Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 42489105 . C A CCDS12594.1:NM_152296.4:c.958Gcc>Tcc_NP_689509.1:p.320A>S Homo sapiens ATPase Na+/K+ transporting subunit alpha 3 (ATP1A3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3wgu 1 I7HD36 88.01 0.0 X-RAY
 2013-10-09 ALA A:323 A:323 3.0 0.026 H -76.2 -33.4 3.0 0.026 0.0 NA
NA
NA
HOH
 2.524
2.644
8.790
3.973
 O
O
O
O
 NA
NA
NA
O
ALA D:323 C:323 2.0 0.017 H -52.5 -41.1 NA NA NA
3wgv 1 I7HD36 88.01 0.0 X-RAY
 2013-10-09 ALA A:323 A:323 3.0 0.026 H -74.9 -27.9 3.0 0.026 0.0 NA
NA
NA
HOH
 3.074
2.674
9.153
3.965
 O
O
O
O
 NA
NA
NA
O
ALA D:323 C:323 1.0 0.009 H -59.5 -39.4 NA NA NA
4xe5 1 Q08DA1 87.61 0.0 X-RAY
 2016-03-09 ALA A:328 A:328 26.0 0.226 H -57.6 -33.3 26.0 0.226 0.0 MG
OBN
HOH
 4.975
3.437
3.868
 O
CA
O
 MG
C22
O
4hqj 1 P05024 87.51 0.0 X-RAY
 2013-10-02 ALA A:328 A:323 1.0 0.009 H -57.5 -82.5 1.0 0.009 0.0 NA
NA
 2.417
3.224
 O
O
 NA
NA
ALA D:328 C:323 1.0 0.009 H -56.7 -81.9 NA NA NA
4hyt 1 P05024 87.51 0.0 X-RAY
 2013-06-26 ALA A:328 A:323 31.0 0.27 H -69.7 -24.9 31.0 0.27 0.0 MG
OBN
HOH
 4.428
3.274
3.572
 O
CA
O
 MG
O23
O
ALA D:328 C:323 31.0 0.27 H -69.5 -25.1 NA NA NA
4res 1 P05024 87.51 0.0 X-RAY
 2015-01-28 ALA A:328 A:323 27.0 0.235 H -65.7 -26.4 27.0 0.235 0.0 BUF
K
K
 3.218
6.024
2.633
 CA
O
O
 O21
K
K
ALA D:328 C:323 27.0 0.235 H -65.6 -26.9 NA NA NA
4ret 1 P05024 87.51 0.0 X-RAY
 2015-01-28 ALA A:328 A:323 30.0 0.261 H -60.6 -30.8 30.0 0.261 0.0 MG
DGX
HOH
 4.777
3.323
3.551
 O
CA
O
 MG
O23
O
ALA D:328 C:323 30.0 0.261 H -60.2 -30.9 NA NA NA
7evx 1 P05024 87.51 0.0 X-RAY
 2021-07-07 ALA A:328 A:323 34.0 0.296 H -64.6 -17.3 34.0 0.296 0.0 MG
JEO
HOH
 4.966
3.791
3.195
 O
CB
O
 MG
OAA
O
ALA D:328 C:323 28.0 0.243 H -65.7 -18.0 NA NA NA
7d91 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 36.0 0.313 H -64.7 -10.8 36.0 0.313 0.0 MG
HOH
 4.135
2.625
 O
O
 MG
O
7d92 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 32.0 0.278 H -65.8 -17.8 32.0 0.278 0.0 MG
H0C
HOH
 4.669
3.216
2.770
 O
CA
O
 MG
O9
O
7d93 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 33.0 0.287 H -65.0 -26.8 33.0 0.287 0.0 MG
H0C
HOH
 4.727
3.524
2.846
 O
CA
O
 MG
O9
O
ALA C:323 C:323 31.0 0.27 H -65.1 -25.9 NA NA NA
7d94 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 30.0 0.261 H -65.1 -29.6 30.0 0.261 0.0 MG
RB
BUF
HOH
 2.896
5.977
3.224
2.564
 O
O
CA
O
 MG
RB
O21
O
ALA D:323 C:323 31.0 0.27 H -65.2 -28.0 NA NA NA
7ddf 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 35.0 0.304 H -63.6 -19.1 35.0 0.304 0.0 MG
HOH
 4.807
3.029
 O
O
 MG
O
ALA D:323 C:323 32.0 0.278 H -62.9 -20.6 NA NA NA
7ddh 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 33.0 0.287 H -63.6 -27.2 33.0 0.287 0.0 MG
DGX
HOH
 4.633
3.294
2.841
 O
CA
O
 MG
O23
O
ALA D:323 C:323 31.0 0.27 H -65.1 -28.5 NA NA NA
7ddi 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 32.0 0.278 H -64.2 -29.7 32.0 0.278 0.0 MG
F9R
HOH
 4.508
3.283
2.749
 O
CA
O
 MG
O23
O
ALA D:323 C:323 29.0 0.252 H -64.7 -29.8 NA NA NA
7ddj 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 32.0 0.278 H -64.4 -27.8 32.0 0.278 0.0 MG
OBN
HOH
 4.590
3.204
2.737
 O
CA
O
 MG
O23
O
ALA D:323 C:323 31.0 0.27 H -64.9 -26.9 NA NA NA
7ddk 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 35.0 0.304 T -61.3 -18.9 35.0 0.304 0.0 MG
E4R
HOH
 4.608
3.628
2.982
 O
CB
O
 MG
C24
O
ALA D:323 C:323 33.0 0.287 H -63.0 -19.5 NA NA NA
7ddl 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ALA A:323 A:323 32.0 0.278 H -63.2 -28.1 32.0 0.278 0.0 MG
BUF
HOH
 4.631
3.176
2.651
 O
CA
O
 MG
O21
O
ALA D:323 C:323 30.0 0.261 H -64.2 -23.8 NA NA NA
3b8e 1 P05024 87.58 0.0 X-RAY
 2007-12-18 ALA A:305 A:323 0.0 0.0 T -84.5 56.7 0.0 0.0 0.0 RB
RB
 7.410
3.979
 C
C
 RB
RB
ALA D:305 C:323 1.0 0.009 T -136.7 24.5 NA NA NA
3kdp 1 P05024 87.58 0.0 X-RAY
 2010-02-16 ALA A:305 A:323 0.0 0.0 T -63.5 -9.8 0.0 0.0 0.0 RB
RB
 6.562
3.897
 O
O
 RB
RB
ALA D:305 C:323 0.0 0.0 T -78.3 9.8 NA NA NA
3n23 1 P05024 87.8 0.0 X-RAY
 2011-01-19 ALA A:299 A:323 13.0 0.113 T -50.6 -36.7 13.0 0.113 0.0 OBN
 2.542
 N
 O23
ALA D:299 C:323 13.0 0.113 T -51.0 -36.2 NA NA NA
2zxe 1 Q4H132 85.56 0.0 X-RAY
 2009-05-19 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 K
K
HOH
 5.775
2.963
5.279
 O
O
O
 K
K
O
3a3y 1 Q4H132 85.56 0.0 X-RAY
 2009-09-08 ALA A:335 A:330 13.0 0.113 G -41.8 -37.8 13.0 0.113 0.0 K
K
OBN
HOH
 5.848
3.638
2.540
7.865
 O
O
N
O
 K
K
O23
O
5avq 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.9 -44.9 0.0 0.0 0.0 K
TL
K
TL
HOH
 5.774
5.774
2.962
2.962
8.258
 O
O
O
O
O
 K
TL
K
TL
O
5avr 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 K
TL
K
TL
HOH
 5.775
5.775
2.963
2.963
8.259
 O
O
O
O
O
 K
TL
K
TL
O
5avs 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.9 -44.8 0.0 0.0 0.0 K
TL
TL
HOH
 5.774
5.774
2.963
8.259
 O
O
O
O
 K
TL
TL
O
5avt 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 K
TL
TL
HOH
 5.776
5.776
2.964
8.260
 O
O
O
O
 K
TL
TL
O
5avu 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 K
TL
TL
HOH
 5.775
5.775
2.963
8.259
 O
O
O
O
 K
TL
TL
O
5avv 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.8 0.0 0.0 0.0 TL
TL
HOH
 5.774
2.962
8.258
 O
O
O
 TL
TL
O
5avw 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 TL
TL
HOH
 5.775
2.963
8.260
 O
O
O
 TL
TL
O
5avx 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.9 -44.9 0.0 0.0 0.0 TL
TL
HOH
 5.774
2.962
8.258
 O
O
O
 TL
TL
O
5avy 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.9 -44.8 0.0 0.0 0.0 TL
TL
HOH
 5.775
2.963
8.259
 O
O
O
 TL
TL
O
5avz 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.8 0.0 0.0 0.0 TL
TL
HOH
 5.775
2.964
8.260
 O
O
O
 TL
TL
O
5aw0 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 TL
TL
HOH
 5.774
2.962
8.259
 O
O
O
 TL
TL
O
5aw1 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.8 0.0 0.0 0.0 K
TL
TL
HOH
 5.775
5.775
2.962
8.259
 O
O
O
O
 K
TL
TL
O
5aw2 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.9 -44.7 0.0 0.0 0.0 TL
TL
HOH
 5.775
2.962
8.260
 O
O
O
 TL
TL
O
5aw3 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.9 -44.9 0.0 0.0 0.0 TL
TL
HOH
 5.775
2.963
8.260
 O
O
O
 TL
TL
O
5aw4 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 K
RB
K
RB
HOH
 5.774
5.774
2.963
2.963
8.259
 O
O
O
O
O
 K
RB
K
RB
O
5aw5 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.9 -44.9 0.0 0.0 0.0 K
RB
K
RB
HOH
 5.774
5.774
2.963
2.963
8.260
 O
O
O
O
O
 K
RB
K
RB
O
5aw6 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.8 0.0 0.0 0.0 K
RB
K
RB
HOH
 5.774
5.774
2.962
2.962
8.258
 O
O
O
O
O
 K
RB
K
RB
O
5aw7 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.7 -44.9 0.0 0.0 0.0 K
RB
RB
HOH
 5.774
5.774
2.963
8.260
 O
O
O
O
 K
RB
RB
O
5aw8 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -65.8 -44.9 0.0 0.0 0.0 RB
RB
HOH
 5.774
2.962
8.259
 O
O
O
 RB
RB
O
5aw9 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ALA A:335 A:330 0.0 0.0 H -55.9 -48.9 0.0 0.0 0.0 K
K
HOH
 5.874
2.966
5.301
 O
O
O
 K
K
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p13637-f1 1 P13637 100.0 0.0 ALA A:320 A:320 0.0 0.0 H -62.1 -16.1
af-p50993-f1 1 P50993 88.81 0.0 ALA A:328 A:328 0.0 0.0 H -62.1 -16.6
af-p05023-f1 1 P05023 88.03 0.0 ALA A:330 A:330 1.0 0.009 H -62.4 -16.6