Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 79990661 . A C CCDS11798.1:NM_005052.2:c.182cAg>cCg_NP_005043.1:p.61Q>P Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6tm1 2 P60763 100.0 1e-143 X-RAY
 2020-01-22 GLN B:61 A:61 124.0 0.689 S -97.7 21.9 97.0 0.539 0.15 A:Q96BY6:0.15
2c2h 1 P60763 99.48 3e-142 X-RAY
 2005-10-13 GLN A:61 A:61 99.0 0.55 S -65.4 153.8 99.0 0.55 0.0 GDP
MG
HOH
 5.477
7.010
3.154
 OE1
OE1
OE1
 O2B
MG
O
GLN B:61 B:61 93.0 0.517 S -80.7 155.7 NA NA NA
1i4d 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 GLN C:61 D:61 99.0 0.55 S -41.0 155.2 99.0 0.55 0.0 MG
GDP
HOH
 6.526
5.571
3.680
 OE1
NE2
OE1
 MG
O1B
O
1i4l 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 GLN C:61 D:61 122.0 0.678 S -56.4 142.0 122.0 0.678 0.0 MG
GDP
HOH
 8.617
7.476
1.744
 NE2
N
OE1
 MG
O3B
O
6tgc 3 P63000 92.71 2e-134 EM
 2020-07-29 GLN C:61 C:61 131.0 0.728 S -72.2 165.6 83.0 0.461 0.267 A:Q92608:0.267
GLN F:61 F:61 130.0 0.722 S -72.2 165.6 81.0 0.45 0.272 D:Q92608:0.272
5fi0 2 P63000 92.71 3e-134 X-RAY
 2016-04-20 GLN B:64 B:61 50.0 0.278 G -85.7 2.1 3.0 0.017 0.261 A:Q8TCU6:0.261
GLN D:64 D:61 51.0 0.283 -86.3 1.0 NA NA NA
GLN F:64 F:61 53.0 0.294 G -85.1 3.4 NA NA NA
GLN H:64 H:61 46.0 0.256 G -84.0 3.2 NA NA NA
1i4t 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 LEU C:61 D:61 101.0 0.594 S -89.6 133.7 101.0 0.594 0.0 MG
GNP
HOH
 8.634
4.617
3.049
 N
CG
CA
 MG
O3G
O
2vrw 1 P63000 95.65 7e-133 X-RAY
 2008-06-17 GLN A:61 A:61 56.0 0.311 -91.9 -12.6 1.0 0.006 0.305 B:P27870:0.306
 HOH
 2.654
 NE2
 O
1e96 1 P15154 92.15 4e-132 X-RAY
 2000-11-17 LEU A:61 A:61 69.0 0.406 S -64.0 134.6 69.0 0.406 0.0 GTP
MG
HOH
 4.144
7.919
3.132
 CG
N
N
 O2G
MG
O
1hh4 1 P15154 92.15 4e-132 X-RAY
 2001-08-28 GLN A:61 A:61 67.0 0.372 -50.3 137.3 62.0 0.344 0.028 C:P52565:0.028
 GDP
MG
HOH
 5.848
6.616
6.542
 OE1
OE1
OE1
 O3B
MG
O
GLN B:61 B:61 70.0 0.389 -56.3 126.9 NA NA NA
1g4u 2 P63000 95.11 8e-132 X-RAY
 2001-01-24 GLN B:61 R:61 95.0 0.528 S -65.3 150.7 6.0 0.033 0.495 A:P74873:0.494
 MG
GDP
AF3
HOH
 7.233
5.857
2.966
2.910
 OE1
NE2
NE2
OE1
 MG
O3B
F3
O
2h7v 1 P63000 95.11 1e-131 X-RAY
 2006-09-19 GLN A:65 A:61 111.0 0.617 S 170.2 -81.2 95.0 0.528 0.089 C:Q05608:0.089
 MG
GDP
HOH
 7.133
7.332
3.034
 NE2
NE2
CA
 MG
O1B
O
GLN B:65 B:61 88.0 0.489 S -169.0 64.5 NA NA NA
2p2l 1 P63000 95.11 1e-131 X-RAY
 2007-05-01 GLN A:65 A:61 49.0 0.272 -58.8 137.3 49.0 0.272 0.0 ZN
HOH
 4.226
2.650
 NE2
O
 ZN
O
GLN B:65 B:61 50.0 0.278 -57.4 136.4 50.0 0.278 0.0 ZN
HOH
 4.191
2.715
 NE2
O
 ZN
O
GLN C:65 C:61 52.0 0.289 -54.5 134.7 52.0 0.289 0.0 ZN
HOH
 4.260
2.720
 NE2
O
 ZN
O
2g0n 1 P60763 100.0 1e-131 X-RAY
 2006-05-30 GLN A:62 A:61 78.0 0.433 S -78.9 152.7 78.0 0.433 0.0 MG
CL
GDP
HOH
 7.071
3.215
5.272
2.961
 NE2
NE2
NE2
OE1
 MG
CL
O3B
O
GLN B:62 B:61 80.0 0.444 S -76.7 150.1 NA NA NA
2ov2 1 P60763 100.0 1e-131 X-RAY
 2007-03-13 GLN A:62 A:61 79.0 0.439 -63.1 123.0 79.0 0.439 0.0 MG
GCP
HOH
 7.885
4.538
2.586
 OE1
N
NE2
 MG
O3G
O
GLN B:62 F:61 77.0 0.428 S -65.3 126.7 NA NA NA
GLN C:62 B:61 74.0 0.411 S -67.4 127.0 NA NA NA
GLN D:62 C:61 80.0 0.444 S -54.9 127.0 NA NA NA
GLN E:62 G:61 74.0 0.411 S -60.4 128.3 NA NA NA
GLN F:62 D:61 78.0 0.433 S -63.9 125.1 NA NA NA
GLN G:62 E:61 78.0 0.433 S -59.6 126.0 NA NA NA
GLN H:62 H:61 78.0 0.433 -61.8 119.3 NA NA NA
2qme 1 P60763 100.0 1e-131 X-RAY
 2007-08-28 GLN A:62 A:61 72.0 0.4 S -63.9 135.3 72.0 0.4 0.0 MG
GCP
HOH
 7.973
4.510
2.782
 NE2
NE2
OE1
 MG
O3G
O
2ic5 1 P60763 100.0 1e-131 X-RAY
 2006-10-10 GLN A:62 A:61 79.0 0.439 S -79.5 156.5 79.0 0.439 0.0 MG
GNP
HOH
 6.868
2.951
2.968
 NE2
NE2
OE1
 MG
O3G
O
GLN B:62 B:61 83.0 0.461 S -78.2 152.1 NA NA NA
1mh1 1 P63000 95.08 9e-131 X-RAY
 1998-01-21 GLN A:63 A:61 97.0 0.539 S -72.4 147.9 97.0 0.539 0.0 MG
GNP
HOH
 8.075
4.262
3.050
 N
OE1
OE1
 MG
O3G
O
1ds6 1 P15153 88.54 2e-129 X-RAY
 2000-07-12 GLN A:61 A:61 77.0 0.428 -49.3 146.4 60.0 0.333 0.095 B:P52566:0.094
 MG
GDP
HOH
 6.800
6.734
3.877
 NE2
NE2
C
 MG
O3B
O
2yin 2 P63000 95.48 2e-127 X-RAY
 2011-05-25 GLN C:80 C:61 96.0 0.533 S -58.8 170.7 NA NA NA
GLN D:80 D:61 96.0 0.533 S -42.3 144.0 81.0 0.45 0.083 B:Q92608:0.083
 HOH
 3.039
 NE2
 O
2fju 1 P63000 95.48 2e-127 X-RAY
 2006-11-21 GLN A:61 A:61 72.0 0.4 S -58.5 135.6 72.0 0.4 0.0 MG
GSP
HOH
 8.545
4.202
3.119
 OE1
CG
CG
 MG
S1G
O
5qqd 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 47.0 0.261 -96.2 0.0 0.0 0.0 0.261 B:O60229:0.261
 HOH
 2.686
 OE1
 O
5qqe 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 50.0 0.278 -99.9 3.8 0.0 0.0 0.278 B:O60229:0.278
 HOH
 2.574
 OE1
 O
5qqf 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 51.0 0.283 -92.1 6.8 0.0 0.0 0.283 B:O60229:0.283
 HOH
 2.609
 OE1
 O
5qqg 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 50.0 0.278 -95.9 10.1 1.0 0.006 0.272 B:O60229:0.272
 HOH
 2.664
 NE2
 O
5qqh 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 49.0 0.272 -100.7 10.8 0.0 0.0 0.272 B:O60229:0.272
 HOH
 2.742
 OE1
 O
5qqi 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 51.0 0.283 -101.2 11.4 1.0 0.006 0.277 B:O60229:0.278
 HOH
 2.688
 OE1
 O
5qqj 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 50.0 0.278 -101.0 1.1 1.0 0.006 0.272 B:O60229:0.272
 HOH
 2.761
 OE1
 O
5qqk 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 48.0 0.267 G -90.8 3.0 0.0 0.0 0.267 B:O60229:0.267
 HOH
 2.696
 NE2
 O
5qql 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 49.0 0.272 -93.6 7.1 0.0 0.0 0.272 B:O60229:0.272
 HOH
 2.647
 NE2
 O
5qqm 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 50.0 0.278 -102.0 5.6 0.0 0.0 0.278 B:O60229:0.278
 HOH
 2.765
 OE1
 O
5qqn 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLN A:62 A:61 49.0 0.272 -102.5 8.7 0.0 0.0 0.272 B:O60229:0.272
 HOH
 2.691
 OE1
 O
5qu9 1 P63000 95.48 2e-127 X-RAY
 2020-01-29 GLN A:62 A:61 52.0 0.289 -96.7 6.7 1.0 0.006 0.283 B:O60229:0.283
 HOH
 2.767
 OE1
 O
1foe 2 P63000 95.48 3e-127 X-RAY
 2001-01-17 GLN B:61 B:61 48.0 0.267 -114.4 1.9 0.0 0.0 0.267 A:Q60610:0.267
 SO4
HOH
 8.216
8.656
 N
O
 O3
O
GLN D:61 D:61 48.0 0.267 -117.6 5.1 NA NA NA
GLN F:61 F:61 47.0 0.261 -117.6 5.6 NA NA NA
GLN H:61 H:61 47.0 0.261 -119.3 5.4 NA NA NA
2nz8 1 P63000 95.48 3e-127 X-RAY
 2007-04-10 GLN A:61 A:61 51.0 0.283 -96.6 2.2 1.0 0.006 0.277 B:O75962:0.278
 HOH
 2.725
 OE1
 O
3bji 2 P63000 95.48 3e-127 X-RAY
 2008-07-15 GLN C:61 C:61 48.0 0.267 -109.9 13.9 NA NA NA
GLN D:61 D:61 54.0 0.3 -98.1 -12.7 4.0 0.022 0.278 A:P15498:0.278
 HOH
 6.665
 N
 O
5o33 1 P63000 95.48 3e-127 X-RAY
 2017-05-31 GLN A:61 A:61 54.0 0.3 -97.8 3.2 0.0 0.0 0.3 B:P97924:0.3
 GDP
EDO
HOH
 8.570
7.383
2.683
 N
NE2
OE1
 O2B
H21
O
3su8 1 P63000 95.48 3e-127 X-RAY
 2011-09-28 GLN A:61 A:61 44.0 0.244 S -71.0 138.3 44.0 0.244 0.0 MG
GNP
 6.678
2.769
 NE2
NE2
 MG
O3G
3sua 1 P63000 95.48 3e-127 X-RAY
 2011-09-07 GLN A:61 A:61 31.0 0.172 S -113.2 144.5 31.0 0.172 0.0 MG
GNP
 4.670
2.767
 NE2
NE2
 MG
O3G
GLN B:61 B:61 31.0 0.172 S -112.5 144.2 NA NA NA
GLN C:61 C:61 31.0 0.172 S -112.8 144.6 NA NA NA
6x1g 2 P63000 95.48 3e-127 X-RAY
 2020-11-25 GLN C:61 B:61 107.0 0.594 S -58.1 143.9 2.0 0.011 0.583 A:B3CVM3:0.583
 HOH
 3.801
 CA
 O
GLN D:61 D:61 108.0 0.6 S -58.4 143.5 NA NA NA
3b13 2 P63000 94.92 7e-127 X-RAY
 2012-03-14 GLN B:68 B:61 113.0 0.628 S -71.3 148.9 91.0 0.506 0.122 A:Q92608:0.122
GLN D:68 D:61 109.0 0.606 S -55.3 148.9 91.0 0.506 0.1 C:Q92608:0.1
1ryf 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 GLN A:63 NA:NA DO NA DO DO DO NA NA NA
GLN B:63 NA:NA DO NA DO DO DO NA NA NA
1ryh 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 GLN A:63 NA:NA DO NA DO DO DO NA NA NA
GLN B:63 NA:NA DO NA DO DO DO NA NA NA
7dpa 2 P63000 94.92 1e-126 EM
 2021-08-04 GLN B:68 B:61 112.0 0.622 -65.6 146.2 86.0 0.478 0.144 A:Q9H7D0:0.144
GLN E:68 E:61 112.0 0.622 -65.6 146.3 87.0 0.483 0.139 D:Q9H7D0:0.139
5n6o 1 P63000 95.45 3e-126 X-RAY
 2017-12-27 GLN A:60 A:61 99.0 0.55 S -56.4 156.2 99.0 0.55 0.0 GDP
MG
HOH
 7.342
8.452
6.799
 N
N
N
 O3B
MG
O
GLN B:60 B:61 71.0 0.394 S -66.1 157.6 NA NA NA
6bc1 1 P63000 95.45 5e-126 X-RAY
 2017-12-13 GLN A:61 A:61 77.0 0.428 S -82.7 151.2 77.0 0.428 0.0 GSP
MG
HOH
 3.673
7.732
5.804
 HG3
HG3
H
 S1G
MG
O
GLN C:61 B:61 77.0 0.428 S -87.0 150.4 NA NA NA
4yon 2 P63000 94.92 5e-126 X-RAY
 2015-07-01 GLN B:63 B:61 51.0 0.283 -98.9 6.3 1.0 0.006 0.277 A:Q8TCU6:0.278
 HOH
 2.799
 OE1
 O
3th5 1 P63000 95.45 8e-126 X-RAY
 2012-07-18 GLN A:88 A:61 73.0 0.406 S -69.0 137.7 73.0 0.406 0.0 GNP
MG
HOH
 4.540
7.803
7.590
 NE2
NE2
N
 O3G
MG
O
GLN B:88 B:61 112.0 0.622 S -61.3 137.9 NA NA NA
3ryt 2 P63000 94.92 1e-125 X-RAY
 2012-01-18 LEU C:64 NA:NA DO NA DO DO DO NA NA NA
1he1 2 P15154 95.43 1e-125 X-RAY
 2001-01-02 GLN C:61 C:61 82.0 0.456 S -66.0 139.7 8.0 0.044 0.412 A:Q51451:0.411
 GDP
AF3
MG
HOH
 5.266
2.735
7.329
2.678
 NE2
NE2
OE1
OE1
 O3B
F1
MG
O
GLN D:61 D:61 83.0 0.461 S -69.4 140.5 NA NA NA
6agp 1 P63000 93.37 1e-125 NMR
 2019-03-20 GLN A:61 A:61 109.0 0.606 -62.0 145.8 109.0 0.606 0.0 GDP
MG
 6.403
6.024
 HE21
HE22
 O3B
MG
3sbd 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 GLN A:71 A:61 76.0 0.422 S -67.4 139.6 76.0 0.422 0.0 GNP
MG
HOH
 4.325
7.829
3.008
 CG
N
NE2
 O3G
MG
O
GLN B:71 B:61 67.0 0.372 S -63.9 142.8 NA NA NA
3sbe 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 GLN A:71 A:61 81.0 0.45 S -58.9 139.4 81.0 0.45 0.0 GNP
MG
HOH
 4.471
7.672
5.915
 CG
N
N
 O3G
MG
O
7ajk 1 P63000 94.89 3e-125 X-RAY
 2020-11-18 LEU A:64 BBB:61 69.0 0.406 S -65.7 162.2 69.0 0.406 0.0 MG
GNP
HOH
 8.062
4.228
3.262
 N
N
CG
 MG
O1G
O
4gzm 1 P63000 94.89 6e-125 X-RAY
 2012-12-12 GLN A:88 A:61 112.0 0.622 S -75.1 157.7 112.0 0.622 0.0 GSP
MG
 5.443
8.515
 N
N
 O2G
MG
GLN B:88 B:61 110.0 0.611 S -74.8 157.5 NA NA NA
4gzl 1 P63000 94.89 1e-124 X-RAY
 2012-12-12 LEU A:88 A:61 60.0 0.353 S -59.8 139.6 60.0 0.353 0.0 GNP
MG
HOH
 4.286
7.842
3.269
 CG
N
CG
 O3G
MG
O
LEU B:88 B:61 63.0 0.371 S -64.6 130.0 NA NA NA
2w2t 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 GLN A:67 A:61 66.0 0.367 S -55.1 143.2 66.0 0.367 0.0 MG
GDP
HOH
 6.726
6.054
2.693
 NE2
NE2
NE2
 MG
O2B
O
2w2x 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 GLN A:67 A:61 57.0 0.317 S -52.1 134.5 57.0 0.317 0.0 GSP
MG
HOH
 4.784
7.912
3.332
 NE2
N
CD
 S1G
MG
O
GLN B:67 B:61 55.0 0.306 S -57.0 135.4 NA NA NA
2wkq 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 LEU A:213 A:604 99.0 0.582 -53.8 130.3 99.0 0.582 0.0 GTP
MG
HOH
 4.778
8.419
3.095
 N
N
N
 O3G
MG
O
2wkr 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 LEU A:213 A:604 87.0 0.512 S -67.7 142.7 87.0 0.512 0.0 GTP
MG
HOH
 4.690
8.365
3.466
 CD2
N
CG
 O2G
MG
O
2wkp 1 O49003,P63000 92.74 8e-124 X-RAY
 2009-08-18 LEU A:213 A:604 90.0 0.529 S -66.0 137.4 90.0 0.529 0.0 GTP
MG
HOH
 4.639
8.428
3.128
 CD2
N
CG
 O2G
MG
O
2w2v 1 P15153 93.22 4e-123 X-RAY
 2009-05-05 GLN A:68 A:61 57.0 0.317 S -55.2 153.0 57.0 0.317 0.0 GTP
HOH
 5.093
3.156
 OE1
OE1
 O3G
O
GLN B:68 B:61 61.0 0.339 S -57.7 151.3 NA NA NA
GLN C:68 C:61 63.0 0.35 S -52.8 157.9 NA NA NA
GLN D:68 D:61 56.0 0.311 S -54.0 146.5 NA NA NA
5hzh 1 P63000,O49003 86.81 4e-90 X-RAY
 2016-12-21 LEU A:213 A:210 90.0 0.529 S -64.5 150.1 90.0 0.529 0.0 GTP
MG
CA
HOH
 4.724
7.986
6.427
5.948
 N
N
CD2
N
 O2G
MG
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60763-f1 1 P60763 100.0 5e-144 GLN A:61 A:61 71.0 0.394 S -86.2 148.0
af-p63000-f1 1 P63000 92.71 8e-135 GLN A:61 A:61 72.0 0.4 S -87.5 148.9
af-p15153-f1 1 P15153 88.54 7e-130 GLN A:61 A:61 70.0 0.389 S -88.7 147.8