Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 79990666 . G A CCDS11798.1:NM_005052.2:c.187Gac>Aac_NP_005043.1:p.63D>N Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6tm1 2 P60763 100.0 1e-143 X-RAY
 2020-01-22 ASP B:63 A:63 150.0 1.0 T -69.7 0.2 150.0 1.0 0.0
2c2h 1 P60763 99.48 3e-142 X-RAY
 2005-10-13 ASP A:63 A:63 131.0 0.873 G -78.6 -3.3 131.0 0.873 0.0 HOH
 2.627
 OD1
 O
ASP B:63 B:63 93.0 NA G -61.4 -20.0 NA NA NA
1i4d 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 ASP C:63 D:63 140.0 0.933 G -45.1 -22.3 107.0 0.713 0.22 A:P53365:0.22
 HOH
 2.950
 OD1
 O
1i4l 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 ASP C:63 D:63 121.0 0.807 G -46.4 -29.6 93.0 0.62 0.187 A:P53365:0.187
 HOH
 2.587
 O
 O
6tgc 3 P63000 92.71 2e-134 EM
 2020-07-29 ASP C:63 C:63 114.0 0.76 G -71.4 13.3 114.0 0.76 0.0
ASP F:63 F:63 114.0 0.76 G -71.4 13.3 114.0 0.76 0.0
5fi0 2 P63000 92.71 3e-134 X-RAY
 2016-04-20 ASP B:66 B:63 129.0 0.86 G -100.2 -3.3 122.0 0.813 0.047 A:Q8TCU6:0.047
ASP D:66 D:63 132.0 0.88 T -98.2 -2.8 NA NA NA
ASP F:66 F:63 134.0 0.893 G -98.8 -5.3 NA NA NA
ASP H:66 H:63 129.0 0.86 G -99.6 -4.6 NA NA NA
1i4t 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 ASP C:63 D:63 114.0 0.76 G -52.9 -26.0 88.0 0.587 0.173 A:P53365:0.173
 GNP
HOH
 8.894
2.633
 OD2
O
 O3G
O
2vrw 1 P63000 95.65 7e-133 X-RAY
 2008-06-17 ASP A:63 A:63 124.0 0.827 T -89.3 4.3 112.0 0.747 0.08 B:P27870:0.08
 HOH
 2.640
 O
 O
1e96 1 P15154 92.15 4e-132 X-RAY
 2000-11-17 ASP A:63 A:63 133.0 0.887 G -60.7 -19.3 133.0 0.887 0.0 GTP
HOH
 9.327
5.904
 N
N
 O2G
O
1hh4 1 P15154 92.15 4e-132 X-RAY
 2001-08-28 ASP A:63 A:63 143.0 0.953 G -71.7 -23.6 93.0 0.62 0.333 C:P52565:0.333
 HOH
 7.476
 OD2
 O
ASP B:63 B:63 149.0 0.993 T -78.7 -36.7 NA NA NA
1g4u 2 P63000 95.11 8e-132 X-RAY
 2001-01-24 ASP B:63 R:63 132.0 0.88 G -77.4 -2.9 39.0 0.26 0.62 A:P74873:0.62
 AF3
HOH
 9.236
2.643
 OD2
CB
 F3
O
2h7v 1 P63000 95.11 1e-131 X-RAY
 2006-09-19 ASP A:67 A:63 109.0 0.727 H -63.3 -46.5 13.0 0.087 0.64 C:Q05608:0.64
 HOH
 7.516
 N
 O
ASP B:67 B:63 118.0 0.787 S 146.8 -40.3 NA NA NA
2p2l 1 P63000 95.11 1e-131 X-RAY
 2007-05-01 ASP A:67 A:63 67.0 0.447 G -61.4 -20.8 67.0 0.447 0.0 ZN
HOH
 1.981
3.572
 OD2
CG
 ZN
O
ASP B:67 B:63 69.0 0.46 G -65.3 -19.1 69.0 0.46 0.0 ZN
HOH
 1.984
3.371
 OD2
O
 ZN
O
ASP C:67 C:63 70.0 0.467 G -61.5 -22.3 70.0 0.467 0.0 ZN
HOH
 1.961
3.425
 OD2
O
 ZN
O
2g0n 1 P60763 100.0 1e-131 X-RAY
 2006-05-30 ASP A:64 A:63 129.0 0.86 G -58.4 -20.9 129.0 0.86 0.0 CL
HOH
 9.506
2.646
 OD2
O
 CL
O
ASP B:64 B:63 125.0 0.833 G -60.3 -22.7 NA NA NA
2ov2 1 P60763 100.0 1e-131 X-RAY
 2007-03-13 ASP A:64 A:63 138.0 0.92 G -58.9 -20.3 138.0 0.92 0.0 GCP
HOH
 9.378
2.712
 N
OD2
 O3G
O
ASP B:64 F:63 124.0 0.827 G -54.6 -22.7 NA NA NA
ASP C:64 B:63 118.0 0.787 G -54.5 -24.2 NA NA NA
ASP D:64 C:63 143.0 0.953 G -60.7 -23.0 NA NA NA
ASP E:64 G:63 128.0 0.853 G -58.4 -25.1 NA NA NA
ASP F:64 D:63 119.0 0.793 G -58.0 -23.1 NA NA NA
ASP G:64 E:63 116.0 0.773 G -63.6 -22.7 NA NA NA
ASP H:64 H:63 123.0 0.82 G -57.8 -22.8 NA NA NA
2qme 1 P60763 100.0 1e-131 X-RAY
 2007-08-28 ASP A:64 A:63 117.0 0.78 G -51.0 -29.9 117.0 0.78 0.0 GCP
HOH
 9.404
2.300
 OD2
OD2
 O3G
O
2ic5 1 P60763 100.0 1e-131 X-RAY
 2006-10-10 ASP A:64 A:63 131.0 0.873 G -60.4 -21.8 131.0 0.873 0.0 GNP
HOH
 9.687
2.610
 OD2
OD1
 O3G
O
ASP B:64 B:63 129.0 0.86 G -66.5 -20.0 NA NA NA
1mh1 1 P63000 95.08 9e-131 X-RAY
 1998-01-21 ASP A:65 A:63 160.0 1.0 G -57.7 -21.3 160.0 1.0 0.0 GNP
HOH
 9.542
2.682
 N
O
 O3G
O
1ds6 1 P15153 88.54 2e-129 X-RAY
 2000-07-12 ASP A:63 A:63 138.0 0.92 G -60.1 -25.5 78.0 0.52 0.4 B:P52566:0.4
 HOH
 2.589
 O
 O
2yin 2 P63000 95.48 2e-127 X-RAY
 2011-05-25 ASP C:82 C:63 133.0 0.887 G -63.5 -27.4 NA NA NA
ASP D:82 D:63 133.0 0.887 G -56.3 -26.3 133.0 0.887 0.0 HOH
 8.694
 O
 O
2fju 1 P63000 95.48 2e-127 X-RAY
 2006-11-21 ASP A:63 A:63 133.0 0.887 G -68.8 -14.2 133.0 0.887 0.0 GSP
HOH
 9.110
6.950
 OD2
N
 S1G
O
5qqd 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 135.0 0.9 T -104.7 7.5 118.0 0.787 0.113 B:O60229:0.113
 HOH
 2.580
 O
 O
5qqe 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 132.0 0.88 T -102.6 5.8 110.0 0.733 0.147 B:O60229:0.147
 HOH
 2.701
 O
 O
5qqf 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 130.0 0.867 T -103.4 1.8 110.0 0.733 0.134 B:O60229:0.133
 HOH
 2.338
 O
 O
5qqg 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 133.0 0.887 T -98.3 7.5 112.0 0.747 0.14 B:O60229:0.14
 HOH
 2.596
 O
 O
5qqh 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 130.0 0.867 T -103.8 7.0 113.0 0.753 0.114 B:O60229:0.113
 HOH
 2.415
 OD1
 O
5qqi 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 131.0 0.873 T -99.1 6.8 110.0 0.733 0.14 B:O60229:0.14
 HOH
 2.396
 OD1
 O
5qqj 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 133.0 0.887 T -103.0 4.9 112.0 0.747 0.14 B:O60229:0.14
 HOH
 2.315
 OD1
 O
5qqk 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 132.0 0.88 G -102.1 4.0 110.0 0.733 0.147 B:O60229:0.147
 HOH
 2.400
 OD1
 O
5qql 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 130.0 0.867 T -96.8 6.4 110.0 0.733 0.134 B:O60229:0.133
 HOH
 2.451
 OD1
 O
5qqm 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 134.0 0.893 T -99.0 8.1 114.0 0.76 0.133 B:O60229:0.133
 HOH
 2.612
 O
 O
5qqn 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASP A:64 A:63 136.0 0.907 T -98.2 2.7 113.0 0.753 0.154 B:O60229:0.153
 HOH
 2.320
 OD1
 O
5qu9 1 P63000 95.48 2e-127 X-RAY
 2020-01-29 ASP A:64 A:63 135.0 0.9 T -104.3 6.6 121.0 0.807 0.093 B:O60229:0.093
 HOH
 2.573
 OD1
 O
1foe 2 P63000 95.48 3e-127 X-RAY
 2001-01-17 ASP B:63 B:63 122.0 0.813 T -103.2 0.6 120.0 0.8 0.013 A:Q60610:0.013
 SO4
HOH
 9.259
3.837
 OD2
O
 O3
O
ASP D:63 D:63 124.0 0.827 T -100.3 0.8 NA NA NA
ASP F:63 F:63 123.0 0.82 T -101.9 0.4 NA NA NA
ASP H:63 H:63 125.0 0.833 T -100.8 -0.5 NA NA NA
2nz8 1 P63000 95.48 3e-127 X-RAY
 2007-04-10 ASP A:63 A:63 131.0 0.873 T -102.5 5.6 118.0 0.787 0.086 B:O75962:0.087
 HOH
 2.595
 O
 O
3bji 2 P63000 95.48 3e-127 X-RAY
 2008-07-15 ASP C:63 C:63 126.0 0.84 T -88.0 -2.9 NA NA NA
ASP D:63 D:63 122.0 0.813 T -100.9 -0.2 109.0 0.727 0.086 A:P15498:0.087
 HOH
 3.533
 OD2
 O
5o33 1 P63000 95.48 3e-127 X-RAY
 2017-05-31 ASP A:63 A:63 136.0 0.907 T -98.9 6.9 116.0 0.773 0.134 B:P97924:0.133
 HOH
 2.846
 OD2
 O
3su8 1 P63000 95.48 3e-127 X-RAY
 2011-09-28 ASP A:63 A:63 136.0 0.907 G -76.0 -34.9 96.0 0.64 0.267 B:O43157:0.267
 GNP
 9.733
 OD2
 O3G
3sua 1 P63000 95.48 3e-127 X-RAY
 2011-09-07 ASP A:63 A:63 119.0 0.793 G -72.2 -51.9 96.0 0.64 0.153 D:O43157:0.153
 GNP
 9.149
 OD2
 O3G
ASP B:63 B:63 118.0 0.787 G -72.8 -51.7 NA NA NA
ASP C:63 C:63 122.0 0.813 G -72.3 -51.8 NA NA NA
6x1g 2 P63000 95.48 3e-127 X-RAY
 2020-11-25 ASP C:63 B:63 148.0 0.987 G -72.4 -6.2 73.0 0.487 0.5 A:B3CVM3:0.5
 HOH
 2.638
 O
 O
ASP D:63 D:63 143.0 0.953 G -72.3 -3.6 NA NA NA
3b13 2 P63000 94.92 7e-127 X-RAY
 2012-03-14 ASP B:70 B:63 145.0 0.967 G -56.9 -23.7 145.0 0.967 0.0
ASP D:70 D:63 139.0 0.927 G -58.6 -24.5 139.0 0.927 0.0
1ryf 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 ASP A:65 NA:NA DO NA DO DO DO NA NA NA
ASP B:65 NA:NA DO NA DO DO DO NA NA NA
1ryh 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 ASP A:65 NA:NA DO NA DO DO DO NA NA NA
ASP B:65 NA:NA DO NA DO DO DO NA NA NA
7dpa 2 P63000 94.92 1e-126 EM
 2021-08-04 ASP B:70 B:63 107.0 0.713 G -62.9 -30.9 107.0 0.713 0.0
ASP E:70 E:63 107.0 0.713 G -62.9 -30.9 107.0 0.713 0.0
5n6o 1 P63000 95.45 3e-126 X-RAY
 2017-12-27 ASP A:62 A:63 127.0 0.847 G -59.4 -25.8 127.0 0.847 0.0 HOH
 9.059
 C
 O
ASP B:62 B:63 143.0 0.953 G -59.3 -24.5 NA NA NA
6bc1 1 P63000 95.45 5e-126 X-RAY
 2017-12-13 ASP A:63 A:63 134.0 0.893 G -55.7 -21.2 134.0 0.893 0.0 GSP
HOH
 9.180
2.297
 H
O
 S1G
O
ASP C:63 B:63 131.0 0.873 G -61.1 -24.2 NA NA NA
4yon 2 P63000 94.92 5e-126 X-RAY
 2015-07-01 ASP B:65 B:63 131.0 0.873 T -102.1 1.8 114.0 0.76 0.113 A:Q8TCU6:0.113
 HOH
 2.523
 O
 O
3th5 1 P63000 95.45 8e-126 X-RAY
 2012-07-18 ASP A:90 A:63 127.0 0.847 G -58.1 -32.9 127.0 0.847 0.0 GNP
HOH
 9.917
8.789
 N
C
 O1G
O
ASP B:90 B:63 129.0 0.86 G -51.9 -29.6 NA NA NA
3ryt 2 P63000 94.92 1e-125 X-RAY
 2012-01-18 ASP C:66 C:63 144.0 0.96 T -79.1 -20.2 130.0 0.867 0.093 A:P70206:0.093
 GNP
 9.321
 N
 O3G
1he1 2 P15154 95.43 1e-125 X-RAY
 2001-01-02 ASP C:63 C:63 111.0 0.74 G -61.3 -19.7 16.0 0.107 0.633 A:Q51451:0.633
 AF3
HOH
 9.662
2.604
 OD2
OD2
 F1
O
ASP D:63 D:63 113.0 0.753 G -61.2 -22.1 NA NA NA
6agp 1 P63000 93.37 1e-125 NMR
 2019-03-20 CYS A:63 A:63 116.0 0.859 G -62.6 -36.0 116.0 0.859 0.0
3sbd 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 ASP A:73 A:63 139.0 0.927 G -61.5 -18.8 139.0 0.927 0.0 GNP
HOH
 9.644
3.605
 N
OD2
 O3G
O
ASP B:73 B:63 127.0 0.847 G -55.3 -21.1 NA NA NA
3sbe 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 ASP A:73 A:63 119.0 0.793 G -58.7 -27.0 119.0 0.793 0.0 GNP
HOH
 9.564
8.554
 N
C
 O3G
O
7ajk 1 P63000 94.89 3e-125 X-RAY
 2020-11-18 ASP A:66 BBB:63 146.0 0.973 G -88.8 -9.2 146.0 0.973 0.0 GNP
HOH
 9.545
7.660
 N
N
 O1G
O
4gzm 1 P63000 94.89 6e-125 X-RAY
 2012-12-12 ASP A:90 A:63 126.0 0.84 G -63.6 -37.3 126.0 0.84 0.0
ASP B:90 B:63 127.0 0.847 G -63.6 -37.1 NA NA NA
4gzl 1 P63000 94.89 1e-124 X-RAY
 2012-12-12 ASP A:90 A:63 133.0 0.887 G -58.6 -15.8 133.0 0.887 0.0 GNP
HOH
 9.010
2.893
 OD1
O
 O3G
O
ASP B:90 B:63 125.0 0.833 G -54.6 -23.9 NA NA NA
2w2t 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 ASP A:69 A:63 152.0 1.0 G -54.0 -21.0 152.0 1.0 0.0 HOH
 2.546
 OD1
 O
2w2x 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 ASP A:69 A:63 134.0 0.893 G -48.3 -34.9 134.0 0.893 0.0 GSP
HOH
 9.456
4.556
 OD1
O
 S1G
O
ASP B:69 B:63 134.0 0.893 G -47.7 -37.0 NA NA NA
2wkq 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 ASP A:215 A:606 151.0 1.0 G -69.0 -5.0 151.0 1.0 0.0 HOH
 2.628
 O
 O
2wkr 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 ASP A:215 A:606 161.0 1.0 G -66.6 -3.2 161.0 1.0 0.0 HOH
 2.686
 O
 O
2wkp 1 O49003,P63000 92.74 8e-124 X-RAY
 2009-08-18 ASP A:215 A:606 163.0 1.0 G -66.6 -5.8 163.0 1.0 0.0 HOH
 2.532
 O
 O
2w2v 1 P15153 93.22 4e-123 X-RAY
 2009-05-05 ASP A:70 A:63 133.0 0.887 G -56.9 -20.2 133.0 0.887 0.0 HOH
 2.698
 OD1
 O
ASP B:70 B:63 149.0 0.993 G -59.9 -21.4 NA NA NA
ASP C:70 C:63 151.0 1.0 G -63.6 -20.4 NA NA NA
ASP D:70 D:63 132.0 0.88 G -62.1 -17.6 NA NA NA
5hzh 1 P63000,O49003 86.81 4e-90 X-RAY
 2016-12-21 ASP A:215 A:212 132.0 0.88 G -65.6 -21.9 132.0 0.88 0.0 GTP
CA
 9.651
2.583
 N
OD1
 O2G
CA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60763-f1 1 P60763 100.0 5e-144 ASP A:63 A:63 138.0 0.92 G -56.1 -23.8
af-p63000-f1 1 P63000 92.71 8e-135 ASP A:63 A:63 140.0 0.933 G -56.2 -23.0
af-p15153-f1 1 P15153 88.54 7e-130 ASP A:63 A:63 141.0 0.94 G -55.8 -23.1