Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7120750 | . | C | A | CCDS12176.1:NM_000208.2:c.3540atG>atT_NP_000199.2:p.1180M>I | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | MET | A:1141 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1141 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | MET | A:1141 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| MET | B:1141 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4xlv | 1 | P06213 | 99.09 | 0.0 |
X-RAY |
2015-03-25 | MET | A:198 | A:1153 | 33.0 | 0.178 | T | -96.0 | -5.6 | 33.0 | 0.178 | 0.0 |
ACP MG MG HOH |
5.219 8.283 8.069 3.041 |
CE CE CE N |
O1G MG MG O |
||
| 4ibm | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2013-08-21 | MET | A:176 | A:1153 | 22.0 | 0.119 | -106.0 | -9.1 | 22.0 | 0.119 | 0.0 |
HOH |
2.623 |
O |
O |
|||
| MET | B:176 | B:1153 | 18.0 | 0.097 | T | -79.1 | -17.2 | NA | NA | NA | |||||||||||||
| 1gag | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2001-01-17 | MET | A:176 | A:1153 | 17.0 | 0.092 | S | -92.2 | -3.0 | 10.0 | 0.054 | 0.038 |
B:None:0.038 |
MG MG 112 HOH |
8.168 6.448 5.331 3.916 |
SD N SD CE |
MG MG NS O |
|
| 1ir3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1998-01-07 | MET | A:176 | A:1153 | 22.0 | 0.119 | T | -95.4 | 0.3 | 18.0 | 0.097 | 0.022 |
B:None:0.022 |
MG MG ANP HOH |
8.364 6.160 8.413 3.027 |
N N N N |
MG MG O2B O |
|
| 1irk | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1995-02-27 | MET | A:176 | A:1153 | 40.0 | NA | -113.1 | 70.9 | 40.0 | NA | NA |
HOH |
3.257 |
O |
O |
|||
| 3eta | 1 | P06213 | 100.0 | 0.0 |
X-RAY |
2009-05-26 | MET | A:175 | A:1153 | 56.0 | 0.303 | S | -109.3 | -8.9 | 56.0 | 0.303 | 0.0 |
351 HOH |
9.104 3.287 |
N CE |
C19 O |
||
| MET | B:175 | B:1153 | 59.0 | 0.319 | S | -110.8 | -10.8 | NA | NA | NA | |||||||||||||
| 5hhw | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2016-04-13 | MET | A:177 | A:1180 | 85.0 | NA | S | -83.2 | -12.5 | 85.0 | NA | NA |
60O HOH |
8.426 2.891 |
N N |
C1 O |
||
| 5e1s | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2015-10-14 | MET | A:178 | A:1153 | 67.0 | 0.362 | -76.0 | 360.0 | 67.0 | 0.362 | 0.0 |
5JA HOH |
9.902 4.004 |
CE CE |
C26 O |
|||
| 1rqq | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2003-12-30 | MET | A:176 | A:1153 | 17.0 | 0.092 | T | -92.9 | 0.3 | 11.0 | 0.059 | 0.033 |
E:None:0.032 |
MN 112 HOH |
8.407 5.599 3.580 |
CG SD CG |
MN NS O |
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| MET | B:176 | B:1153 | 36.0 | 0.195 | T | -91.2 | -2.2 | 22.0 | 0.119 | 0.076 |
F:None:0.076 |
MN 112 HOH |
6.942 4.039 2.897 |
CE CE CE |
MN NS O |
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| 2auh | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-01 | MET | A:176 | A:1153 | 13.0 | 0.07 | T | -97.6 | -4.3 | 2.0 | 0.011 | 0.059 |
B:Q14449:0.059 |
CA CA |
6.155 5.838 |
N N |
CA CA |
|
| 2b4s | 2 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-15 | MET | B:176 | B:1153 | 20.0 | 0.108 | T | -121.9 | 12.6 | 20.0 | 0.108 | 0.0 |
HOH |
2.907 |
N |
O |
||
| MET | D:176 | D:1153 | 18.0 | 0.097 | T | -124.2 | 4.6 | 18.0 | 0.097 | 0.0 |
HOH |
2.889 |
N |
O |
|||||||||
| 3bu3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:176 | A:1153 | 30.0 | 0.162 | T | -114.3 | 5.1 | 27.0 | 0.146 | 0.016 |
B:P81122:0.016 |
HOH |
2.915 |
N |
O |
|
| 3bu5 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:176 | A:1153 | 33.0 | 0.178 | T | -103.5 | 2.0 | 29.0 | 0.157 | 0.021 |
B:P81122:0.022 |
MG ATP HOH |
8.430 5.432 2.957 |
N N N |
MG O1G O |
|
| 3bu6 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:176 | A:1153 | 31.0 | 0.168 | T | -128.3 | 1.8 | 28.0 | 0.151 | 0.017 |
B:P81122:0.016 |
HOH |
2.902 |
N |
O |
|
| 1p14 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2003-07-22 | MET | A:176 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 1i44 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2001-03-07 | MET | A:176 | A:1153 | 103.0 | 0.557 | -79.9 | 122.3 | 103.0 | 0.557 | 0.0 |
MG ACP HOH |
5.780 4.954 2.412 |
N CE O |
MG O1G O |
|||
| 3ekk | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-23 | MET | A:177 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3ekn | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-30 | MET | A:177 | A:1153 | 58.0 | 0.314 | -59.0 | 119.7 | 58.0 | 0.314 | 0.0 |
HOH |
2.820 |
N |
O |
|||
| 2z8c | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2008-08-12 | MET | A:173 | A:1153 | 32.0 | 0.173 | T | -100.7 | -2.8 | 23.0 | 0.124 | 0.049 |
B:P35568:0.049 |
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| 2oj9 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2007-05-01 | MET | A:177 | A:1126 | 47.0 | 0.254 | S | 70.4 | -33.4 | 47.0 | 0.254 | 0.0 |
BMI HOH |
4.102 2.595 |
CE O |
C4 O |
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| 3nw5 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:177 | A:1126 | 54.0 | 0.292 | -42.5 | -57.1 | 54.0 | 0.292 | 0.0 |
LGX HOH |
5.616 3.168 |
CG SD |
C17 O |
|||
| 3nw6 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:177 | A:1126 | 46.0 | 0.249 | -67.2 | 117.6 | 46.0 | 0.249 | 0.0 |
LGW HOH |
3.360 2.631 |
CE O |
C21 O |
|||
| 3nw7 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:177 | A:1126 | 28.0 | 0.151 | -112.5 | -13.8 | 28.0 | 0.151 | 0.0 |
LGV HOH |
3.290 2.460 |
CE O |
O28 O |
|||
| 3i81 | 1 | P08069 | 80.07 | 7e-177 |
X-RAY |
2009-12-22 | MET | A:177 | A:1126 | 56.0 | 0.303 | -100.7 | 10.4 | 56.0 | 0.303 | 0.0 |
EBI HOH |
3.271 3.136 |
O N |
C29 O |
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| 3d94 | 1 | P08069 | 81.06 | 1e-176 |
X-RAY |
2008-07-29 | MET | A:171 | A:1126 | 61.0 | 0.33 | G | -54.9 | -34.3 | 37.0 | 0.2 | 0.13 |
A:P08069:0.13 |
CA D94 HOH |
7.595 6.143 2.660 |
SD N O |
CA C17 O |
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| 1jqh | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2002-04-19 | MET | A:178 | A:1156 | 47.0 | 0.254 | -151.1 | 149.3 | 47.0 | 0.254 | 0.0 |
ANP HOH |
9.918 2.824 |
N O |
O1G O |
|||
| MET | B:178 | B:1156 | 63.0 | 0.341 | -153.0 | 127.2 | NA | NA | NA | ||||||||||||||
| MET | C:178 | C:1156 | 61.0 | 0.33 | -142.5 | -174.5 | NA | NA | NA | ||||||||||||||
| 2zm3 | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-06-10 | MET | A:178 | A:1156 | 52.0 | 0.281 | T | -109.6 | 5.0 | 52.0 | 0.281 | 0.0 |
HOH |
3.146 |
N |
O |
||
| MET | B:178 | B:1156 | 49.0 | 0.265 | T | -111.3 | 1.7 | NA | NA | NA | |||||||||||||
| MET | C:178 | C:1156 | 50.0 | 0.27 | T | -127.7 | 3.0 | NA | NA | NA | |||||||||||||
| MET | D:178 | D:1156 | 61.0 | 0.33 | T | -114.4 | -0.3 | NA | NA | NA | |||||||||||||
| 3f5p | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-12-30 | MET | A:178 | A:1156 | 43.0 | 0.232 | S | -119.0 | -1.9 | 43.0 | 0.232 | 0.0 |
741 |
8.953 |
N |
C29 |
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| MET | B:178 | B:1156 | 48.0 | 0.259 | T | -119.1 | -4.9 | NA | NA | NA | |||||||||||||
| MET | C:178 | C:1156 | 47.0 | 0.254 | T | -127.6 | -7.7 | NA | NA | NA | |||||||||||||
| MET | D:178 | D:1156 | 48.0 | 0.259 | T | -119.3 | 4.0 | NA | NA | NA | |||||||||||||
| MET | E:178 | E:1156 | 56.0 | 0.303 | T | -113.1 | 1.2 | NA | NA | NA | |||||||||||||
| MET | F:178 | F:1156 | 43.0 | 0.232 | T | -110.4 | -0.8 | NA | NA | NA | |||||||||||||
| MET | G:178 | G:1156 | 42.0 | 0.227 | T | -117.5 | -5.7 | NA | NA | NA | |||||||||||||
| MET | H:178 | H:1156 | 58.0 | 0.314 | T | -119.6 | -4.0 | NA | NA | NA | |||||||||||||
| MET | I:178 | I:1156 | 52.0 | 0.281 | T | -115.4 | -2.4 | NA | NA | NA | |||||||||||||
| MET | J:178 | J:1156 | 49.0 | 0.265 | T | -120.0 | -2.4 | NA | NA | NA | |||||||||||||
| MET | K:178 | K:1156 | 46.0 | 0.249 | T | -109.5 | -6.9 | NA | NA | NA | |||||||||||||
| MET | L:178 | M:1156 | 60.0 | 0.324 | S | -108.4 | 0.8 | NA | NA | NA | |||||||||||||
| MET | M:178 | L:1156 | 44.0 | 0.238 | T | -108.5 | -6.9 | NA | NA | NA | |||||||||||||
| MET | N:178 | R:1156 | 45.0 | 0.243 | T | -113.0 | -2.1 | NA | NA | NA | |||||||||||||
| MET | O:178 | S:1156 | 50.0 | 0.27 | T | -110.4 | -3.0 | NA | NA | NA | |||||||||||||
| MET | P:178 | T:1156 | 42.0 | 0.227 | T | -110.7 | -7.3 | NA | NA | NA | |||||||||||||
| 4d2r | 1 | P08069 | 81.06 | 2e-176 |
X-RAY |
2015-04-22 | MET | A:172 | A:1156 | 53.0 | 0.286 | -90.9 | 88.5 | 53.0 | 0.286 | 0.0 |
DYK HOH |
3.203 3.601 |
CE O |
N4 O |
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| 1k3a | 1 | P08069 | 80.94 | 4e-175 |
X-RAY |
2001-11-28 | MET | A:169 | A:1126 | 28.0 | 0.151 | T | -111.9 | 3.8 | 22.0 | 0.119 | 0.032 |
B:P35568:0.032 |
ACP HOH |
7.741 2.883 |
N N |
O1G O |
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| 3qqu | 1 | P08069 | 80.94 | 6e-175 |
X-RAY |
2011-04-20 | MET | A:171 | A:1153 | 53.0 | 0.286 | 67.8 | -151.0 | 53.0 | 0.286 | 0.0 |
01P HOH |
3.311 5.132 |
SD CE |
C17 O |
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| MET | B:171 | B:1153 | 59.0 | 0.319 | 61.0 | -139.2 | NA | NA | NA | ||||||||||||||
| MET | C:171 | C:1153 | 69.0 | 0.373 | -68.5 | -157.4 | NA | NA | NA | ||||||||||||||
| MET | D:171 | D:1153 | 66.0 | 0.357 | -82.6 | 150.5 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | MET | A:1180 | A:1180 | 97.0 | 0.524 | -42.4 | 101.0 | ||