Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr17 79991613 . C A CCDS11798.1:NM_005052.2:c.487Cgg>Agg_NP_005043.1:p.163R>R Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6tm1 2 P60763 100.0 1e-143 X-RAY
 2020-01-22 ARG B:163 A:163 51.0 NA T -57.5 148.5 34.0 NA NA A:Q96BY6:NA
2c2h 1 P60763 99.48 3e-142 X-RAY
 2005-10-13 ARG A:163 A:163 170.0 0.756 T -60.6 125.1 170.0 0.756 0.0 GDP
GDP
HOH
 7.551
2.869
3.536
 O
NH1
CD
 O6
O3A
O
ARG B:163 B:163 49.0 NA T -62.3 125.0 NA NA NA
1i4d 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 ARG C:163 D:163 171.0 0.76 T -66.7 129.7 171.0 0.76 0.0 GDP
HOH
 7.474
3.236
 O
NH1
 O6
O
1i4l 2 P63000 92.71 2e-134 X-RAY
 2001-05-16 ARG C:163 D:163 182.0 0.809 T -60.6 119.4 182.0 0.809 0.0 GDP
HOH
 8.491
4.845
 O
C
 O6
O
6tgc 3 P63000 92.71 2e-134 EM
 2020-07-29 ARG C:163 C:163 81.0 0.36 B -136.0 171.7 81.0 0.36 0.0
ARG F:163 F:163 82.0 0.364 B -135.9 171.8 82.0 0.364 0.0
5fi0 2 P63000 92.71 3e-134 X-RAY
 2016-04-20 ARG B:166 B:163 172.0 0.764 T -58.6 115.3 172.0 0.764 0.0
ARG D:166 D:163 176.0 0.782 T -58.7 113.6 NA NA NA
ARG F:166 F:163 151.0 0.671 T -57.9 115.7 NA NA NA
ARG H:166 H:163 156.0 0.693 T -59.2 114.6 NA NA NA
1i4t 2 P63000 92.19 3e-133 X-RAY
 2001-05-16 ARG C:163 D:163 191.0 0.849 T -49.4 118.3 191.0 0.849 0.0 GNP
HOH
 8.189
5.598
 O
O
 O6
O
2vrw 1 P63000 95.65 7e-133 X-RAY
 2008-06-17 ARG A:163 A:163 190.0 0.844 T -63.3 126.9 190.0 0.844 0.0 HOH
 3.766
 CA
 O
1e96 1 P15154 92.15 4e-132 X-RAY
 2000-11-17 ARG A:163 A:163 189.0 0.84 T -66.7 131.0 189.0 0.84 0.0 GTP
HOH
 7.836
3.133
 O
NH1
 O6
O
1hh4 1 P15154 92.15 4e-132 X-RAY
 2001-08-28 ARG A:163 A:163 166.0 0.738 B -85.1 125.9 166.0 0.738 0.0 GDP
HOH
 7.750
3.216
 N
CD
 O6
O
ARG B:163 B:163 131.0 0.582 B -90.5 131.7 NA NA NA
1g4u 2 P63000 95.11 8e-132 X-RAY
 2001-01-24 ARG B:163 R:163 174.0 0.773 T -69.5 125.6 174.0 0.773 0.0 GDP
HOH
 7.941
2.706
 O
NH2
 O6
O
2h7v 1 P63000 95.11 1e-131 X-RAY
 2006-09-19 ARG A:167 A:163 190.0 0.844 T -61.4 -51.5 190.0 0.844 0.0 GDP
 7.881
 N
 O6
ARG B:167 B:163 168.0 0.747 T -66.4 131.0 NA NA NA
2p2l 1 P63000 95.11 1e-131 X-RAY
 2007-05-01 ARG A:167 A:163 121.0 0.538 T -59.7 121.0 121.0 0.538 0.0 GDP
HOH
 7.681
2.292
 O
NE
 O6
O
ARG B:167 B:163 119.0 0.529 B -111.6 120.7 119.0 0.529 0.0 GDP
HOH
 7.521
2.520
 N
N
 O6
O
ARG C:167 C:163 136.0 0.604 T -55.0 117.8 136.0 0.604 0.0 GDP
HOH
 7.726
2.930
 O
NH1
 O6
O
2g0n 1 P60763 100.0 1e-131 X-RAY
 2006-05-30 ARG A:164 A:163 174.0 0.773 T -63.1 124.5 174.0 0.773 0.0 GDP
HOH
 7.636
3.207
 O
NH2
 O6
O
ARG B:164 B:163 171.0 0.76 T -58.8 129.1 NA NA NA
2ov2 1 P60763 100.0 1e-131 X-RAY
 2007-03-13 ARG A:164 A:163 180.0 0.8 T -57.2 127.6 180.0 0.8 0.0 CL
GCP
HOH
 4.081
7.746
3.452
 NE
O
CA
 CL
O6
O
ARG B:164 F:163 175.0 0.778 T -63.6 121.5 NA NA NA
ARG C:164 B:163 179.0 0.796 T -63.0 124.3 NA NA NA
ARG D:164 C:163 92.0 NA T -65.9 123.2 NA NA NA
ARG E:164 G:163 174.0 0.773 T -63.7 122.1 NA NA NA
ARG F:164 D:163 174.0 0.773 T -63.5 123.8 NA NA NA
ARG G:164 E:163 173.0 0.769 T -60.0 123.3 NA NA NA
ARG H:164 H:163 168.0 0.747 T -62.6 125.6 NA NA NA
2qme 1 P60763 100.0 1e-131 X-RAY
 2007-08-28 ARG A:164 A:163 69.0 NA T -59.7 122.9 69.0 NA NA GCP
GOL
HOH
 7.572
3.634
3.729
 O
CA
CB
 O6
O2
O
2ic5 1 P60763 100.0 1e-131 X-RAY
 2006-10-10 ARG A:164 A:163 177.0 0.787 T -60.7 124.5 177.0 0.787 0.0 GNP
HOH
 7.550
3.382
 O
NH2
 O6
O
ARG B:164 B:163 174.0 0.773 T -65.7 127.8 NA NA NA
1mh1 1 P63000 95.08 9e-131 X-RAY
 1998-01-21 ARG A:165 A:163 157.0 0.698 T -60.4 122.3 157.0 0.698 0.0 GNP
HOH
 7.706
2.942
 O
NE
 O6
O
1ds6 1 P15153 88.54 2e-129 X-RAY
 2000-07-12 ARG A:163 A:163 155.0 0.689 T -65.1 124.3 155.0 0.689 0.0 GDP
HOH
 7.767
3.805
 O
CG
 O6
O
2yin 2 P63000 95.48 2e-127 X-RAY
 2011-05-25 ARG C:182 C:163 110.0 0.489 T -82.1 134.4 NA NA NA
ARG D:182 D:163 108.0 0.48 T -69.3 124.8 108.0 0.48 0.0 HOH
 3.639
 NH2
 O
2fju 1 P63000 95.48 2e-127 X-RAY
 2006-11-21 ARG A:163 A:163 166.0 0.738 T -66.0 119.3 166.0 0.738 0.0 GSP
HOH
 7.649
2.855
 O
NE
 O6
O
5qqd 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 175.0 0.778 T -59.4 122.4 175.0 0.778 0.0 EDO
JGA
HOH
 6.588
7.395
2.589
 NH1
O
NH1
 C1
N11
O
5qqe 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 179.0 0.796 T -63.2 124.2 179.0 0.796 0.0 EDO
N5S
HOH
 7.174
7.365
2.434
 NH1
O
NH1
 C1
N2
O
5qqf 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 176.0 0.782 T -74.4 125.2 176.0 0.782 0.0 EDO
N5V
HOH
 6.607
7.496
2.584
 NH1
O
NH1
 C1
N2
O
5qqg 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 176.0 0.782 T -72.0 124.5 176.0 0.782 0.0 EDO
N64
HOH
 7.105
7.493
2.701
 NH1
O
NH1
 C1
N4
O
5qqh 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 172.0 0.764 T -68.5 123.7 172.0 0.764 0.0 EDO
N67
HOH
 7.281
7.395
2.443
 NH1
O
NE
 C1
N3
O
5qqi 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 172.0 0.764 T -68.3 127.7 172.0 0.764 0.0 EDO
N6D
HOH
 6.985
7.806
2.590
 NH1
O
NH1
 C1
N2
O
5qqj 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 175.0 0.778 T -59.0 119.7 175.0 0.778 0.0 EDO
N6J
HOH
 7.160
7.505
2.344
 NH1
O
NH1
 C1
N6
O
5qqk 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 171.0 0.76 T -74.3 123.9 171.0 0.76 0.0 EDO
N6V
HOH
 6.975
7.353
2.918
 NH1
O
NH1
 C1
N4
O
5qql 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 173.0 0.769 T -80.8 127.8 173.0 0.769 0.0 EDO
N71
HOH
 7.502
7.440
2.696
 NH1
O
NH1
 C2
N2
O
5qqm 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 172.0 0.764 T -71.8 126.2 172.0 0.764 0.0 EDO
N74
HOH
 7.163
7.380
2.643
 NH1
O
NH1
 C1
N4
O
5qqn 1 P63000 95.48 2e-127 X-RAY
 2019-12-18 ARG A:164 A:163 175.0 0.778 T -70.1 121.7 175.0 0.778 0.0 EDO
N5D
HOH
 7.269
7.516
2.724
 NH1
O
NE
 C1
C2
O
5qu9 1 P63000 95.48 2e-127 X-RAY
 2020-01-29 ARG A:164 A:163 170.0 0.756 T -57.7 127.8 170.0 0.756 0.0 EDO
HOH
 7.475
2.174
 NH1
NH1
 C1
O
1foe 2 P63000 95.48 3e-127 X-RAY
 2001-01-17 ARG B:163 B:163 153.0 0.68 T -79.8 131.8 153.0 0.68 0.0 HOH
 4.825
 C
 O
ARG D:163 D:163 150.0 0.667 T -80.1 133.1 NA NA NA
ARG F:163 F:163 153.0 0.68 T -81.0 131.7 NA NA NA
ARG H:163 H:163 152.0 0.676 T -80.9 133.7 NA NA NA
2nz8 1 P63000 95.48 3e-127 X-RAY
 2007-04-10 ARG A:163 A:163 183.0 0.813 T -60.3 126.8 183.0 0.813 0.0 HOH
 2.775
 NE
 O
3bji 2 P63000 95.48 3e-127 X-RAY
 2008-07-15 ARG C:163 C:163 52.0 NA T -39.7 -41.1 NA NA NA
ARG D:163 D:163 59.0 NA T -80.7 114.3 59.0 NA NA HOH
 7.921
 O
 O
5o33 1 P63000 95.48 3e-127 X-RAY
 2017-05-31 ARG A:163 A:163 177.0 0.787 T -58.3 125.3 177.0 0.787 0.0 EDO
GDP
HOH
 9.181
7.730
3.236
 CD
O
N
 H22
O6
O
3su8 1 P63000 95.48 3e-127 X-RAY
 2011-09-28 ARG A:163 A:163 178.0 0.791 T -72.3 124.2 178.0 0.791 0.0 GNP
 7.959
 O
 O6
3sua 1 P63000 95.48 3e-127 X-RAY
 2011-09-07 ARG A:163 A:163 153.0 0.68 T -74.1 119.1 153.0 0.68 0.0 GNP
 7.634
 N
 O6
ARG B:163 B:163 153.0 0.68 T -73.0 118.1 NA NA NA
ARG C:163 C:163 148.0 0.658 T -73.9 118.8 NA NA NA
6x1g 2 P63000 95.48 3e-127 X-RAY
 2020-11-25 ARG C:163 B:163 149.0 0.662 T -58.1 125.4 149.0 0.662 0.0 HOH
 3.467
 CD
 O
ARG D:163 D:163 151.0 0.671 T -57.1 125.3 NA NA NA
3b13 2 P63000 94.92 7e-127 X-RAY
 2012-03-14 ARG B:170 B:163 184.0 0.818 T -54.8 123.3 184.0 0.818 0.0
ARG D:170 D:163 187.0 0.831 T -62.0 124.7 187.0 0.831 0.0
1ryf 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 ARG A:184 A:182 139.0 0.618 T -60.3 128.8 139.0 0.618 0.0 GDP
HOH
 7.453
3.101
 O
NH2
 O6
O
ARG B:184 B:182 141.0 0.627 T -66.1 129.1 NA NA NA
1ryh 1 P63000 86.57 9e-127 X-RAY
 2004-01-27 ARG A:184 A:182 141.0 0.627 T -62.0 129.9 141.0 0.627 0.0 GNP
HOH
 7.591
2.737
 O
NH2
 O6
O
ARG B:184 B:182 145.0 0.644 T -62.1 126.3 NA NA NA
7dpa 2 P63000 94.92 1e-126 EM
 2021-08-04 ARG B:170 B:163 184.0 0.818 T -58.7 113.7 105.0 0.467 0.351 C:Q92556:0.351
ARG E:170 E:163 188.0 0.836 T -58.7 113.7 109.0 0.484 0.352 F:Q92556:0.351
5n6o 1 P63000 95.45 3e-126 X-RAY
 2017-12-27 ARG A:162 A:163 172.0 0.764 T -73.6 122.8 172.0 0.764 0.0 GDP
HOH
 7.631
3.361
 O
NE
 O6
O
ARG B:162 B:163 171.0 0.76 T -66.7 125.7 NA NA NA
6bc1 1 P63000 95.45 5e-126 X-RAY
 2017-12-13 ARG A:163 A:163 154.0 0.684 T -68.0 120.5 154.0 0.684 0.0 GSP
HOH
 7.372
2.907
 H
HD3
 O6
O
ARG C:163 B:163 147.0 0.653 T -69.9 124.1 NA NA NA
4yon 2 P63000 94.92 5e-126 X-RAY
 2015-07-01 ARG B:165 B:163 180.0 0.8 T -66.5 125.4 180.0 0.8 0.0 HOH
 2.512
 NH1
 O
3th5 1 P63000 95.45 8e-126 X-RAY
 2012-07-18 ARG A:190 A:163 145.0 0.644 T -67.3 119.8 145.0 0.644 0.0 GNP
HOH
 7.642
3.331
 O
CD
 O6
O
ARG B:190 B:163 142.0 0.631 T -62.1 116.8 NA NA NA
3ryt 2 P63000 94.92 1e-125 X-RAY
 2012-01-18 ARG C:166 C:163 40.0 NA B -77.3 98.7 40.0 NA NA GNP
 7.751
 N
 O6
1he1 2 P15154 95.43 1e-125 X-RAY
 2001-01-02 ARG C:163 C:163 146.0 0.649 T -66.3 127.2 146.0 0.649 0.0 GDP
HOH
 7.642
2.757
 O
NH2
 O6
O
ARG D:163 D:163 139.0 0.618 T -63.9 125.5 NA NA NA
6agp 1 P63000 93.37 1e-125 NMR
 2019-03-20 ARG A:163 A:163 154.0 0.684 T -63.8 115.9 154.0 0.684 0.0 GDP
 7.164
 H
 O6
3sbd 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 ARG A:173 A:163 138.0 0.613 T -62.8 127.3 138.0 0.613 0.0 GNP
HOH
 7.733
2.656
 O
NH2
 O6
O
ARG B:173 B:163 151.0 0.671 T -67.1 131.9 NA NA NA
3sbe 1 P63000 94.89 2e-125 X-RAY
 2012-07-18 ARG A:173 A:163 147.0 0.653 T -67.5 122.9 147.0 0.653 0.0 GNP
HOH
 7.422
3.522
 O
CD
 O6
O
7ajk 1 P63000 94.89 3e-125 X-RAY
 2020-11-18 ARG A:166 BBB:163 178.0 0.791 T -72.4 107.9 178.0 0.791 0.0 GNP
HOH
 8.380
4.219
 N
CB
 O6
O
4gzm 1 P63000 94.89 6e-125 X-RAY
 2012-12-12 ARG A:190 A:163 128.0 0.569 B -78.7 111.2 128.0 0.569 0.0 GSP
 7.676
 N
 O6
ARG B:190 B:163 131.0 0.582 B -77.5 110.4 NA NA NA
4gzl 1 P63000 94.89 1e-124 X-RAY
 2012-12-12 ARG A:190 A:163 138.0 0.613 T -61.9 131.5 138.0 0.613 0.0 GNP
IPA
HOH
 7.751
2.766
4.282
 O
NH1
CG
 O6
C1
O
ARG B:190 B:163 136.0 0.604 T -57.3 123.4 NA NA NA
2w2t 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 ARG A:169 A:163 51.0 NA T -54.8 117.1 51.0 NA NA GDP
HOH
 7.866
3.767
 O
CB
 O6
O
2w2x 1 P15153 93.26 4e-124 X-RAY
 2009-05-05 ARG A:169 A:163 170.0 0.756 T -58.5 117.7 170.0 0.756 0.0 GSP
HOH
 7.807
5.125
 O
O
 O6
O
ARG B:169 B:163 45.0 NA T -57.2 120.0 NA NA NA
2wkq 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 ARG A:315 A:706 162.0 0.72 T -58.4 124.8 162.0 0.72 0.0 GTP
CL
HOH
 7.842
3.276
2.541
 O
NH1
NH2
 O6
CL
O
2wkr 1 O49003,P63000 92.74 5e-124 X-RAY
 2009-08-18 ARG A:315 A:706 176.0 0.782 T -62.5 127.9 176.0 0.782 0.0 GTP
CL
HOH
 7.843
3.695
2.734
 O
CB
NH1
 O6
CL
O
2wkp 1 O49003,P63000 92.74 8e-124 X-RAY
 2009-08-18 ARG A:315 A:706 107.0 0.476 T -57.6 123.6 107.0 0.476 0.0 GTP
HOH
 7.837
3.003
 O
NH2
 O6
O
2w2v 1 P15153 93.22 4e-123 X-RAY
 2009-05-05 ARG A:170 A:163 182.0 0.809 T -66.8 124.7 182.0 0.809 0.0 GTP
HOH
 7.925
3.765
 N
C
 O6
O
ARG B:170 B:163 48.0 NA T -63.3 110.1 NA NA NA
ARG C:170 C:163 117.0 0.52 T -67.9 121.2 NA NA NA
ARG D:170 D:163 115.0 0.511 T -65.5 131.4 NA NA NA
5hzh 1 P63000,O49003 86.81 4e-90 X-RAY
 2016-12-21 ARG A:315 A:312 152.0 0.676 T -70.9 120.5 152.0 0.676 0.0 GTP
HOH
 7.804
3.842
 O
NH2
 O6
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p60763-f1 1 P60763 100.0 5e-144 ARG A:163 A:163 155.0 0.689 T -58.7 125.2
af-p63000-f1 1 P63000 92.71 8e-135 ARG A:163 A:163 156.0 0.693 T -58.3 125.0
af-p15153-f1 1 P15153 88.54 7e-130 ARG A:163 A:163 162.0 0.72 T -58.9 125.3