Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 79990854 . G A CCDS11798.1:NM_005052.2:c.257aGc>aAc_NP_005043.1:p.86S>N Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6tm1 2 P60763 100.0 1e-143 X-RAY
 2020-01-22 SER B:86 A:86 52.0 0.452 -94.1 103.3 52.0 0.452 0.0
2c2h 1 P60763 99.48 3e-142 X-RAY
 2005-10-13 SER A:86 A:86 43.0 0.374 -128.0 88.2 43.0 0.374 0.0 GDP
HOH
 9.743
4.067
 CB
CB
 O4'
O
SER B:86 B:86 49.0 0.426 -128.1 86.6 NA NA NA
1i4d 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 SER C:86 D:86 35.0 0.304 -137.6 93.0 35.0 0.304 0.0 GDP
HOH
 9.304
3.748
 CB
C
 O4'
O
1i4l 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 SER C:86 D:86 27.0 0.235 -119.2 93.8 27.0 0.235 0.0 GDP
HOH
 9.798
7.959
 CB
C
 O4'
O
6tgc 3 P63000 92.71 2e-134 EM
 2020-07-29 SER C:86 C:86 54.0 0.47 S -146.4 96.4 54.0 0.47 0.0
SER F:86 F:86 51.0 0.443 S -146.4 96.4 51.0 0.443 0.0
5fi0 2 P63000 92.71 3e-134 X-RAY
 2016-04-20 SER B:89 B:86 38.0 0.33 -134.5 93.5 38.0 0.33 0.0
SER D:89 D:86 39.0 0.339 -133.3 92.5 NA NA NA
SER F:89 F:86 39.0 0.339 -135.0 93.5 NA NA NA
SER H:89 H:86 42.0 0.365 -137.1 95.8 NA NA NA
1i4t 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 SER C:86 D:86 33.0 0.287 -124.6 90.6 33.0 0.287 0.0 GNP
HOH
 9.603
3.501
 CB
CB
 O4'
O
2vrw 1 P63000 95.65 7e-133 X-RAY
 2008-06-17 SER A:86 A:86 42.0 0.365 -140.5 91.2 42.0 0.365 0.0 HOH
 3.411
 OG
 O
1e96 1 P15154 92.15 4e-132 X-RAY
 2000-11-17 SER A:86 A:86 42.0 0.365 -128.9 90.0 42.0 0.365 0.0 GTP
HOH
 9.730
3.908
 CB
CB
 O4'
O
1hh4 1 P15154 92.15 4e-132 X-RAY
 2001-08-28 SER A:86 A:86 38.0 0.33 -140.2 88.4 38.0 0.33 0.0 GDP
HOH
 9.884
3.735
 CB
OG
 O4'
O
SER B:86 B:86 37.0 0.322 -144.6 86.9 NA NA NA
1g4u 2 P63000 95.11 8e-132 X-RAY
 2001-01-24 SER B:86 R:86 45.0 0.391 -142.2 88.3 45.0 0.391 0.0 HOH
 2.947
 OG
 O
2h7v 1 P63000 95.11 1e-131 X-RAY
 2006-09-19 SER A:90 A:86 42.0 0.365 -151.5 90.8 42.0 0.365 0.0 GDP
HOH
 9.813
6.940
 CB
O
 O4'
O
SER B:90 B:86 41.0 0.357 -155.3 79.0 NA NA NA
2p2l 1 P63000 95.11 1e-131 X-RAY
 2007-05-01 SER A:90 A:86 40.0 0.348 -130.9 91.0 40.0 0.348 0.0 GDP
HOH
 9.645
3.235
 CB
OG
 O4'
O
SER B:90 B:86 41.0 0.357 -128.1 91.6 41.0 0.357 0.0 GDP
HOH
 9.840
2.483
 CB
OG
 O4'
O
SER C:90 C:86 42.0 0.365 -130.7 91.5 42.0 0.365 0.0 GDP
HOH
 9.642
2.866
 CB
OG
 O4'
O
2g0n 1 P60763 100.0 1e-131 X-RAY
 2006-05-30 SER A:87 A:86 44.0 0.383 -131.8 91.0 44.0 0.383 0.0 GDP
HOH
 9.815
4.191
 CB
OG
 O4'
O
SER B:87 B:86 44.0 0.383 -128.5 91.6 NA NA NA
2ov2 1 P60763 100.0 1e-131 X-RAY
 2007-03-13 SER A:87 A:86 43.0 0.374 -131.5 90.5 43.0 0.374 0.0 GCP
HOH
 9.674
3.053
 CB
OG
 O4'
O
SER B:87 F:86 41.0 0.357 -130.8 90.0 NA NA NA
SER C:87 B:86 43.0 0.374 -128.2 88.3 NA NA NA
SER D:87 C:86 43.0 0.374 -128.1 91.2 NA NA NA
SER E:87 G:86 42.0 0.365 -128.1 93.8 NA NA NA
SER F:87 D:86 44.0 0.383 -129.7 94.5 NA NA NA
SER G:87 E:86 41.0 0.357 -132.5 88.7 NA NA NA
SER H:87 H:86 41.0 0.357 -126.7 90.6 NA NA NA
2qme 1 P60763 100.0 1e-131 X-RAY
 2007-08-28 SER A:87 A:86 42.0 0.365 -134.2 88.6 42.0 0.365 0.0 GCP
HOH
 9.902
3.458
 CB
OG
 O4'
O
2ic5 1 P60763 100.0 1e-131 X-RAY
 2006-10-10 SER A:87 A:86 43.0 0.374 -133.3 88.9 43.0 0.374 0.0 GNP
HOH
 9.868
3.800
 CB
OG
 O4'
O
SER B:87 B:86 43.0 0.374 -130.8 87.3 NA NA NA
1mh1 1 P63000 95.08 9e-131 X-RAY
 1998-01-21 SER A:88 A:86 42.0 0.365 -131.8 93.9 42.0 0.365 0.0 HOH
 2.708
 OG
 O
1ds6 1 P15153 88.54 2e-129 X-RAY
 2000-07-12 SER A:86 A:86 39.0 0.339 -137.9 92.9 39.0 0.339 0.0 GDP
HOH
 9.625
3.650
 CB
OG
 O4'
O
2yin 2 P63000 95.48 2e-127 X-RAY
 2011-05-25 SER C:105 C:86 32.0 0.278 -132.4 88.6 NA NA NA
SER D:105 D:86 32.0 0.278 -134.9 92.5 32.0 0.278 0.0
2fju 1 P63000 95.48 2e-127 X-RAY
 2006-11-21 SER A:86 A:86 40.0 0.348 -144.0 88.7 40.0 0.348 0.0 GSP
HOH
 9.977
3.678
 CB
OG
 O4'
O
5qqd 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 25.0 0.217 -128.2 89.3 25.0 0.217 0.0 HOH
 2.388
 OG
 O
5qqe 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 26.0 0.226 -135.3 93.8 26.0 0.226 0.0 HOH
 2.562
 OG
 O
5qqf 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 28.0 0.243 -142.3 88.7 28.0 0.243 0.0 HOH
 2.516
 OG
 O
5qqg 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 26.0 0.226 -136.5 95.2 26.0 0.226 0.0 HOH
 2.524
 OG
 O
5qqh 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 27.0 0.235 -135.6 97.9 27.0 0.235 0.0 N67
HOH
 7.258
2.546
 CB
OG
 C
O
5qqi 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 28.0 0.243 -129.9 101.0 28.0 0.243 0.0 HOH
 2.615
 OG
 O
5qqj 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 26.0 0.226 -128.2 99.2 26.0 0.226 0.0 HOH
 2.585
 OG
 O
5qqk 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 27.0 0.235 -139.6 93.6 27.0 0.235 0.0 HOH
 2.523
 OG
 O
5qql 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 25.0 0.217 -136.2 95.9 25.0 0.217 0.0 HOH
 2.192
 OG
 O
5qqm 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 27.0 0.235 -131.2 100.3 27.0 0.235 0.0 HOH
 2.384
 OG
 O
5qqn 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 SER A:87 A:86 27.0 0.235 -130.4 94.3 27.0 0.235 0.0 HOH
 2.426
 OG
 O
5qu9 1 P63000 95.48 2e-127 X-RAY
 2020-01-29 SER A:87 A:86 27.0 0.235 -131.6 94.0 27.0 0.235 0.0 HOH
 2.550
 OG
 O
1foe 2 P63000 95.48 3e-127 X-RAY
 2001-01-17 SER B:86 B:86 38.0 0.33 -139.3 84.0 38.0 0.33 0.0
SER D:86 D:86 37.0 0.322 -140.0 83.8 NA NA NA
SER F:86 F:86 37.0 0.322 -139.1 84.0 NA NA NA
SER H:86 H:86 38.0 0.33 -138.0 83.3 NA NA NA
2nz8 1 P63000 95.48 3e-127 X-RAY
 2007-04-10 SER A:86 A:86 28.0 0.243 -131.9 92.1 28.0 0.243 0.0 HOH
 3.443
 OG
 O
3bji 2 P63000 95.48 3e-127 X-RAY
 2008-07-15 SER C:86 C:86 38.0 0.33 -143.1 93.0 NA NA NA
SER D:86 D:86 29.0 0.252 -172.8 123.8 29.0 0.252 0.0
5o33 1 P63000 95.48 3e-127 X-RAY
 2017-05-31 SER A:86 A:86 43.0 0.374 -132.0 91.8 43.0 0.374 0.0 GDP
HOH
 9.841
2.522
 CB
OG
 O4'
O
3su8 1 P63000 95.48 3e-127 X-RAY
 2011-09-28 SER A:86 A:86 46.0 0.4 -88.0 111.1 46.0 0.4 0.0 GNP
 9.975
 CB
 O4'
3sua 1 P63000 95.48 3e-127 X-RAY
 2011-09-07 SER A:86 A:86 43.0 0.374 -148.6 121.9 43.0 0.374 0.0
SER B:86 B:86 44.0 0.383 -146.1 120.9 NA NA NA
SER C:86 C:86 44.0 0.383 -148.4 121.9 NA NA NA
6x1g 2 P63000 95.48 3e-127 X-RAY
 2020-11-25 SER C:86 B:86 26.0 0.226 -135.1 95.9 26.0 0.226 0.0 HOH
 4.181
 CB
 O
SER D:86 D:86 41.0 0.357 -131.3 97.9 NA NA NA
3b13 2 P63000 94.92 7e-127 X-RAY
 2012-03-14 SER B:93 B:86 26.0 0.226 -126.3 83.9 26.0 0.226 0.0
SER D:93 D:86 34.0 0.296 -125.3 89.3 34.0 0.296 0.0
1ryf 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 SER A:107 A:105 43.0 0.374 -133.2 93.1 43.0 0.374 0.0 GDP
HOH
 9.960
2.692
 CB
OG
 O4'
O
SER B:107 B:105 41.0 0.357 -134.7 91.0 NA NA NA
1ryh 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 SER A:107 A:105 41.0 0.357 -137.3 87.3 41.0 0.357 0.0 HOH
 2.878
 OG
 O
SER B:107 B:105 40.0 0.348 -133.5 90.2 NA NA NA
7dpa 2 P63000 94.92 1e-126 EM
 2021-08-04 SER B:93 B:86 21.0 0.183 -135.3 114.0 21.0 0.183 0.0
SER E:93 E:86 21.0 0.183 -135.3 114.1 21.0 0.183 0.0
5n6o 1 P63000 95.45 3e-126 X-RAY
 2017-12-27 SER A:85 A:86 37.0 0.322 -128.7 100.0 37.0 0.322 0.0 GDP
HOH
 9.351
3.114
 CB
OG
 H5''
O
SER B:85 B:86 43.0 0.374 -146.9 85.2 NA NA NA
6bc1 1 P63000 95.45 5e-126 X-RAY
 2017-12-13 SER A:86 A:86 45.0 0.391 -134.0 86.1 45.0 0.391 0.0 GSP
HOH
 8.581
2.710
 HB2
HB2
 H5'2
O
SER C:86 B:86 46.0 0.4 -133.1 90.8 NA NA NA
4yon 2 P63000 94.92 5e-126 X-RAY
 2015-07-01 SER B:88 B:86 29.0 0.252 -134.6 93.7 29.0 0.252 0.0 HOH
 2.627
 OG
 O
3th5 1 P63000 95.45 8e-126 X-RAY
 2012-07-18 SER A:113 A:86 41.0 0.357 -140.3 91.1 41.0 0.357 0.0 GNP
HOH
 9.819
6.013
 CB
O
 O4'
O
SER B:113 B:86 44.0 0.383 -121.4 91.8 NA NA NA
3ryt 2 P63000 94.92 1e-125 X-RAY
 2012-01-18 SER C:89 C:86 41.0 0.357 -129.3 79.9 41.0 0.357 0.0
1he1 2 P15154 95.43 1e-125 X-RAY
 2001-01-02 SER C:86 C:86 39.0 0.339 -135.9 90.2 39.0 0.339 0.0 GDP
HOH
 9.915
3.675
 CB
OG
 O4'
O
SER D:86 D:86 40.0 0.348 -135.7 91.3 NA NA NA
6agp 1 P63000 93.37 1e-125 NMR
 2019-03-20 SER A:86 A:86 40.0 0.348 -132.2 103.8 40.0 0.348 0.0 GDP
 8.530
 HB2
 H5'
3sbd 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 SER A:96 A:86 41.0 0.357 -130.3 97.3 41.0 0.357 0.0 GNP
HOH
 9.985
3.326
 CB
OG
 O4'
O
SER B:96 B:86 40.0 0.348 -137.4 90.1 NA NA NA
3sbe 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 SER A:96 A:86 41.0 0.357 -123.4 97.6 41.0 0.357 0.0 GNP
HOH
 9.971
2.954
 CB
OG
 O4'
O
7ajk 1 P63000 94.89 3e-125 X-RAY
 2020-11-18 SER A:89 BBB:86 38.0 0.33 -157.1 81.7 38.0 0.33 0.0 HOH
 6.527
 O
 O
4gzm 1 P63000 94.89 6e-125 X-RAY
 2012-12-12 SER A:113 A:86 42.0 0.365 -90.8 106.1 42.0 0.365 0.0 GSP
 9.596
 CB
 O4'
SER B:113 B:86 42.0 0.365 -91.4 105.8 NA NA NA
4gzl 1 P63000 94.89 1e-124 X-RAY
 2012-12-12 SER A:113 A:86 43.0 0.374 -138.9 91.6 43.0 0.374 0.0 GNP
HOH
 9.815
3.731
 CB
C
 O4'
O
SER B:113 B:86 42.0 0.365 -133.6 91.9 NA NA NA
2w2t 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 SER A:92 A:86 41.0 0.357 -135.0 95.9 41.0 0.357 0.0 GDP
HOH
 9.741
3.541
 CB
OG
 O4'
O
2w2x 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 SER A:92 A:86 54.0 0.47 -163.9 94.5 54.0 0.47 0.0 HOH
 3.663
 OG
 O
SER B:92 B:86 36.0 0.313 -151.2 87.4 NA NA NA
2wkq 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 SER A:238 A:629 43.0 0.374 -131.7 97.9 43.0 0.374 0.0 GTP
CL
HOH
 9.902
3.927
2.613
 CB
CB
OG
 O4'
CL
O
2wkr 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 SER A:238 A:629 43.0 0.374 -131.6 98.1 43.0 0.374 0.0 GTP
CL
HOH
 9.721
3.791
2.803
 CB
CB
OG
 O4'
CL
O
2wkp 1 O49003,P63000 92.74 8e-124 X-RAY
 2009-08-18 SER A:238 A:629 43.0 0.374 -131.0 95.5 43.0 0.374 0.0 GTP
HOH
 9.986
2.656
 CB
OG
 O4'
O
2w2v 1 P15153 93.22 4e-123 X-RAY
 2009-05-05 SER A:93 A:86 38.0 0.33 -150.5 93.0 38.0 0.33 0.0 GTP
HOH
 9.781
3.491
 CB
OG
 O4'
O
SER B:93 B:86 37.0 0.322 -141.0 93.7 NA NA NA
SER C:93 C:86 35.0 0.304 -147.4 99.7 NA NA NA
SER D:93 D:86 36.0 0.313 -131.4 92.3 NA NA NA
5hzh 1 P63000,O49003 86.81 4e-90 X-RAY
 2016-12-21 SER A:238 A:235 41.0 0.357 -138.9 92.9 41.0 0.357 0.0 GTP
HOH
 9.600
6.752
 CB
O
 O4'
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60763-f1 1 P60763 100.0 5e-144 SER A:86 A:86 43.0 0.374 -130.6 89.5
af-p63000-f1 1 P63000 92.71 8e-135 SER A:86 A:86 43.0 0.374 -131.0 89.1
af-p15153-f1 1 P15153 88.54 7e-130 SER A:86 A:86 43.0 0.374 -129.3 90.9