Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7267887 . G A CCDS12176.1:NM_000208.2:c.121Cgg>Tgg_NP_000199.2:p.41R>W Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:14 A:14 144.0 0.64 E -143.8 150.7 33.0 0.147 0.493 C:P01308+A6XGL2:0.356
B:P06213:0.173
ARG B:14 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:14 A:14 139.0 0.618 E -138.7 122.7 45.0 0.2 0.418 C:P01308+A6XGL2:0.293
B:P06213:0.138
ARG B:14 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:14 A:14 99.0 0.44 -148.9 137.6 99.0 0.44 0.0
ARG B:14 C:14 98.0 0.436 -149.0 137.6 NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:41 A:14 104.0 0.462 -135.6 155.1 1.0 0.004 0.458 D:P01308:0.391
C:P01308:0.036
B:P06213:0.151
ARG B:41 B:14 136.0 0.604 -143.7 124.8 136.0 0.604 0.0
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:41 A:14 109.0 0.484 E -127.2 127.1 8.0 0.036 0.448 D:P01308:0.342
B:P06213:0.133
ARG B:41 B:14 131.0 0.582 E -131.3 126.6 108.0 0.48 0.102 E:P01308:0.102
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:41 A:14 102.0 0.453 E -140.8 145.6 4.0 0.018 0.435 D:P01308:0.324
B:P06213:0.156
ARG B:41 B:14 134.0 0.596 E -145.7 141.6 53.0 0.236 0.36 F:P01308:0.018
E:P01308:0.36
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:41 A:14 140.0 0.622 S -130.8 12.7 18.0 0.08 0.542 B:P06213:0.116
D:P01308:0.44
ARG B:41 B:14 77.0 0.342 -151.9 116.8 77.0 0.342 0.0
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:14 A:14 104.0 0.462 E -131.5 158.5 1.0 0.004 0.458 C:A6XGL2:0.307
B:P06213:0.227
ARG B:14 C:14 103.0 0.458 E -131.5 158.4 2.0 0.009 0.449 A:P06213:0.227
D:A6XGL2:0.298
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:14 A:14 104.0 0.462 E -131.5 158.4 1.0 0.004 0.458 C:A6XGL2:0.302
B:P06213:0.231
ARG B:14 B:14 103.0 0.458 E -131.5 158.4 2.0 0.009 0.449 A:P06213:0.227
D:A6XGL2:0.298
6ce7 1 P06213 99.89 0.0 EM
 2018-03-14 ARG A:14 B:14 136.0 0.604 -135.2 140.2 136.0 0.604 0.0
ARG B:14 A:14 133.0 0.591 E -136.1 157.7 18.0 0.08 0.511 E:P06213:0.28
D:P01318:0.36
6ce9 1 P06213 98.6 0.0 EM
 2018-03-14 ARG A:14 A:14 138.0 0.613 E -135.3 146.4 14.0 0.062 0.551 G:P01318:0.422
H:P06213:0.249
 NAG
 5.063
 O
 O5
ARG B:14 B:14 138.0 0.613 E -135.3 146.4 17.0 0.076 0.537 C:P06213:0.209
E:P01318:0.413
 NAG
 5.029
 O
 O5
6ceb 1 P06213 98.6 0.0 EM
 2018-03-14 ARG A:14 A:14 144.0 0.64 E -137.0 149.7 15.0 0.067 0.573 G:P01318:0.422
H:P06213:0.267
 NAG
 5.123
 O
 O5
ARG B:14 B:14 143.0 0.636 E -137.3 144.6 17.0 0.076 0.56 E:P01318:0.409
C:P06213:0.244
 NAG
 4.886
 O
 O6
6hn4 1 P06213,P03069 95.7 0.0 EM
 2018-11-21 ARG A:14 NA:NA DO NA DO DO DO NA NA NA
ARG B:14 F:14 131.0 0.582 E -128.3 162.1 131.0 0.582 0.0 NAG
 5.551
 O
 O5
6hn5 3 P06213,P03069 95.7 0.0 EM
 2018-11-21 ARG C:14 E:14 89.0 0.396 -136.9 160.9 5.0 0.022 0.374 B:P01308:0.244
D:P06213+P03069:0.156
 NAG
 5.740
 O
 C8
ARG D:14 NA:NA DO NA DO DO DO NA NA NA
4zxb 5 P06213 95.48 0.0 X-RAY
 2016-02-24 ARG E:14 E:14 109.0 0.484 E -128.8 162.6 87.0 0.387 0.097 E:P06213:0.098
 NAG
 5.792
 O
 O6
6sof 1 P06213 100.0 0.0 EM
 2019-11-13 ARG A:14 A:14 105.0 0.467 -140.0 31.1 16.0 0.071 0.396 H:P01308:0.244
C:P06213:0.182
ARG C:14 C:14 119.0 0.529 -155.7 121.7 34.0 0.151 0.378 A:P06213:0.111
F:P01308:0.351
7qid 1 P06213 100.0 0.0 EM
 2022-02-02 ARG A:14 A:14 116.0 0.516 E -141.0 128.3 33.0 0.147 0.369 C:P06213:0.156
F:P01308:0.227
ARG C:14 C:14 117.0 0.52 E -159.9 132.8 117.0 0.52 0.0
5kqv 5 P06213 99.83 0.0 X-RAY
 2017-07-19 ARG E:14 E:14 101.0 0.449 E -131.9 164.0 46.0 0.204 0.245 A:P01317:0.098
F:P06213:0.16
ARG F:14 F:14 102.0 0.453 E -131.8 162.8 38.0 0.169 0.284 G:P01317:0.129
E:P06213:0.173
2hr7 1 P06213 99.59 0.0 X-RAY
 2006-08-15 ARG A:14 A:14 122.0 0.542 E -133.8 154.4 32.0 0.142 0.4 B:P06213:0.4
 NAG
P33
GOL
HOH
 4.304
6.683
9.303
3.205
 O
NH2
NH2
O
 O7
C6
O2
O
ARG B:14 B:14 110.0 0.489 E -131.1 171.6 110.0 0.489 0.0 P33
GOL
GOL
HOH
 3.310
8.493
3.524
3.162
 NH1
NH2
NH2
N
 C17
C3
O3
O
4oga 5 P06213 99.68 0.0 X-RAY
 2014-08-27 ARG E:14 E:14 96.0 0.427 E -134.3 156.1 5.0 0.022 0.405 B:P01308:0.244
F:P06213:0.222
 NAG
 6.759
 O
 O7
4xss 2 P06213 99.68 0.0 X-RAY
 2015-06-10 ARG B:14 E:14 105.0 0.467 E -132.8 160.2 17.0 0.076 0.391 C:None:0.213
A:P05019:0.271
 NAG
 6.719
 O
 O5
4xst 1 P06213 99.68 0.0 X-RAY
 2015-06-10 ARG A:14 E:14 160.0 0.711 E -127.9 155.5 140.0 0.622 0.089 B:P15127:0.089
5j3h 4 P06213 99.68 0.0 X-RAY
 2016-06-15 ARG D:14 E:14 112.0 0.498 E -136.0 168.9 82.0 0.364 0.134 A:None:0.133
 NAG
 5.757
 O
 O7
6vep 5 P06213 99.68 0.0 X-RAY
 2020-06-03 ARG E:14 E:14 102.0 0.453 E -138.1 171.0 18.0 0.08 0.373 F:P06213:0.196
B:P01308:0.284
 NAG
FUC
 7.070
7.129
 O
O
 C1
O2
ARG K:14 K:14 105.0 0.467 E -135.8 171.1 NA NA NA
ARG Q:14 Q:14 104.0 0.462 E -137.4 170.9 NA NA NA
ARG W:14 W:14 109.0 0.484 E -136.9 171.5 NA NA NA
6veq 3 P06213 99.68 0.0 X-RAY
 2020-06-03 ARG C:14 E:14 82.0 0.364 E -153.0 169.6 9.0 0.04 0.324 D:P06213:0.249
B:A0A0B5A8Q2:0.053
A:A0A0B5AC95:0.031
 NAG
 5.980
 O
 O7
ARG G:14 K:14 89.0 0.396 E -151.3 169.0 NA NA NA
7kd6 4 P06213 99.68 0.0 X-RAY
 2021-10-13 ARG D:14 E:14 109.0 0.484 -136.3 169.1 31.0 0.138 0.346 E:None:0.2
A:None:0.191
 NAG
FUC
HOH
 6.768
6.167
3.451
 O
O
N
 O5
O2
O
ARG I:14 K:14 119.0 0.529 E -135.1 170.4 NA NA NA
ARG N:14 Q:14 110.0 0.489 E -135.6 166.2 NA NA NA
ARG S:14 W:14 109.0 0.484 E -134.7 166.8 NA NA NA
3w11 5 P06213 99.68 0.0 X-RAY
 2013-01-09 ARG E:14 E:14 105.0 0.467 E -132.3 157.2 42.0 0.187 0.28 A:P01308:0.062
F:P06213:0.227
 NAG
 6.745
 O
 C8
3w12 1 P06213 99.68 0.0 X-RAY
 2013-01-09 ARG A:14 E:14 101.0 0.449 E -140.0 154.7 24.0 0.107 0.342 F:P06213:0.289
D:P01308:0.076
3w13 1 P06213 99.68 0.0 X-RAY
 2013-01-09 ARG A:14 E:14 100.0 0.444 E -137.6 149.1 22.0 0.098 0.346 D:P01308:0.044
F:P06213:0.307

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 ARG A:41 A:41 48.0 0.213 E -122.7 150.4