Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 49248953 . G A CCDS32682.1:NM_001018136.2:c.792tgG>tgA_NP_001018146.1:p.264W>* Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1nsk 1 P22392 100.0 9e-113 X-RAY
 1995-10-15 TRP A:149 R:149 232.0 0.91 H -95.8 -12.6 39.0 0.153 0.757 D:P22392:0.714
E:P22392:0.129
TRP B:149 L:149 234.0 0.918 H -95.8 -12.6 39.0 0.153 0.765 F:P22392:0.718
C:P22392:0.118
TRP C:149 T:149 230.0 0.902 H -98.3 -10.0 36.0 0.141 0.761 A:P22392:0.718
B:P22392:0.118
TRP D:149 U:149 232.0 0.91 H -98.8 -10.4 38.0 0.149 0.761 F:P22392:0.11
C:P22392:0.718
TRP E:149 N:149 230.0 0.902 H -99.2 -10.6 35.0 0.137 0.765 A:P22392:0.125
B:P22392:0.718
TRP F:149 O:149 228.0 0.894 H -97.8 -9.4 38.0 0.149 0.745 D:P22392:0.106
E:P22392:0.706
7kpf 1 P22392 100.0 9e-113 X-RAY
 2022-02-02 TRP A:149 A:149 226.0 0.886 H -98.0 -15.5 40.0 0.157 0.729 D:P22392:0.118
B:P22392:0.69
 MG
HOH
 9.996
2.726
 O
O
 MG
O
TRP B:149 B:149 226.0 0.886 H -97.4 -15.2 33.0 0.129 0.757 F:P22392:0.706
C:P22392:0.11
 MG
HOH
 6.265
2.619
 HH2
O
 MG
O
TRP C:149 C:149 227.0 0.89 H -97.5 -15.2 63.0 0.247 0.643 D:P22392:0.596
B:P22392:0.118
 GOL
HOH
 9.344
2.782
 HZ3
O
 HO1
O
TRP D:149 D:149 224.0 0.878 H -100.0 -7.7 59.0 0.231 0.647 A:P22392:0.11
E:P22392:0.604
 HOH
 2.455
 O
 O
TRP E:149 E:149 231.0 0.906 H -99.3 -7.2 41.0 0.161 0.745 F:P22392:0.11
C:P22392:0.702
 HOH
 2.622
 O
 O
TRP F:149 F:149 234.0 0.918 H -101.1 -8.3 45.0 0.176 0.742 A:P22392:0.702
E:P22392:0.122
 HOH
 4.772
 O
 O
1nue 1 P22392 100.0 7e-112 X-RAY
 1996-04-03 TRP A:148 A:149 228.0 0.894 H -95.5 -14.3 39.0 0.153 0.741 F:P22392:0.114
C:P22392:0.686
 HOH
 2.775
 O
 O
TRP B:148 B:149 228.0 0.894 H -100.1 -11.3 43.0 0.169 0.725 D:P22392:0.114
A:P22392:0.678
 HOH
 2.678
 O
 O
TRP C:148 C:149 229.0 0.898 H -100.7 -11.1 38.0 0.149 0.749 E:P22392:0.122
B:P22392:0.702
 HOH
 2.562
 O
 O
TRP D:148 D:149 228.0 0.894 H -95.9 -11.8 39.0 0.153 0.741 E:P22392:0.69
B:P22392:0.114
 HOH
 2.872
 O
 O
TRP E:148 E:149 231.0 0.906 H -98.9 -12.2 41.0 0.161 0.745 F:P22392:0.69
C:P22392:0.118
 HOH
 2.613
 O
 O
TRP F:148 F:149 231.0 0.906 H -95.2 -9.4 37.0 0.145 0.761 D:P22392:0.714
A:P22392:0.106
 HOH
 2.627
 O
 O
3bbb 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 TRP A:148 A:149 234.0 0.918 H -103.3 -14.4 43.0 0.169 0.749 C:P22392:0.702
F:P22392:0.118
 HOH
 2.782
 O
 O
TRP B:148 B:149 232.0 0.91 H -98.7 -10.3 42.0 0.165 0.745 D:P22392:0.106
A:P22392:0.702
 HOH
 2.699
 O
 O
TRP C:148 C:149 225.0 0.882 H -100.1 -12.9 37.0 0.145 0.737 E:P22392:0.106
B:P22392:0.702
 HOH
 2.710
 O
 O
TRP D:148 D:149 233.0 0.914 H -104.1 -14.7 41.0 0.161 0.753 E:P22392:0.702
B:P22392:0.106
 HOH
 2.748
 O
 O
TRP E:148 E:149 229.0 0.898 H -102.7 -14.2 40.0 0.157 0.741 F:P22392:0.698
C:P22392:0.106
 HOH
 2.694
 O
 O
TRP F:148 F:149 231.0 0.906 H -97.6 -10.2 40.0 0.157 0.749 A:P22392:0.11
D:P22392:0.706
 HOH
 2.731
 O
 O
3bbf 1 P22392 100.0 7e-112 X-RAY
 2008-09-23 TRP A:148 A:149 231.0 0.906 H -96.3 -12.8 42.0 0.165 0.741 F:P22392:0.11
C:P22392:0.682
 HOH
 2.595
 O
 O
TRP B:148 B:149 236.0 0.925 H -95.6 -13.9 40.0 0.157 0.768 D:P22392:0.118
A:P22392:0.702
 DTT
HOH
 5.610
2.742
 CD1
O
 C4
O
TRP C:148 C:149 240.0 0.941 H -93.8 -12.9 41.0 0.161 0.78 E:P22392:0.118
B:P22392:0.722
 DTT
HOH
 5.136
2.691
 CD1
O
 S4
O
TRP D:148 D:149 239.0 0.937 H -91.5 -13.0 39.0 0.153 0.784 E:P22392:0.714
B:P22392:0.133
 DTT
HOH
 4.377
2.665
 CD1
O
 S4
O
TRP E:148 E:149 231.0 0.906 H -99.3 -13.2 44.0 0.173 0.733 F:P22392:0.667
C:P22392:0.137
 DTT
HOH
 5.324
2.663
 CD1
O
 S4
O
TRP F:148 F:149 238.0 0.933 H -97.0 -10.3 42.0 0.165 0.768 D:P22392:0.698
A:P22392:0.114
 HOH
 2.666
 O
 O
3bbc 1 P22392 99.34 7e-111 X-RAY
 2008-09-23 TRP A:148 A:149 233.0 0.914 H -101.0 -13.7 40.0 0.157 0.757 C:P22392:0.714
F:P22392:0.11
 HOH
 2.701
 O
 O
TRP B:148 B:149 229.0 0.898 H -103.0 -17.0 39.0 0.153 0.745 D:P22392:0.114
A:P22392:0.706
 HOH
 2.715
 O
 O
TRP C:148 C:149 233.0 0.914 H -100.1 -13.5 41.0 0.161 0.753 E:P22392:0.118
B:P22392:0.706
 HOH
 2.781
 O
 O
TRP D:148 D:149 228.0 0.894 H -99.3 -14.8 36.0 0.141 0.753 E:P22392:0.71
B:P22392:0.102
 HOH
 2.715
 O
 O
TRP E:148 E:149 233.0 0.914 H -105.3 -15.8 39.0 0.153 0.761 F:P22392:0.718
C:P22392:0.118
 HOH
 2.707
 O
 O
TRP F:148 F:149 234.0 0.918 H -98.8 -16.1 42.0 0.165 0.753 D:P22392:0.714
A:P22392:0.106
 HOH
 2.718
 O
 O
1bhn 1 P52174 90.13 1e-102 X-RAY
 1999-02-16 TRP A:149 A:149 210.0 0.824 H -98.0 -33.6 35.0 0.137 0.687 C:P52174:0.647
F:P52174:0.106
 HOH
 3.534
 O
 O
TRP B:149 B:149 217.0 0.851 H -90.3 -15.9 38.0 0.149 0.702 A:P52174:0.671
E:P52174:0.098
 HOH
 2.609
 O
 O
TRP C:149 C:149 222.0 0.871 H -126.4 -28.5 33.0 0.129 0.742 D:P52174:0.122
B:P52174:0.69
 HOH
 5.522
 CB
 O
TRP D:149 D:149 230.0 0.902 H -67.5 -19.0 36.0 0.141 0.761 F:P52174:0.718
C:P52174:0.098
 HOH
 2.650
 O
 O
TRP E:149 E:149 207.0 0.812 H -106.4 -21.0 35.0 0.137 0.675 D:P52174:0.631
B:P52174:0.098
 HOH
 2.874
 O
 O
TRP F:149 F:149 232.0 0.91 H -90.0 -13.9 43.0 0.169 0.741 A:P52174:0.094
E:P52174:0.694
 HOH
 2.898
 O
 O
1be4 1 P52175 90.07 7e-102 X-RAY
 1999-01-13 TRP A:148 A:149 236.0 0.925 H -89.3 -26.0 51.0 0.2 0.725 C:P52175:0.122
C:P52175:0.659
 HOH
 2.469
 NE1
 O
TRP B:148 B:149 217.0 0.851 G -109.4 16.8 37.0 0.145 0.706 B:P52175:0.118
A:P52175:0.659
 HOH
 2.309
 O
 O
TRP C:148 C:149 223.0 0.875 H -76.4 -25.9 38.0 0.149 0.726 A:P52175:0.125
B:P52175:0.667
 HOH
 3.031
 O
 O
5ui4 1 P15531 88.16 3e-100 X-RAY
 2018-01-17 TRP A:156 A:149 236.0 0.925 H -97.4 -9.0 42.0 0.165 0.76 C:P15531:0.718
E:P15531:0.106
 A7Z
HOH
 9.772
2.842
 CZ3
O
 CZ
O
TRP B:156 B:149 234.0 0.918 H -97.1 -9.0 43.0 0.169 0.749 A:P15531:0.706
D:P15531:0.106
 A7Z
HOH
 9.975
2.754
 CZ3
O
 CZ
O
TRP C:156 C:149 232.0 0.91 H -97.2 -9.2 41.0 0.161 0.749 F:P15531:0.102
B:P15531:0.706
 HOH
 2.944
 O
 O
TRP D:156 D:149 235.0 0.922 H -97.3 -9.1 42.0 0.165 0.757 F:P15531:0.718
B:P15531:0.098
 HOH
 2.845
 O
 O
TRP E:156 E:149 232.0 0.91 H -97.0 -9.0 42.0 0.165 0.745 A:P15531:0.094
D:P15531:0.698
 HOH
 2.666
 O
 O
TRP F:156 F:149 233.0 0.914 H -97.2 -9.3 39.0 0.153 0.761 E:P15531:0.714
C:P15531:0.11
 A7Z
HOH
 9.858
2.742
 CZ3
O
 CZ
O
1jxv 1 P15531 88.16 3e-100 X-RAY
 2002-04-10 TRP A:149 A:149 230.0 0.902 H -104.2 -10.1 43.0 0.169 0.733 F:P15531:0.118
B:P15531:0.702
 HOH
 2.398
 O
 O
TRP B:149 B:149 230.0 0.902 H -103.8 -8.3 44.0 0.173 0.729 C:P15531:0.69
E:P15531:0.11
 HOH
 2.462
 O
 O
TRP C:149 C:149 232.0 0.91 H -102.5 -9.0 42.0 0.165 0.745 D:P15531:0.11
A:P15531:0.718
 HOH
 2.683
 O
 O
TRP D:149 D:149 232.0 0.91 H -103.1 -7.8 42.0 0.165 0.745 C:P15531:0.114
E:P15531:0.71
 HOH
 2.665
 O
 O
TRP E:149 E:149 231.0 0.906 H -101.9 -8.9 45.0 0.176 0.73 F:P15531:0.69
B:P15531:0.114
 HOH
 2.709
 O
 O
TRP F:149 F:149 232.0 0.91 H -102.0 -9.7 43.0 0.169 0.741 A:P15531:0.118
D:P15531:0.706
 HOH
 2.763
 O
 O
2hvd 1 P15531 88.16 3e-100 X-RAY
 2006-09-19 TRP A:149 A:149 234.0 0.918 H -89.4 -18.1 38.0 0.149 0.769 C:P15531:0.725
B:P15531:0.11
 HOH
 2.930
 O
 O
TRP B:149 B:149 236.0 0.925 H -86.3 -16.2 39.0 0.153 0.772 A:P15531:0.11
A:P15531:0.741
 HOH
 2.627
 O
 O
TRP C:149 C:149 233.0 0.914 H -98.4 -14.4 40.0 0.157 0.757 C:P15531:0.11
B:P15531:0.718
 HOH
 2.653
 O
 O
4eno 1 P15531 88.16 3e-100 X-RAY
 2013-03-27 TRP A:149 A:149 51.0 0.2 -84.4 69.5 51.0 0.2 0.0 HOH
 6.920
 CD1
 O
TRP B:149 B:149 114.0 0.447 -114.8 360.0 114.0 0.447 0.0 HOH
 2.135
 O
 O
3l7u 1 P15531 88.16 9e-100 X-RAY
 2010-11-10 TRP A:169 A:149 238.0 0.933 H -97.2 -11.6 45.0 0.176 0.757 C:P15531:0.114
C:P15531:0.718
 PO4
HOH
 7.261
2.758
 CD1
O
 O4
O
TRP B:169 B:149 234.0 0.918 H -103.4 -3.0 39.0 0.153 0.765 B:P15531:0.11
A:P15531:0.725
 HOH
 2.658
 O
 O
TRP C:169 C:149 234.0 0.918 H -100.1 -8.2 40.0 0.157 0.761 A:P15531:0.11
B:P15531:0.725
 PO4
HOH
 7.064
2.650
 CD1
O
 O4
O
2hve 1 P15531 87.5 2e-99 X-RAY
 2006-09-19 TRP A:149 A:149 231.0 0.906 H -91.6 -20.4 40.0 0.157 0.749 C:P15531:0.706
B:P15531:0.114
 HOH
 2.850
 O
 O
TRP B:149 B:149 233.0 0.914 H -90.0 -12.5 38.0 0.149 0.765 A:P15531:0.114
A:P15531:0.725
 HOH
 3.131
 NE1
 O
TRP C:149 C:149 229.0 0.898 H -100.0 -7.5 41.0 0.161 0.737 C:P15531:0.114
B:P15531:0.698
 HOH
 2.658
 O
 O
1ucn 1 P15531 86.84 8e-98 X-RAY
 2003-09-30 TRP A:149 A:149 230.0 0.902 H -100.8 -10.7 45.0 0.176 0.726 C:P15531:0.686
B:P15531:0.122
 HOH
 2.803
 O
 O
TRP B:149 B:149 236.0 0.925 H -97.6 -6.9 43.0 0.169 0.756 A:P15531:0.718
A:P15531:0.122
 TRS
HOH
 8.552
2.852
 N
O
 C3
O
TRP C:149 C:149 230.0 0.902 H -100.0 -10.0 44.0 0.173 0.729 C:P15531:0.114
B:P15531:0.694
 HOH
 2.818
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p22392-f1 1 P22392 100.0 4e-113 TRP A:149 A:149 234.0 0.918 H -105.6 -10.0
af-p15531-f1 1 P15531 88.16 1e-100 TRP A:149 A:149 236.0 0.925 H -102.8 -12.9
af-o60361-f1 1 O60361 96.35 7e-96 TRP A:134 A:134 227.0 0.89 H -105.7 -11.4