Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 42489092 | . | T | A | CCDS12594.1:NM_152296.4:c.971gAg>gTg_NP_689509.1:p.324E>V | Homo sapiens ATPase Na+/K+ transporting subunit alpha 3 (ATP1A3), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3wgu | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | GLU | A:327 | A:327 | 9.0 | 0.047 | T | -50.9 | -31.9 | 9.0 | 0.047 | 0.0 |
NA NA PC1 HOH |
3.334 6.752 8.485 3.895 |
OE2 OE2 CB OE1 |
NA NA C39 O |
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| GLU | D:327 | C:327 | 15.0 | 0.079 | T | -56.4 | -55.7 | NA | NA | NA | |||||||||||||
| 3wgv | 1 | I7HD36 | 88.01 | 0.0 |
X-RAY |
2013-10-09 | GLU | A:327 | A:327 | 11.0 | 0.058 | T | -53.6 | -29.0 | 11.0 | 0.058 | 0.0 |
NA NA PC1 EFO HOH |
2.818 6.716 8.501 7.887 4.261 |
OE2 OE2 CB O OE1 |
NA NA C39 O36 O |
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| GLU | D:327 | C:327 | 15.0 | 0.079 | T | -45.5 | -52.8 | NA | NA | NA | |||||||||||||
| 4xe5 | 1 | Q08DA1 | 87.61 | 0.0 |
X-RAY |
2016-03-09 | GLU | A:332 | A:332 | 6.0 | 0.032 | T | -55.5 | -43.8 | 6.0 | 0.032 | 0.0 |
MG OBN HOH |
4.449 2.885 2.801 |
OE1 OE2 OE2 |
MG O23 O |
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| 4hqj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-10-02 | GLU | A:332 | A:327 | 8.0 | 0.042 | S | -61.2 | -47.4 | 8.0 | 0.042 | 0.0 |
NA NA |
2.428 6.180 |
OE2 OE2 |
NA NA |
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| GLU | D:332 | C:327 | 10.0 | 0.053 | S | -61.0 | -46.5 | NA | NA | NA | |||||||||||||
| 4hyt | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2013-06-26 | GLU | A:332 | A:327 | 9.0 | 0.047 | S | -77.8 | -34.3 | 9.0 | 0.047 | 0.0 |
MG OBN HOH |
4.455 4.129 3.282 |
OE2 OE2 OE2 |
MG O23 O |
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| GLU | D:332 | C:327 | 9.0 | 0.047 | S | -77.6 | -33.4 | NA | NA | NA | |||||||||||||
| 4res | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | GLU | A:332 | A:327 | 5.0 | 0.026 | H | -49.3 | -34.3 | 5.0 | 0.026 | 0.0 |
BUF K K |
2.936 5.929 2.875 |
OE2 N OE2 |
O24 K K |
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| GLU | D:332 | C:327 | 5.0 | 0.026 | H | -48.6 | -34.4 | NA | NA | NA | |||||||||||||
| 4ret | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2015-01-28 | GLU | A:332 | A:327 | 6.0 | 0.032 | H | -52.5 | -53.5 | 6.0 | 0.032 | 0.0 |
MG DGX HOH |
4.170 3.197 2.395 |
OE1 OE2 OE1 |
MG O23 O |
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| GLU | D:332 | C:327 | 8.0 | 0.042 | H | -52.7 | -53.5 | NA | NA | NA | |||||||||||||
| 7evx | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-07-07 | GLU | A:332 | A:327 | 15.0 | 0.079 | S | -68.5 | -48.5 | 15.0 | 0.079 | 0.0 |
MG JEO HOH |
2.570 9.415 2.788 |
OE2 OE2 OE2 |
MG OAA O |
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| GLU | D:332 | C:327 | 8.0 | 0.042 | S | -70.2 | -48.9 | NA | NA | NA | |||||||||||||
| 7d91 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 9.0 | 0.047 | S | -71.1 | -58.5 | 9.0 | 0.047 | 0.0 |
MG PCW HOH |
2.388 9.763 2.687 |
OE2 OE1 OE2 |
MG C32 O |
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| 7d92 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 13.0 | 0.068 | S | -74.9 | -55.5 | 13.0 | 0.068 | 0.0 |
MG H0C HOH |
2.304 5.936 2.742 |
OE2 OE2 OE2 |
MG O9 O |
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| 7d93 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 11.0 | 0.058 | S | -70.9 | -37.0 | 11.0 | 0.058 | 0.0 |
MG H0C HOH |
2.279 5.906 2.713 |
OE2 CD OE2 |
MG O9 O |
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| GLU | C:327 | C:327 | 15.0 | 0.079 | S | -69.4 | -35.2 | NA | NA | NA | |||||||||||||
| 7d94 | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 11.0 | 0.058 | S | -70.5 | -38.2 | 11.0 | 0.058 | 0.0 |
MG RB BUF HOH |
2.067 4.736 3.620 2.608 |
OE1 OE1 OE1 OE1 |
MG RB O24 O |
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| GLU | D:327 | C:327 | 11.0 | 0.058 | S | -69.7 | -37.5 | NA | NA | NA | |||||||||||||
| 7ddf | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 13.0 | 0.068 | S | -72.4 | -54.5 | 13.0 | 0.068 | 0.0 |
MG HOH |
2.249 2.659 |
OE2 OE2 |
MG O |
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| GLU | D:327 | C:327 | 13.0 | 0.068 | S | -69.8 | -51.8 | NA | NA | NA | |||||||||||||
| 7ddh | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 13.0 | 0.068 | S | -71.8 | -54.1 | 13.0 | 0.068 | 0.0 |
MG DGX HOH |
2.348 5.202 2.654 |
OE2 OE2 OE2 |
MG O23 O |
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| GLU | D:327 | C:327 | 15.0 | 0.079 | S | -71.4 | -52.2 | NA | NA | NA | |||||||||||||
| 7ddi | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 10.0 | 0.053 | S | -68.4 | -50.3 | 10.0 | 0.053 | 0.0 |
MG F9R HOH |
2.299 5.099 2.673 |
OE2 CD OE2 |
MG O23 O |
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| GLU | D:327 | C:327 | 10.0 | 0.053 | T | -67.1 | -47.7 | NA | NA | NA | |||||||||||||
| 7ddj | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 10.0 | 0.053 | S | -69.2 | -36.6 | 10.0 | 0.053 | 0.0 |
MG OBN HOH |
2.330 5.792 2.631 |
OE2 OE2 OE2 |
MG O23 O |
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| GLU | D:327 | C:327 | 10.0 | 0.053 | S | -68.9 | -35.8 | NA | NA | NA | |||||||||||||
| 7ddk | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 13.0 | 0.068 | S | -68.8 | -43.4 | 13.0 | 0.068 | 0.0 |
MG E4R HOH |
2.363 6.163 2.663 |
OE2 OE2 OE2 |
MG C24 O |
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| GLU | D:327 | C:327 | 12.0 | 0.063 | S | -68.9 | -44.0 | NA | NA | NA | |||||||||||||
| 7ddl | 1 | P05024 | 87.51 | 0.0 |
X-RAY |
2021-01-27 | GLU | A:327 | A:327 | 9.0 | 0.047 | S | -75.1 | -38.4 | 9.0 | 0.047 | 0.0 |
MG BUF HOH |
2.240 3.968 2.758 |
OE2 CD OE2 |
MG O24 O |
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| GLU | D:327 | C:327 | 12.0 | 0.063 | S | -74.3 | -36.5 | NA | NA | NA | |||||||||||||
| 3b8e | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2007-12-18 | GLU | A:309 | A:327 | 11.0 | 0.058 | S | -33.4 | -48.7 | 11.0 | 0.058 | 0.0 |
RB RB |
6.083 3.391 |
OE1 OE1 |
RB RB |
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| GLU | D:309 | C:327 | 10.0 | 0.053 | T | -42.6 | -19.8 | NA | NA | NA | |||||||||||||
| 3kdp | 1 | P05024 | 87.58 | 0.0 |
X-RAY |
2010-02-16 | GLU | A:309 | A:327 | 5.0 | 0.026 | 41.1 | -92.7 | 5.0 | 0.026 | 0.0 |
RB RB |
6.235 3.093 |
OE1 OE1 |
RB RB |
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| GLU | D:309 | C:327 | 8.0 | 0.042 | H | -50.9 | -57.7 | NA | NA | NA | |||||||||||||
| 3n23 | 1 | P05024 | 87.8 | 0.0 |
X-RAY |
2011-01-19 | GLU | A:303 | A:327 | 1.0 | 0.005 | S | -90.2 | -32.4 | 1.0 | 0.005 | 0.0 |
OBN |
5.935 |
OE2 |
O23 |
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| GLU | D:303 | C:327 | 1.0 | 0.005 | S | -88.6 | -34.7 | NA | NA | NA | |||||||||||||
| 2zxe | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-05-19 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
K K HOH |
6.000 3.250 3.260 |
N OE1 N |
K K O |
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| 3a3y | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2009-09-08 | GLU | A:339 | A:334 | 13.0 | 0.068 | T | -68.6 | -27.1 | 13.0 | 0.068 | 0.0 |
K K OBN HOH |
6.259 3.693 6.202 3.290 |
OE1 OE1 OE2 N |
K K O21 O |
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| 5avq | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
K TL K TL HOH |
6.001 6.001 3.249 3.249 6.398 |
N N OE1 OE1 N |
K TL K TL O |
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| 5avr | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
K TL K TL HOH |
6.001 6.001 3.251 3.251 6.398 |
N N OE1 OE1 N |
K TL K TL O |
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| 5avs | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
K TL TL HOH |
6.001 6.001 3.250 6.399 |
N N OE1 N |
K TL TL O |
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| 5avt | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -31.0 | 8.0 | 0.042 | 0.0 |
K TL TL HOH |
6.000 6.000 3.250 6.398 |
N N OE1 N |
K TL TL O |
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| 5avu | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -30.9 | 8.0 | 0.042 | 0.0 |
K TL TL HOH |
6.001 6.001 3.250 6.399 |
N N OE1 N |
K TL TL O |
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| 5avv | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.000 3.250 6.399 |
N OE1 N |
TL TL O |
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| 5avw | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.000 3.250 6.398 |
N OE1 N |
TL TL O |
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| 5avx | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -30.9 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.001 3.250 6.398 |
N OE1 N |
TL TL O |
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| 5avy | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -30.9 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.000 3.251 6.399 |
N OE1 N |
TL TL O |
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| 5avz | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.001 3.249 6.399 |
N OE1 N |
TL TL O |
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| 5aw0 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -30.9 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.000 3.250 6.399 |
N OE1 N |
TL TL O |
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| 5aw1 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -30.9 | 8.0 | 0.042 | 0.0 |
K TL TL HOH |
6.000 6.000 3.251 6.399 |
N N OE1 N |
K TL TL O |
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| 5aw2 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.000 3.251 6.398 |
N OE1 N |
TL TL O |
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| 5aw3 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
TL TL HOH |
6.000 3.250 6.399 |
N OE1 N |
TL TL O |
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| 5aw4 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -31.0 | 8.0 | 0.042 | 0.0 |
K RB K RB HOH |
6.000 6.000 3.251 3.251 6.397 |
N N OE1 OE1 N |
K RB K RB O |
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| 5aw5 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -30.8 | 8.0 | 0.042 | 0.0 |
K RB K RB HOH |
5.999 5.999 3.250 3.250 6.397 |
N N OE1 OE1 N |
K RB K RB O |
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| 5aw6 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.1 | -31.0 | 8.0 | 0.042 | 0.0 |
K RB K RB HOH |
6.000 6.000 3.250 3.250 6.398 |
N N OE1 OE1 N |
K RB K RB O |
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| 5aw7 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -31.0 | 8.0 | 0.042 | 0.0 |
K RB RB HOH |
6.001 6.001 3.250 6.398 |
N N OE1 N |
K RB RB O |
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| 5aw8 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -54.2 | -31.0 | 8.0 | 0.042 | 0.0 |
RB RB HOH |
5.999 3.250 6.397 |
N OE1 N |
RB RB O |
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| 5aw9 | 1 | Q4H132 | 85.56 | 0.0 |
X-RAY |
2015-09-02 | GLU | A:339 | A:334 | 8.0 | 0.042 | T | -53.4 | -29.4 | 8.0 | 0.042 | 0.0 |
K K HOH |
5.980 3.356 3.322 |
N OE1 N |
K K O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p13637-f1 | 1 | P13637 | 100.0 | 0.0 | GLU | A:324 | A:324 | 7.0 | 0.037 | T | -64.5 | -33.8 | |
| af-p50993-f1 | 1 | P50993 | 88.81 | 0.0 | GLU | A:332 | A:332 | 6.0 | 0.032 | T | -64.9 | -33.8 | |
| af-p05023-f1 | 1 | P05023 | 88.03 | 0.0 | GLU | A:334 | A:334 | 6.0 | 0.032 | T | -63.7 | -34.2 | |