Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr19 7125349 . C A CCDS12176.1:NM_000208.2:c.3203cGg>cTg_NP_000199.2:p.1068R>L Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7bw7 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1041 NA:NA DO NA DO DO DO NA NA NA
ARG B:1041 NA:NA DO NA DO DO DO NA NA NA
7bw8 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1041 NA:NA DO NA DO DO DO NA NA NA
ARG B:1041 NA:NA DO NA DO DO DO NA NA NA
7bwa 1 P06213 100.0 0.0 EM
 2021-04-14 ARG A:1041 NA:NA DO NA DO DO DO NA NA NA
ARG B:1041 NA:NA DO NA DO DO DO NA NA NA
7pg0 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1056 NA:NA DO NA DO DO DO NA NA NA
ARG B:1056 NA:NA DO NA DO DO DO NA NA NA
7pg2 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1056 NA:NA DO NA DO DO DO NA NA NA
ARG B:1056 NA:NA DO NA DO DO DO NA NA NA
7pg3 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1056 NA:NA DO NA DO DO DO NA NA NA
ARG B:1056 NA:NA DO NA DO DO DO NA NA NA
7pg4 1 P06213 99.13 0.0 EM
 2022-02-02 ARG A:1056 NA:NA DO NA DO DO DO NA NA NA
ARG B:1056 NA:NA DO NA DO DO DO NA NA NA
6pxv 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:1029 NA:NA DO NA DO DO DO NA NA NA
ARG B:1029 NA:NA DO NA DO DO DO NA NA NA
6pxw 1 P06213 98.6 0.0 EM
 2019-09-04 ARG A:1029 NA:NA DO NA DO DO DO NA NA NA
ARG B:1029 NA:NA DO NA DO DO DO NA NA NA
4xlv 1 P06213 99.09 0.0 X-RAY
 2015-03-25 ARG A:86 A:1041 111.0 0.493 H -66.9 -39.0 21.0 0.093 0.4 A:P06213:0.4
 ACP
HOH
 9.310
2.734
 N
O
 O3G
O
4ibm 1 P06213 99.67 0.0 X-RAY
 2013-08-21 ARG A:64 A:1041 42.0 0.187 H -63.5 -40.2 42.0 0.187 0.0 HOH
 2.780
 NH2
 O
ARG B:64 B:1041 100.0 0.444 H -64.6 -37.6 NA NA NA
1gag 1 P06213 99.35 0.0 X-RAY
 2001-01-17 ARG A:64 A:1041 106.0 0.471 H -65.4 -31.2 106.0 0.471 0.0 MG
HOH
 9.683
7.993
 N
N
 MG
O
1ir3 1 P06213 99.35 0.0 X-RAY
 1998-01-07 ARG A:64 A:1041 106.0 0.471 H -70.4 -36.7 67.0 0.298 0.173 A:P06213:0.173
 HOH
 2.955
 O
 O
1irk 1 P06213 99.35 0.0 X-RAY
 1995-02-27 ARG A:64 A:1041 50.0 0.222 H -69.8 -39.2 50.0 0.222 0.0 HOH
 2.776
 O
 O
3eta 1 P06213 100.0 0.0 X-RAY
 2009-05-26 ARG A:63 A:1041 105.0 0.467 H -60.4 -43.0 105.0 0.467 0.0 HOH
 3.508
 NH1
 O
ARG B:63 B:1041 106.0 0.471 H -60.3 -44.2 NA NA NA
5hhw 1 P06213 99.35 0.0 X-RAY
 2016-04-13 ARG A:65 A:1068 56.0 0.249 H -63.7 -41.4 56.0 0.249 0.0 60O
HOH
 8.526
2.798
 O
O
 C31
O
5e1s 1 P06213 99.35 0.0 X-RAY
 2015-10-14 ARG A:66 A:1041 66.0 0.293 H -69.2 -39.6 66.0 0.293 0.0 HOH
 4.691
 CB
 O
1rqq 1 P06213 99.35 0.0 X-RAY
 2003-12-30 ARG A:64 A:1041 98.0 0.436 H -67.4 -40.8 98.0 0.436 0.0 HOH
 6.198
 C
 O
ARG B:64 B:1041 91.0 0.404 H -66.8 -42.4 91.0 0.404 0.0
2auh 1 P06213 99.35 0.0 X-RAY
 2005-11-01 ARG A:64 A:1041 90.0 0.4 H -47.7 -60.2 90.0 0.4 0.0 CA
 7.647
 O
 CA
2b4s 2 P06213 99.35 0.0 X-RAY
 2005-11-15 ARG B:64 B:1041 90.0 0.4 H -62.3 -43.3 15.0 0.067 0.333 D:P06213:0.333
 HOH
 3.032
 NH1
 O
ARG D:64 D:1041 93.0 0.413 H -63.2 -36.2 17.0 0.076 0.337 B:P06213:0.338
 HOH
 3.141
 CZ
 O
3bu3 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:64 A:1041 125.0 0.556 H -62.7 -42.1 125.0 0.556 0.0 HOH
 2.821
 NH2
 O
3bu5 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:64 A:1041 122.0 0.542 H -59.9 -40.2 122.0 0.542 0.0 ATP
HOH
 9.734
2.642
 N
NH2
 O2G
O
3bu6 1 P06213 99.35 0.0 X-RAY
 2008-02-19 ARG A:64 A:1041 148.0 0.658 H -63.0 -45.9 148.0 0.658 0.0 HOH
 7.042
 N
 O
1p14 1 P06213 99.02 0.0 X-RAY
 2003-07-22 ARG A:64 A:1041 63.0 0.28 H -65.4 -35.7 63.0 0.28 0.0 HOH
 4.931
 NH1
 O
1i44 1 P06213 99.02 0.0 X-RAY
 2001-03-07 ARG A:64 A:1041 56.0 0.249 H -63.2 -33.0 56.0 0.249 0.0 HOH
 7.942
 O
 O
3ekk 1 P06213 99.02 0.0 X-RAY
 2008-12-23 ARG A:65 A:1041 59.0 0.262 H -65.2 -43.8 59.0 0.262 0.0 HOH
 2.665
 O
 O
3ekn 1 P06213 99.02 0.0 X-RAY
 2008-12-30 ARG A:65 A:1041 72.0 0.32 H -57.3 -43.7 72.0 0.32 0.0 HOH
 2.571
 O
 O
2z8c 1 P06213 99.67 0.0 X-RAY
 2008-08-12 ARG A:61 A:1041 91.0 0.404 H -45.9 -43.1 91.0 0.404 0.0
2oj9 1 P08069 80.07 6e-177 X-RAY
 2007-05-01 ARG A:65 A:1014 32.0 0.142 H -74.2 -37.3 32.0 0.142 0.0 HOH
 6.740
 CG
 O
3nw5 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:65 A:1014 25.0 0.111 H -65.3 -44.1 25.0 0.111 0.0 HOH
 2.707
 NH2
 O
3nw6 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:65 A:1014 25.0 0.111 H -69.4 -45.8 25.0 0.111 0.0 HOH
 2.667
 NH2
 O
3nw7 1 P08069 80.07 6e-177 X-RAY
 2010-07-28 ARG A:65 A:1014 29.0 0.129 H -57.8 -45.8 29.0 0.129 0.0 HOH
 2.770
 NH1
 O
3i81 1 P08069 80.07 7e-177 X-RAY
 2009-12-22 ARG A:65 A:1014 15.0 0.067 H -66.8 -43.6 15.0 0.067 0.0 HOH
 3.973
 CD
 O
3d94 1 P08069 81.06 1e-176 X-RAY
 2008-07-29 ARG A:59 A:1014 22.0 0.098 H -61.6 -39.7 22.0 0.098 0.0 CA
D94
HOH
 8.389
8.431
2.734
 N
O
NH1
 CA
C19
O
1jqh 1 P08069 80.53 1e-176 X-RAY
 2002-04-19 ARG A:66 A:1044 42.0 0.187 H -56.6 -34.3 42.0 0.187 0.0 HOH
 4.577
 NH2
 O
ARG B:66 B:1044 43.0 0.191 H -58.0 -34.0 NA NA NA
ARG C:66 C:1044 43.0 0.191 H -57.5 -34.2 NA NA NA
2zm3 1 P08069 80.53 1e-176 X-RAY
 2008-06-10 ARG A:66 A:1044 12.0 0.053 H -65.9 -41.3 12.0 0.053 0.0 HOH
 3.321
 CD
 O
ARG B:66 B:1044 16.0 0.071 H -68.5 -41.4 NA NA NA
ARG C:66 C:1044 31.0 0.138 H -65.8 -43.0 NA NA NA
ARG D:66 D:1044 20.0 0.089 H -63.7 -44.5 NA NA NA
3f5p 1 P08069 80.53 1e-176 X-RAY
 2008-12-30 ARG A:66 A:1044 22.0 0.098 H -63.9 -52.2 22.0 0.098 0.0 741
 9.189
 O
 C28
ARG B:66 B:1044 21.0 0.093 H -63.5 -48.9 NA NA NA
ARG C:66 C:1044 22.0 0.098 H -68.0 -28.5 NA NA NA
ARG D:66 D:1044 23.0 0.102 H -60.7 -40.1 NA NA NA
ARG E:66 E:1044 24.0 0.107 H -78.2 -22.6 NA NA NA
ARG F:66 F:1044 24.0 0.107 H -77.6 -32.6 NA NA NA
ARG G:66 G:1044 18.0 0.08 H -69.2 -31.3 NA NA NA
ARG H:66 H:1044 25.0 0.111 H -66.4 -34.9 NA NA NA
ARG I:66 I:1044 21.0 0.093 H -70.8 -28.7 NA NA NA
ARG J:66 J:1044 19.0 0.084 H -71.3 -32.1 NA NA NA
ARG K:66 K:1044 22.0 0.098 H -66.7 -35.4 NA NA NA
ARG L:66 M:1044 21.0 0.093 H -69.1 -28.4 NA NA NA
ARG M:66 L:1044 17.0 0.076 H -57.6 -46.2 NA NA NA
ARG N:66 R:1044 24.0 0.107 H -84.6 -34.0 NA NA NA
ARG O:66 S:1044 19.0 0.084 H -78.1 -26.0 NA NA NA
ARG P:66 T:1044 18.0 0.08 H -57.7 -47.1 NA NA NA
4d2r 1 P08069 81.06 2e-176 X-RAY
 2015-04-22 ARG A:60 A:1044 22.0 0.098 H -69.3 -23.4 22.0 0.098 0.0 HOH
 4.276
 CD
 O
1k3a 1 P08069 80.94 4e-175 X-RAY
 2001-11-28 ARG A:57 A:1014 82.0 0.364 H -60.1 -38.1 82.0 0.364 0.0 HOH
 4.405
 NH2
 O
3qqu 1 P08069 80.94 6e-175 X-RAY
 2011-04-20 ARG A:59 A:1041 66.0 0.293 H -80.1 -7.6 66.0 0.293 0.0 HOH
 8.309
 O
 O
ARG B:59 B:1041 70.0 0.311 H -62.6 -27.5 NA NA NA
ARG C:59 C:1041 40.0 0.178 H -70.3 -33.4 NA NA NA
ARG D:59 D:1041 72.0 0.32 H -72.9 -23.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06213-f1 1 P06213 100.0 0.0 ARG A:1068 A:1068 50.0 0.222 H -70.9 -39.1