Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7122913 . G A CCDS12176.1:NM_000208.2:c.3346Cgt>Tgt_NP_000199.2:p.1116R>C Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1089 NA:NA DO NA DO DO DO NA NA NA
ARG B:1089 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1089 NA:NA DO NA DO DO DO NA NA NA
ARG B:1089 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1089 NA:NA DO NA DO DO DO NA NA NA
ARG B:1089 NA:NA DO NA DO DO DO NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1104 NA:NA DO NA DO DO DO NA NA NA
ARG B:1104 NA:NA DO NA DO DO DO NA NA NA
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1104 NA:NA DO NA DO DO DO NA NA NA
ARG B:1104 NA:NA DO NA DO DO DO NA NA NA
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1104 NA:NA DO NA DO DO DO NA NA NA
ARG B:1104 NA:NA DO NA DO DO DO NA NA NA
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1104 NA:NA DO NA DO DO DO NA NA NA
ARG B:1104 NA:NA DO NA DO DO DO NA NA NA
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:1077 NA:NA DO NA DO DO DO NA NA NA
ARG B:1077 NA:NA DO NA DO DO DO NA NA NA
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:1077 NA:NA DO NA DO DO DO NA NA NA
ARG B:1077 NA:NA DO NA DO DO DO NA NA NA
4xlv 1 P06213 99.09 0.0 X-RAY
 2015-03-25 ARG A:134 A:1089 93.0 0.413 H -57.3 -35.0 93.0 0.413 0.0 HOH
 2.999
 O
 O
4ibm 1 P06213 99.67 0.0 X-RAY
 2013-08-21 ARG A:112 A:1089 69.0 0.307 H -64.3 -33.2 69.0 0.307 0.0 HOH
 2.747
 NH1
 O
ARG B:112 B:1089 68.0 0.302 H -60.1 -31.4 NA NA NA
1gag 1 P06213 99.35 0.0 X-RAY
 2001-01-17 ARG A:112 A:1089 99.0 0.44 H -62.1 -33.8 99.0 0.44 0.0 HOH
 7.716
 O
 O
1ir3 1 P06213 99.35 0.0 X-RAY
 1998-01-07 ARG A:112 A:1089 92.0 0.409 H -62.1 -33.9 92.0 0.409 0.0 HOH
 2.886
 O
 O
1irk 1 P06213 99.35 0.0 X-RAY
 1995-02-27 ARG A:112 A:1089 68.0 0.302 H -60.9 -31.3 68.0 0.302 0.0 HOH
 2.792
 O
 O
3eta 1 P06213 100.0 0.0 X-RAY
 2009-05-26 ARG A:111 A:1089 72.0 0.32 H -63.4 -29.0 72.0 0.32 0.0 HOH
 3.039
 O
 O
ARG B:111 B:1089 66.0 0.293 H -69.2 -29.5 NA NA NA
5hhw 1 P06213 99.35 0.0 X-RAY
 2016-04-13 ARG A:113 A:1116 95.0 0.422 H -62.4 -31.1 95.0 0.422 0.0 60O
HOH
 9.987
2.727
 NH1
O
 C26
O
5e1s 1 P06213 99.35 0.0 X-RAY
 2015-10-14 ARG A:114 A:1089 104.0 0.462 H -64.8 -34.1 104.0 0.462 0.0 5JA
HOH
 8.198
3.748
 C
NH2
 O38
O
1rqq 1 P06213 99.35 0.0 X-RAY
 2003-12-30 ARG A:112 A:1089 91.0 0.404 H -68.9 -28.2 91.0 0.404 0.0 112
HOH
 9.942
4.019
 NH1
NH2
 O3G
O
ARG B:112 B:1089 96.0 0.427 H -67.9 -31.1 96.0 0.427 0.0 HOH
 4.119
 CB
 O
2auh 1 P06213 99.35 0.0 X-RAY
 2005-11-01 ARG A:112 A:1089 88.0 0.391 H -46.7 -21.8 56.0 0.249 0.142 B:Q14449:0.142
2b4s 2 P06213 99.35 0.0 X-RAY
 2005-11-15 ARG B:112 B:1089 86.0 0.382 H -63.9 -36.2 86.0 0.382 0.0 HOH
 3.325
 NH2
 O
ARG D:112 D:1089 95.0 0.422 H -65.3 -36.0 95.0 0.422 0.0 HOH
 4.523
 NH2
 O
3bu3 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:112 A:1089 93.0 0.413 H -66.1 -32.3 66.0 0.293 0.12 B:P81122:0.12
 HOH
 2.625
 O
 O
3bu5 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:112 A:1089 90.0 0.4 H -64.3 -32.6 63.0 0.28 0.12 B:P81122:0.12
 HOH
 2.624
 O
 O
3bu6 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:112 A:1089 88.0 0.391 H -62.8 -31.9 71.0 0.316 0.075 B:P81122:0.076
 HOH
 2.588
 O
 O
1p14 1 P06213 99.02 0.0 X-RAY
 2003-07-22 ARG A:112 A:1089 87.0 0.387 H -63.5 -19.9 87.0 0.387 0.0 HOH
 3.956
 CB
 O
1i44 1 P06213 99.02 0.0 X-RAY
 2001-03-07 ARG A:112 A:1089 101.0 0.449 H -69.2 -17.7 101.0 0.449 0.0 HOH
 2.468
 NH1
 O
3ekk 1 P06213 99.02 0.0 X-RAY
 2008-12-23 ARG A:113 A:1089 102.0 0.453 H -62.1 -25.9 102.0 0.453 0.0 GS2
HOH
 9.116
3.776
 CD
CD
 C23
O
3ekn 1 P06213 99.02 0.0 X-RAY
 2008-12-30 ARG A:113 A:1089 90.0 0.4 H -64.3 -31.1 90.0 0.4 0.0 GS3
HOH
 8.273
3.446
 CB
NH1
 C26
O
2z8c 1 P06213 99.67 0.0 X-RAY
 2008-08-12 ARG A:109 A:1089 97.0 0.431 H -51.4 -41.7 97.0 0.431 0.0 S91
 9.822
 CD
 O2
2oj9 1 P08069 80.07 6e-177 X-RAY
 2007-05-01 ARG A:113 A:1062 81.0 0.36 H -63.0 -30.1 81.0 0.36 0.0 HOH
 3.624
 NH2
 O
3nw5 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:113 A:1062 90.0 0.4 H -65.9 -26.9 90.0 0.4 0.0 LGX
HOH
 8.809
3.079
 NH1
NH1
 F32
O
3nw6 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:113 A:1062 74.0 0.329 H -69.9 -28.8 74.0 0.329 0.0 HOH
 3.156
 NH1
 O
3nw7 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:113 A:1062 78.0 0.347 H -61.3 -34.3 78.0 0.347 0.0 HOH
 4.146
 NH2
 O
3i81 1 P08069 80.07 7e-177 X-RAY
 2009-12-22 ARG A:113 A:1062 83.0 0.369 H -70.9 -25.6 83.0 0.369 0.0 HOH
 3.324
 O
 O
3d94 1 P08069 81.06 1e-176 X-RAY
 2008-07-29 ARG A:107 A:1062 111.0 0.493 H -56.7 -35.6 111.0 0.493 0.0 D94
HOH
 9.998
3.690
 CG
NH1
 C28
O
1jqh 1 P08069 80.53 1e-176 X-RAY
 2002-04-19 ARG A:114 A:1092 118.0 0.524 H -62.2 -25.7 118.0 0.524 0.0 HOH
 7.713
 O
 O
ARG B:114 B:1092 107.0 0.476 H -63.0 -27.5 NA NA NA
ARG C:114 C:1092 110.0 0.489 H -63.7 -31.0 NA NA NA
2zm3 1 P08069 80.53 1e-176 X-RAY
 2008-06-10 ARG A:114 A:1092 110.0 0.489 H -66.5 -35.1 110.0 0.489 0.0 575
HOH
 9.485
3.886
 C
O
 C9
O
ARG B:114 B:1092 108.0 0.48 H -75.1 -27.3 NA NA NA
ARG C:114 C:1092 113.0 0.502 H -71.0 -26.7 NA NA NA
ARG D:114 D:1092 99.0 0.44 H -61.0 -37.5 NA NA NA
3f5p 1 P08069 80.53 1e-176 X-RAY
 2008-12-30 ARG A:114 A:1092 99.0 0.44 H -65.8 -26.7 99.0 0.44 0.0
ARG B:114 B:1092 106.0 0.471 H -55.3 -41.1 NA NA NA
ARG C:114 C:1092 110.0 0.489 H -59.9 -35.0 NA NA NA
ARG D:114 D:1092 114.0 0.507 H -72.0 -30.0 NA NA NA
ARG E:114 E:1092 120.0 0.533 H -83.1 -24.5 NA NA NA
ARG F:114 F:1092 115.0 0.511 H -67.6 -30.5 NA NA NA
ARG G:114 G:1092 110.0 0.489 H -70.6 -33.2 NA NA NA
ARG H:114 H:1092 108.0 0.48 H -72.2 -42.4 NA NA NA
ARG I:114 I:1092 116.0 0.516 H -56.4 -46.6 NA NA NA
ARG J:114 J:1092 99.0 0.44 H -74.3 -39.3 NA NA NA
ARG K:114 K:1092 131.0 0.582 H -64.0 -25.5 NA NA NA
ARG L:114 M:1092 104.0 0.462 H -58.7 -31.2 NA NA NA
ARG M:114 L:1092 108.0 0.48 H -70.7 -30.2 NA NA NA
ARG N:114 R:1092 107.0 0.476 H -63.9 -28.1 NA NA NA
ARG O:114 S:1092 102.0 0.453 H -67.7 -30.5 NA NA NA
ARG P:114 T:1092 108.0 0.48 H -61.6 -34.8 NA NA NA
4d2r 1 P08069 81.06 2e-176 X-RAY
 2015-04-22 ARG A:108 A:1092 73.0 0.324 H -63.3 -29.1 73.0 0.324 0.0 HOH
 2.878
 NH1
 O
1k3a 1 P08069 80.94 4e-175 X-RAY
 2001-11-28 ARG A:105 A:1062 102.0 0.453 H -59.9 -41.3 102.0 0.453 0.0 HOH
 4.055
 CG
 O
3qqu 1 P08069 80.94 6e-175 X-RAY
 2011-04-20 ARG A:107 A:1089 81.0 0.36 H -71.2 -13.9 81.0 0.36 0.0 HOH
 3.088
 NH1
 O
ARG B:107 B:1089 72.0 0.32 H -53.7 -45.2 NA NA NA
ARG C:107 C:1089 66.0 0.293 H -49.9 -23.6 NA NA NA
ARG D:107 D:1089 74.0 0.329 H -46.7 -32.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 ARG A:1116 A:1116 98.0 0.436 H -62.7 -33.7