Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 42474351 | . | G | A | CCDS12594.1:NM_152296.4:c.2528gCc>gTc_NP_689509.1:p.843A>V | Homo sapiens ATPase Na+/K+ transporting subunit alpha 3 (ATP1A3), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3wgu | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | ALA | A:846 | A:846 | 3.0 | 0.026 | I | -63.9 | -30.8 | 3.0 | 0.026 | 0.0 |
NA NA PC1 CLR |
8.839 7.756 8.340 6.879 |
O CB C C |
NA NA C38 C15 |
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| ALA | D:846 | C:846 | 4.0 | 0.035 | I | -69.5 | -55.2 | NA | NA | NA | |||||||||||||
| 3wgv | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | ALA | A:846 | A:846 | 3.0 | 0.026 | I | -61.9 | -25.6 | 3.0 | 0.026 | 0.0 |
NA NA CLR PC1 |
8.916 7.796 6.579 8.189 |
O CB C C |
NA NA C15 C38 |
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| ALA | D:846 | C:846 | 2.0 | 0.017 | I | -65.0 | -56.1 | NA | NA | NA | |||||||||||||
| 4xe5 | 1 | Q08DA1 | 87.61 | 0.0 |
X-RAY |
2016-03-09 | ALA | A:851 | A:851 | 4.0 | 0.035 | I | -59.4 | -57.7 | 4.0 | 0.035 | 0.0 |
HOH |
9.674 |
CB |
O |
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| 4hqj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-10-02 | ALA | A:851 | A:846 | 0.0 | 0.0 | I | -85.9 | -36.7 | 0.0 | 0.0 | 0.0 |
NA |
6.759 |
O |
NA |
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| ALA | D:851 | C:846 | 0.0 | 0.0 | I | -86.3 | -36.4 | NA | NA | NA | |||||||||||||
| 4hyt | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-06-26 | ALA | A:851 | A:846 | 2.0 | 0.017 | I | -57.7 | -56.0 | 2.0 | 0.017 | 0.0 |
17F 17F HOH |
7.874 8.086 9.476 |
N C CB |
C18 C20 O |
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| ALA | D:851 | C:846 | 2.0 | 0.017 | I | -58.8 | -55.7 | NA | NA | NA | |||||||||||||
| 4res | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | ALA | A:851 | A:846 | 1.0 | 0.009 | I | -55.2 | -55.1 | 1.0 | 0.009 | 0.0 |
K |
8.933 |
CB |
K |
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| ALA | D:851 | C:846 | 1.0 | 0.009 | I | -55.7 | -54.4 | NA | NA | NA | |||||||||||||
| 4ret | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | ALA | A:851 | A:846 | 2.0 | 0.017 | I | -56.9 | -57.5 | 2.0 | 0.017 | 0.0 |
17F HOH |
8.569 9.563 |
C CB |
C1Y O |
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| ALA | D:851 | C:846 | 3.0 | 0.026 | I | -56.6 | -57.5 | NA | NA | NA | |||||||||||||
| 7evx | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-07-07 | ALA | A:851 | A:846 | 1.0 | 0.009 | I | -68.7 | -63.1 | 1.0 | 0.009 | 0.0 |
CLR HOH |
8.572 9.636 |
C CB |
C6 O |
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| ALA | D:851 | C:846 | 2.0 | 0.017 | I | -69.6 | -63.9 | NA | NA | NA | |||||||||||||
| 7d91 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 2.0 | 0.017 | I | -69.6 | -63.5 | 2.0 | 0.017 | 0.0 |
PCW |
9.522 |
N |
O31 |
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| 7d92 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 2.0 | 0.017 | I | -70.7 | -62.1 | 2.0 | 0.017 | 0.0 |
PCW CLR HOH |
9.921 7.558 9.535 |
N C CB |
O31 C15 O |
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| 7d93 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 1.0 | 0.009 | I | -63.1 | -64.3 | 1.0 | 0.009 | 0.0 |
HOH |
9.404 |
CB |
O |
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| ALA | C:846 | C:846 | 1.0 | 0.009 | I | -63.4 | -64.6 | NA | NA | NA | |||||||||||||
| 7d94 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 1.0 | 0.009 | I | -62.8 | -63.3 | 1.0 | 0.009 | 0.0 |
RB |
9.423 |
CB |
RB |
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| ALA | D:846 | C:846 | 0.0 | 0.0 | I | -63.0 | -64.4 | NA | NA | NA | |||||||||||||
| 7ddf | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 1.0 | 0.009 | I | -64.2 | -60.7 | 1.0 | 0.009 | 0.0 |
CLR HOH |
8.546 9.594 |
C CB |
C6 O |
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| ALA | D:846 | C:846 | 2.0 | 0.017 | I | -63.8 | -61.5 | NA | NA | NA | |||||||||||||
| 7ddh | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 1.0 | 0.009 | I | -70.2 | -64.9 | 1.0 | 0.009 | 0.0 |
CLR HOH |
8.607 9.560 |
C CB |
C6 O |
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| ALA | D:846 | C:846 | 2.0 | 0.017 | I | -69.5 | -65.4 | NA | NA | NA | |||||||||||||
| 7ddi | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 1.0 | 0.009 | I | -70.9 | -66.4 | 1.0 | 0.009 | 0.0 |
HOH |
9.815 |
CB |
O |
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| ALA | D:846 | C:846 | 2.0 | 0.017 | I | -69.7 | -65.7 | NA | NA | NA | |||||||||||||
| 7ddj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 0.0 | 0.0 | I | -62.2 | -63.8 | 0.0 | 0.0 | 0.0 |
HOH |
9.563 |
CB |
O |
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| ALA | D:846 | C:846 | 1.0 | 0.009 | I | -62.4 | -64.8 | NA | NA | NA | |||||||||||||
| 7ddk | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 1.0 | 0.009 | I | -69.0 | -63.0 | 1.0 | 0.009 | 0.0 |
CLR HOH |
8.652 9.769 |
C CB |
C6 O |
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| ALA | D:846 | C:846 | 1.0 | 0.009 | I | -70.2 | -63.0 | NA | NA | NA | |||||||||||||
| 7ddl | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ALA | A:846 | A:846 | 1.0 | 0.009 | I | -63.6 | -63.2 | 1.0 | 0.009 | 0.0 |
CLR HOH |
8.679 9.598 |
C CB |
C6 O |
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| ALA | D:846 | C:846 | 1.0 | 0.009 | I | -62.7 | -63.6 | NA | NA | NA | |||||||||||||
| 3b8e | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2007-12-18 | ALA | A:828 | A:846 | 2.0 | 0.017 | T | -141.4 | -16.6 | 2.0 | 0.017 | 0.0 |
RB PC1 |
8.961 8.192 |
O N |
RB C14 |
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| ALA | D:828 | C:846 | 2.0 | 0.017 | T | -151.4 | -80.6 | NA | NA | NA | |||||||||||||
| 3kdp | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2010-02-16 | ALA | A:828 | A:846 | 0.0 | 0.0 | H | -78.0 | -25.4 | 0.0 | 0.0 | 0.0 |
RB CLR |
9.047 7.910 |
O C |
RB C15 |
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| ALA | D:828 | C:846 | 1.0 | 0.009 | H | -75.2 | -27.6 | NA | NA | NA | |||||||||||||
| 3n23 | 1 | P05024 | 87.8 | 0.0 |
X-RAY |
2011-01-19 | ALA | A:822 | A:846 | 3.0 | 0.026 | I | -68.9 | -36.3 | 3.0 | 0.026 | 0.0 | ||||||
| ALA | D:822 | C:846 | 4.0 | 0.035 | I | -68.1 | -36.6 | NA | NA | NA | |||||||||||||
| 2zxe | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-05-19 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.4 | 0.0 | 0.0 | 0.0 |
K CLR HOH |
9.411 7.226 9.788 |
O C C |
K C15 O |
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| 3a3y | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-09-08 | ALA | A:858 | A:853 | 2.0 | 0.017 | I | -73.0 | -45.0 | 2.0 | 0.017 | 0.0 |
K CLR |
9.267 7.077 |
CB C |
K C7 |
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| 5avq | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.4 | 0.0 | 0.0 | 0.0 |
K TL CLR |
9.411 9.411 7.226 |
O O C |
K TL C15 |
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| 5avr | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.3 | 0.0 | 0.0 | 0.0 |
K TL CLR |
9.410 9.410 7.227 |
O O C |
K TL C15 |
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| 5avs | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.8 | -44.4 | 0.0 | 0.0 | 0.0 |
K TL CLR |
9.411 9.411 7.226 |
O O C |
K TL C15 |
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| 5avt | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -73.0 | -44.2 | 0.0 | 0.0 | 0.0 |
K TL CLR |
9.411 9.411 7.226 |
O O C |
K TL C15 |
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| 5avu | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.4 | 0.0 | 0.0 | 0.0 |
K TL CLR |
9.410 9.410 7.226 |
O O C |
K TL C15 |
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| 5avv | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.4 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.411 7.226 |
O C |
TL C15 |
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| 5avw | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.3 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.411 7.228 |
O C |
TL C15 |
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| 5avx | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.8 | -44.3 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.411 7.227 |
O C |
TL C15 |
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| 5avy | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.3 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.409 7.226 |
O C |
TL C15 |
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| 5avz | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.8 | -44.5 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.410 7.227 |
O C |
TL C15 |
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| 5aw0 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.8 | -44.4 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.411 7.227 |
O C |
TL C15 |
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| 5aw1 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.3 | 0.0 | 0.0 | 0.0 |
K TL CLR |
9.411 9.411 7.226 |
O O C |
K TL C15 |
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| 5aw2 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.5 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.411 7.226 |
O C |
TL C15 |
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| 5aw3 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.3 | 0.0 | 0.0 | 0.0 |
TL CLR |
9.412 7.226 |
O C |
TL C15 |
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| 5aw4 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.3 | 0.0 | 0.0 | 0.0 |
K RB CLR |
9.411 9.411 7.226 |
O O C |
K RB C15 |
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| 5aw5 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.4 | 0.0 | 0.0 | 0.0 |
K RB CLR |
9.411 9.411 7.226 |
O O C |
K RB C15 |
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| 5aw6 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.4 | 0.0 | 0.0 | 0.0 |
K RB CLR |
9.411 9.411 7.226 |
O O C |
K RB C15 |
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| 5aw7 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.3 | 0.0 | 0.0 | 0.0 |
K RB CLR |
9.410 9.410 7.226 |
O O C |
K RB C15 |
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| 5aw8 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 0.0 | 0.0 | I | -72.9 | -44.4 | 0.0 | 0.0 | 0.0 |
RB CLR |
9.412 7.226 |
O C |
RB C15 |
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| 5aw9 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ALA | A:858 | A:853 | 1.0 | 0.009 | I | -74.9 | -43.4 | 1.0 | 0.009 | 0.0 |
K CLR HOH |
9.383 7.013 9.725 |
CB C CB |
K C15 O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p13637-f1 | 1 | P13637 | 100.0 | 0.0 | ALA | A:843 | A:843 | 2.0 | 0.017 | I | -69.7 | -61.2 | |
| af-p50993-f1 | 1 | P50993 | 88.81 | 0.0 | ALA | A:850 | A:850 | 4.0 | 0.035 | I | -69.9 | -61.4 | |
| af-p05023-f1 | 1 | P05023 | 88.03 | 0.0 | ALA | A:853 | A:853 | 3.0 | 0.026 | I | -69.4 | -63.6 | |