Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 42474640 | . | T | A | CCDS12594.1:NM_152296.4:c.2318aAt>aTt_NP_689509.1:p.773N>I | Homo sapiens ATPase Na+/K+ transporting subunit alpha 3 (ATP1A3), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3wgu | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | ASN | A:776 | A:776 | 4.0 | 0.025 | H | -51.7 | -50.2 | 4.0 | 0.025 | 0.0 |
NA NA NA PC1 CLR HOH |
4.798 3.063 6.405 7.417 8.147 5.604 |
OD1 OD1 N CB O OD1 |
NA NA NA C3A C27 O |
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| ASN | D:776 | C:776 | 3.0 | 0.019 | H | -42.8 | -53.1 | NA | NA | NA | |||||||||||||
| 3wgv | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | ASN | A:776 | A:776 | 5.0 | 0.031 | H | -59.2 | -41.6 | 5.0 | 0.031 | 0.0 |
NA NA NA CLR PC1 HOH |
5.166 3.052 6.813 8.012 7.451 5.264 |
OD1 OD1 N O CB OD1 |
NA NA NA C27 C3A O |
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| ASN | D:776 | C:776 | 4.0 | 0.025 | H | -56.4 | -50.5 | NA | NA | NA | |||||||||||||
| 4xe5 | 1 | Q08DA1 | 87.61 | 0.0 |
X-RAY |
2016-03-09 | ASN | A:781 | A:781 | 0.0 | 0.0 | H | -66.0 | -34.0 | 0.0 | 0.0 | 0.0 |
MG OBN HOH |
2.134 6.802 3.002 |
OD1 OD1 OD1 |
MG O23 O |
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| 4hqj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-10-02 | ASN | A:781 | A:776 | 3.0 | 0.019 | H | -65.8 | -61.1 | 3.0 | 0.019 | 0.0 |
NA NA NA |
5.552 2.409 5.780 |
OD1 OD1 N |
NA NA NA |
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| ASN | D:781 | C:776 | 3.0 | 0.019 | H | -65.5 | -61.8 | NA | NA | NA | |||||||||||||
| 4hyt | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-06-26 | ASN | A:781 | A:776 | 0.0 | 0.0 | H | -71.9 | -18.9 | 0.0 | 0.0 | 0.0 |
MG OBN HOH |
2.469 6.751 3.084 |
OD1 OD1 OD1 |
MG O23 O |
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| ASN | D:781 | C:776 | 0.0 | 0.0 | H | -71.9 | -19.3 | NA | NA | NA | |||||||||||||
| 4res | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | ASN | A:781 | A:776 | 0.0 | 0.0 | H | -68.6 | -34.7 | 0.0 | 0.0 | 0.0 |
BUF K K |
6.346 2.740 3.703 |
OD1 OD1 OD1 |
O24 K K |
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| ASN | D:781 | C:776 | 0.0 | 0.0 | H | -68.5 | -34.2 | NA | NA | NA | |||||||||||||
| 4ret | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | ASN | A:781 | A:776 | 0.0 | 0.0 | H | -78.9 | -19.5 | 0.0 | 0.0 | 0.0 |
MG DGX HOH |
2.274 6.573 2.828 |
OD1 OD1 OD1 |
MG O23 O |
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| ASN | D:781 | C:776 | 0.0 | 0.0 | H | -79.1 | -19.2 | NA | NA | NA | |||||||||||||
| 7evx | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-07-07 | ASN | A:781 | A:776 | 0.0 | 0.0 | H | -67.0 | -39.1 | 0.0 | 0.0 | 0.0 |
MG JEO HOH |
4.352 8.955 2.643 |
ND2 O ND2 |
MG OAA O |
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| ASN | D:781 | C:776 | 0.0 | 0.0 | H | -68.3 | -39.4 | NA | NA | NA | |||||||||||||
| 7d91 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | T | -69.9 | -24.7 | 0.0 | 0.0 | 0.0 |
MG HOH |
2.433 3.808 |
OD1 OD1 |
MG O |
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| 7d92 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | T | -70.1 | -32.3 | 0.0 | 0.0 | 0.0 |
MG H0C CLR HOH |
4.402 7.561 9.657 2.471 |
ND2 ND2 C ND2 |
MG O9 C16 O |
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| 7d93 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | H | -70.5 | -37.1 | 0.0 | 0.0 | 0.0 |
MG H0C HOH |
4.162 7.731 2.419 |
ND2 ND2 ND2 |
MG O9 O |
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| ASN | C:776 | C:776 | 0.0 | 0.0 | H | -70.2 | -38.5 | NA | NA | NA | |||||||||||||
| 7d94 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | T | -68.7 | -37.1 | 0.0 | 0.0 | 0.0 |
MG RB BUF HOH |
2.972 2.884 6.963 4.545 |
OD1 OD1 OD1 OD1 |
MG RB O24 O |
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| ASN | D:776 | C:776 | 0.0 | 0.0 | T | -67.9 | -38.1 | NA | NA | NA | |||||||||||||
| 7ddf | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | H | -70.8 | -36.1 | 0.0 | 0.0 | 0.0 |
MG HOH |
4.205 2.633 |
ND2 ND2 |
MG O |
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| ASN | D:776 | C:776 | 0.0 | 0.0 | H | -69.5 | -36.1 | NA | NA | NA | |||||||||||||
| 7ddh | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | H | -69.8 | -36.3 | 0.0 | 0.0 | 0.0 |
MG DGX HOH |
4.130 7.097 2.569 |
ND2 ND2 ND2 |
MG O21 O |
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| ASN | D:776 | C:776 | 0.0 | 0.0 | H | -70.2 | -36.4 | NA | NA | NA | |||||||||||||
| 7ddi | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | H | -70.3 | -36.0 | 0.0 | 0.0 | 0.0 |
MG F9R HOH |
4.169 7.211 2.541 |
ND2 ND2 ND2 |
MG O21 O |
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| ASN | D:776 | C:776 | 0.0 | 0.0 | H | -69.6 | -35.9 | NA | NA | NA | |||||||||||||
| 7ddj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 1.0 | 0.006 | H | -70.1 | -37.6 | 1.0 | 0.006 | 0.0 |
MG OBN HOH |
4.034 7.360 2.411 |
ND2 ND2 ND2 |
MG O21 O |
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| ASN | D:776 | C:776 | 2.0 | 0.013 | H | -70.9 | -38.7 | NA | NA | NA | |||||||||||||
| 7ddk | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 0.0 | 0.0 | H | -69.9 | -35.0 | 0.0 | 0.0 | 0.0 |
MG E4R HOH |
4.259 7.533 2.600 |
ND2 ND2 ND2 |
MG O23 O |
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| ASN | D:776 | C:776 | 0.0 | 0.0 | H | -70.2 | -35.3 | NA | NA | NA | |||||||||||||
| 7ddl | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | ASN | A:776 | A:776 | 2.0 | 0.013 | T | -82.3 | -32.4 | 2.0 | 0.013 | 0.0 |
MG BUF HOH |
4.200 6.430 2.601 |
ND2 ND2 ND2 |
MG O24 O |
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| ASN | D:776 | C:776 | 2.0 | 0.013 | T | -82.8 | -31.9 | NA | NA | NA | |||||||||||||
| 3b8e | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2007-12-18 | ASN | A:758 | A:776 | 5.0 | 0.031 | T | -72.1 | -48.3 | 5.0 | 0.031 | 0.0 |
RB RB |
3.555 3.486 |
N OD1 |
RB RB |
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| ASN | D:758 | C:776 | 2.0 | 0.013 | S | -54.6 | -64.0 | NA | NA | NA | |||||||||||||
| 3kdp | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2010-02-16 | ASN | A:758 | A:776 | 0.0 | 0.0 | T | -71.2 | -30.1 | 0.0 | 0.0 | 0.0 |
RB RB |
2.940 2.869 |
OD1 OD1 |
RB RB |
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| ASN | D:758 | C:776 | 0.0 | 0.0 | T | -71.0 | -31.1 | NA | NA | NA | |||||||||||||
| 3n23 | 1 | P05024 | 87.8 | 0.0 |
X-RAY |
2011-01-19 | ASN | A:752 | A:776 | 1.0 | 0.006 | T | -71.1 | -45.8 | 1.0 | 0.006 | 0.0 |
OBN |
7.725 |
OD1 |
O23 |
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| ASN | D:752 | C:776 | 1.0 | 0.006 | T | -71.7 | -45.2 | NA | NA | NA | |||||||||||||
| 2zxe | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-05-19 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.6 | 0.0 | 0.0 | 0.0 |
K K CLR HOH |
2.823 3.017 9.933 4.083 |
OD1 OD1 O ND2 |
K K C26 O |
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| 3a3y | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-09-08 | ASN | A:788 | A:783 | 0.0 | 0.0 | H | -50.2 | -54.1 | 0.0 | 0.0 | 0.0 |
K K OBN HOH |
3.239 3.127 8.181 5.712 |
OD1 OD1 O OD1 |
K K O23 O |
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| 5avq | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.9 | -36.6 | 0.0 | 0.0 | 0.0 |
K TL K TL CLR HOH |
2.823 2.823 3.018 3.018 9.934 5.484 |
OD1 OD1 OD1 OD1 O OD1 |
K TL K TL C26 O |
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| 5avr | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.9 | -36.6 | 0.0 | 0.0 | 0.0 |
K TL K TL CLR HOH |
2.824 2.824 3.017 3.017 9.933 5.486 |
OD1 OD1 OD1 OD1 O OD1 |
K TL K TL C26 O |
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| 5avs | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.6 | 0.0 | 0.0 | 0.0 |
K TL TL CLR HOH |
2.822 2.822 3.017 9.933 5.484 |
OD1 OD1 OD1 O OD1 |
K TL TL C26 O |
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| 5avt | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.7 | -36.8 | 0.0 | 0.0 | 0.0 |
K TL TL CLR HOH |
2.823 2.823 3.017 9.933 5.485 |
OD1 OD1 OD1 O OD1 |
K TL TL C26 O |
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| 5avu | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.6 | 0.0 | 0.0 | 0.0 |
K TL TL CLR HOH |
2.823 2.823 3.017 9.933 5.485 |
OD1 OD1 OD1 O OD1 |
K TL TL C26 O |
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| 5avv | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.6 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.823 3.017 9.934 5.485 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5avw | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.9 | -36.5 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.824 3.018 9.933 5.486 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5avx | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.7 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.822 3.018 9.933 5.484 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5avy | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.6 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.822 3.017 9.934 5.484 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5avz | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.7 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.823 3.018 9.933 5.485 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5aw0 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.7 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.822 3.017 9.933 5.485 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5aw1 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.7 | -36.7 | 0.0 | 0.0 | 0.0 |
K TL TL CLR HOH |
2.823 2.823 3.016 9.933 5.485 |
OD1 OD1 OD1 O OD1 |
K TL TL C26 O |
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| 5aw2 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.6 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.823 3.017 9.934 5.485 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5aw3 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.9 | -36.6 | 0.0 | 0.0 | 0.0 |
TL TL CLR HOH |
2.824 3.018 9.933 5.486 |
OD1 OD1 O OD1 |
TL TL C26 O |
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| 5aw4 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.7 | 0.0 | 0.0 | 0.0 |
K RB K RB CLR HOH |
2.823 2.823 3.016 3.016 9.933 5.485 |
OD1 OD1 OD1 OD1 O OD1 |
K RB K RB C26 O |
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| 5aw5 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.7 | 0.0 | 0.0 | 0.0 |
K RB K RB CLR HOH |
2.823 2.823 3.017 3.017 9.933 5.486 |
OD1 OD1 OD1 OD1 O OD1 |
K RB K RB C26 O |
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| 5aw6 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.8 | -36.7 | 0.0 | 0.0 | 0.0 |
K RB K RB CLR HOH |
2.823 2.823 3.018 3.018 9.933 5.485 |
OD1 OD1 OD1 OD1 O OD1 |
K RB K RB C26 O |
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| 5aw7 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.9 | -36.6 | 0.0 | 0.0 | 0.0 |
K RB RB CLR HOH |
2.823 2.823 3.018 9.934 5.486 |
OD1 OD1 OD1 O OD1 |
K RB RB C26 O |
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| 5aw8 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -69.9 | -36.6 | 0.0 | 0.0 | 0.0 |
RB RB CLR HOH |
2.823 3.017 9.933 5.486 |
OD1 OD1 O OD1 |
RB RB C26 O |
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| 5aw9 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | ASN | A:788 | A:783 | 0.0 | 0.0 | T | -68.1 | -45.5 | 0.0 | 0.0 | 0.0 |
K K CLR HOH |
3.104 2.802 9.929 4.010 |
OD1 OD1 O ND2 |
K K C26 O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p13637-f1 | 1 | P13637 | 100.0 | 0.0 | ASN | A:773 | A:773 | 0.0 | 0.0 | H | -59.3 | -32.9 | |
| af-p50993-f1 | 1 | P50993 | 88.81 | 0.0 | ASN | A:780 | A:780 | 0.0 | 0.0 | H | -59.6 | -32.7 | |
| af-p05023-f1 | 1 | P05023 | 88.03 | 0.0 | ASN | A:783 | A:783 | 0.0 | 0.0 | H | -58.1 | -32.2 | |