Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 49248943 . C A CCDS32682.1:NM_001018136.2:c.782gCt>gAt_NP_001018146.1:p.261A>D Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1nsk 1 P22392 100.0 9e-113 X-RAY
 1995-10-15 ALA A:146 R:146 45.0 0.391 T -103.4 15.8 20.0 0.174 0.217 D:P22392:0.148
E:P22392:0.096
ALA B:146 L:146 44.0 0.383 T -103.7 16.0 19.0 0.165 0.218 F:P22392:0.148
C:P22392:0.096
ALA C:146 T:146 45.0 0.391 T -104.6 18.4 20.0 0.174 0.217 A:P22392:0.165
B:P22392:0.096
ALA D:146 U:146 45.0 0.391 T -104.2 13.4 20.0 0.174 0.217 F:P22392:0.096
C:P22392:0.148
ALA E:146 N:146 44.0 0.383 T -103.9 13.1 20.0 0.174 0.209 A:P22392:0.096
B:P22392:0.148
ALA F:146 O:146 45.0 0.391 T -104.9 18.4 20.0 0.174 0.217 D:P22392:0.096
E:P22392:0.157
7kpf 1 P22392 100.0 9e-113 X-RAY
 2022-02-02 ALA A:146 A:146 42.0 0.365 T -95.4 10.3 19.0 0.165 0.2 D:P22392:0.087
B:P22392:0.139
 HOH
 3.043
 HB3
 O
ALA B:146 B:146 42.0 0.365 T -95.0 10.7 20.0 0.174 0.191 F:P22392:0.122
C:P22392:0.087
 HOH
 3.607
 C
 O
ALA C:146 C:146 43.0 0.374 T -94.1 7.8 21.0 0.183 0.191 D:P22392:0.13
B:P22392:0.087
 HOH
 3.089
 HB3
 O
ALA D:146 D:146 45.0 0.391 T -100.8 12.0 21.0 0.183 0.208 A:P22392:0.096
E:P22392:0.13
 HOH
 2.917
 HB3
 O
ALA E:146 E:146 45.0 0.391 T -101.8 12.0 21.0 0.183 0.208 F:P22392:0.087
C:P22392:0.139
 HOH
 3.630
 HA
 O
ALA F:146 F:146 45.0 0.391 T -101.7 12.3 21.0 0.183 0.208 A:P22392:0.139
E:P22392:0.096
 HOH
 4.175
 H
 O
1nue 1 P22392 100.0 7e-112 X-RAY
 1996-04-03 ALA A:145 A:146 44.0 0.383 T -94.0 0.3 22.0 0.191 0.192 F:P22392:0.07
C:P22392:0.122
 HOH
 3.795
 CB
 O
ALA B:145 B:146 43.0 0.374 T -94.5 9.4 20.0 0.174 0.2 D:P22392:0.078
A:P22392:0.13
 HOH
 3.561
 C
 O
ALA C:145 C:146 44.0 0.383 T -94.5 6.2 21.0 0.183 0.2 E:P22392:0.078
B:P22392:0.139
 HOH
 4.698
 C
 O
ALA D:145 D:146 43.0 0.374 T -96.5 6.3 21.0 0.183 0.191 E:P22392:0.122
B:P22392:0.078
 HOH
 3.878
 CB
 O
ALA E:145 E:146 45.0 0.391 T -99.5 9.7 21.0 0.183 0.208 F:P22392:0.13
C:P22392:0.096
B:P22392:0.009
 HOH
 4.926
 N
 O
ALA F:145 F:146 44.0 0.383 T -96.4 6.4 22.0 0.191 0.192 D:P22392:0.139
A:P22392:0.061
 HOH
 3.743
 C
 O
3bbb 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 ALA A:145 A:146 45.0 0.391 T -97.1 8.9 21.0 0.183 0.208 C:P22392:0.13
F:P22392:0.096
 HOH
 3.060
 CB
 O
ALA B:145 B:146 45.0 0.391 T -100.4 10.7 21.0 0.183 0.208 D:P22392:0.096
A:P22392:0.13
 HOH
 2.883
 N
 O
ALA C:145 C:146 43.0 0.374 T -95.4 9.1 20.0 0.174 0.2 E:P22392:0.087
B:P22392:0.13
 HOH
 3.529
 CB
 O
ALA D:145 D:146 44.0 0.383 T -94.6 8.2 21.0 0.183 0.2 E:P22392:0.13
B:P22392:0.087
 HOH
 3.042
 N
 O
ALA E:145 E:146 45.0 0.391 T -93.6 9.2 20.0 0.174 0.217 F:P22392:0.139
C:P22392:0.104
 HOH
 2.900
 N
 O
ALA F:145 F:146 45.0 0.391 T -99.8 13.8 20.0 0.174 0.217 A:P22392:0.104
D:P22392:0.139
 HOH
 2.870
 N
 O
3bbf 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 ALA A:145 A:146 47.0 0.409 T -81.7 -2.2 28.0 0.243 0.166 F:P22392:0.043
C:P22392:0.104
D:P22392:0.026
 HOH
 3.454
 CB
 O
ALA B:145 B:146 43.0 0.374 T -92.9 13.9 22.0 0.191 0.183 D:P22392:0.07
A:P22392:0.122
 DTT
HOH
 3.125
3.327
 CB
CB
 O2
O
ALA C:145 C:146 46.0 0.4 T -85.7 -5.1 26.0 0.226 0.174 F:P22392:0.009
E:P22392:0.052
B:P22392:0.122
 DTT
HOH
 2.473
3.170
 CB
CB
 O2
O
ALA D:145 D:146 43.0 0.374 T -82.0 -7.8 26.0 0.226 0.148 E:P22392:0.096
B:P22392:0.052
 DTT
HOH
 3.317
2.757
 CB
CB
 O2
O
ALA E:145 E:146 44.0 0.383 T -86.5 -1.8 25.0 0.217 0.166 F:P22392:0.113
C:P22392:0.061
B:P22392:0.017
 DTT
HOH
 3.568
4.482
 N
C
 S4
O
ALA F:145 F:146 45.0 0.391 T -88.6 2.7 27.0 0.235 0.156 D:P22392:0.13
A:P22392:0.017
 HOH
 3.928
 C
 O
3bbc 1 P22392 99.34 7e-111 X-RAY
 2008-09-23 ALA A:145 A:146 46.0 0.4 T -94.0 2.9 24.0 0.209 0.191 C:P22392:0.13
F:P22392:0.078
 HOH
 3.305
 CB
 O
ALA B:145 B:146 37.0 0.322 T -100.7 8.6 14.0 0.122 0.2 D:P22392:0.096
A:P22392:0.122
 HOH
 3.576
 C
 O
ALA C:145 C:146 45.0 0.391 T -97.9 12.4 20.0 0.174 0.217 E:P22392:0.096
B:P22392:0.139
 HOH
 3.492
 C
 O
ALA D:145 D:146 44.0 0.383 T -98.1 11.3 20.0 0.174 0.209 E:P22392:0.139
B:P22392:0.087
 HOH
 2.858
 CB
 O
ALA E:145 E:146 46.0 0.4 T -93.8 9.8 22.0 0.191 0.209 F:P22392:0.139
C:P22392:0.087
 HOH
 2.947
 CB
 O
ALA F:145 F:146 47.0 0.409 T -99.7 12.4 21.0 0.183 0.226 D:P22392:0.139
A:P22392:0.113
 HOH
 2.960
 N
 O
1bhn 1 P52174 90.13 1e-102 X-RAY
 1999-02-16 ALA A:146 A:146 35.0 0.304 T -92.7 5.6 14.0 0.122 0.182 C:P52174:0.122
F:P52174:0.078
 HOH
 5.024
 CB
 O
ALA B:146 B:146 35.0 0.304 T -118.2 29.4 14.0 0.122 0.182 A:P52174:0.104
E:P52174:0.096
 HOH
 4.625
 CB
 O
ALA C:146 C:146 31.0 0.27 T -97.2 -8.7 14.0 0.122 0.148 D:P52174:0.07
B:P52174:0.078
 HOH
 3.438
 CB
 O
ALA D:146 D:146 32.0 0.278 T -118.3 3.0 13.0 0.113 0.165 F:P52174:0.104
C:P52174:0.07
 HOH
 4.905
 CB
 O
ALA E:146 E:146 41.0 0.357 T -106.8 2.2 16.0 0.139 0.218 D:P52174:0.122
B:P52174:0.122
 HOH
 4.692
 CB
 O
ALA F:146 F:146 40.0 0.348 T -62.7 14.1 15.0 0.13 0.218 A:P52174:0.104
E:P52174:0.13
 HOH
 4.647
 CB
 O
1be4 1 P52175 90.07 7e-102 X-RAY
 1999-01-13 ALA A:145 A:146 31.0 0.27 S -111.9 39.2 15.0 0.13 0.14 C:P52175:0.061
C:P52175:0.087
 HOH
 3.710
 CA
 O
ALA B:145 B:146 23.0 0.2 T -164.3 57.8 10.0 0.087 0.113 B:P52175:0.096
A:P52175:0.043
 HOH
 3.379
 N
 O
ALA C:145 C:146 36.0 0.313 T -53.5 -22.6 21.0 0.183 0.13 C:P52175:0.009
A:P52175:0.078
B:P52175:0.07
 HOH
 2.799
 CB
 O
5ui4 1 P15531 88.16 3e-100 X-RAY
 2018-01-17 ALA A:153 A:146 39.0 0.339 T -93.1 12.6 15.0 0.13 0.209 D:P15531:0.009
C:P15531:0.139
E:P15531:0.096
 HOH
 4.754
 CB
 O
ALA B:153 B:146 37.0 0.322 T -93.4 12.6 14.0 0.122 0.2 A:P15531:0.13
F:P15531:0.009
D:P15531:0.087
 HOH
 4.886
 CB
 O
ALA C:153 C:146 37.0 0.322 T -93.5 12.5 13.0 0.113 0.209 F:P15531:0.078
B:P15531:0.13
 HOH
 4.895
 CB
 O
ALA D:153 D:146 38.0 0.33 T -93.5 12.6 15.0 0.13 0.2 F:P15531:0.13
B:P15531:0.078
 HOH
 4.645
 CB
 O
ALA E:153 E:146 39.0 0.339 T -92.9 12.3 14.0 0.122 0.217 A:P15531:0.087
D:P15531:0.139
 HOH
 4.677
 CB
 O
ALA F:153 F:146 38.0 0.33 T -93.4 12.6 15.0 0.13 0.2 E:P15531:0.13
C:P15531:0.078
 HOH
 4.539
 CB
 O
1jxv 1 P15531 88.16 3e-100 X-RAY
 2002-04-10 ALA A:146 A:146 35.0 0.304 T -100.7 4.6 13.0 0.113 0.191 D:P15531:0.009
F:P15531:0.087
B:P15531:0.122
 HOH
 4.275
 N
 O
ALA B:146 B:146 35.0 0.304 T -103.5 6.2 13.0 0.113 0.191 C:P15531:0.122
E:P15531:0.078
 HOH
 6.109
 O
 O
ALA C:146 C:146 34.0 0.296 T -103.2 3.5 12.0 0.104 0.192 D:P15531:0.078
A:P15531:0.13
 HOH
 4.942
 N
 O
ALA D:146 D:146 34.0 0.296 T -101.3 5.5 12.0 0.104 0.192 C:P15531:0.078
E:P15531:0.13
 HOH
 4.272
 CB
 O
ALA E:146 E:146 33.0 0.287 T -102.0 4.1 12.0 0.104 0.183 C:P15531:0.009
F:P15531:0.122
B:P15531:0.078
 HOH
 3.106
 C
 O
ALA F:146 F:146 35.0 0.304 T -100.5 4.2 12.0 0.104 0.2 A:P15531:0.096
D:P15531:0.122
B:P15531:0.009
 HOH
 3.463
 C
 O
2hvd 1 P15531 88.16 3e-100 X-RAY
 2006-09-19 ALA A:146 A:146 34.0 0.296 T -98.6 0.7 13.0 0.113 0.183 C:P15531:0.113
B:P15531:0.078
A:P15531:0.009
 HOH
 3.681
 CB
 O
ALA B:146 B:146 34.0 0.296 T -110.1 10.2 11.0 0.096 0.2 A:P15531:0.096
A:P15531:0.122
 HOH
 3.628
 CB
 O
ALA C:146 C:146 34.0 0.296 T -96.3 7.4 12.0 0.104 0.192 C:P15531:0.087
B:P15531:0.122
 HOH
 3.362
 C
 O
4eno 1 P15531 88.16 3e-100 X-RAY
 2013-03-27 ALA A:146 A:146 52.0 0.452 T -54.8 -41.9 52.0 0.452 0.0 HOH
 3.412
 CB
 O
ALA B:146 B:146 44.0 0.383 T -54.6 -39.3 44.0 0.383 0.0 HOH
 2.596
 O
 O
3l7u 1 P15531 88.16 9e-100 X-RAY
 2010-11-10 ALA A:166 A:146 35.0 0.304 T -102.7 11.5 13.0 0.113 0.191 C:P15531:0.087
C:P15531:0.122
 PO4
HOH
 3.457
3.679
 CB
CB
 O4
O
ALA B:166 B:146 36.0 0.313 T -99.7 7.6 13.0 0.113 0.2 B:P15531:0.087
A:P15531:0.122
 HOH
 3.496
 C
 O
ALA C:166 C:146 35.0 0.304 T -102.6 11.6 13.0 0.113 0.191 A:P15531:0.096
B:P15531:0.122
 PO4
HOH
 3.731
3.539
 CB
C
 O2
O
2hve 1 P15531 87.5 2e-99 X-RAY
 2006-09-19 ALA A:146 A:146 35.0 0.304 T -101.9 -1.6 12.0 0.104 0.2 C:P15531:0.122
B:P15531:0.096
 HOH
 4.292
 CB
 O
ALA B:146 B:146 35.0 0.304 T -109.5 7.6 12.0 0.104 0.2 A:P15531:0.096
A:P15531:0.139
 HOH
 4.572
 CB
 O
ALA C:146 C:146 34.0 0.296 T -95.9 2.5 13.0 0.113 0.183 C:P15531:0.078
B:P15531:0.122
 HOH
 3.651
 CB
 O
1ucn 1 P15531 86.84 8e-98 X-RAY
 2003-09-30 ALA A:146 A:146 35.0 0.304 T -110.5 6.6 11.0 0.096 0.208 C:P15531:0.13
B:P15531:0.096
 HOH
 3.650
 CB
 O
ALA B:146 B:146 36.0 0.313 T -95.9 -0.5 13.0 0.113 0.2 A:P15531:0.122
A:P15531:0.087
 TRS
HOH
 9.949
3.466
 O
CB
 O3
O
ALA C:146 C:146 35.0 0.304 T -98.2 8.8 13.0 0.113 0.191 C:P15531:0.087
B:P15531:0.13
 HOH
 3.424
 C
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p22392-f1 1 P22392 100.0 4e-113 ALA A:146 A:146 37.0 0.322 T -93.0 5.0
af-p15531-f1 1 P15531 88.16 1e-100 ALA A:146 A:146 40.0 0.348 T -88.4 1.4
af-o60361-f1 1 O60361 96.35 7e-96 ALA A:131 A:131 40.0 0.348 T -88.9 -2.1