Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 6694496 . A C CCDS32883.1:NM_000064.2:c.3100Tgg>Ggg_NP_000055.2:p.1034W>G Homo sapiens complement component 3 (C3), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6ru5 2 P01024 100.0 0.0 X-RAY
 2019-08-21 TRP B:363 B:1034 19.0 0.075 H -64.8 -22.0 19.0 0.075 0.0
2a73 2 P01024 100.0 0.0 X-RAY
 2005-09-27 TRP B:362 B:1012 17.0 0.067 H -62.9 -24.2 17.0 0.067 0.0
2icf 2 P01024 100.0 0.0 X-RAY
 2006-11-07 TRP B:286 B:1012 21.0 0.082 H -33.5 -39.7 2.0 0.008 0.074 A:P01024:0.075
2wii 2 P01024 100.0 0.0 X-RAY
 2009-06-09 TRP B:286 B:1012 23.0 0.09 H -64.6 -12.2 5.0 0.02 0.07 A:P01024:0.071
 GOL
HOH
 9.791
6.526
 CZ3
CZ3
 O1
O
2win 2 P01024 100.0 0.0 X-RAY
 2009-06-09 TRP B:286 B:1012 18.0 0.071 H -68.7 -16.6 5.0 0.02 0.051 A:P01024:0.051
TRP D:286 D:1012 17.0 0.067 H -68.7 -16.7 NA NA NA
TRP F:286 F:1012 18.0 0.071 H -68.7 -16.6 NA NA NA
TRP H:286 H:1012 23.0 0.09 H -61.7 -32.2 4.0 0.016 0.074 G:P01024:0.075
3g6j 2 P01024 100.0 0.0 X-RAY
 2009-03-10 TRP B:286 B:1012 16.0 0.063 H -75.5 -15.4 2.0 0.008 0.055 A:P01024:0.055
TRP D:286 D:1012 27.0 0.106 H -64.2 -37.2 NA NA NA
3l5n 2 P01024 100.0 0.0 X-RAY
 2010-08-04 TRP B:286 B:1012 28.0 0.11 H -51.9 -23.9 11.0 0.043 0.067 A:P01024:0.067
5o32 2 P01024 100.0 0.0 X-RAY
 2017-06-28 TRP B:286 B:1034 21.0 0.082 H -70.0 -11.8 4.0 0.016 0.066 A:P01024:0.067
TRP G:286 F:1034 24.0 0.094 H -70.5 -12.7 6.0 0.024 0.07 F:P01024:0.071
5o35 2 P01024 100.0 0.0 X-RAY
 2017-06-28 TRP B:286 B:1034 24.0 0.094 H -69.9 -11.3 6.0 0.024 0.07 A:P01024:0.071
6rur 4 P01024 100.0 0.0 X-RAY
 2019-08-21 TRP F:286 B:1012 21.0 0.082 H -69.1 -16.2 10.0 0.039 0.043 E:P01024:0.043
TRP H:286 H:1012 27.0 0.106 H -69.6 -16.6 8.0 0.031 0.075 G:P01024:0.075
6ruv 5 P01024 100.0 0.0 X-RAY
 2019-08-21 TRP H:286 B:1012 23.0 0.09 H -69.9 -16.5 8.0 0.031 0.059 G:P01024:0.059
TRP J:286 H:1012 24.0 0.094 H -69.9 -17.3 10.0 0.039 0.055 I:P01024:0.055
7bag 2 P01024 100.0 0.0 X-RAY
 2022-01-12 TRP B:286 B:1012 24.0 0.094 H -66.9 -25.4 4.0 0.016 0.078 A:P01024:0.078
 HOH
 3.123
 N
 O
2i07 2 P01024 99.89 0.0 X-RAY
 2006-10-24 TRP B:286 B:1012 13.0 0.051 H -46.9 -27.6 3.0 0.012 0.039 A:P01024:0.039
2xwj 2 P01024 99.89 0.0 X-RAY
 2011-01-12 TRP B:286 B:1012 21.0 0.082 H -73.3 -2.2 14.0 0.055 0.027 A:P01024:0.027
TRP D:286 D:1012 22.0 0.086 H -73.5 -2.1 NA NA NA
TRP F:286 F:1012 23.0 0.09 H -73.6 -2.2 NA NA NA
TRP H:286 H:1012 20.0 0.078 H -73.1 -2.5 NA NA NA
5fo7 2 P01024 99.89 0.0 X-RAY
 2016-04-06 TRP B:286 B:1034 20.0 0.078 H -70.4 -11.8 6.0 0.024 0.054 A:P01024:0.055
5fo8 2 P01024 99.89 0.0 X-RAY
 2016-04-06 TRP B:286 B:1034 24.0 0.094 H -68.0 -37.3 8.0 0.031 0.063 A:P01024:0.063
 EDO
EDO
EDO
EDO
EDO
EDO
HOH
 6.274
5.987
8.131
6.051
3.277
7.990
3.711
 O
O
CZ2
CZ3
N
CZ3
O
 C1
O1
O1
O2
O2
C1
O
5fo9 2 P01024 99.89 0.0 X-RAY
 2016-04-06 TRP B:286 B:1034 37.0 0.145 H -55.9 -30.7 NA NA NA
TRP E:286 E:1034 28.0 0.11 H -55.2 -29.3 7.0 0.027 0.083 D:P01024:0.082
5foa 2 P01024 99.89 0.0 X-RAY
 2016-04-06 TRP B:286 B:1034 86.0 0.337 H -47.6 -27.0 12.0 0.047 0.29 A:P01024:0.29
TRP D:286 D:1034 25.0 0.098 H -48.2 -25.1 NA NA NA
5fob 2 P01024 99.89 0.0 X-RAY
 2016-04-06 TRP B:286 B:1034 26.0 0.102 H -66.6 -21.8 4.0 0.016 0.086 A:P01024:0.086
 IOD
HOH
 3.808
6.996
 CB
CZ2
 I
O
6ehg 2 P01024 99.78 0.0 X-RAY
 2018-02-14 TRP B:286 B:1034 22.0 0.086 S -66.9 -28.3 4.0 0.016 0.07 A:P01024:0.071
6yo6 2 ? 99.78 0.0 X-RAY
 2021-02-24 TRP B:286 B:1034 22.0 0.086 S -66.8 -28.4 6.0 0.024 0.062 A:None:0.063
2xwb 2 P01024 99.89 0.0 X-RAY
 2011-01-12 TRP B:283 B:1012 17.0 0.067 H -67.4 -17.0 4.0 0.016 0.051 A:P01024:0.051
TRP D:283 D:1012 17.0 0.067 H -67.1 -17.4 NA NA NA
6rmt 1 P01024 99.68 0.0 X-RAY
 2020-11-18 TRP A:41 A:41 19.0 0.075 H -70.8 -20.1 19.0 0.075 0.0 HOH
 2.058
 H
 O
TRP B:41 B:41 16.0 0.063 H -70.4 -30.6 16.0 0.063 0.0 CL
HOH
 7.058
2.266
 CE2
H
 CL
O
6rmu 1 P01024 99.68 0.0 X-RAY
 2020-11-18 TRP A:41 A:41 23.0 0.09 H -72.3 -30.0 6.0 0.024 0.066 C:P01024:0.016
B:Q931F4:0.047
 HOH
 2.304
 H
 O
TRP C:41 B:41 22.0 0.086 H -73.5 -27.5 6.0 0.024 0.062 D:Q931F4:0.047
A:P01024:0.016
 HOH
 6.493
 HD1
 O
2wy7 1 P01024 99.35 0.0 X-RAY
 2010-12-01 TRP A:41 A:48 19.0 0.075 H -66.0 -31.2 19.0 0.075 0.0 HOH
 3.269
 N
 O
2wy8 1 P01024 99.35 0.0 X-RAY
 2010-12-01 TRP A:41 A:48 19.0 0.075 H -66.7 -29.6 10.0 0.039 0.036 B:C8LN82:0.035
 HOH
 3.233
 N
 O
3oed 1 P01024 99.35 0.0 X-RAY
 2011-05-11 TRP A:41 A:41 15.0 0.059 T -78.5 -35.7 15.0 0.059 0.0 HOH
 2.873
 CB
 O
TRP C:41 B:41 17.0 0.067 H -62.9 -29.7 NA NA NA
3oxu 1 P01024 99.68 0.0 X-RAY
 2011-02-16 TRP A:48 A:41 9.0 0.035 H -64.3 -37.5 NA NA NA
TRP B:48 B:41 15.0 0.059 H -60.4 -28.5 15.0 0.059 0.0 HOH
 3.099
 N
 O
TRP C:48 C:41 20.0 0.078 H -76.3 -27.7 NA NA NA
3rj3 1 P01024 99.68 0.0 X-RAY
 2012-03-14 TRP A:48 A:41 10.0 0.039 H -62.1 -20.7 10.0 0.039 0.0 HOH
 4.249
 N
 O
TRP B:48 B:41 16.0 0.063 S -71.0 -28.5 NA NA NA
TRP C:48 C:41 18.0 0.071 H -72.9 -17.9 NA NA NA
4ont 2 P01024 99.68 0.0 X-RAY
 2014-11-26 TRP B:48 A:41 12.0 0.047 H -66.3 -40.8 NA NA NA
TRP D:48 B:41 14.0 0.055 H -60.8 -30.9 14.0 0.055 0.0 GOL
HOH
 8.450
3.594
 CD1
CD1
 O1
O
TRP F:48 C:41 20.0 0.078 H -75.9 -47.6 NA NA NA
4zh1 1 P01024 99.68 0.0 X-RAY
 2016-01-13 TRP A:48 A:41 14.0 0.055 H -67.8 -34.9 14.0 0.055 0.0 HOH
 2.623
 N
 O
TRP B:48 B:41 13.0 0.051 H -64.7 -32.7 NA NA NA
TRP C:48 C:41 18.0 0.071 H -64.8 -32.9 NA NA NA
1ghq 1 P01024 99.02 0.0 X-RAY
 2001-06-13 TRP A:41 A:41 21.0 0.082 H -59.1 -33.1 21.0 0.082 0.0 HOH
 3.004
 N
 O
4m76 1 P01024 99.66 0.0 X-RAY
 2013-10-02 TRP A:44 A:1034 19.0 0.075 S -80.1 -10.5 19.0 0.075 0.0
5nbq 1 P01024 99.66 0.0 X-RAY
 2017-12-06 TRP A:41 A:1034 47.0 0.184 T -78.6 -8.4 47.0 0.184 0.0
TRP B:41 B:1034 23.0 0.09 H -71.0 -17.7 NA NA NA
TRP C:41 C:1034 21.0 0.082 H -70.8 -17.8 NA NA NA
2gox 1 P01024 98.98 0.0 X-RAY
 2007-03-20 TRP A:44 A:1034 18.0 0.071 S -87.3 -36.4 5.0 0.02 0.051 B:P68799:0.051
 HOH
 3.518
 N
 O
TRP C:44 C:1034 16.0 0.063 H -79.6 -35.2 NA NA NA
2noj 1 P01024 98.98 0.0 X-RAY
 2007-08-14 TRP A:44 A:1034 21.0 0.082 H -46.4 -33.9 8.0 0.031 0.051 B:Q99UV2:0.051
 HOH
 9.490
 CZ2
 O
TRP C:44 C:1034 22.0 0.086 S -63.7 -43.2 NA NA NA
TRP E:44 E:1034 26.0 0.102 G -54.6 -33.5 NA NA NA
TRP G:44 G:1034 24.0 0.094 S -70.1 -52.8 NA NA NA
3d5r 1 P01024 98.98 0.0 X-RAY
 2008-09-09 TRP A:44 A:45 14.0 0.055 S -68.3 -41.8 4.0 0.016 0.039 B:A6QG59:0.039
 HOH
 6.038
 CD1
 O
TRP C:44 B:45 16.0 0.063 S -71.1 -38.7 NA NA NA
3d5s 1 P01024 98.98 0.0 X-RAY
 2008-09-16 TRP A:44 A:45 18.0 0.071 S -72.7 -42.3 6.0 0.024 0.047 B:A6QG59:0.047
 HOH
 9.348
 NE1
 O
TRP C:44 B:45 17.0 0.067 S -70.9 -42.6 NA NA NA
1c3d 1 P01024 99.32 0.0 X-RAY
 1998-10-07 TRP A:41 A:41 18.0 0.071 S -61.8 -28.0 18.0 0.071 0.0 HOH
 7.528
 CZ3
 O
2xqw 1 P01024 99.32 0.0 X-RAY
 2011-02-02 TRP A:41 A:41 22.0 0.086 H -65.3 -24.4 22.0 0.086 0.0 HOH
 4.716
 CD1
 O
TRP B:41 B:41 19.0 0.075 H -66.8 -4.3 17.0 0.067 0.008 C:P08603:0.008
 HOH
 6.670
 CE3
 O
1qqf 1 P01026 84.06 7e-156 X-RAY
 2000-07-31 TRP A:25 A:1034 20.0 0.078 H -72.2 -19.1 20.0 0.078 0.0 HOH
 3.041
 N
 O
1qsj 1 P01026 84.06 7e-156 X-RAY
 2000-07-31 TRP A:25 A:1034 20.0 0.078 H -75.4 -22.0 20.0 0.078 0.0 HOH
 3.892
 CH2
 O
TRP B:25 B:1034 17.0 0.067 H -74.1 -22.5 17.0 0.067 0.0 HOH
 2.944
 N
 O
TRP C:25 C:1034 18.0 0.071 H -74.6 -22.3 NA NA NA
TRP D:25 D:1034 21.0 0.082 H -74.4 -22.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p01024-f1 1 P01024 100.0 0.0 TRP A:1034 A:1034 18.0 0.071 H -59.3 -26.0