Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 79990663 . G A CCDS11798.1:NM_005052.2:c.184Gag>Aag_NP_005043.1:p.62E>K Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6tm1 2 P60763 100.0 1e-143 X-RAY
 2020-01-22 GLU B:62 A:62 60.0 NA S 65.9 -57.0 60.0 NA NA
2c2h 1 P60763 99.48 3e-142 X-RAY
 2005-10-13 GLU A:62 A:62 93.0 NA G -57.1 -35.4 93.0 NA NA HOH
 4.982
 O
 O
GLU B:62 B:62 71.0 NA G -56.4 -32.9 NA NA NA
1i4d 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 GLU C:62 D:62 147.0 0.774 G -63.9 -46.5 147.0 0.774 0.0 HOH
 4.697
 O
 O
1i4l 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 GLU C:62 D:62 151.0 0.795 G -50.5 -35.4 151.0 0.795 0.0 HOH
 4.477
 O
 O
6tgc 3 P63000 92.71 2e-134 EM
 2020-07-29 GLU C:62 C:62 119.0 0.626 G -78.4 -8.4 119.0 0.626 0.0
GLU F:62 F:62 119.0 0.626 G -78.4 -8.4 119.0 0.626 0.0
5fi0 2 P63000 92.71 3e-134 X-RAY
 2016-04-20 GLU B:65 B:62 29.0 0.153 G -58.6 -31.6 22.0 0.116 0.037 A:Q8TCU6:0.037
GLU D:65 D:62 26.0 0.137 T -59.5 -30.6 NA NA NA
GLU F:65 F:62 32.0 0.168 G -58.9 -31.7 NA NA NA
GLU H:65 H:62 33.0 0.174 G -59.4 -32.4 NA NA NA
1i4t 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 GLU C:62 D:62 147.0 0.774 G -30.9 -41.0 147.0 0.774 0.0 GNP
HOH
 8.612
2.866
 N
N
 O1G
O
2vrw 1 P63000 95.65 7e-133 X-RAY
 2008-06-17 GLU A:62 A:62 24.0 0.126 T -59.0 -34.0 17.0 0.089 0.037 B:P27870:0.037
 HOH
 2.838
 OE2
 O
1e96 1 P15154 92.15 4e-132 X-RAY
 2000-11-17 GLU A:62 A:62 140.0 0.737 G -55.1 -31.5 140.0 0.737 0.0 GTP
HOH
 7.794
3.470
 N
N
 O2G
O
1hh4 1 P15154 92.15 4e-132 X-RAY
 2001-08-28 GLU A:62 A:62 146.0 0.768 G -66.9 -10.6 146.0 0.768 0.0 HOH
 8.959
 OE2
 O
GLU B:62 B:62 134.0 0.705 T -67.5 3.8 NA NA NA
1g4u 2 P63000 95.11 8e-132 X-RAY
 2001-01-24 GLU B:62 R:62 156.0 0.821 G -76.6 -16.3 117.0 0.616 0.205 A:P74873:0.205
 AF3
HOH
 8.276
3.369
 N
OE1
 F2
O
2h7v 1 P63000 95.11 1e-131 X-RAY
 2006-09-19 GLU A:66 A:62 121.0 0.637 S -165.1 -53.5 106.0 0.558 0.079 C:Q05608:0.079
 HOH
 4.741
 N
 O
GLU B:66 B:62 152.0 0.8 S 50.3 52.2 NA NA NA
2p2l 1 P63000 95.11 1e-131 X-RAY
 2007-05-01 GLU A:66 A:62 8.0 0.042 G -49.1 -44.7 8.0 0.042 0.0 ZN
HOH
 4.553
2.739
 CB
N
 ZN
O
GLU B:66 B:62 7.0 0.037 G -47.7 -45.8 7.0 0.037 0.0 ZN
HOH
 4.462
2.733
 CB
OE1
 ZN
O
GLU C:66 C:62 8.0 0.042 G -49.5 -44.5 8.0 0.042 0.0 ZN
HOH
 4.543
2.731
 CB
OE1
 ZN
O
2g0n 1 P60763 100.0 1e-131 X-RAY
 2006-05-30 GLU A:63 A:62 155.0 0.816 G -54.1 -32.3 155.0 0.816 0.0 CL
HOH
 8.333
2.669
 N
OE1
 CL
O
GLU B:63 B:62 155.0 0.816 G -55.0 -28.1 NA NA NA
2ov2 1 P60763 100.0 1e-131 X-RAY
 2007-03-13 GLU A:63 A:62 136.0 0.716 G -51.2 -37.3 136.0 0.716 0.0 GCP
HOH
 7.731
2.531
 N
OE2
 O3G
O
GLU B:63 F:62 138.0 0.726 G -66.1 -26.6 NA NA NA
GLU C:63 B:62 135.0 0.711 G -63.8 -23.7 NA NA NA
GLU D:63 C:62 76.0 NA G -61.3 -28.3 NA NA NA
GLU E:63 G:62 142.0 0.747 G -69.0 -18.7 NA NA NA
GLU F:63 D:62 139.0 0.732 G -45.2 -40.3 NA NA NA
GLU G:63 E:62 135.0 0.711 G -65.7 -14.9 NA NA NA
GLU H:63 H:62 137.0 0.721 G -50.3 -36.1 NA NA NA
2qme 1 P60763 100.0 1e-131 X-RAY
 2007-08-28 GLU A:63 A:62 147.0 0.774 G -59.2 -23.4 147.0 0.774 0.0 GCP
HOH
 8.102
2.901
 N
N
 O2G
O
2ic5 1 P60763 100.0 1e-131 X-RAY
 2006-10-10 GLU A:63 A:62 154.0 0.811 G -60.6 -29.2 154.0 0.811 0.0 GNP
HOH
 8.545
2.750
 N
OE1
 O2G
O
GLU B:63 B:62 152.0 0.8 G -56.1 -25.0 NA NA NA
1mh1 1 P63000 95.08 9e-131 X-RAY
 1998-01-21 GLU A:64 A:62 154.0 0.811 G -57.7 -32.6 154.0 0.811 0.0 GNP
HOH
 8.018
2.531
 N
OE2
 O1G
O
1ds6 1 P15153 88.54 2e-129 X-RAY
 2000-07-12 GLU A:62 A:62 150.0 0.789 G -64.5 -30.7 147.0 0.774 0.015 B:P52566:0.016
 HOH
 3.599
 N
 O
2yin 2 P63000 95.48 2e-127 X-RAY
 2011-05-25 GLU C:81 C:62 141.0 0.742 S -93.4 -23.1 NA NA NA
GLU D:81 D:62 144.0 0.758 G -74.0 -25.6 144.0 0.758 0.0 HOH
 8.103
 N
 O
2fju 1 P63000 95.48 2e-127 X-RAY
 2006-11-21 GLU A:62 A:62 146.0 0.768 G -71.1 -8.6 146.0 0.768 0.0 GSP
HOH
 7.829
3.330
 N
OE1
 O3G
O
5qqd 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 36.0 0.189 T -60.4 -25.4 31.0 0.163 0.026 B:O60229:0.026
 HOH
 2.803
 OE2
 O
5qqe 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 36.0 0.189 T -57.9 -27.3 30.0 0.158 0.031 B:O60229:0.032
 HOH
 2.706
 OE2
 O
5qqf 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 35.0 0.184 T -66.0 -18.8 27.0 0.142 0.042 B:O60229:0.042
 HOH
 2.770
 OE2
 O
5qqg 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 33.0 0.174 T -67.0 -25.5 28.0 0.147 0.027 B:O60229:0.026
 HOH
 2.724
 OE2
 O
5qqh 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 35.0 0.184 T -64.9 -23.9 29.0 0.153 0.031 B:O60229:0.032
 HOH
 2.811
 OE2
 O
5qqi 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 33.0 0.174 T -62.0 -29.0 28.0 0.147 0.027 B:O60229:0.026
 HOH
 2.642
 OE2
 O
5qqj 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 36.0 0.189 T -52.0 -31.0 29.0 0.153 0.036 B:O60229:0.037
 HOH
 2.733
 OE2
 O
5qqk 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 37.0 0.195 G -53.5 -28.1 30.0 0.158 0.037 B:O60229:0.037
 HOH
 2.706
 OE2
 O
5qql 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 33.0 0.174 T -64.7 -24.3 26.0 0.137 0.037 B:O60229:0.037
 HOH
 2.862
 OE2
 O
5qqm 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 37.0 0.195 T -56.8 -29.1 29.0 0.153 0.042 B:O60229:0.042
 HOH
 2.684
 OE2
 O
5qqn 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 GLU A:63 A:62 36.0 0.189 T -62.1 -27.3 29.0 0.153 0.036 B:O60229:0.037
 HOH
 2.857
 OE2
 O
5qu9 1 P63000 95.48 2e-127 X-RAY
 2020-01-29 GLU A:63 A:62 37.0 0.195 T -61.4 -24.3 33.0 0.174 0.021 B:O60229:0.021
 HOH
 2.978
 OE2
 O
1foe 2 P63000 95.48 3e-127 X-RAY
 2001-01-17 GLU B:62 B:62 19.0 0.1 T -61.8 -16.4 19.0 0.1 0.0 SO4
HOH
 4.155
8.096
 OE2
C
 O3
O
GLU D:62 D:62 19.0 0.1 T -64.8 -18.3 NA NA NA
GLU F:62 F:62 19.0 0.1 T -66.4 -16.5 NA NA NA
GLU H:62 H:62 18.0 0.095 T -66.1 -17.0 NA NA NA
2nz8 1 P63000 95.48 3e-127 X-RAY
 2007-04-10 GLU A:62 A:62 30.0 0.158 T -58.7 -24.2 26.0 0.137 0.021 B:O75962:0.021
 HOH
 3.107
 OE1
 O
3bji 2 P63000 95.48 3e-127 X-RAY
 2008-07-15 GLU C:62 C:62 24.0 0.126 T -92.6 -9.8 NA NA NA
GLU D:62 D:62 30.0 0.158 T -63.4 -24.2 24.0 0.126 0.032 A:P15498:0.032
 HOH
 6.324
 CG
 O
5o33 1 P63000 95.48 3e-127 X-RAY
 2017-05-31 GLU A:62 A:62 30.0 0.158 T -59.0 -25.3 26.0 0.137 0.021 B:P97924:0.021
 GDP
HOH
 4.591
2.789
 OE2
N
 O2B
O
3su8 1 P63000 95.48 3e-127 X-RAY
 2011-09-28 GLU A:62 A:62 147.0 0.774 G -71.3 -9.9 147.0 0.774 0.0 GNP
 8.197
 N
 O1G
3sua 1 P63000 95.48 3e-127 X-RAY
 2011-09-07 GLU A:62 A:62 161.0 0.847 S -69.4 -15.3 159.0 0.837 0.01 D:O43157:0.011
 GNP
 8.525
 N
 O1G
GLU B:62 B:62 162.0 0.853 S -68.6 -15.8 NA NA NA
GLU C:62 C:62 160.0 0.842 S -69.1 -15.8 NA NA NA
6x1g 2 P63000 95.48 3e-127 X-RAY
 2020-11-25 GLU C:62 B:62 158.0 0.832 G -61.1 -31.1 138.0 0.726 0.106 A:B3CVM3:0.105
 HOH
 5.350
 N
 O
GLU D:62 D:62 155.0 0.816 G -67.6 -23.7 NA NA NA
3b13 2 P63000 94.92 7e-127 X-RAY
 2012-03-14 GLU B:69 B:62 142.0 0.747 G -71.6 -26.1 142.0 0.747 0.0
GLU D:69 D:62 142.0 0.747 G -76.9 -18.0 142.0 0.747 0.0
1ryf 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 GLU A:64 NA:NA DO NA DO DO DO NA NA NA
GLU B:64 NA:NA DO NA DO DO DO NA NA NA
1ryh 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 GLU A:64 NA:NA DO NA DO DO DO NA NA NA
GLU B:64 NA:NA DO NA DO DO DO NA NA NA
7dpa 2 P63000 94.92 1e-126 EM
 2021-08-04 GLU B:69 B:62 170.0 0.895 S -77.0 -35.3 170.0 0.895 0.0
GLU E:69 E:62 172.0 0.905 S -77.0 -35.4 172.0 0.905 0.0
5n6o 1 P63000 95.45 3e-126 X-RAY
 2017-12-27 GLU A:61 A:62 157.0 0.826 G -54.1 -35.8 157.0 0.826 0.0 HOH
 8.630
 OE1
 O
GLU B:61 B:62 157.0 0.826 G -60.9 -30.5 NA NA NA
6bc1 1 P63000 95.45 5e-126 X-RAY
 2017-12-13 GLU A:62 A:62 142.0 0.747 G -64.8 -34.8 142.0 0.747 0.0 GSP
HOH
 8.223
4.477
 H
O
 S1G
O
GLU C:62 B:62 150.0 0.789 G -66.6 -26.4 NA NA NA
4yon 2 P63000 94.92 5e-126 X-RAY
 2015-07-01 GLU B:64 B:62 11.0 0.058 T -65.6 -22.7 11.0 0.058 0.0 HOH
 2.679
 OE1
 O
3th5 1 P63000 95.45 8e-126 X-RAY
 2012-07-18 GLU A:89 A:62 147.0 0.774 G -62.8 -19.2 147.0 0.774 0.0 GNP
 8.026
 N
 O1G
GLU B:89 B:62 144.0 0.758 G -57.5 -30.7 NA NA NA
3ryt 2 P63000 94.92 1e-125 X-RAY
 2012-01-18 GLU C:65 C:62 168.0 0.884 360.0 -1.7 168.0 0.884 0.0 GNP
 8.076
 N
 O3G
1he1 2 P15154 95.43 1e-125 X-RAY
 2001-01-02 GLU C:62 C:62 137.0 0.721 G -59.9 -24.0 105.0 0.553 0.168 A:Q51451:0.168
 AF3
HOH
 8.243
2.837
 N
N
 F2
O
GLU D:62 D:62 138.0 0.726 G -61.7 -24.0 NA NA NA
6agp 1 P63000 93.37 1e-125 NMR
 2019-03-20 GLU A:62 A:62 156.0 0.821 G -61.5 -30.5 156.0 0.821 0.0
3sbd 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 GLU A:72 A:62 146.0 0.768 G -50.1 -31.8 146.0 0.768 0.0 GNP
HOH
 7.833
2.591
 N
OE2
 O1G
O
GLU B:72 B:62 134.0 0.705 G -60.1 -31.3 NA NA NA
3sbe 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 GLU A:72 A:62 142.0 0.747 G -62.8 -19.8 142.0 0.747 0.0 GNP
HOH
 8.028
8.061
 N
N
 O3G
O
7ajk 1 P63000 94.89 3e-125 X-RAY
 2020-11-18 GLU A:65 BBB:62 152.0 0.8 G -87.1 -7.9 152.0 0.8 0.0 GNP
HOH
 7.896
6.826
 N
N
 O1G
O
4gzm 1 P63000 94.89 6e-125 X-RAY
 2012-12-12 GLU A:89 A:62 151.0 0.795 G -73.3 -6.1 151.0 0.795 0.0 GSP
 8.968
 N
 O2G
GLU B:89 B:62 151.0 0.795 G -73.6 -5.7 NA NA NA
4gzl 1 P63000 94.89 1e-124 X-RAY
 2012-12-12 GLU A:89 A:62 153.0 0.805 G -64.1 -18.5 153.0 0.805 0.0 GNP
HOH
 7.866
2.899
 N
N
 O3G
O
GLU B:89 B:62 151.0 0.795 G -55.6 -22.6 NA NA NA
2w2t 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 GLU A:68 A:62 64.0 NA G -58.2 -36.1 64.0 NA NA HOH
 3.129
 N
 O
2w2x 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 GLU A:68 A:62 133.0 0.7 G -72.6 -23.1 133.0 0.7 0.0 GSP
HOH
 8.411
6.592
 N
N
 S1G
O
GLU B:68 B:62 144.0 0.758 G -72.1 -23.4 NA NA NA
2wkq 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 GLU A:214 A:605 140.0 0.737 G -62.5 -31.4 140.0 0.737 0.0 GTP
HOH
 8.303
2.763
 N
OE1
 O3G
O
2wkr 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 GLU A:214 A:605 144.0 0.758 G -64.8 -29.5 144.0 0.758 0.0 GTP
HOH
 8.280
2.635
 N
OE1
 O3G
O
2wkp 1 O49003,P63000 92.74 8e-124 X-RAY
 2009-08-18 GLU A:214 A:605 141.0 0.742 G -59.6 -34.4 141.0 0.742 0.0 GTP
HOH
 8.361
2.673
 N
OE1
 O3G
O
2w2v 1 P15153 93.22 4e-123 X-RAY
 2009-05-05 GLU A:69 A:62 145.0 0.763 G -64.6 -33.2 145.0 0.763 0.0 HOH
 2.620
 OE1
 O
GLU B:69 B:62 150.0 0.789 G -61.4 -31.9 NA NA NA
GLU C:69 C:62 148.0 0.779 G -72.2 -26.7 NA NA NA
GLU D:69 D:62 149.0 0.784 G -63.0 -26.6 NA NA NA
5hzh 1 P63000,O49003 86.81 4e-90 X-RAY
 2016-12-21 GLU A:214 A:211 120.0 0.632 G -66.3 -27.1 120.0 0.632 0.0 GTP
CA
HOH
 8.113
6.403
8.466
 N
C
N
 O2G
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60763-f1 1 P60763 100.0 5e-144 GLU A:62 A:62 143.0 0.753 G -65.4 -29.6
af-p63000-f1 1 P63000 92.71 8e-135 GLU A:62 A:62 144.0 0.758 G -65.0 -30.1
af-p15153-f1 1 P15153 88.54 7e-130 GLU A:62 A:62 146.0 0.768 G -65.3 -30.3