Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 79991375 . G A CCDS11798.1:NM_005052.2:c.348aaG>aaA_NP_005043.1:p.116K>K Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6tm1 2 P60763 100.0 1e-143 X-RAY
 2020-01-22 LYS B:116 A:116 16.0 NA 54.1 57.7 16.0 NA NA
2c2h 1 P60763 99.48 3e-142 X-RAY
 2005-10-13 LYS A:116 A:116 71.0 0.355 67.5 39.1 71.0 0.355 0.0 GDP
GDP
HOH
 3.134
7.635
2.820
 NZ
O
N
 O4'
O2A
O
LYS B:116 B:116 66.0 0.33 59.2 37.8 NA NA NA
1i4d 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 LYS C:116 D:116 75.0 0.375 58.6 35.6 75.0 0.375 0.0 GDP
HOH
 2.851
4.977
 NZ
NZ
 O4'
O
1i4l 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 LYS C:116 D:116 74.0 0.37 72.3 69.2 74.0 0.37 0.0 GDP
HOH
 2.982
2.792
 NZ
CB
 O4'
O
6tgc 3 P63000 92.71 2e-134 EM
 2020-07-29 LYS C:116 C:116 54.0 0.27 56.1 18.8 54.0 0.27 0.0
LYS F:116 F:116 54.0 0.27 56.0 18.9 54.0 0.27 0.0
5fi0 2 P63000 92.71 3e-134 X-RAY
 2016-04-20 LYS B:119 B:116 59.0 0.295 53.3 39.2 59.0 0.295 0.0
LYS D:119 D:116 65.0 0.325 51.8 40.6 NA NA NA
LYS F:119 F:116 70.0 0.35 54.0 38.1 NA NA NA
LYS H:119 H:116 62.0 0.31 52.2 41.2 NA NA NA
1i4t 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 LYS C:116 D:116 76.0 0.38 79.1 67.3 76.0 0.38 0.0 GNP
HOH
 3.004
6.241
 NZ
CD
 O4'
O
2vrw 1 P63000 95.65 7e-133 X-RAY
 2008-06-17 LYS A:116 A:116 64.0 0.32 61.4 39.3 64.0 0.32 0.0 HOH
 2.685
 NZ
 O
1e96 1 P15154 92.15 4e-132 X-RAY
 2000-11-17 LYS A:116 A:116 70.0 0.35 61.6 37.4 70.0 0.35 0.0 GTP
HOH
 3.136
2.807
 NZ
N
 O4'
O
1hh4 1 P15154 92.15 4e-132 X-RAY
 2001-08-28 LYS A:116 A:116 64.0 0.32 58.7 34.9 64.0 0.32 0.0 GDP
HOH
 3.407
6.877
 NZ
C
 O4'
O
LYS B:116 B:116 63.0 0.315 53.2 35.4 NA NA NA
1g4u 2 P63000 95.11 8e-132 X-RAY
 2001-01-24 LYS B:116 R:116 72.0 0.36 60.7 43.6 52.0 0.26 0.1 A:P74873:0.1
 GDP
AF3
HOH
 3.054
9.691
3.057
 NZ
NZ
N
 O4'
F3
O
2h7v 1 P63000 95.11 1e-131 X-RAY
 2006-09-19 LYS A:120 A:116 66.0 0.33 65.1 45.2 66.0 0.33 0.0 GDP
 3.353
 CE
 O4'
LYS B:120 B:116 70.0 0.35 57.8 40.5 NA NA NA
2p2l 1 P63000 95.11 1e-131 X-RAY
 2007-05-01 LYS A:120 A:116 68.0 0.34 55.2 42.9 68.0 0.34 0.0 GDP
HOH
 2.963
2.837
 NZ
NZ
 O4'
O
LYS B:120 B:116 71.0 0.355 57.5 42.3 71.0 0.355 0.0 GDP
HOH
 2.916
2.908
 NZ
NZ
 O4'
O
LYS C:120 C:116 69.0 0.345 61.1 40.1 69.0 0.345 0.0 GDP
HOH
 2.983
2.936
 NZ
NZ
 O4'
O
2g0n 1 P60763 100.0 1e-131 X-RAY
 2006-05-30 LYS A:117 A:116 72.0 0.36 55.2 41.6 72.0 0.36 0.0 GDP
HOH
 3.037
2.779
 NZ
NZ
 O4'
O
LYS B:117 B:116 70.0 0.35 61.5 38.5 NA NA NA
2ov2 1 P60763 100.0 1e-131 X-RAY
 2007-03-13 LYS A:117 A:116 66.0 0.33 62.3 40.2 66.0 0.33 0.0 GCP
HOH
 3.076
3.069
 NZ
NZ
 O4'
O
LYS B:117 F:116 67.0 0.335 62.7 38.0 NA NA NA
LYS C:117 B:116 68.0 0.34 66.1 42.4 NA NA NA
LYS D:117 C:116 66.0 0.33 63.8 38.7 NA NA NA
LYS E:117 G:116 70.0 0.35 59.6 45.7 NA NA NA
LYS F:117 D:116 69.0 0.345 60.2 37.6 NA NA NA
LYS G:117 E:116 69.0 0.345 58.4 41.8 NA NA NA
LYS H:117 H:116 67.0 0.335 63.7 38.7 NA NA NA
2qme 1 P60763 100.0 1e-131 X-RAY
 2007-08-28 LYS A:117 A:116 69.0 0.345 62.6 37.2 69.0 0.345 0.0 GCP
HOH
 3.037
2.836
 NZ
NZ
 O4'
O
2ic5 1 P60763 100.0 1e-131 X-RAY
 2006-10-10 LYS A:117 A:116 70.0 0.35 57.4 37.1 70.0 0.35 0.0 GNP
HOH
 3.152
2.989
 NZ
N
 O4'
O
LYS B:117 B:116 69.0 0.345 59.9 41.7 NA NA NA
1mh1 1 P63000 95.08 9e-131 X-RAY
 1998-01-21 LYS A:118 A:116 68.0 0.34 58.9 41.9 68.0 0.34 0.0 GNP
HOH
 3.125
2.935
 NZ
N
 O4'
O
1ds6 1 P15153 88.54 2e-129 X-RAY
 2000-07-12 LYS A:116 A:116 71.0 0.355 58.8 44.3 71.0 0.355 0.0 GDP
HOH
 2.946
2.937
 NZ
NZ
 O4'
O
2yin 2 P63000 95.48 2e-127 X-RAY
 2011-05-25 LYS C:135 C:116 63.0 0.315 50.6 44.5 NA NA NA
LYS D:135 D:116 62.0 0.31 44.1 42.3 62.0 0.31 0.0 HOH
 2.887
 N
 O
2fju 1 P63000 95.48 2e-127 X-RAY
 2006-11-21 LYS A:116 A:116 65.0 0.325 58.8 40.4 65.0 0.325 0.0 GSP
HOH
 3.275
2.790
 NZ
NZ
 O4'
O
5qqd 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 70.0 0.35 61.0 35.7 70.0 0.35 0.0 JGA
HOH
 3.132
2.983
 N
NZ
 N11
O
5qqe 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 69.0 0.345 68.5 36.4 69.0 0.345 0.0 N5S
HOH
 3.199
3.186
 N
NZ
 N2
O
5qqf 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 69.0 0.345 59.2 40.7 69.0 0.345 0.0 N5V
HOH
 3.193
3.210
 N
NZ
 N2
O
5qqg 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 71.0 0.355 62.5 36.2 71.0 0.355 0.0 N64
HOH
 3.328
3.556
 N
NZ
 N4
O
5qqh 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 69.0 0.345 61.1 37.4 69.0 0.345 0.0 N67
HOH
 3.148
3.334
 N
NZ
 N3
O
5qqi 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 66.0 0.33 59.4 40.3 66.0 0.33 0.0 N6D
HOH
 3.193
3.234
 N
NZ
 N2
O
5qqj 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 73.0 0.365 63.7 35.6 73.0 0.365 0.0 N6J
HOH
 3.103
2.873
 N
NZ
 N6
O
5qqk 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 71.0 0.355 57.7 40.9 71.0 0.355 0.0 N6V
HOH
 3.208
2.924
 N
NZ
 N4
O
5qql 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 70.0 0.35 62.1 42.2 70.0 0.35 0.0 N71
HOH
 3.218
3.466
 N
NZ
 O3
O
5qqm 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 68.0 0.34 69.6 33.1 68.0 0.34 0.0 N74
HOH
 3.257
3.077
 N
NZ
 N4
O
5qqn 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 LYS A:117 A:116 70.0 0.35 63.5 38.9 70.0 0.35 0.0 N5D
HOH
 3.331
3.186
 N
NZ
 C2
O
5qu9 1 P63000 95.48 2e-127 X-RAY
 2020-01-29 LYS A:117 A:116 72.0 0.36 59.5 37.8 72.0 0.36 0.0 EDO
HOH
 9.945
2.869
 O
NZ
 O1
O
1foe 2 P63000 95.48 3e-127 X-RAY
 2001-01-17 LYS B:116 B:116 64.0 0.32 59.5 34.1 64.0 0.32 0.0 SO4
HOH
 6.348
3.944
 CE
CD
 O4
O
LYS D:116 D:116 64.0 0.32 58.6 32.9 NA NA NA
LYS F:116 F:116 63.0 0.315 59.9 34.3 NA NA NA
LYS H:116 H:116 63.0 0.315 60.0 34.0 NA NA NA
2nz8 1 P63000 95.48 3e-127 X-RAY
 2007-04-10 LYS A:116 A:116 65.0 0.325 56.2 40.2 65.0 0.325 0.0 HOH
 2.883
 N
 O
3bji 2 P63000 95.48 3e-127 X-RAY
 2008-07-15 LYS C:116 C:116 60.0 0.3 59.0 39.9 NA NA NA
LYS D:116 D:116 81.0 0.405 65.0 63.2 81.0 0.405 0.0 HOH
 8.785
 C
 O
5o33 1 P63000 95.48 3e-127 X-RAY
 2017-05-31 LYS A:116 A:116 73.0 0.365 56.4 41.4 73.0 0.365 0.0 EDO
GDP
HOH
 9.854
3.031
2.955
 O
NZ
NZ
 HO1
O4'
O
3su8 1 P63000 95.48 3e-127 X-RAY
 2011-09-28 LYS A:116 A:116 68.0 0.34 62.7 69.8 68.0 0.34 0.0 GNP
 3.343
 NZ
 O4'
3sua 1 P63000 95.48 3e-127 X-RAY
 2011-09-07 LYS A:116 A:116 64.0 0.32 65.5 47.5 64.0 0.32 0.0 GNP
 3.411
 CE
 O4'
LYS B:116 B:116 63.0 0.315 65.3 47.0 NA NA NA
LYS C:116 C:116 65.0 0.325 65.5 47.7 NA NA NA
6x1g 2 P63000 95.48 3e-127 X-RAY
 2020-11-25 LYS C:116 B:116 61.0 0.305 60.3 31.1 61.0 0.305 0.0 HOH
 2.887
 N
 O
LYS D:116 D:116 64.0 0.32 62.4 32.2 NA NA NA
3b13 2 P63000 94.92 7e-127 X-RAY
 2012-03-14 LYS B:123 B:116 60.0 0.3 53.1 31.2 60.0 0.3 0.0
LYS D:123 D:116 73.0 0.365 55.4 29.5 73.0 0.365 0.0
1ryf 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 LYS A:137 A:135 71.0 0.355 58.0 41.6 71.0 0.355 0.0 GDP
HOH
 3.081
2.934
 NZ
NZ
 O4'
O
LYS B:137 B:135 71.0 0.355 59.4 39.1 NA NA NA
1ryh 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 LYS A:137 A:135 71.0 0.355 63.0 39.6 71.0 0.355 0.0 GNP
HOH
 3.151
2.928
 NZ
NZ
 O4'
O
LYS B:137 B:135 69.0 0.345 64.1 41.3 NA NA NA
7dpa 2 P63000 94.92 1e-126 EM
 2021-08-04 LYS B:123 B:116 52.0 0.26 57.2 48.0 52.0 0.26 0.0
LYS E:123 E:116 53.0 0.265 57.3 47.9 53.0 0.265 0.0
5n6o 1 P63000 95.45 3e-126 X-RAY
 2017-12-27 LYS A:115 A:116 68.0 0.34 58.3 40.6 68.0 0.34 0.0 GDP
HOH
 2.853
6.675
 NZ
C
 O4'
O
LYS B:115 B:116 72.0 0.36 58.4 37.1 NA NA NA
6bc1 1 P63000 95.45 5e-126 X-RAY
 2017-12-13 LYS A:116 A:116 67.0 0.335 55.6 51.0 67.0 0.335 0.0 GSP
HOH
 2.526
2.375
 HE2
HZ2
 O4'
O
LYS C:116 B:116 66.0 0.33 50.5 54.2 NA NA NA
4yon 2 P63000 94.92 5e-126 X-RAY
 2015-07-01 LYS B:118 B:116 60.0 0.3 58.5 37.7 60.0 0.3 0.0 HOH
 2.982
 NZ
 O
3th5 1 P63000 95.45 8e-126 X-RAY
 2012-07-18 LYS A:143 A:116 67.0 0.335 59.0 38.9 67.0 0.335 0.0 GNP
HOH
 3.359
6.887
 CE
C
 O4'
O
LYS B:143 B:116 69.0 0.345 60.7 38.7 NA NA NA
3ryt 2 P63000 94.92 1e-125 X-RAY
 2012-01-18 LYS C:119 C:116 73.0 0.365 57.5 52.0 73.0 0.365 0.0 GNP
 3.369
 CA
 O6
1he1 2 P15154 95.43 1e-125 X-RAY
 2001-01-02 LYS C:116 C:116 70.0 0.35 59.1 38.8 51.0 0.255 0.095 A:Q51451:0.095
 GDP
AF3
HOH
 3.349
9.604
2.858
 NZ
NZ
NZ
 O4'
F1
O
LYS D:116 D:116 70.0 0.35 56.1 43.4 NA NA NA
6agp 1 P63000 93.37 1e-125 NMR
 2019-03-20 LYS A:116 A:116 70.0 0.35 64.6 43.0 70.0 0.35 0.0 GDP
MG
 2.317
9.580
 HZ1
HZ3
 O4'
MG
3sbd 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 LYS A:126 A:116 72.0 0.36 62.8 32.9 72.0 0.36 0.0 GNP
HOH
 3.214
3.050
 NZ
N
 O4'
O
LYS B:126 B:116 73.0 0.365 61.0 35.9 NA NA NA
3sbe 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 LYS A:126 A:116 66.0 0.33 72.1 27.2 66.0 0.33 0.0 GNP
HOH
 3.225
5.284
 CE
NZ
 O4'
O
7ajk 1 P63000 94.89 3e-125 X-RAY
 2020-11-18 LYS A:119 BBB:116 73.0 0.365 50.7 59.8 73.0 0.365 0.0 GNP
HOH
 3.356
6.025
 CA
C
 O6
O
4gzm 1 P63000 94.89 6e-125 X-RAY
 2012-12-12 LYS A:143 A:116 65.0 0.325 51.0 51.8 65.0 0.325 0.0 GSP
 3.802
 CE
 O4'
LYS B:143 B:116 63.0 0.315 51.0 51.3 NA NA NA
4gzl 1 P63000 94.89 1e-124 X-RAY
 2012-12-12 LYS A:143 A:116 75.0 0.375 52.9 44.9 75.0 0.375 0.0 GNP
IPA
HOH
 3.006
6.765
3.021
 NZ
C
N
 O4'
O2
O
LYS B:143 B:116 69.0 0.345 57.3 38.1 NA NA NA
2w2t 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 LYS A:122 A:116 69.0 0.345 57.5 32.7 69.0 0.345 0.0 GDP
HOH
 2.999
2.871
 NZ
N
 O4'
O
2w2x 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 LYS A:122 A:116 61.0 0.305 68.3 30.6 61.0 0.305 0.0 GSP
HOH
 3.186
9.037
 NZ
NZ
 O4'
O
LYS B:122 B:116 20.0 NA 70.8 32.1 NA NA NA
2wkq 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 LYS A:268 A:659 67.0 0.335 60.3 39.2 67.0 0.335 0.0 GTP
CL
CL
HOH
 3.202
3.089
6.621
2.857
 NZ
NZ
C
N
 O4'
CL
CL
O
2wkr 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 LYS A:268 A:659 67.0 0.335 58.8 43.3 67.0 0.335 0.0 GTP
CL
CL
HOH
 3.068
6.675
3.173
2.907
 NZ
C
NZ
N
 O4'
CL
CL
O
2wkp 1 O49003,P63000 92.74 8e-124 X-RAY
 2009-08-18 LYS A:268 A:659 69.0 0.345 59.8 37.7 69.0 0.345 0.0 GTP
HOH
 3.276
2.824
 NZ
NZ
 O4'
O
2w2v 1 P15153 93.22 4e-123 X-RAY
 2009-05-05 LYS A:123 A:116 68.0 0.34 56.8 39.7 68.0 0.34 0.0 GTP
HOH
 2.785
2.644
 NZ
N
 O4'
O
LYS B:123 B:116 68.0 0.34 59.1 35.6 NA NA NA
LYS C:123 C:116 64.0 0.32 60.0 35.2 NA NA NA
LYS D:123 D:116 71.0 0.355 62.6 36.4 NA NA NA
5hzh 1 P63000,O49003 86.81 4e-90 X-RAY
 2016-12-21 LYS A:268 A:265 60.0 0.3 59.3 51.6 60.0 0.3 0.0 GTP
HOH
 3.281
3.278
 CE
N
 O4'
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60763-f1 1 P60763 100.0 5e-144 LYS A:116 A:116 67.0 0.335 59.2 40.4
af-p63000-f1 1 P63000 92.71 8e-135 LYS A:116 A:116 67.0 0.335 59.5 40.3
af-p15153-f1 1 P15153 88.54 7e-130 LYS A:116 A:116 67.0 0.335 60.6 41.8