Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 42474628 | . | A | C | CCDS12594.1:NM_152296.4:c.2330aTc>aGc_NP_689509.1:p.777I>S | Homo sapiens ATPase Na+/K+ transporting subunit alpha 3 (ATP1A3), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3wgu | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | ILE | A:780 | A:780 | 27.0 | 0.154 | H | -119.2 | -20.8 | 27.0 | 0.154 | 0.0 |
NA NA PC1 PC1 CLR |
9.452 7.893 4.476 6.474 5.788 |
CG2 CG2 CD1 CD1 CG1 |
NA NA C3C C3A C27 |
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| ILE | D:780 | C:780 | 19.0 | 0.109 | H | -108.4 | -32.0 | NA | NA | NA | |||||||||||||
| 3wgv | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | ILE | A:780 | A:780 | 27.0 | 0.154 | H | -118.7 | -19.5 | 27.0 | 0.154 | 0.0 |
NA NA CLR PC1 PC1 |
9.738 7.839 5.616 4.500 6.523 |
CG2 CG2 CD1 CD1 CD1 |
NA NA C27 C3C C3A |
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| ILE | D:780 | C:780 | 22.0 | 0.126 | H | -101.7 | -29.6 | NA | NA | NA | |||||||||||||
| 4xe5 | 1 | Q08DA1 | 87.61 | 0.0 |
X-RAY |
2016-03-09 | ILE | A:785 | A:785 | 9.0 | 0.051 | H | -78.1 | -46.3 | 9.0 | 0.051 | 0.0 |
MG OBN HOH |
6.613 6.181 6.167 |
CG1 O CG1 |
MG C16 O |
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| 4hqj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-10-02 | ILE | A:785 | A:780 | 11.0 | 0.063 | H | -87.9 | -38.6 | 11.0 | 0.063 | 0.0 |
NA NA |
9.889 7.209 |
CD1 CG1 |
NA NA |
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| ILE | D:785 | C:780 | 12.0 | 0.069 | H | -88.7 | -39.2 | NA | NA | NA | |||||||||||||
| 4hyt | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-06-26 | ILE | A:785 | A:780 | 7.0 | 0.04 | H | -77.4 | -42.5 | 7.0 | 0.04 | 0.0 |
MG OBN HOH |
6.494 6.260 6.082 |
CG1 O CG1 |
MG C16 O |
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| ILE | D:785 | C:780 | 8.0 | 0.046 | H | -77.3 | -41.7 | NA | NA | NA | |||||||||||||
| 4res | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | ILE | A:785 | A:780 | 9.0 | 0.051 | H | -76.5 | -43.8 | 9.0 | 0.051 | 0.0 |
BUF K K |
6.186 7.776 5.900 |
CG1 CG1 CG1 |
C23 K K |
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| ILE | D:785 | C:780 | 11.0 | 0.063 | H | -76.7 | -44.2 | NA | NA | NA | |||||||||||||
| 4ret | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | ILE | A:785 | A:780 | 8.0 | 0.046 | H | -78.8 | -41.6 | 8.0 | 0.046 | 0.0 |
MG DGX HOH |
6.655 6.167 5.817 |
CG1 O CG1 |
MG C16 O |
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| ILE | D:785 | C:780 | 8.0 | 0.046 | H | -78.6 | -41.5 | NA | NA | NA | |||||||||||||
| 7evx | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-07-07 | ILE | A:785 | A:780 | 6.0 | 0.034 | H | -101.9 | -37.1 | 6.0 | 0.034 | 0.0 |
MG JEO CLR HOH |
6.968 5.977 8.762 5.585 |
CG1 CA O CD1 |
MG OAA C26 O |
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| ILE | D:785 | C:780 | 5.0 | 0.029 | H | -101.2 | -39.2 | NA | NA | NA | |||||||||||||
| 7d91 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 12.0 | 0.069 | H | -86.0 | -38.5 | 12.0 | 0.069 | 0.0 |
MG HOH |
6.370 5.333 |
CG1 CG1 |
MG O |
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| 7d92 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 8.0 | 0.046 | H | -87.5 | -38.9 | 8.0 | 0.046 | 0.0 |
MG H0C CLR HOH |
6.989 6.731 8.981 5.464 |
CG1 O O CG1 |
MG C23 C26 O |
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| 7d93 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 7.0 | 0.04 | H | -103.8 | -37.0 | 7.0 | 0.04 | 0.0 |
MG H0C HOH |
6.843 6.761 5.218 |
CG1 O CD1 |
MG C23 O |
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| ILE | C:780 | C:780 | 7.0 | 0.04 | H | -103.1 | -38.4 | NA | NA | NA | |||||||||||||
| 7d94 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 6.0 | 0.034 | H | -93.8 | -35.3 | 6.0 | 0.034 | 0.0 |
MG RB BUF HOH |
6.120 7.760 6.377 5.802 |
CD1 CD1 CA CG1 |
MG RB C16 O |
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| ILE | D:780 | C:780 | 6.0 | 0.034 | H | -92.0 | -37.1 | NA | NA | NA | |||||||||||||
| 7ddf | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 8.0 | 0.046 | H | -102.2 | -36.2 | 8.0 | 0.046 | 0.0 |
MG CLR HOH |
6.817 8.829 5.356 |
CG1 O CD1 |
MG C26 O |
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| ILE | D:780 | C:780 | 8.0 | 0.046 | H | -102.0 | -37.0 | NA | NA | NA | |||||||||||||
| 7ddh | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 13.0 | 0.074 | H | -105.2 | -36.9 | 13.0 | 0.074 | 0.0 |
MG DGX CLR HOH |
6.816 6.239 8.671 5.387 |
CG1 CA O CD1 |
MG C16 C26 O |
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| ILE | D:780 | C:780 | 13.0 | 0.074 | H | -105.1 | -37.5 | NA | NA | NA | |||||||||||||
| 7ddi | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 11.0 | 0.063 | H | -102.4 | -38.2 | 11.0 | 0.063 | 0.0 |
MG F9R HOH |
6.755 6.202 5.352 |
CG1 CG2 CD1 |
MG C16 O |
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| ILE | D:780 | C:780 | 7.0 | 0.04 | H | -102.4 | -39.3 | NA | NA | NA | |||||||||||||
| 7ddj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 5.0 | 0.029 | H | -104.1 | -36.9 | 5.0 | 0.029 | 0.0 |
MG OBN HOH |
6.855 6.215 5.256 |
CG1 O CD1 |
MG C16 O |
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| ILE | D:780 | C:780 | 5.0 | 0.029 | H | -104.3 | -37.7 | NA | NA | NA | |||||||||||||
| 7ddk | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 7.0 | 0.04 | H | -102.4 | -34.2 | 7.0 | 0.04 | 0.0 |
MG E4R CLR HOH |
6.819 6.392 8.600 5.372 |
CG1 CG1 O CD1 |
MG O23 C26 O |
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| ILE | D:780 | C:780 | 6.0 | 0.034 | H | -100.9 | -36.6 | NA | NA | NA | |||||||||||||
| 7ddl | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ILE | A:780 | A:780 | 8.0 | 0.046 | H | -102.7 | -35.6 | 8.0 | 0.046 | 0.0 |
MG BUF CLR HOH |
7.101 6.471 8.679 5.408 |
CG1 O O CD1 |
MG C16 C26 O |
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| ILE | D:780 | C:780 | 7.0 | 0.04 | H | -102.3 | -36.7 | NA | NA | NA | |||||||||||||
| 3b8e | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2007-12-18 | ILE | A:762 | A:780 | 11.0 | 0.063 | H | -82.1 | -70.5 | 11.0 | 0.063 | 0.0 |
RB RB PC1 |
8.138 6.896 9.192 |
N N CD1 |
RB RB O14 |
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| ILE | D:762 | C:780 | 16.0 | 0.091 | T | -105.1 | -59.7 | NA | NA | NA | |||||||||||||
| 3kdp | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2010-02-16 | ILE | A:762 | A:780 | 6.0 | 0.034 | H | -79.1 | -54.2 | 6.0 | 0.034 | 0.0 |
RB RB CLR |
8.430 7.222 7.703 |
CG1 CG1 C |
RB RB C27 |
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| ILE | D:762 | C:780 | 8.0 | 0.046 | H | -79.2 | -54.0 | NA | NA | NA | |||||||||||||
| 3n23 | 1 | P05024 | 87.8 | 0.0 |
X-RAY |
2011-01-19 | ILE | A:756 | A:780 | 3.0 | 0.017 | H | -86.0 | -64.2 | 3.0 | 0.017 | 0.0 |
OBN |
6.444 |
CA |
O23 |
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| ILE | D:756 | C:780 | 3.0 | 0.017 | H | -85.4 | -64.3 | NA | NA | NA | |||||||||||||
| 2zxe | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-05-19 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
K K CLR HOH |
8.457 6.835 6.950 4.504 |
CD1 CG1 CG2 CD1 |
K K C26 O |
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| 3a3y | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-09-08 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -88.9 | -57.7 | 6.0 | 0.034 | 0.0 |
K K OBN CLR |
8.203 6.838 6.097 7.007 |
CG1 CG1 CG2 C |
K K O23 C26 |
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| 5avq | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
K TL K TL CLR |
8.456 8.456 6.835 6.835 6.950 |
CD1 CD1 CG1 CG1 CG2 |
K TL K TL C26 |
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| 5avr | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.8 | 6.0 | 0.034 | 0.0 |
K TL K TL CLR |
8.458 8.458 6.836 6.836 6.950 |
CD1 CD1 CG1 CG1 CG2 |
K TL K TL C26 |
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| 5avs | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
K TL TL CLR |
8.457 8.457 6.836 6.951 |
CD1 CD1 CG1 CG2 |
K TL TL C26 |
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| 5avt | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.0 | -51.7 | 6.0 | 0.034 | 0.0 |
K TL TL CLR |
8.458 8.458 6.835 6.950 |
CD1 CD1 CG1 CG2 |
K TL TL C26 |
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| 5avu | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
K TL TL CLR |
8.457 8.457 6.835 6.949 |
CD1 CD1 CG1 CG2 |
K TL TL C26 |
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| 5avv | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.457 6.836 6.951 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5avw | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.458 6.835 6.950 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5avx | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.455 6.835 6.951 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5avy | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.8 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.456 6.835 6.951 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5avz | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.8 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.456 6.836 6.950 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5aw0 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.2 | -51.7 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.456 6.836 6.951 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5aw1 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.0 | -51.8 | 6.0 | 0.034 | 0.0 |
K TL TL CLR |
8.457 8.457 6.835 6.949 |
CD1 CD1 CG1 CG2 |
K TL TL C26 |
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| 5aw2 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.2 | -51.8 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.457 6.835 6.950 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5aw3 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
TL TL CLR |
8.458 6.836 6.950 |
CD1 CG1 CG2 |
TL TL C26 |
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| 5aw4 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
K RB K RB CLR |
8.457 8.457 6.836 6.836 6.950 |
CD1 CD1 CG1 CG1 CG2 |
K RB K RB C26 |
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| 5aw5 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.2 | -51.6 | 6.0 | 0.034 | 0.0 |
K RB K RB CLR |
8.457 8.457 6.836 6.836 6.949 |
CD1 CD1 CG1 CG1 CG2 |
K RB K RB C26 |
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| 5aw6 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.2 | -51.6 | 6.0 | 0.034 | 0.0 |
K RB K RB CLR |
8.456 8.456 6.834 6.834 6.949 |
CD1 CD1 CG1 CG1 CG2 |
K RB K RB C26 |
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| 5aw7 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.2 | -51.7 | 6.0 | 0.034 | 0.0 |
K RB RB CLR |
8.457 8.457 6.835 6.950 |
CD1 CD1 CG1 CG2 |
K RB RB C26 |
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| 5aw8 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -82.1 | -51.7 | 6.0 | 0.034 | 0.0 |
RB RB CLR |
8.457 6.835 6.950 |
CD1 CG1 CG2 |
RB RB C26 |
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| 5aw9 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ILE | A:792 | A:787 | 6.0 | 0.034 | H | -78.5 | -57.5 | 6.0 | 0.034 | 0.0 |
K K CLR HOH |
8.324 6.763 6.975 4.572 |
CD1 CG1 CG2 CD1 |
K K C26 O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p13637-f1 | 1 | P13637 | 100.0 | 0.0 | ILE | A:777 | A:777 | 3.0 | 0.017 | H | -73.7 | -46.4 | |
| af-p50993-f1 | 1 | P50993 | 88.81 | 0.0 | ILE | A:784 | A:784 | 4.0 | 0.023 | H | -73.2 | -47.0 | |
| af-p05023-f1 | 1 | P05023 | 88.03 | 0.0 | ILE | A:787 | A:787 | 4.0 | 0.023 | H | -74.5 | -46.0 | |