1 P15531 86.84 8e-98 X-RAY
 2003-09-30 ILE A:116 A:116 0.0 0.0 S 41.5 -16.1 0.0 0.0 0.0 PO4
ADP
HOH
 7.713
6.929
3.152
 C
N
CG2
 O4
O2'
O
ILE B:116 B:116 0.0 0.0 39.1 -14.0 0.0 0.0 0.0 PO4
ADP
HOH
 7.547
7.052
3.281
 C
N
CG2
 O3
O2'
O
ILE C:116 C:116 0.0 0.0 S 38.1 -22.0 0.0 0.0 0.0 PO4
ADP
HOH
 7.228
6.820
3.361
 O
N
CG2
 O4
O2'
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p22392-f1 1 P22392 100.0 4e-113 ILE A:116 A:116 0.0 0.0 54.8 -24.4
af-p15531-f1 1 P15531 88.16 1e-100 ILE A:116 A:116 0.0 0.0 50.9 -21.4
af-o60361-f1 1 O60361 96.35 7e-96 ILE A:101 A:101 55.0 0.314 53.1 -26.7