Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7119574 . C A CCDS12176.1:NM_000208.2:c.3680tGg>tTg_NP_000199.2:p.1227W>L Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 TRP A:1200 NA:NA DO NA DO DO DO NA NA NA
TRP B:1200 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 TRP A:1200 NA:NA DO NA DO DO DO NA NA NA
TRP B:1200 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 TRP A:1200 NA:NA DO NA DO DO DO NA NA NA
TRP B:1200 NA:NA DO NA DO DO DO NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:1215 NA:NA DO NA DO DO DO NA NA NA
TRP B:1215 NA:NA DO NA DO DO DO NA NA NA
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:1215 NA:NA DO NA DO DO DO NA NA NA
TRP B:1215 NA:NA DO NA DO DO DO NA NA NA
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:1215 NA:NA DO NA DO DO DO NA NA NA
TRP B:1215 NA:NA DO NA DO DO DO NA NA NA
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 TRP A:1215 NA:NA DO NA DO DO DO NA NA NA
TRP B:1215 NA:NA DO NA DO DO DO NA NA NA
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 TRP A:1188 NA:NA DO NA DO DO DO NA NA NA
TRP B:1188 NA:NA DO NA DO DO DO NA NA NA
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 TRP A:1188 NA:NA DO NA DO DO DO NA NA NA
TRP B:1188 NA:NA DO NA DO DO DO NA NA NA
4xlv 1 P06213 99.09 0.0 X-RAY
 2015-03-25 TRP A:245 A:1200 23.0 0.09 H -65.0 -45.4 23.0 0.09 0.0 HOH
 3.860
 NE1
 O
4ibm 1 P06213 99.67 0.0 X-RAY
 2013-08-21 TRP A:223 A:1200 14.0 0.055 H -58.0 -42.4 14.0 0.055 0.0 HOH
 3.229
 NE1
 O
TRP B:223 B:1200 15.0 0.059 H -60.9 -42.1 NA NA NA
1gag 1 P06213 99.35 0.0 X-RAY
 2001-01-17 TRP A:223 A:1200 25.0 0.098 H -63.1 -43.5 25.0 0.098 0.0 HOH
 3.640
 CZ2
 O
1ir3 1 P06213 99.35 0.0 X-RAY
 1998-01-07 TRP A:223 A:1200 22.0 0.086 H -66.6 -40.9 22.0 0.086 0.0 HOH
 3.394
 CH2
 O
1irk 1 P06213 99.35 0.0 X-RAY
 1995-02-27 TRP A:223 A:1200 20.0 0.078 H -60.2 -35.7 20.0 0.078 0.0 EMC
HOH
 7.595
3.414
 O
CH2
 C2
O
3eta 1 P06213 100.0 0.0 X-RAY
 2009-05-26 TRP A:222 A:1200 15.0 0.059 H -61.7 -40.7 15.0 0.059 0.0 HOH
 3.706
 CZ2
 O
TRP B:222 B:1200 17.0 0.067 H -63.6 -43.5 NA NA NA
5hhw 1 P06213 99.35 0.0 X-RAY
 2016-04-13 TRP A:224 A:1227 16.0 0.063 H -63.8 -41.3 16.0 0.063 0.0 HOH
 3.391
 CH2
 O
5e1s 1 P06213 99.35 0.0 X-RAY
 2015-10-14 TRP A:225 A:1200 15.0 0.059 H -63.1 -38.5 15.0 0.059 0.0 HOH
 5.809
 CZ3
 O
1rqq 1 P06213 99.35 0.0 X-RAY
 2003-12-30 TRP A:223 A:1200 11.0 0.043 H -62.5 -41.6 11.0 0.043 0.0 HOH
 5.123
 CZ3
 O
TRP B:223 B:1200 21.0 0.082 H -63.7 -41.0 21.0 0.082 0.0 HOH
 3.262
 NE1
 O
2auh 1 P06213 99.35 0.0 X-RAY
 2005-11-01 TRP A:223 A:1200 19.0 0.075 H -60.7 -37.8 19.0 0.075 0.0
2b4s 2 P06213 99.35 0.0 X-RAY
 2005-11-15 TRP B:223 B:1200 22.0 0.086 H -63.1 -41.9 22.0 0.086 0.0 HOH
 5.336
 CZ3
 O
TRP D:223 D:1200 7.0 0.027 H -64.3 -44.5 7.0 0.027 0.0 HOH
 5.787
 CZ3
 O
3bu3 1 P06213 99.35 0.0 X-RAY
 2008-02-19 TRP A:223 A:1200 16.0 0.063 H -63.1 -42.3 16.0 0.063 0.0 HOH
 3.483
 CH2
 O
3bu5 1 P06213 99.35 0.0 X-RAY
 2008-02-19 TRP A:223 A:1200 13.0 0.051 H -68.7 -39.8 13.0 0.051 0.0 HOH
 3.573
 CH2
 O
3bu6 1 P06213 99.35 0.0 X-RAY
 2008-02-19 TRP A:223 A:1200 18.0 0.071 H -64.1 -45.6 18.0 0.071 0.0 HOH
 3.358
 NE1
 O
1p14 1 P06213 99.02 0.0 X-RAY
 2003-07-22 TRP A:223 A:1200 22.0 0.086 H -65.3 -38.9 22.0 0.086 0.0 HOH
 3.566
 CH2
 O
1i44 1 P06213 99.02 0.0 X-RAY
 2001-03-07 TRP A:223 A:1200 19.0 0.075 H -59.8 -46.7 19.0 0.075 0.0 HOH
 5.443
 CH2
 O
3ekk 1 P06213 99.02 0.0 X-RAY
 2008-12-23 TRP A:224 A:1200 14.0 0.055 H -67.3 -37.6 14.0 0.055 0.0 HOH
 3.445
 CZ2
 O
3ekn 1 P06213 99.02 0.0 X-RAY
 2008-12-30 TRP A:224 A:1200 16.0 0.063 H -64.3 -37.4 16.0 0.063 0.0 HOH
 3.832
 CZ2
 O
2z8c 1 P06213 99.67 0.0 X-RAY
 2008-08-12 TRP A:220 A:1200 20.0 0.078 H -61.1 -41.5 20.0 0.078 0.0
2oj9 1 P08069 80.07 6e-177 X-RAY
 2007-05-01 TRP A:224 A:1173 16.0 0.063 H -62.8 -42.5 16.0 0.063 0.0 HOH
 3.040
 CH2
 O
3nw5 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 TRP A:224 A:1173 15.0 0.059 H -67.1 -34.8 15.0 0.059 0.0 HOH
 3.344
 CZ2
 O
3nw6 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 TRP A:224 A:1173 14.0 0.055 H -70.6 -38.0 14.0 0.055 0.0 HOH
 3.164
 CH2
 O
3nw7 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 TRP A:224 A:1173 17.0 0.067 H -60.7 -39.3 17.0 0.067 0.0 HOH
 3.223
 CH2
 O
3i81 1 P08069 80.07 7e-177 X-RAY
 2009-12-22 TRP A:224 A:1173 18.0 0.071 H -62.5 -39.5 18.0 0.071 0.0 HOH
 3.294
 CH2
 O
3d94 1 P08069 81.06 1e-176 X-RAY
 2008-07-29 TRP A:218 A:1173 12.0 0.047 H -59.1 -40.2 12.0 0.047 0.0 HOH
 4.062
 CZ2
 O
1jqh 1 P08069 80.53 1e-176 X-RAY
 2002-04-19 TRP A:225 A:1203 14.0 0.055 H -73.3 -31.4 14.0 0.055 0.0 HOH
 3.910
 CZ2
 O
TRP B:225 B:1203 14.0 0.055 H -72.2 -32.4 NA NA NA
TRP C:225 C:1203 15.0 0.059 H -71.7 -32.2 NA NA NA
2zm3 1 P08069 80.53 1e-176 X-RAY
 2008-06-10 TRP A:225 A:1203 20.0 0.078 H -58.8 -43.3 20.0 0.078 0.0 HOH
 3.617
 CZ2
 O
TRP B:225 B:1203 17.0 0.067 H -56.2 -44.8 NA NA NA
TRP C:225 C:1203 20.0 0.078 H -56.9 -43.2 NA NA NA
TRP D:225 D:1203 15.0 0.059 H -65.6 -36.2 NA NA NA
3f5p 1 P08069 80.53 1e-176 X-RAY
 2008-12-30 TRP A:225 A:1203 16.0 0.063 H -63.9 -34.7 16.0 0.063 0.0
TRP B:225 B:1203 22.0 0.086 H -67.7 -40.9 NA NA NA
TRP C:225 C:1203 18.0 0.071 H -47.4 -47.5 NA NA NA
TRP D:225 D:1203 20.0 0.078 H -52.3 -46.4 NA NA NA
TRP E:225 E:1203 16.0 0.063 H -47.4 -45.8 NA NA NA
TRP F:225 F:1203 16.0 0.063 H -46.4 -50.7 NA NA NA
TRP G:225 G:1203 16.0 0.063 H -53.4 -50.3 NA NA NA
TRP H:225 H:1203 19.0 0.075 H -58.5 -43.4 NA NA NA
TRP I:225 I:1203 19.0 0.075 H -62.7 -40.1 NA NA NA
TRP J:225 J:1203 20.0 0.078 H -58.7 -42.4 NA NA NA
TRP K:225 K:1203 18.0 0.071 H -56.7 -40.7 NA NA NA
TRP L:225 M:1203 16.0 0.063 H -62.3 -35.9 NA NA NA
TRP M:225 L:1203 14.0 0.055 H -59.3 -42.7 NA NA NA
TRP N:225 R:1203 21.0 0.082 H -55.4 -47.2 NA NA NA
TRP O:225 S:1203 15.0 0.059 H -58.3 -29.0 NA NA NA
TRP P:225 T:1203 17.0 0.067 H -59.6 -46.4 NA NA NA
4d2r 1 P08069 81.06 2e-176 X-RAY
 2015-04-22 TRP A:219 A:1203 9.0 0.035 H -63.8 -38.6 9.0 0.035 0.0 HOH
 3.787
 CZ2
 O
1k3a 1 P08069 80.94 4e-175 X-RAY
 2001-11-28 TRP A:216 A:1173 10.0 0.039 H -60.9 -43.9 10.0 0.039 0.0 HOH
 3.940
 CZ2
 O
3qqu 1 P08069 80.94 6e-175 X-RAY
 2011-04-20 TRP A:218 A:1200 17.0 0.067 H -63.8 -32.5 17.0 0.067 0.0 HOH
 8.328
 O
 O
TRP B:218 B:1200 19.0 0.075 H -64.1 -49.5 NA NA NA
TRP C:218 C:1200 17.0 0.067 H -69.6 -42.4 NA NA NA
TRP D:218 D:1200 17.0 0.067 H -46.3 -56.1 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 TRP A:1227 A:1227 17.0 0.067 H -66.0 -41.5