Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7125359 | . | G | A | CCDS12176.1:NM_000208.2:c.3193Ctc>Ttc_NP_000199.2:p.1065L>F | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | LEU | A:1038 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1038 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | LEU | A:1038 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1038 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | LEU | A:1038 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1038 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | LEU | A:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1053 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | LEU | A:1026 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1026 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | LEU | A:1026 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:1026 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4xlv | 1 | P06213 | 99.09 | 0.0 |
X-RAY |
2015-03-25 | LEU | A:83 | A:1038 | 135.0 | 0.794 | H | -57.8 | -46.2 | 90.0 | 0.529 | 0.265 |
A:P06213:0.265 |
HOH |
3.822 |
CB |
O |
|
| 4ibm | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2013-08-21 | LEU | A:61 | A:1038 | 145.0 | 0.853 | H | -62.6 | -36.5 | 145.0 | 0.853 | 0.0 |
HOH |
2.959 |
N |
O |
||
| LEU | B:61 | B:1038 | 129.0 | 0.759 | H | -59.1 | -38.3 | NA | NA | NA | |||||||||||||
| 1gag | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2001-01-17 | LEU | A:61 | A:1038 | 129.0 | 0.759 | H | -54.3 | -50.0 | 129.0 | 0.759 | 0.0 | ||||||
| 1ir3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1998-01-07 | LEU | A:61 | A:1038 | 130.0 | 0.765 | H | -60.4 | -43.7 | 113.0 | 0.665 | 0.1 |
A:P06213:0.1 |
HOH |
5.105 |
O |
O |
|
| 1irk | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1995-02-27 | LEU | A:61 | A:1038 | 127.0 | 0.747 | H | -63.0 | -43.9 | 127.0 | 0.747 | 0.0 |
HOH |
6.323 |
O |
O |
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| 3eta | 1 | P06213 | 100.0 | 0.0 |
X-RAY |
2009-05-26 | LEU | A:60 | A:1038 | 137.0 | 0.806 | H | -59.9 | -45.8 | 137.0 | 0.806 | 0.0 |
HOH |
3.506 |
N |
O |
||
| LEU | B:60 | B:1038 | 133.0 | 0.782 | H | -50.3 | -47.9 | NA | NA | NA | |||||||||||||
| 5hhw | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2016-04-13 | LEU | A:62 | A:1065 | 118.0 | 0.694 | H | -60.1 | -40.1 | 118.0 | 0.694 | 0.0 |
HOH |
5.785 |
CD1 |
O |
||
| 5e1s | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2015-10-14 | LEU | A:63 | A:1038 | 128.0 | 0.753 | H | -56.8 | -43.0 | 128.0 | 0.753 | 0.0 |
HOH |
4.301 |
CD1 |
O |
||
| 1rqq | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2003-12-30 | LEU | A:61 | A:1038 | 119.0 | 0.7 | H | -56.5 | -45.8 | 119.0 | 0.7 | 0.0 |
HOH |
5.305 |
O |
O |
||
| LEU | B:61 | B:1038 | 114.0 | 0.671 | H | -62.7 | -36.5 | 114.0 | 0.671 | 0.0 | |||||||||||||
| 2auh | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-01 | LEU | A:61 | A:1038 | 151.0 | 0.888 | H | -51.4 | -31.2 | 60.0 | 0.353 | 0.535 |
B:Q14449:0.535 |
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| 2b4s | 2 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-15 | LEU | B:61 | B:1038 | 133.0 | 0.782 | H | -56.9 | -49.2 | 1.0 | 0.006 | 0.776 |
D:P06213:0.776 |
HOH |
4.719 |
CD2 |
O |
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| LEU | D:61 | D:1038 | 136.0 | 0.8 | H | -60.8 | -52.9 | 2.0 | 0.012 | 0.788 |
B:P06213:0.788 |
HOH |
3.631 |
CB |
O |
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| 3bu3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | LEU | A:61 | A:1038 | 108.0 | 0.635 | H | -55.6 | -41.1 | 108.0 | 0.635 | 0.0 |
HOH |
3.508 |
N |
O |
||
| 3bu5 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | LEU | A:61 | A:1038 | 111.0 | 0.653 | H | -61.4 | -39.5 | 111.0 | 0.653 | 0.0 |
HOH |
2.898 |
N |
O |
||
| 3bu6 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | LEU | A:61 | A:1038 | 126.0 | 0.741 | H | -51.2 | -45.4 | 126.0 | 0.741 | 0.0 |
HOH |
3.522 |
N |
O |
||
| 1p14 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2003-07-22 | LEU | A:61 | A:1038 | 110.0 | 0.647 | H | -58.8 | -42.4 | 110.0 | 0.647 | 0.0 |
HOH |
6.373 |
CD2 |
O |
||
| 1i44 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2001-03-07 | LEU | A:61 | A:1038 | 117.0 | 0.688 | H | -52.0 | -46.3 | 117.0 | 0.688 | 0.0 | ||||||
| 3ekk | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-23 | LEU | A:62 | A:1038 | 127.0 | 0.747 | H | -59.2 | -41.3 | 127.0 | 0.747 | 0.0 |
HOH |
3.542 |
CA |
O |
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| 3ekn | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-30 | LEU | A:62 | A:1038 | 130.0 | 0.765 | H | -56.3 | -39.2 | 130.0 | 0.765 | 0.0 |
HOH |
6.161 |
O |
O |
||
| 2z8c | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2008-08-12 | LEU | A:58 | A:1038 | 100.0 | 0.588 | H | -49.0 | -37.1 | 100.0 | 0.588 | 0.0 | ||||||
| 2oj9 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2007-05-01 | MET | A:62 | A:1011 | 138.0 | 0.746 | H | -57.5 | -41.8 | 138.0 | 0.746 | 0.0 |
HOH |
3.613 |
N |
O |
||
| 3nw5 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:62 | A:1011 | 146.0 | 0.789 | H | -65.0 | -43.7 | 146.0 | 0.789 | 0.0 |
HOH |
3.565 |
CB |
O |
||
| 3nw6 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:62 | A:1011 | 144.0 | 0.778 | H | -58.9 | -43.2 | 144.0 | 0.778 | 0.0 |
HOH |
6.812 |
CA |
O |
||
| 3nw7 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:62 | A:1011 | 152.0 | 0.822 | H | -58.9 | -38.6 | 152.0 | 0.822 | 0.0 |
HOH |
3.134 |
N |
O |
||
| 3i81 | 1 | P08069 | 80.07 | 7e-177 |
X-RAY |
2009-12-22 | MET | A:62 | A:1011 | 113.0 | 0.611 | H | -61.4 | -34.7 | 113.0 | 0.611 | 0.0 |
HOH |
3.422 |
CE |
O |
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| 3d94 | 1 | P08069 | 81.06 | 1e-176 |
X-RAY |
2008-07-29 | MET | A:56 | A:1011 | 120.0 | 0.649 | H | -60.7 | -37.6 | 120.0 | 0.649 | 0.0 |
HOH |
3.600 |
N |
O |
||
| 1jqh | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2002-04-19 | MET | A:63 | A:1041 | 122.0 | 0.659 | H | -76.5 | -50.8 | 122.0 | 0.659 | 0.0 |
HOH |
6.555 |
O |
O |
||
| MET | B:63 | B:1041 | 120.0 | 0.649 | H | -76.2 | -50.3 | NA | NA | NA | |||||||||||||
| MET | C:63 | C:1041 | 113.0 | 0.611 | H | -76.7 | -51.3 | NA | NA | NA | |||||||||||||
| 2zm3 | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-06-10 | MET | A:63 | A:1041 | 132.0 | 0.714 | H | -57.8 | -34.1 | 132.0 | 0.714 | 0.0 |
HOH |
3.087 |
N |
O |
||
| MET | B:63 | B:1041 | 127.0 | 0.686 | H | -51.8 | -40.2 | NA | NA | NA | |||||||||||||
| MET | C:63 | C:1041 | 135.0 | 0.73 | H | -55.8 | -44.1 | NA | NA | NA | |||||||||||||
| MET | D:63 | D:1041 | 133.0 | 0.719 | H | -58.9 | -38.0 | NA | NA | NA | |||||||||||||
| 3f5p | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-12-30 | MET | A:63 | A:1041 | 124.0 | 0.67 | H | -64.0 | -37.4 | 124.0 | 0.67 | 0.0 | ||||||
| MET | B:63 | B:1041 | 131.0 | 0.708 | H | -66.7 | -41.1 | NA | NA | NA | |||||||||||||
| MET | C:63 | C:1041 | 132.0 | 0.714 | H | -57.9 | -43.3 | NA | NA | NA | |||||||||||||
| MET | D:63 | D:1041 | 126.0 | 0.681 | H | -68.0 | -37.0 | NA | NA | NA | |||||||||||||
| MET | E:63 | E:1041 | 121.0 | 0.654 | H | -59.3 | -39.6 | NA | NA | NA | |||||||||||||
| MET | F:63 | F:1041 | 129.0 | 0.697 | S | -95.5 | -26.0 | NA | NA | NA | |||||||||||||
| MET | G:63 | G:1041 | 132.0 | 0.714 | H | -58.9 | -41.5 | NA | NA | NA | |||||||||||||
| MET | H:63 | H:1041 | 128.0 | 0.692 | H | -63.6 | -40.3 | NA | NA | NA | |||||||||||||
| MET | I:63 | I:1041 | 129.0 | 0.697 | H | -60.1 | -37.4 | NA | NA | NA | |||||||||||||
| MET | J:63 | J:1041 | 125.0 | 0.676 | H | -61.2 | -29.7 | NA | NA | NA | |||||||||||||
| MET | K:63 | K:1041 | 125.0 | 0.676 | H | -59.6 | -40.8 | NA | NA | NA | |||||||||||||
| MET | L:63 | M:1041 | 127.0 | 0.686 | H | -61.6 | -34.8 | NA | NA | NA | |||||||||||||
| MET | M:63 | L:1041 | 125.0 | 0.676 | H | -53.2 | -38.6 | NA | NA | NA | |||||||||||||
| MET | N:63 | R:1041 | 129.0 | 0.697 | H | -64.4 | -37.9 | NA | NA | NA | |||||||||||||
| MET | O:63 | S:1041 | 121.0 | 0.654 | H | -63.1 | -40.8 | NA | NA | NA | |||||||||||||
| MET | P:63 | T:1041 | 122.0 | 0.659 | H | -50.3 | -36.2 | NA | NA | NA | |||||||||||||
| 4d2r | 1 | P08069 | 81.06 | 2e-176 |
X-RAY |
2015-04-22 | MET | A:57 | A:1041 | 106.0 | 0.573 | H | -66.0 | -36.6 | 106.0 | 0.573 | 0.0 |
HOH |
5.008 |
SD |
O |
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| 1k3a | 1 | P08069 | 80.94 | 4e-175 |
X-RAY |
2001-11-28 | MET | A:54 | A:1011 | 126.0 | 0.681 | H | -60.4 | -40.6 | 126.0 | 0.681 | 0.0 |
HOH |
3.159 |
N |
O |
||
| 3qqu | 1 | P08069 | 80.94 | 6e-175 |
X-RAY |
2011-04-20 | MET | A:56 | A:1038 | 132.0 | 0.714 | T | -65.5 | -4.8 | 132.0 | 0.714 | 0.0 | ||||||
| MET | B:56 | B:1038 | 136.0 | 0.735 | H | -58.4 | -12.4 | NA | NA | NA | |||||||||||||
| MET | C:56 | C:1038 | 140.0 | 0.757 | T | -68.4 | 10.0 | NA | NA | NA | |||||||||||||
| MET | D:56 | D:1038 | 81.0 | NA | H | -71.3 | -26.3 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | LEU | A:1065 | A:1065 | 132.0 | 0.776 | H | -55.9 | -37.0 | |