Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 79990873 . T A CCDS11798.1:NM_005052.2:c.276aaT>aaA_NP_005043.1:p.92N>K Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6tm1 2 P60763 100.0 1e-143 X-RAY
 2020-01-22 ASN B:92 A:92 43.0 NA H -84.5 -1.3 43.0 NA NA
2c2h 1 P60763 99.48 3e-142 X-RAY
 2005-10-13 ASN A:92 A:92 52.0 0.325 H -71.0 -17.4 52.0 0.325 0.0 HOH
 4.267
 ND2
 O
ASN B:92 B:92 48.0 0.3 H -69.0 -18.2 NA NA NA
1i4d 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 ASN C:92 D:92 49.0 0.306 H -59.9 -17.0 49.0 0.306 0.0 HOH
 7.280
 ND2
 O
1i4l 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 ASN C:92 D:92 54.0 0.338 H -63.3 -8.6 54.0 0.338 0.0 HOH
 8.117
 O
 O
6tgc 3 P63000 92.71 2e-134 EM
 2020-07-29 ASN C:92 C:92 60.0 0.375 H -43.3 -18.8 60.0 0.375 0.0
ASN F:92 F:92 61.0 0.381 H -43.4 -18.6 61.0 0.381 0.0
5fi0 2 P63000 92.71 3e-134 X-RAY
 2016-04-20 ASN B:95 B:92 44.0 0.275 H -65.6 -12.6 44.0 0.275 0.0
ASN D:95 D:92 50.0 0.312 H -66.8 -12.2 NA NA NA
ASN F:95 F:92 51.0 0.319 H -64.4 -10.6 NA NA NA
ASN H:95 H:92 56.0 0.35 H -64.8 -9.8 NA NA NA
1i4t 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 ASN C:92 D:92 53.0 0.331 H -65.2 -12.0 53.0 0.331 0.0 HOH
 7.571
 ND2
 O
2vrw 1 P63000 95.65 7e-133 X-RAY
 2008-06-17 ASN A:92 A:92 54.0 0.338 H -66.0 -20.8 54.0 0.338 0.0 HOH
 3.172
 OD1
 O
1e96 1 P15154 92.15 4e-132 X-RAY
 2000-11-17 ASN A:92 A:92 55.0 0.344 H -71.2 -7.5 55.0 0.344 0.0 HOH
 4.609
 CB
 O
1hh4 1 P15154 92.15 4e-132 X-RAY
 2001-08-28 ASN A:92 A:92 57.0 0.356 H -69.8 -2.1 57.0 0.356 0.0 HOH
 9.145
 N
 O
ASN B:92 B:92 46.0 0.287 H -74.5 -6.1 NA NA NA
1g4u 2 P63000 95.11 8e-132 X-RAY
 2001-01-24 ASN B:92 R:92 56.0 0.35 H -71.7 -0.9 56.0 0.35 0.0 HOH
 3.346
 ND2
 O
2h7v 1 P63000 95.11 1e-131 X-RAY
 2006-09-19 ASN A:96 A:92 51.0 0.319 H -72.1 -11.5 51.0 0.319 0.0 HOH
 4.327
 CB
 O
ASN B:96 B:92 54.0 0.338 H -77.1 -13.9 NA NA NA
2p2l 1 P63000 95.11 1e-131 X-RAY
 2007-05-01 ASN A:96 A:92 50.0 0.312 H -67.0 -16.2 50.0 0.312 0.0 HOH
 2.687
 OD1
 O
ASN B:96 B:92 49.0 0.306 H -71.8 -13.9 49.0 0.306 0.0 HOH
 2.776
 OD1
 O
ASN C:96 C:92 50.0 0.312 H -70.0 -14.0 50.0 0.312 0.0 HOH
 2.655
 OD1
 O
2g0n 1 P60763 100.0 1e-131 X-RAY
 2006-05-30 ASN A:93 A:92 53.0 0.331 H -65.7 -18.8 53.0 0.331 0.0 HOH
 2.807
 OD1
 O
ASN B:93 B:92 50.0 0.312 H -69.9 -13.6 NA NA NA
2ov2 1 P60763 100.0 1e-131 X-RAY
 2007-03-13 ASN A:93 A:92 51.0 0.319 H -75.2 -13.3 51.0 0.319 0.0 HOH
 3.461
 OD1
 O
ASN B:93 F:92 55.0 0.344 H -72.7 -16.3 NA NA NA
ASN C:93 B:92 53.0 0.331 H -69.3 -14.1 NA NA NA
ASN D:93 C:92 54.0 0.338 H -72.3 -14.8 NA NA NA
ASN E:93 G:92 53.0 0.331 H -72.6 -19.6 NA NA NA
ASN F:93 D:92 52.0 0.325 H -70.5 -15.6 NA NA NA
ASN G:93 E:92 53.0 0.331 H -68.2 -16.2 NA NA NA
ASN H:93 H:92 55.0 0.344 H -69.9 -15.9 NA NA NA
2qme 1 P60763 100.0 1e-131 X-RAY
 2007-08-28 ASN A:93 A:92 54.0 0.338 H -71.2 -15.2 54.0 0.338 0.0 HOH
 2.458
 OD1
 O
2ic5 1 P60763 100.0 1e-131 X-RAY
 2006-10-10 ASN A:93 A:92 53.0 0.331 H -66.7 -19.5 53.0 0.331 0.0 HOH
 3.507
 ND2
 O
ASN B:93 B:92 50.0 0.312 H -69.0 -16.5 NA NA NA
1mh1 1 P63000 95.08 9e-131 X-RAY
 1998-01-21 ASN A:94 A:92 53.0 0.331 H -64.4 -17.8 53.0 0.331 0.0 HOH
 2.798
 OD1
 O
1ds6 1 P15153 88.54 2e-129 X-RAY
 2000-07-12 ASN A:92 A:92 53.0 0.331 H -67.4 -21.5 53.0 0.331 0.0 HOH
 4.344
 CB
 O
2yin 2 P63000 95.48 2e-127 X-RAY
 2011-05-25 ASN C:111 C:92 54.0 0.338 H -67.7 -16.9 NA NA NA
ASN D:111 D:92 53.0 0.331 H -65.1 -21.5 53.0 0.331 0.0
2fju 1 P63000 95.48 2e-127 X-RAY
 2006-11-21 ASN A:92 A:92 51.0 0.319 H -68.9 -16.4 51.0 0.319 0.0 HOH
 3.508
 ND2
 O
5qqd 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 48.0 0.3 H -67.1 -21.0 48.0 0.3 0.0 HOH
 2.814
 OD1
 O
5qqe 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 49.0 0.306 H -70.1 -20.7 49.0 0.306 0.0 HOH
 2.862
 OD1
 O
5qqf 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 50.0 0.312 H -65.5 -18.6 50.0 0.312 0.0 HOH
 2.705
 OD1
 O
5qqg 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 50.0 0.312 H -66.1 -18.8 50.0 0.312 0.0 HOH
 3.031
 ND2
 O
5qqh 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 48.0 0.3 H -73.2 -17.0 48.0 0.3 0.0 HOH
 3.008
 OD1
 O
5qqi 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 47.0 0.294 H -67.1 -12.0 47.0 0.294 0.0 HOH
 2.973
 ND2
 O
5qqj 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 47.0 0.294 H -70.6 -21.9 47.0 0.294 0.0 HOH
 3.100
 ND2
 O
5qqk 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 47.0 0.294 H -70.2 -20.6 47.0 0.294 0.0 HOH
 2.931
 ND2
 O
5qql 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 48.0 0.3 H -67.4 -22.8 48.0 0.3 0.0 HOH
 2.960
 ND2
 O
5qqm 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 48.0 0.3 H -66.7 -19.4 48.0 0.3 0.0 HOH
 2.933
 OD1
 O
5qqn 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ASN A:93 A:92 48.0 0.3 H -73.0 -16.2 48.0 0.3 0.0 HOH
 2.809
 ND2
 O
5qu9 1 P63000 95.48 2e-127 X-RAY
 2020-01-29 ASN A:93 A:92 50.0 0.312 H -69.8 -15.6 50.0 0.312 0.0 HOH
 2.881
 OD1
 O
1foe 2 P63000 95.48 3e-127 X-RAY
 2001-01-17 ASN B:92 B:92 48.0 0.3 H -66.9 -21.7 48.0 0.3 0.0
ASN D:92 D:92 48.0 0.3 H -63.2 -20.3 NA NA NA
ASN F:92 F:92 48.0 0.3 H -63.6 -19.3 NA NA NA
ASN H:92 H:92 48.0 0.3 H -66.6 -19.7 NA NA NA
2nz8 1 P63000 95.48 3e-127 X-RAY
 2007-04-10 ASN A:92 A:92 51.0 0.319 H -70.0 -17.6 51.0 0.319 0.0 HOH
 3.762
 OD1
 O
3bji 2 P63000 95.48 3e-127 X-RAY
 2008-07-15 ASN C:92 C:92 53.0 0.331 H -65.7 -27.6 NA NA NA
ASN D:92 D:92 56.0 0.35 H -56.9 -24.1 56.0 0.35 0.0
5o33 1 P63000 95.48 3e-127 X-RAY
 2017-05-31 ASN A:92 A:92 52.0 0.325 H -68.9 -16.7 52.0 0.325 0.0 HOH
 2.733
 OD1
 O
3su8 1 P63000 95.48 3e-127 X-RAY
 2011-09-28 ASN A:92 A:92 51.0 0.319 H -69.5 -13.5 51.0 0.319 0.0
3sua 1 P63000 95.48 3e-127 X-RAY
 2011-09-07 ASN A:92 A:92 59.0 0.369 H -70.9 -6.9 59.0 0.369 0.0
ASN B:92 B:92 58.0 0.362 H -71.2 -7.0 NA NA NA
ASN C:92 C:92 58.0 0.362 H -71.0 -7.0 NA NA NA
6x1g 2 P63000 95.48 3e-127 X-RAY
 2020-11-25 ASN C:92 B:92 52.0 0.325 H -68.2 -19.2 52.0 0.325 0.0 HOH
 3.421
 OD1
 O
ASN D:92 D:92 51.0 0.319 H -67.1 -19.5 NA NA NA
3b13 2 P63000 94.92 7e-127 X-RAY
 2012-03-14 ASN B:99 B:92 50.0 0.312 H -72.1 -10.5 50.0 0.312 0.0
ASN D:99 D:92 52.0 0.325 H -62.7 -19.0 52.0 0.325 0.0
1ryf 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 ASN A:113 A:111 53.0 0.331 H -67.2 -15.2 53.0 0.331 0.0 HOH
 2.467
 OD1
 O
ASN B:113 B:111 49.0 0.306 H -70.1 -15.6 NA NA NA
1ryh 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 ASN A:113 A:111 54.0 0.338 H -65.3 -20.6 54.0 0.338 0.0 HOH
 2.358
 OD1
 O
ASN B:113 B:111 49.0 0.306 H -68.9 -18.1 NA NA NA
7dpa 2 P63000 94.92 1e-126 EM
 2021-08-04 ASN B:99 B:92 61.0 0.381 H -64.0 -32.8 61.0 0.381 0.0
ASN E:99 E:92 61.0 0.381 H -64.0 -32.8 61.0 0.381 0.0
5n6o 1 P63000 95.45 3e-126 X-RAY
 2017-12-27 ASN A:91 A:92 47.0 0.294 H -67.2 -13.3 47.0 0.294 0.0 HOH
 4.487
 ND2
 O
ASN B:91 B:92 55.0 0.344 H -69.3 -11.9 NA NA NA
6bc1 1 P63000 95.45 5e-126 X-RAY
 2017-12-13 ASN A:92 A:92 51.0 0.319 H -73.6 -10.4 51.0 0.319 0.0 HOH
 2.104
 OD1
 O
ASN C:92 B:92 51.0 0.319 H -80.7 -5.9 NA NA NA
4yon 2 P63000 94.92 5e-126 X-RAY
 2015-07-01 ASN B:94 B:92 49.0 0.306 H -69.2 -17.1 49.0 0.306 0.0 HOH
 2.664
 OD1
 O
3th5 1 P63000 95.45 8e-126 X-RAY
 2012-07-18 ASN A:119 A:92 52.0 0.325 H -70.7 -11.9 52.0 0.325 0.0 HOH
 4.755
 CB
 O
ASN B:119 B:92 53.0 0.331 H -56.1 -16.7 NA NA NA
3ryt 2 P63000 94.92 1e-125 X-RAY
 2012-01-18 ASN C:95 C:92 62.0 0.388 H -74.3 -1.6 62.0 0.388 0.0
1he1 2 P15154 95.43 1e-125 X-RAY
 2001-01-02 ASN C:92 C:92 54.0 0.338 H -68.4 -16.7 54.0 0.338 0.0 HOH
 2.527
 OD1
 O
ASN D:92 D:92 54.0 0.338 H -66.9 -16.0 NA NA NA
6agp 1 P63000 93.37 1e-125 NMR
 2019-03-20 ASN A:92 A:92 55.0 0.344 H -66.5 -25.0 55.0 0.344 0.0
3sbd 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 ASN A:102 A:92 49.0 0.306 H -61.7 -18.6 49.0 0.306 0.0 HOH
 4.416
 ND2
 O
ASN B:102 B:92 50.0 0.312 H -65.0 -21.1 NA NA NA
3sbe 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 ASN A:102 A:92 52.0 0.325 H -56.5 -12.3 52.0 0.325 0.0 HOH
 4.930
 CB
 O
7ajk 1 P63000 94.89 3e-125 X-RAY
 2020-11-18 ASN A:95 BBB:92 50.0 0.312 H -54.1 -21.6 50.0 0.312 0.0 HOH
 4.523
 CB
 O
4gzm 1 P63000 94.89 6e-125 X-RAY
 2012-12-12 ASN A:119 A:92 52.0 0.325 H -62.1 -12.0 52.0 0.325 0.0
ASN B:119 B:92 52.0 0.325 H -61.2 -11.7 NA NA NA
4gzl 1 P63000 94.89 1e-124 X-RAY
 2012-12-12 ASN A:119 A:92 48.0 0.3 H -64.7 -17.9 48.0 0.3 0.0 HOH
 3.411
 ND2
 O
ASN B:119 B:92 47.0 0.294 H -68.0 -18.3 NA NA NA
2w2t 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 ASN A:98 A:92 49.0 0.306 H -72.9 -13.4 49.0 0.306 0.0 HOH
 2.712
 OD1
 O
2w2x 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 ASN A:98 A:92 56.0 0.35 H -57.5 -27.3 56.0 0.35 0.0 HOH
 4.657
 ND2
 O
ASN B:98 B:92 57.0 0.356 H -60.2 -23.7 NA NA NA
2wkq 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 HIS A:244 A:635 75.0 0.385 H -68.1 -20.4 75.0 0.385 0.0 HOH
 3.369
 CD2
 O
2wkr 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 HIS A:244 A:635 76.0 0.39 H -63.0 -22.7 76.0 0.39 0.0 HOH
 3.573
 CD2
 O
2wkp 1 O49003,P63000 92.74 8e-124 X-RAY
 2009-08-18 HIS A:244 A:635 77.0 0.395 H -69.9 -16.7 77.0 0.395 0.0 HOH
 3.441
 ND1
 O
2w2v 1 P15153 93.22 4e-123 X-RAY
 2009-05-05 ASN A:99 A:92 56.0 0.35 H -61.9 -14.4 56.0 0.35 0.0 HOH
 4.730
 CB
 O
ASN B:99 B:92 53.0 0.331 H -60.8 -11.3 NA NA NA
ASN C:99 C:92 52.0 0.325 H -70.4 -9.1 NA NA NA
ASN D:99 D:92 56.0 0.35 H -66.7 -8.8 NA NA NA
5hzh 1 P63000,O49003 86.81 4e-90 X-RAY
 2016-12-21 ASN A:244 A:241 52.0 0.325 H -70.4 -17.0 52.0 0.325 0.0 HOH
 4.606
 CB
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60763-f1 1 P60763 100.0 5e-144 ASN A:92 A:92 52.0 0.325 H -66.7 -16.4
af-p63000-f1 1 P63000 92.71 8e-135 ASN A:92 A:92 53.0 0.331 H -64.6 -19.2
af-p15153-f1 1 P15153 88.54 7e-130 ASN A:92 A:92 55.0 0.344 H -66.9 -17.4