Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7122656 | . | C | A | CCDS12176.1:NM_000208.2:c.3498atG>atT_NP_000199.2:p.1166M>I | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1139 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1139 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1139 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1139 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1139 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1139 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1154 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | MET | A:1127 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1127 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | MET | A:1127 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1127 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4xlv | 1 | P06213 | 99.09 | 0.0 |
X-RAY |
2015-03-25 | MET | A:184 | A:1139 | 41.0 | 0.222 | E | -106.4 | 147.6 | 41.0 | 0.222 | 0.0 |
ACP MG MG HOH |
3.424 5.432 9.846 3.983 |
CE CE CE CE |
C8 MG MG O |
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| 4ibm | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2013-08-21 | MET | A:162 | A:1139 | 34.0 | 0.184 | E | -129.2 | 160.9 | 34.0 | 0.184 | 0.0 |
IR1 HOH |
3.586 3.191 |
CE CE |
C16 O |
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| MET | B:162 | B:1139 | 31.0 | 0.168 | E | -128.0 | 160.6 | NA | NA | NA | |||||||||||||
| 1gag | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2001-01-17 | MET | A:162 | A:1139 | 37.0 | 0.2 | E | -106.9 | 158.8 | 37.0 | 0.2 | 0.0 |
MG MG 112 HOH |
5.951 8.861 4.193 3.866 |
CE CE CE CE |
MG MG C8 O |
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| 1ir3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1998-01-07 | MET | A:162 | A:1139 | 42.0 | 0.227 | E | -113.8 | 154.4 | 42.0 | 0.227 | 0.0 |
MG MG ANP HOH |
5.875 8.591 3.910 3.983 |
CE CE SD CE |
MG MG C8 O |
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| 1irk | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1995-02-27 | MET | A:162 | A:1139 | 10.0 | 0.054 | E | -132.5 | 156.1 | 10.0 | 0.054 | 0.0 |
HOH |
3.473 |
CE |
O |
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| 3eta | 1 | P06213 | 100.0 | 0.0 |
X-RAY |
2009-05-26 | MET | A:161 | A:1139 | 24.0 | 0.13 | E | -122.5 | 151.4 | 24.0 | 0.13 | 0.0 |
351 HOH |
3.583 6.758 |
CE CG |
O23 O |
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| MET | B:161 | B:1139 | 25.0 | 0.135 | E | -113.9 | 155.8 | NA | NA | NA | |||||||||||||
| 5hhw | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2016-04-13 | MET | A:163 | A:1166 | 45.0 | 0.243 | E | -118.9 | 154.4 | 45.0 | 0.243 | 0.0 |
60O HOH |
3.556 3.574 |
CE SD |
C13 O |
||
| 5e1s | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2015-10-14 | MET | A:164 | A:1139 | 48.0 | 0.259 | E | -121.8 | 151.3 | 48.0 | 0.259 | 0.0 |
5JA HOH |
3.347 4.552 |
CE SD |
N3 O |
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| 1rqq | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2003-12-30 | MET | A:162 | A:1139 | 47.0 | 0.254 | E | -114.6 | 154.3 | 47.0 | 0.254 | 0.0 |
MN 112 HOH |
7.474 3.200 5.810 |
SD CE SD |
MN C4 O |
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| MET | B:162 | B:1139 | 42.0 | 0.227 | E | -112.7 | 152.1 | 42.0 | 0.227 | 0.0 |
MN 112 HOH |
7.260 3.464 5.481 |
SD CE SD |
MN C4 O |
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| 2auh | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-01 | MET | A:162 | A:1139 | 38.0 | 0.205 | E | -115.4 | 146.7 | 38.0 | 0.205 | 0.0 |
CA CA |
8.475 9.699 |
CE CE |
CA CA |
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| 2b4s | 2 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-15 | MET | B:162 | B:1139 | 36.0 | 0.195 | E | -124.2 | 153.7 | 36.0 | 0.195 | 0.0 |
HOH |
4.558 |
SD |
O |
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| MET | D:162 | D:1139 | 36.0 | 0.195 | E | -121.2 | 161.3 | 36.0 | 0.195 | 0.0 |
HOH |
4.168 |
CG |
O |
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| 3bu3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:162 | A:1139 | 38.0 | 0.205 | E | -124.4 | 153.5 | 14.0 | 0.076 | 0.129 |
B:P81122:0.13 |
HOH |
3.839 |
CG |
O |
|
| 3bu5 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:162 | A:1139 | 40.0 | 0.216 | E | -119.0 | 153.4 | 40.0 | 0.216 | 0.0 |
MG ATP HOH |
5.587 3.886 3.619 |
CE CE CG |
MG C3' O |
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| 3bu6 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:162 | A:1139 | 41.0 | 0.222 | E | -129.1 | 153.0 | 13.0 | 0.07 | 0.152 |
B:P81122:0.151 |
HOH |
3.594 |
CE |
O |
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| 1p14 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2003-07-22 | MET | A:162 | A:1139 | 49.0 | 0.265 | E | -121.7 | 153.5 | 49.0 | 0.265 | 0.0 |
HOH |
3.919 |
CE |
O |
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| 1i44 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2001-03-07 | MET | A:162 | A:1139 | 53.0 | 0.286 | E | -126.1 | 160.3 | 53.0 | 0.286 | 0.0 |
MG ACP HOH |
8.150 3.672 4.816 |
SD CE CE |
MG C2' O |
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| 3ekk | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-23 | MET | A:163 | A:1139 | 51.0 | 0.276 | E | -119.6 | 154.6 | 51.0 | 0.276 | 0.0 |
GS2 HOH |
3.427 3.462 |
CE CG |
N3 O |
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| 3ekn | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-30 | MET | A:163 | A:1139 | 49.0 | 0.265 | E | -116.2 | 164.2 | 49.0 | 0.265 | 0.0 |
GS3 HOH |
3.129 4.908 |
CE SD |
C8 O |
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| 2z8c | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2008-08-12 | MET | A:159 | A:1139 | 42.0 | 0.227 | E | -108.0 | 150.7 | 42.0 | 0.227 | 0.0 |
S91 |
3.761 |
SD |
C9 |
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| 2oj9 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2007-05-01 | MET | A:163 | A:1112 | 38.0 | 0.205 | E | -121.3 | 160.9 | 38.0 | 0.205 | 0.0 |
BMI HOH |
3.482 5.616 |
CE SD |
N2 O |
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| 3nw5 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:163 | A:1112 | 53.0 | 0.286 | E | -121.0 | 149.1 | 53.0 | 0.286 | 0.0 |
LGX HOH |
4.069 3.271 |
CE CE |
O25 O |
||
| 3nw6 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:163 | A:1112 | 49.0 | 0.265 | E | -116.3 | 156.2 | 49.0 | 0.265 | 0.0 |
LGW HOH |
3.378 3.360 |
SD CG |
C27 O |
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| 3nw7 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:163 | A:1112 | 51.0 | 0.276 | E | -127.1 | 153.7 | 51.0 | 0.276 | 0.0 |
LGV HOH |
3.309 4.983 |
SD SD |
C2 O |
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| 3i81 | 1 | P08069 | 80.07 | 7e-177 |
X-RAY |
2009-12-22 | MET | A:163 | A:1112 | 50.0 | 0.27 | E | -117.5 | 151.2 | 50.0 | 0.27 | 0.0 |
EBI HOH |
3.410 4.272 |
SD CE |
C33 O |
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| 3d94 | 1 | P08069 | 81.06 | 1e-176 |
X-RAY |
2008-07-29 | MHO | A:157 | A:1112 | NA | NA | NA | NA | NA | NA | NA | NA |
D94 HOH |
3.582 3.273 |
CE SD |
C2 O |
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| 1jqh | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2002-04-19 | MET | A:164 | A:1142 | 53.0 | 0.286 | E | -121.1 | 155.9 | 53.0 | 0.286 | 0.0 |
MG ANP HOH |
6.374 3.652 5.382 |
SD CE SD |
MG N3 O |
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| MET | B:164 | B:1142 | 51.0 | 0.276 | E | -118.7 | 155.6 | NA | NA | NA | |||||||||||||
| MET | C:164 | C:1142 | 51.0 | 0.276 | E | -120.5 | 156.7 | NA | NA | NA | |||||||||||||
| 2zm3 | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-06-10 | MET | A:164 | A:1142 | 49.0 | 0.265 | E | -130.4 | 153.3 | 49.0 | 0.265 | 0.0 |
575 HOH |
3.308 5.079 |
CE SD |
C12 O |
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| MET | B:164 | B:1142 | 62.0 | 0.335 | E | -124.6 | 154.9 | NA | NA | NA | |||||||||||||
| MET | C:164 | C:1142 | 57.0 | 0.308 | E | -126.9 | 146.3 | NA | NA | NA | |||||||||||||
| MET | D:164 | D:1142 | 47.0 | 0.254 | E | -116.8 | 148.6 | NA | NA | NA | |||||||||||||
| 3f5p | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-12-30 | MET | A:164 | A:1142 | 60.0 | 0.324 | E | -105.1 | 158.9 | 60.0 | 0.324 | 0.0 |
741 |
3.209 |
CE |
C5 |
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| MET | B:164 | B:1142 | 54.0 | 0.292 | E | -120.9 | 153.7 | NA | NA | NA | |||||||||||||
| MET | C:164 | C:1142 | 56.0 | 0.303 | E | -119.0 | 158.7 | NA | NA | NA | |||||||||||||
| MET | D:164 | D:1142 | 62.0 | 0.335 | E | -124.9 | 155.7 | NA | NA | NA | |||||||||||||
| MET | E:164 | E:1142 | 53.0 | 0.286 | E | -114.1 | 154.0 | NA | NA | NA | |||||||||||||
| MET | F:164 | F:1142 | 56.0 | 0.303 | E | -115.7 | 163.8 | NA | NA | NA | |||||||||||||
| MET | G:164 | G:1142 | 57.0 | 0.308 | E | -117.5 | 154.2 | NA | NA | NA | |||||||||||||
| MET | H:164 | H:1142 | 61.0 | 0.33 | E | -104.6 | 152.4 | NA | NA | NA | |||||||||||||
| MET | I:164 | I:1142 | 59.0 | 0.319 | E | -117.2 | 155.5 | NA | NA | NA | |||||||||||||
| MET | J:164 | J:1142 | 57.0 | 0.308 | E | -125.3 | 158.3 | NA | NA | NA | |||||||||||||
| MET | K:164 | K:1142 | 57.0 | 0.308 | E | -99.0 | 158.3 | NA | NA | NA | |||||||||||||
| MET | L:164 | M:1142 | 57.0 | 0.308 | E | -103.3 | 161.9 | NA | NA | NA | |||||||||||||
| MET | M:164 | L:1142 | 53.0 | 0.286 | E | -131.7 | 159.0 | NA | NA | NA | |||||||||||||
| MET | N:164 | R:1142 | 61.0 | 0.33 | E | -113.9 | 154.8 | NA | NA | NA | |||||||||||||
| MET | O:164 | S:1142 | 59.0 | 0.319 | E | -113.6 | 164.0 | NA | NA | NA | |||||||||||||
| MET | P:164 | T:1142 | 57.0 | 0.308 | E | -115.3 | 159.9 | NA | NA | NA | |||||||||||||
| 4d2r | 1 | P08069 | 81.06 | 2e-176 |
X-RAY |
2015-04-22 | MET | A:158 | A:1142 | 52.0 | 0.281 | E | -119.4 | 154.3 | 52.0 | 0.281 | 0.0 |
DYK HOH |
3.670 3.333 |
CE CG |
C16 O |
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| 1k3a | 1 | P08069 | 80.94 | 4e-175 |
X-RAY |
2001-11-28 | MET | A:155 | A:1112 | 53.0 | 0.286 | E | -122.7 | 159.1 | 53.0 | 0.286 | 0.0 |
ACP HOH |
3.297 3.183 |
CE SD |
C5 O |
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| 3qqu | 1 | P08069 | 80.94 | 6e-175 |
X-RAY |
2011-04-20 | MET | A:157 | A:1139 | 26.0 | 0.141 | E | -112.0 | 153.7 | 26.0 | 0.141 | 0.0 |
01P HOH |
3.351 7.737 |
CE CE |
C17 O |
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| MET | B:157 | B:1139 | 28.0 | 0.151 | E | -114.6 | 150.6 | NA | NA | NA | |||||||||||||
| MET | C:157 | C:1139 | 29.0 | 0.157 | E | -114.7 | 167.4 | NA | NA | NA | |||||||||||||
| MET | D:157 | D:1139 | 26.0 | 0.141 | E | -120.0 | 162.9 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | MET | A:1166 | A:1166 | 56.0 | 0.303 | E | -114.2 | 147.6 | |