Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr19 | 7122746 | . | C | A | CCDS12176.1:NM_000208.2:c.3408atG>atT_NP_000199.2:p.1136M>I | Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
7bw7 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1109 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1109 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7bw8 | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1109 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1109 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7bwa | 1 | P06213 | 100.0 | 0.0 |
EM |
2021-04-14 | MET | A:1109 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1109 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7pg0 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7pg2 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7pg3 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
7pg4 | 1 | P06213 | 99.13 | 0.0 |
EM |
2022-02-02 | MET | A:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1124 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
6pxv | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | MET | A:1097 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1097 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
6pxw | 1 | P06213 | 98.6 | 0.0 |
EM |
2019-09-04 | MET | A:1097 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
MET | B:1097 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
4xlv | 1 | P06213 | 99.09 | 0.0 |
X-RAY |
2015-03-25 | MET | A:154 | A:1109 | 22.0 | 0.119 | H | -72.1 | -37.2 | 22.0 | 0.119 | 0.0 |
HOH |
3.467 |
CE |
O |
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4ibm | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2013-08-21 | MET | A:132 | A:1109 | 20.0 | 0.108 | H | -67.8 | -42.2 | 20.0 | 0.108 | 0.0 |
HOH |
3.298 |
CE |
O |
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MET | B:132 | B:1109 | 23.0 | 0.124 | H | -63.5 | -42.3 | NA | NA | NA | |||||||||||||
1gag | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2001-01-17 | MET | A:132 | A:1109 | 24.0 | 0.13 | H | -77.4 | -42.0 | 24.0 | 0.13 | 0.0 |
HOH |
7.225 |
CE |
O |
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1ir3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1998-01-07 | MET | A:132 | A:1109 | 16.0 | 0.086 | H | -68.7 | -39.5 | 16.0 | 0.086 | 0.0 |
HOH |
3.816 |
SD |
O |
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1irk | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
1995-02-27 | MET | A:132 | A:1109 | 10.0 | 0.054 | H | -62.0 | -45.9 | 10.0 | 0.054 | 0.0 |
EMC HOH |
3.068 4.791 |
SD N |
C2 O |
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3eta | 1 | P06213 | 100.0 | 0.0 |
X-RAY |
2009-05-26 | MET | A:131 | A:1109 | 23.0 | 0.124 | H | -67.4 | -42.9 | 23.0 | 0.124 | 0.0 |
HOH |
3.735 |
CE |
O |
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MET | B:131 | B:1109 | 32.0 | 0.173 | H | -62.0 | -46.2 | NA | NA | NA | |||||||||||||
5hhw | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2016-04-13 | MET | A:133 | A:1136 | 19.0 | 0.103 | H | -67.4 | -42.4 | 19.0 | 0.103 | 0.0 |
EDO HOH |
9.963 3.351 |
CE CE |
O1 O |
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5e1s | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2015-10-14 | MET | A:134 | A:1109 | 22.0 | 0.119 | H | -64.5 | -45.9 | 22.0 | 0.119 | 0.0 |
HOH |
4.746 |
N |
O |
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1rqq | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2003-12-30 | MET | A:132 | A:1109 | 21.0 | 0.114 | H | -70.9 | -43.9 | 21.0 | 0.114 | 0.0 |
HOH |
7.008 |
N |
O |
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MET | B:132 | B:1109 | 27.0 | 0.146 | H | -69.2 | -45.7 | 27.0 | 0.146 | 0.0 |
HOH |
8.685 |
CE |
O |
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2auh | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-01 | MET | A:132 | A:1109 | 15.0 | 0.081 | H | -63.3 | -59.9 | 15.0 | 0.081 | 0.0 | ||||||
2b4s | 2 | P06213 | 99.35 | 0.0 |
X-RAY |
2005-11-15 | MET | B:132 | B:1109 | 23.0 | 0.124 | H | -70.0 | -43.7 | 23.0 | 0.124 | 0.0 |
SO4 HOH |
8.185 4.583 |
CE N |
O3 O |
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MET | D:132 | D:1109 | 21.0 | 0.114 | H | -60.1 | -45.9 | 21.0 | 0.114 | 0.0 |
HOH |
6.796 |
N |
O |
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3bu3 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:132 | A:1109 | 25.0 | 0.135 | H | -64.4 | -40.4 | 25.0 | 0.135 | 0.0 |
HOH |
3.063 |
CE |
O |
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3bu5 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:132 | A:1109 | 21.0 | 0.114 | H | -59.7 | -42.0 | 21.0 | 0.114 | 0.0 |
HOH |
2.718 |
CE |
O |
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3bu6 | 1 | P06213 | 99.35 | 0.0 |
X-RAY |
2008-02-19 | MET | A:132 | A:1109 | 22.0 | 0.119 | H | -60.3 | -43.5 | 22.0 | 0.119 | 0.0 |
HOH |
3.083 |
CE |
O |
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1p14 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2003-07-22 | MET | A:132 | A:1109 | 20.0 | 0.108 | H | -67.6 | -39.8 | 20.0 | 0.108 | 0.0 |
HOH |
3.135 |
CE |
O |
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1i44 | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2001-03-07 | MET | A:132 | A:1109 | 25.0 | 0.135 | H | -68.7 | -37.7 | 25.0 | 0.135 | 0.0 |
HOH |
4.587 |
N |
O |
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3ekk | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-23 | MET | A:133 | A:1109 | 22.0 | 0.119 | H | -65.5 | -40.5 | 22.0 | 0.119 | 0.0 |
HOH |
3.475 |
CE |
O |
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3ekn | 1 | P06213 | 99.02 | 0.0 |
X-RAY |
2008-12-30 | MET | A:133 | A:1109 | 19.0 | 0.103 | H | -64.0 | -43.9 | 19.0 | 0.103 | 0.0 |
HOH |
3.392 |
CE |
O |
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2z8c | 1 | P06213 | 99.67 | 0.0 |
X-RAY |
2008-08-12 | MET | A:129 | A:1109 | 24.0 | 0.13 | H | -59.6 | -50.5 | 24.0 | 0.13 | 0.0 | ||||||
2oj9 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2007-05-01 | MET | A:133 | A:1082 | 18.0 | 0.097 | H | -69.4 | -35.8 | 18.0 | 0.097 | 0.0 |
HOH |
3.827 |
CE |
O |
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3nw5 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:133 | A:1082 | 16.0 | 0.086 | H | -68.7 | -38.1 | 16.0 | 0.086 | 0.0 |
HOH |
4.148 |
SD |
O |
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3nw6 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:133 | A:1082 | 16.0 | 0.086 | H | -65.8 | -41.7 | 16.0 | 0.086 | 0.0 |
HOH |
4.351 |
CE |
O |
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3nw7 | 1 | P08069 | 80.07 | 6e-177 |
X-RAY |
2010-07-28 | MET | A:133 | A:1082 | 16.0 | 0.086 | H | -66.8 | -38.1 | 16.0 | 0.086 | 0.0 |
HOH |
4.026 |
SD |
O |
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3i81 | 1 | P08069 | 80.07 | 7e-177 |
X-RAY |
2009-12-22 | MET | A:133 | A:1082 | 15.0 | 0.081 | H | -70.9 | -40.5 | 15.0 | 0.081 | 0.0 |
HOH |
3.669 |
SD |
O |
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3d94 | 1 | P08069 | 81.06 | 1e-176 |
X-RAY |
2008-07-29 | MET | A:127 | A:1082 | 18.0 | 0.097 | H | -57.6 | -44.8 | 18.0 | 0.097 | 0.0 |
HOH |
4.952 |
N |
O |
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1jqh | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2002-04-19 | MET | A:134 | A:1112 | 12.0 | 0.065 | H | -61.0 | -41.8 | 12.0 | 0.065 | 0.0 |
HOH |
4.698 |
N |
O |
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MET | B:134 | B:1112 | 3.0 | 0.016 | H | -60.0 | -42.8 | NA | NA | NA | |||||||||||||
MET | C:134 | C:1112 | 13.0 | 0.07 | H | -60.9 | -42.2 | NA | NA | NA | |||||||||||||
2zm3 | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-06-10 | MET | A:134 | A:1112 | 13.0 | 0.07 | H | -65.5 | -36.7 | 13.0 | 0.07 | 0.0 |
HOH |
6.390 |
N |
O |
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MET | B:134 | B:1112 | 1.0 | 0.005 | H | -63.7 | -44.3 | NA | NA | NA | |||||||||||||
MET | C:134 | C:1112 | 18.0 | 0.097 | H | -70.8 | -33.0 | NA | NA | NA | |||||||||||||
MET | D:134 | D:1112 | 6.0 | 0.032 | H | -66.3 | -36.5 | NA | NA | NA | |||||||||||||
3f5p | 1 | P08069 | 80.53 | 1e-176 |
X-RAY |
2008-12-30 | MET | A:134 | A:1112 | 1.0 | 0.005 | H | -67.6 | -46.2 | 1.0 | 0.005 | 0.0 |
HOH |
7.642 |
N |
O |
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MET | B:134 | B:1112 | 1.0 | 0.005 | H | -59.2 | -50.8 | NA | NA | NA | |||||||||||||
MET | C:134 | C:1112 | 1.0 | 0.005 | H | -66.8 | -48.3 | NA | NA | NA | |||||||||||||
MET | D:134 | D:1112 | 2.0 | 0.011 | H | -71.0 | -54.5 | NA | NA | NA | |||||||||||||
MET | E:134 | E:1112 | 1.0 | 0.005 | H | -66.4 | -41.4 | NA | NA | NA | |||||||||||||
MET | F:134 | F:1112 | 1.0 | 0.005 | H | -68.7 | -55.8 | NA | NA | NA | |||||||||||||
MET | G:134 | G:1112 | 1.0 | 0.005 | H | -64.9 | -44.7 | NA | NA | NA | |||||||||||||
MET | H:134 | H:1112 | 1.0 | 0.005 | H | -64.6 | -47.2 | NA | NA | NA | |||||||||||||
MET | I:134 | I:1112 | 8.0 | 0.043 | H | -64.4 | -44.1 | NA | NA | NA | |||||||||||||
MET | J:134 | J:1112 | 12.0 | 0.065 | H | -65.7 | -39.5 | NA | NA | NA | |||||||||||||
MET | K:134 | K:1112 | 9.0 | 0.049 | H | -72.4 | -49.9 | NA | NA | NA | |||||||||||||
MET | L:134 | M:1112 | 9.0 | 0.049 | H | -67.3 | -54.0 | NA | NA | NA | |||||||||||||
MET | M:134 | L:1112 | 10.0 | 0.054 | H | -61.7 | -48.0 | NA | NA | NA | |||||||||||||
MET | N:134 | R:1112 | 11.0 | 0.059 | H | -75.4 | -42.4 | NA | NA | NA | |||||||||||||
MET | O:134 | S:1112 | 8.0 | 0.043 | H | -62.8 | -52.1 | NA | NA | NA | |||||||||||||
MET | P:134 | T:1112 | 6.0 | 0.032 | H | -62.0 | -47.9 | NA | NA | NA | |||||||||||||
4d2r | 1 | P08069 | 81.06 | 2e-176 |
X-RAY |
2015-04-22 | MET | A:128 | A:1112 | 14.0 | 0.076 | H | -68.4 | -40.2 | 14.0 | 0.076 | 0.0 |
HOH |
3.540 |
CE |
O |
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1k3a | 1 | P08069 | 80.94 | 4e-175 |
X-RAY |
2001-11-28 | MET | A:125 | A:1082 | 17.0 | 0.092 | H | -66.1 | -42.2 | 17.0 | 0.092 | 0.0 |
HOH |
4.606 |
N |
O |
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3qqu | 1 | P08069 | 80.94 | 6e-175 |
X-RAY |
2011-04-20 | MET | A:127 | A:1109 | 16.0 | 0.086 | H | -73.1 | -36.3 | 16.0 | 0.086 | 0.0 |
HOH |
2.705 |
CE |
O |
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MET | B:127 | B:1109 | 12.0 | 0.065 | H | -70.4 | -54.5 | NA | NA | NA | |||||||||||||
MET | C:127 | C:1109 | 13.0 | 0.07 | H | -69.0 | -47.2 | NA | NA | NA | |||||||||||||
MET | D:127 | D:1109 | 9.0 | 0.049 | H | -74.6 | -56.2 | NA | NA | NA |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
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ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-p06213-f1 | 1 | P06213 | 100.0 | 0.0 | MET | A:1136 | A:1136 | 21.0 | 0.114 | H | -63.0 | -43.2 |