Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 42489109 . G A CCDS12594.1:NM_152296.4:c.954atC>atT_NP_689509.1:p.318I>I Homo sapiens ATPase Na+/K+ transporting subunit alpha 3 (ATP1A3), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3wgu 1 I7HD36 88.01 0.0 X-RAY
 2013-10-09 ILE A:321 A:321 12.0 0.069 H -58.6 -51.0 12.0 0.069 0.0 NA
NA
HOH
 5.126
7.704
7.472
 O
O
O
 NA
NA
O
ILE D:321 C:321 14.0 0.08 H -59.6 -57.3 NA NA NA
3wgv 1 I7HD36 88.01 0.0 X-RAY
 2013-10-09 ILE A:321 A:321 10.0 0.057 H -49.6 -55.6 10.0 0.057 0.0 NA
NA
EFO
HOH
 5.218
7.717
8.357
7.488
 O
O
CG2
O
 NA
NA
O32
O
ILE D:321 C:321 16.0 0.091 H -61.3 -52.2 NA NA NA
4xe5 1 Q08DA1 87.61 0.0 X-RAY
 2016-03-09 ILE A:326 A:326 32.0 0.183 H -57.0 -41.4 32.0 0.183 0.0 MG
OBN
HOH
 9.935
6.869
8.850
 O
C
O
 MG
C22
O
4hqj 1 P05024 87.51 0.0 X-RAY
 2013-10-02 ILE A:326 A:321 22.0 0.126 H -57.8 -52.9 22.0 0.126 0.0 NA
NA
 5.289
7.243
 O
O
 NA
NA
ILE D:326 C:321 22.0 0.126 H -57.9 -55.5 NA NA NA
4hyt 1 P05024 87.51 0.0 X-RAY
 2013-06-26 ILE A:326 A:321 26.0 0.149 H -69.5 -58.4 26.0 0.149 0.0 MG
OBN
HOH
 9.070
6.482
8.146
 O
C
O
 MG
C22
O
ILE D:326 C:321 25.0 0.143 H -69.1 -58.4 NA NA NA
4res 1 P05024 87.51 0.0 X-RAY
 2015-01-28 ILE A:326 A:321 30.0 0.171 H -50.5 -45.3 30.0 0.171 0.0 BUF
K
 6.520
7.067
 C
O
 C21
K
ILE D:326 C:321 28.0 0.16 H -49.8 -45.4 NA NA NA
4ret 1 P05024 87.51 0.0 X-RAY
 2015-01-28 ILE A:326 A:321 28.0 0.16 H -56.2 -52.2 28.0 0.16 0.0 MG
DGX
HOH
 9.582
6.335
8.356
 O
C
O
 MG
C22
O
ILE D:326 C:321 28.0 0.16 H -56.4 -51.9 NA NA NA
7evx 1 P05024 87.51 0.0 X-RAY
 2021-07-07 ILE A:326 A:321 26.0 0.149 H -72.8 -44.1 26.0 0.149 0.0 MG
JEO
HOH
 9.656
7.700
7.500
 O
N
O
 MG
OAA
O
ILE D:326 C:321 30.0 0.171 H -74.2 -42.9 NA NA NA
7d91 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 30.0 0.171 H -69.2 -41.5 30.0 0.171 0.0 MG
PCW
HOH
 8.869
8.227
7.196
 O
CD1
O
 MG
C12
O
7d92 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 34.0 0.194 H -69.3 -43.1 34.0 0.194 0.0 MG
H0C
HOH
 9.233
6.241
7.324
 O
C
O
 MG
O9
O
7d93 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 28.0 0.16 H -71.1 -47.1 28.0 0.16 0.0 MG
H0C
HOH
 9.533
6.816
7.336
 O
C
O
 MG
O9
O
ILE C:321 C:321 32.0 0.183 H -71.9 -46.9 NA NA NA
7d94 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 25.0 0.143 H -70.1 -47.9 25.0 0.143 0.0 MG
BUF
HOH
 7.395
6.498
6.665
 O
C
O
 MG
C21
O
ILE D:321 C:321 28.0 0.16 H -70.1 -47.1 NA NA NA
7ddf 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 32.0 0.183 H -69.3 -42.8 32.0 0.183 0.0 MG
HOH
 9.807
7.960
 O
O
 MG
O
ILE D:321 C:321 35.0 0.2 H -67.1 -44.3 NA NA NA
7ddh 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 29.0 0.166 H -71.1 -47.3 29.0 0.166 0.0 MG
DGX
HOH
 9.555
6.427
7.721
 O
C
O
 MG
O23
O
ILE D:321 C:321 31.0 0.177 H -69.1 -45.6 NA NA NA
7ddi 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 31.0 0.177 H -63.3 -48.8 31.0 0.177 0.0 MG
F9R
HOH
 9.359
6.225
7.462
 O
C
O
 MG
C22
O
ILE D:321 C:321 32.0 0.183 H -62.7 -48.7 NA NA NA
7ddj 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 30.0 0.171 H -70.7 -46.1 30.0 0.171 0.0 MG
PCW
OBN
HOH
 9.363
9.170
6.188
7.418
 O
CD1
C
O
 MG
C12
O23
O
ILE D:321 C:321 33.0 0.189 H -71.1 -45.2 NA NA NA
7ddk 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 28.0 0.16 H -74.9 -49.2 28.0 0.16 0.0 MG
E4R
HOH
 9.402
6.365
7.574
 O
N
O
 MG
O2
O
ILE D:321 C:321 30.0 0.171 H -74.4 -48.0 NA NA NA
7ddl 1 P05024 87.51 0.0 X-RAY
 2021-01-27 ILE A:321 A:321 29.0 0.166 H -70.7 -47.7 29.0 0.166 0.0 MG
BUF
HOH
 9.391
6.538
7.280
 O
C
O
 MG
O21
O
ILE D:321 C:321 29.0 0.166 H -71.1 -46.5 NA NA NA
3b8e 1 P05024 87.58 0.0 X-RAY
 2007-12-18 ILE A:303 A:321 7.0 0.04 H -58.8 -66.3 7.0 0.04 0.0 RB
RB
 9.486
5.503
 O
O
 RB
RB
ILE D:303 C:321 10.0 0.057 H -56.6 -61.8 NA NA NA
3kdp 1 P05024 87.58 0.0 X-RAY
 2010-02-16 ILE A:303 A:321 12.0 0.069 H -55.6 -85.3 12.0 0.069 0.0 RB
RB
 9.916
5.908
 O
O
 RB
RB
ILE D:303 C:321 6.0 0.034 T -56.7 -75.8 NA NA NA
3n23 1 P05024 87.8 0.0 X-RAY
 2011-01-19 ILE A:297 A:321 31.0 0.177 T -127.7 -61.7 31.0 0.177 0.0 OBN
 4.711
 C
 O23
ILE D:297 C:321 34.0 0.194 T -127.7 -61.1 NA NA NA
2zxe 1 Q4H132 85.56 0.0 X-RAY
 2009-05-19 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 K
K
HOH
 9.701
5.827
6.989
 O
O
O
 K
K
O
3a3y 1 Q4H132 85.56 0.0 X-RAY
 2009-09-08 ILE A:333 A:328 28.0 0.16 S -106.2 -77.3 28.0 0.16 0.0 K
K
OBN
HOH
 9.476
6.069
2.682
9.716
 O
O
N
O
 K
K
O23
O
5avq 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.2 10.0 0.057 0.0 K
TL
K
TL
 9.700
9.700
5.826
5.826
 O
O
O
O
 K
TL
K
TL
5avr 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.2 10.0 0.057 0.0 K
TL
K
TL
 9.702
9.702
5.828
5.828
 O
O
O
O
 K
TL
K
TL
5avs 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 K
TL
TL
 9.700
9.700
5.827
 O
O
O
 K
TL
TL
5avt 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.3 10.0 0.057 0.0 K
TL
TL
 9.702
9.702
5.828
 O
O
O
 K
TL
TL
5avu 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 K
TL
TL
 9.701
9.701
5.827
 O
O
O
 K
TL
TL
5avv 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 TL
TL
 9.701
5.827
 O
O
 TL
TL
5avw 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.2 10.0 0.057 0.0 TL
TL
 9.701
5.828
 O
O
 TL
TL
5avx 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.2 10.0 0.057 0.0 TL
TL
 9.701
5.828
 O
O
 TL
TL
5avy 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.2 10.0 0.057 0.0 TL
TL
 9.701
5.827
 O
O
 TL
TL
5avz 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.2 10.0 0.057 0.0 TL
TL
 9.700
5.827
 O
O
 TL
TL
5aw0 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 TL
TL
 9.701
5.828
 O
O
 TL
TL
5aw1 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.4 -54.3 10.0 0.057 0.0 K
TL
TL
 9.700
9.700
5.827
 O
O
O
 K
TL
TL
5aw2 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 TL
TL
 9.701
5.827
 O
O
 TL
TL
5aw3 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 TL
TL
 9.701
5.828
 O
O
 TL
TL
5aw4 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.2 10.0 0.057 0.0 K
RB
K
RB
 9.700
9.700
5.828
5.828
 O
O
O
O
 K
RB
K
RB
5aw5 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.4 -54.3 10.0 0.057 0.0 K
RB
K
RB
 9.699
9.699
5.827
5.827
 O
O
O
O
 K
RB
K
RB
5aw6 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.3 10.0 0.057 0.0 K
RB
K
RB
 9.700
9.700
5.826
5.826
 O
O
O
O
 K
RB
K
RB
5aw7 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.5 -54.2 10.0 0.057 0.0 K
RB
RB
 9.701
9.701
5.827
 O
O
O
 K
RB
RB
5aw8 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 10.0 0.057 H -56.6 -54.1 10.0 0.057 0.0 RB
RB
 9.701
5.827
 O
O
 RB
RB
5aw9 1 Q4H132 85.56 0.0 X-RAY
 2015-09-02 ILE A:333 A:328 8.0 0.046 H -60.0 -55.5 8.0 0.046 0.0 K
K
HOH
 9.616
5.839
6.965
 O
O
O
 K
K
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p13637-f1 1 P13637 100.0 0.0 ILE A:318 A:318 21.0 0.12 H -64.0 -46.9
af-p50993-f1 1 P50993 88.81 0.0 ILE A:326 A:326 19.0 0.109 H -64.4 -47.6
af-p05023-f1 1 P05023 88.03 0.0 ILE A:328 A:328 20.0 0.114 H -62.3 -49.7